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Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study.

Identifieur interne : 000134 ( PubMed/Corpus ); précédent : 000133; suivant : 000135

Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study.

Auteurs : Kathleen Gali ; Heike Spaderna ; Jacqueline M A. Smits ; Katrina A. Bramstedt ; Gerdi Weidner

Source :

RBID : pubmed:27207399

English descriptors

Abstract

We examined the association of smoking status at time of listing with waitlist mortality among heart transplant (HTx) candidates.

DOI: 10.1177/1526924816640687
PubMed: 27207399

Links to Exploration step

pubmed:27207399

Le document en format XML

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<title xml:lang="en">Smoking Status at Time of Listing for a Heart Transplant Predicts Mortality on the Waiting List: A Multicenter Prospective Observational Study.</title>
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<name sortKey="Gali, Kathleen" sort="Gali, Kathleen" uniqKey="Gali K" first="Kathleen" last="Gali">Kathleen Gali</name>
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<nlm:affiliation>Department of Public Health, University of California, Merced, CA, USA.</nlm:affiliation>
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<name sortKey="Spaderna, Heike" sort="Spaderna, Heike" uniqKey="Spaderna H" first="Heike" last="Spaderna">Heike Spaderna</name>
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<nlm:affiliation>Department of Health Psychology, Trier University, Trier, Germany.</nlm:affiliation>
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<name sortKey="Smits, Jacqueline M A" sort="Smits, Jacqueline M A" uniqKey="Smits J" first="Jacqueline M A" last="Smits">Jacqueline M A. Smits</name>
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<nlm:affiliation>Eurotransplant International Foundation, Leiden, the Netherlands.</nlm:affiliation>
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<name sortKey="Bramstedt, Katrina A" sort="Bramstedt, Katrina A" uniqKey="Bramstedt K" first="Katrina A" last="Bramstedt">Katrina A. Bramstedt</name>
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<term>Heart Failure (surgery)</term>
<term>Heart Transplantation</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Proportional Hazards Models</term>
<term>Prospective Studies</term>
<term>Smoking (epidemiology)</term>
<term>Smoking Cessation (statistics & numerical data)</term>
<term>Time Factors</term>
<term>Waiting Lists (mortality)</term>
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<term>Smoking</term>
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<term>Heart Failure</term>
<term>Waiting Lists</term>
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<term>Male</term>
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<div type="abstract" xml:lang="en">We examined the association of smoking status at time of listing with waitlist mortality among heart transplant (HTx) candidates.</div>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We examined the association of smoking status at time of listing with waitlist mortality among heart transplant (HTx) candidates.</AbstractText>
<AbstractText Label="PARTICIPANTS AND DESIGN" NlmCategory="METHODS">Data were analyzed from 316 participants (aged 53 ± 11; 18% female) of the Waiting for a New Heart Study, a prospective observational study of patients newly listed for HTx at 17 hospitals.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the study period (April 2005 to March 2010), 14% of those who never smoked died, 18% among former smokers died, and almost half (42%) died among those who reported smoking at time of wait listing. Multivariate Cox regression models controlling for age, sex, and disease severity revealed smoking at time of listing was associated with significantly higher risk of mortality compared to never smoking (hazard ratio [HR] = 3.43; P = .03). The relationship between smoking and mortality risk appeared to follow a dose-dependent pattern: adjusted HRs were 1.80 for those who quit ≤1 year ago, 1.25 for those who quit >1 to 10 years ago, and 0.90 for those quit >10 years ago, compared to never smokers. Smoking at time of listing may increase risk of mortality during the waiting period, indicating the need for improved strategies to achieve smoking cessation as early as possible in the course of HTx.</AbstractText>
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