Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.
Identifieur interne : 000043 ( PubMed/Corpus ); précédent : 000042; suivant : 000044Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.
Auteurs : Simone Gross ; Andrea Fischer ; Marco Rosati ; Lara Matiasek ; Daniele Corlazzoli ; Rodolfo Cappello ; Laura Porcarelli ; Tom Harcourt-Brown ; Konrad Jurina ; Laurent Garosi ; Thomas Flegel ; Pia Quitt ; Jessica Molin ; Velia-Isabel Huelsmeyer ; Henning Schenk ; Gualtiero Gandini ; Kirsten Gnirs ; Stéphane Blot ; Aurélien Jeandel ; Massimo Baroni ; Shenja Loderstedt ; Gianluca Abbiati ; Carola Leithaeuser ; Sabine Schulze ; Marion Kornberg ; Mark Lowrie ; Kaspar MatiasekSource :
- Neuromuscular disorders : NMD [ 1873-2364 ] ; 2016.
Abstract
Recent views on Guillain-Barré syndrome (GBS) question the accuracy of classification into axonal and demyelinating subtypes that represent convergent neurophysiological phenotypes rather than immunological targets. Instead it has been proposed to clarify the primarily affected fibre subunit in nerve biopsies. As nerve biopsies rarely are part of routine work-up in human patients we evaluated tissues taken from companion animals affected by GBS-like polyradiculoneuropathy to screen for distribution of immune cells, targeted fibre components and segregating non-inflammatory lesions. We identified that immune responses were directed either at Schmidt-Lanterman clefts, the paranode-node complex or both. Based on infiltrative and non-inflammatory changes, four subtypes and/or stages were distinguished, some of which indicate localisation of primary target antigens while others represent convergent late stage pictures, as a consequence to epitope spreading. The impact of histological subtyping onto clinical management and prognosis remains to be evaluated in future clinical trials. Natural development and clinical manifestation of large animal dysimmune neuropathy may reflect human Guillain-Barré syndrome more accurately than experimental models and therefore provide complementary clues for translational research.
DOI: 10.1016/j.nmd.2016.08.015
PubMed: 27743643
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.</title><author><name sortKey="Gross, Simone" sort="Gross, Simone" uniqKey="Gross S" first="Simone" last="Gross">Simone Gross</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Andrea" sort="Fischer, Andrea" uniqKey="Fischer A" first="Andrea" last="Fischer">Andrea Fischer</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rosati, Marco" sort="Rosati, Marco" uniqKey="Rosati M" first="Marco" last="Rosati">Marco Rosati</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Matiasek, Lara" sort="Matiasek, Lara" uniqKey="Matiasek L" first="Lara" last="Matiasek">Lara Matiasek</name><affiliation><nlm:affiliation>Neurology Referral Service, Tierklinik Haar, Haar, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Corlazzoli, Daniele" sort="Corlazzoli, Daniele" uniqKey="Corlazzoli D" first="Daniele" last="Corlazzoli">Daniele Corlazzoli</name><affiliation><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cappello, Rodolfo" sort="Cappello, Rodolfo" uniqKey="Cappello R" first="Rodolfo" last="Cappello">Rodolfo Cappello</name><affiliation><nlm:affiliation>North Downs Specialist Referrals, Bletchingley, Surrey, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Porcarelli, Laura" sort="Porcarelli, Laura" uniqKey="Porcarelli L" first="Laura" last="Porcarelli">Laura Porcarelli</name><affiliation><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Harcourt Brown, Tom" sort="Harcourt Brown, Tom" uniqKey="Harcourt Brown T" first="Tom" last="Harcourt-Brown">Tom Harcourt-Brown</name><affiliation><nlm:affiliation>Section of Neurology, Langford Veterinary Services, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jurina, Konrad" sort="Jurina, Konrad" uniqKey="Jurina K" first="Konrad" last="Jurina">Konrad Jurina</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Garosi, Laurent" sort="Garosi, Laurent" uniqKey="Garosi L" first="Laurent" last="Garosi">Laurent Garosi</name><affiliation><nlm:affiliation>Neurology Referral Service, Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Flegel, Thomas" sort="Flegel, Thomas" uniqKey="Flegel T" first="Thomas" last="Flegel">Thomas Flegel</name><affiliation><nlm:affiliation>Neurology Unit, Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Quitt, Pia" sort="Quitt, Pia" uniqKey="Quitt P" first="Pia" last="Quitt">Pia Quitt</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Molin, Jessica" sort="Molin, Jessica" uniqKey="Molin J" first="Jessica" last="Molin">Jessica Molin</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Huelsmeyer, Velia Isabel" sort="Huelsmeyer, Velia Isabel" uniqKey="Huelsmeyer V" first="Velia-Isabel" last="Huelsmeyer">Velia-Isabel Huelsmeyer</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schenk, Henning" sort="Schenk, Henning" uniqKey="Schenk H" first="Henning" last="Schenk">Henning Schenk</name><affiliation><nlm:affiliation>Neurology Service, Tierklinik