Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic.
Identifieur interne : 000121 ( PubMed/Corpus ); précédent : 000120; suivant : 000122Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic.
Auteurs : André Schulz ; Jan Hendrik Matthey ; Claus Vögele ; Violetta Schaan ; Hartmut Sch Chinger ; Julia Adler ; Manfred E. Beutel ; Matthias MichalSource :
- Psychiatry research [ 1872-7123 ] ; 2016.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adult, Baroreflex (physiology), Brain (physiopathology), Brain Stem (physiopathology), Depersonalization (physiopathology), Evoked Potentials (physiology), Female, Heart (physiopathology), Heart Rate (physiology), Humans, Male, Reflex, Startle (physiology), Visceral Afferents (physiopathology).
- MESH :
- physiology : Baroreflex, Evoked Potentials, Heart Rate, Reflex, Startle.
- physiopathology : Brain, Brain Stem, Depersonalization, Heart, Visceral Afferents.
- Acoustic Stimulation, Adult, Female, Humans, Male.
Abstract
Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105dB(A), 50ms) elicited 0, 100, 200, 300, 400 and 500ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300ms than at 0 and 400ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.
DOI: 10.1016/j.psychres.2016.03.051
PubMed: 27078753
Links to Exploration step
pubmed:27078753Le document en format XML
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Electronic address: andre.schulz@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Matthey, Jan Hendrik" sort="Matthey, Jan Hendrik" uniqKey="Matthey J" first="Jan Hendrik" last="Matthey">Jan Hendrik Matthey</name><affiliation><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: mattjanh@students.uni-mainz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Vogele, Claus" sort="Vogele, Claus" uniqKey="Vogele C" first="Claus" last="Vögele">Claus Vögele</name><affiliation><nlm:affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: claus.voegele@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Schaan, Violetta" sort="Schaan, Violetta" uniqKey="Schaan V" first="Violetta" last="Schaan">Violetta Schaan</name><affiliation><nlm:affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: violetta.schaan@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation><nlm:affiliation>Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. 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Electronic address: andre.schulz@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Matthey, Jan Hendrik" sort="Matthey, Jan Hendrik" uniqKey="Matthey J" first="Jan Hendrik" last="Matthey">Jan Hendrik Matthey</name><affiliation><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: mattjanh@students.uni-mainz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Vogele, Claus" sort="Vogele, Claus" uniqKey="Vogele C" first="Claus" last="Vögele">Claus Vögele</name><affiliation><nlm:affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: claus.voegele@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Schaan, Violetta" sort="Schaan, Violetta" uniqKey="Schaan V" first="Violetta" last="Schaan">Violetta Schaan</name><affiliation><nlm:affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: violetta.schaan@uni.lu.</nlm:affiliation></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation><nlm:affiliation>Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. Electronic address: schaechi@uni-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Adler, Julia" sort="Adler, Julia" uniqKey="Adler J" first="Julia" last="Adler">Julia Adler</name><affiliation><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: julia.adler@uni-mainz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Beutel, Manfred E" sort="Beutel, Manfred E" uniqKey="Beutel M" first="Manfred E" last="Beutel">Manfred E. Beutel</name><affiliation><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: manfred.beutel@unimedizin-mainz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Michal, Matthias" sort="Michal, Matthias" uniqKey="Michal M" first="Matthias" last="Michal">Matthias Michal</name><affiliation><nlm:affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: matthias.michal@unimedizin-mainz.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Baroreflex (physiology)</term><term>Brain (physiopathology)</term><term>Brain Stem (physiopathology)</term><term>Depersonalization (physiopathology)</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Heart (physiopathology)</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Male</term><term>Reflex, Startle (physiology)</term><term>Visceral Afferents (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Baroreflex</term><term>Evoked Potentials</term><term>Heart Rate</term><term>Reflex, Startle</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Brain Stem</term><term>Depersonalization</term><term>Heart</term><term>Visceral Afferents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105dB(A), 50ms) elicited 0, 100, 200, 300, 400 and 500ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300ms than at 0 and 400ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27078753</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7123</ISSN><JournalIssue CitedMedium="Internet"><Volume>240</Volume><PubDate><Year>2016</Year><Month>Jun</Month><Day>30</Day></PubDate></JournalIssue><Title>Psychiatry research</Title><ISOAbbreviation>Psychiatry Res</ISOAbbreviation></Journal><ArticleTitle>Cardiac modulation of startle is altered in depersonalization-/derealization disorder: Evidence for impaired brainstem representation of baro-afferent neural traffic.</ArticleTitle><Pagination><MedlinePgn>4-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.psychres.2016.03.051</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0165-1781(15)30487-X</ELocationID><Abstract><AbstractText>Patients with depersonalization-/derealization disorder (DPD) show altered heartbeat-evoked brain potentials, which are considered psychophysiological indicators of cortical representation of visceral-afferent neural signals. The aim of the current investigation was to clarify whether the impaired CNS representation of visceral-afferent neural signals in DPD is restricted to the cortical level or is also present in sub-cortical structures. We used cardiac modulation of startle (CMS) to assess baro-afferent signal transmission at brainstem level in 22 DPD and 23 healthy control individuals. The CMS paradigm involved acoustic startle stimuli (105dB(A), 50ms) elicited 0, 100, 200, 300, 400 and 500ms after a cardiac R-wave. In healthy control individuals, we observed lower startle responses at 100 and 300ms than at 0 and 400ms after an R-wave. In DPD patients, no effect of the cardiac cycle on startle response magnitude was found. We conclude that the representation of visceral-afferent neural signals at brainstem level may be deficient in DPD. This effect may be due to increased peripheral sympathetic tone or to dysregulated signal processing at brainstem level.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schulz</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg; Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. Electronic address: andre.schulz@uni.lu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matthey</LastName><ForeName>Jan Hendrik</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: mattjanh@students.uni-mainz.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vögele</LastName><ForeName>Claus</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: claus.voegele@uni.lu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaan</LastName><ForeName>Violetta</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute for Health and Behaviour, Research Unit INSIDE, University of Luxembourg, 11, Porte des Sciences, L-4366 Esch-sur-Alzette, Luxembourg. Electronic address: violetta.schaan@uni.lu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Psychophysiology, Institute of Psychobiology, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. Electronic address: schaechi@uni-trier.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: julia.adler@uni-mainz.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beutel</LastName><ForeName>Manfred E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: manfred.beutel@unimedizin-mainz.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michal</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, D-55131 Mainz, Germany. Electronic address: matthias.michal@unimedizin-mainz.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Psychiatry Res</MedlineTA><NlmUniqueID>7911385</NlmUniqueID><ISSNLinking>0165-1781</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000161" MajorTopicYN="N">Acoustic Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017704" MajorTopicYN="N">Baroreflex</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001933" MajorTopicYN="N">Brain Stem</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003861" MajorTopicYN="N">Depersonalization</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005071" MajorTopicYN="N">Evoked Potentials</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013216" MajorTopicYN="N">Reflex, Startle</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017833" MajorTopicYN="N">Visceral Afferents</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arterial baroreflex</Keyword><Keyword MajorTopicYN="N">Autonomic stress response</Keyword><Keyword MajorTopicYN="N">Depersonalization</Keyword><Keyword MajorTopicYN="N">Interoception</Keyword><Keyword MajorTopicYN="N">Startle eye blink</Keyword><Keyword MajorTopicYN="N">Symptom perception</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27078753</ArticleId><ArticleId IdType="pii">S0165-1781(15)30487-X</ArticleId><ArticleId IdType="doi">10.1016/j.psychres.2016.03.051</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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