Lueneburg, Lueneburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gandini, Gualtiero" sort="Gandini, Gualtiero" uniqKey="Gandini G" first="Gualtiero" last="Gandini">Gualtiero Gandini</name><affiliation><nlm:affiliation>Department of Veterinary Medical Science, University of Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gnirs, Kirsten" sort="Gnirs, Kirsten" uniqKey="Gnirs K" first="Kirsten" last="Gnirs">Kirsten Gnirs</name><affiliation><nlm:affiliation>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blot, Stephane" sort="Blot, Stephane" uniqKey="Blot S" first="Stéphane" last="Blot">Stéphane Blot</name><affiliation><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jeandel, Aurelien" sort="Jeandel, Aurelien" uniqKey="Jeandel A" first="Aurélien" last="Jeandel">Aurélien Jeandel</name><affiliation><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Baroni, Massimo" sort="Baroni, Massimo" uniqKey="Baroni M" first="Massimo" last="Baroni">Massimo Baroni</name><affiliation><nlm:affiliation>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Loderstedt, Shenja" sort="Loderstedt, Shenja" uniqKey="Loderstedt S" first="Shenja" last="Loderstedt">Shenja Loderstedt</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Abbiati, Gianluca" sort="Abbiati, Gianluca" uniqKey="Abbiati G" first="Gianluca" last="Abbiati">Gianluca Abbiati</name><affiliation><nlm:affiliation>Clinica Veterinaria Malpensa, Samarate, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Leithaeuser, Carola" sort="Leithaeuser, Carola" uniqKey="Leithaeuser C" first="Carola" last="Leithaeuser">Carola Leithaeuser</name><affiliation><nlm:affiliation>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Sabine" sort="Schulze, Sabine" uniqKey="Schulze S" first="Sabine" last="Schulze">Sabine Schulze</name><affiliation><nlm:affiliation>Small Animal Clinic Fuerstenwalde, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kornberg, Marion" sort="Kornberg, Marion" uniqKey="Kornberg M" first="Marion" last="Kornberg">Marion Kornberg</name><affiliation><nlm:affiliation>Small Animal Clinic Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lowrie, Mark" sort="Lowrie, Mark" uniqKey="Lowrie M" first="Mark" last="Lowrie">Mark Lowrie</name><affiliation><nlm:affiliation>Dovecote Veterinary Hospital, Castle Donington, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: kaspar.matiasek@neuropathologie.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27743643</idno><idno type="pmid">27743643</idno><idno type="doi">10.1016/j.nmd.2016.08.015</idno><idno type="wicri:Area/PubMed/Corpus">000043</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.</title><author><name sortKey="Gross, Simone" sort="Gross, Simone" uniqKey="Gross S" first="Simone" last="Gross">Simone Gross</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fischer, Andrea" sort="Fischer, Andrea" uniqKey="Fischer A" first="Andrea" last="Fischer">Andrea Fischer</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rosati, Marco" sort="Rosati, Marco" uniqKey="Rosati M" first="Marco" last="Rosati">Marco Rosati</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Matiasek, Lara" sort="Matiasek, Lara" uniqKey="Matiasek L" first="Lara" last="Matiasek">Lara Matiasek</name><affiliation><nlm:affiliation>Neurology Referral Service, Tierklinik Haar, Haar, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Corlazzoli, Daniele" sort="Corlazzoli, Daniele" uniqKey="Corlazzoli D" first="Daniele" last="Corlazzoli">Daniele Corlazzoli</name><affiliation><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cappello, Rodolfo" sort="Cappello, Rodolfo" uniqKey="Cappello R" first="Rodolfo" last="Cappello">Rodolfo Cappello</name><affiliation><nlm:affiliation>North Downs Specialist Referrals, Bletchingley, Surrey, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Porcarelli, Laura" sort="Porcarelli, Laura" uniqKey="Porcarelli L" first="Laura" last="Porcarelli">Laura Porcarelli</name><affiliation><nlm:affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Harcourt Brown, Tom" sort="Harcourt Brown, Tom" uniqKey="Harcourt Brown T" first="Tom" last="Harcourt-Brown">Tom Harcourt-Brown</name><affiliation><nlm:affiliation>Section of Neurology, Langford Veterinary Services, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jurina, Konrad" sort="Jurina, Konrad" uniqKey="Jurina K" first="Konrad" last="Jurina">Konrad Jurina</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Garosi, Laurent" sort="Garosi, Laurent" uniqKey="Garosi L" first="Laurent" last="Garosi">Laurent Garosi</name><affiliation><nlm:affiliation>Neurology Referral Service, Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Flegel, Thomas" sort="Flegel, Thomas" uniqKey="Flegel T" first="Thomas" last="Flegel">Thomas Flegel</name><affiliation><nlm:affiliation>Neurology Unit, Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Quitt, Pia" sort="Quitt, Pia" uniqKey="Quitt P" first="Pia" last="Quitt">Pia Quitt</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Molin, Jessica" sort="Molin, Jessica" uniqKey="Molin J" first="Jessica" last="Molin">Jessica Molin</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Huelsmeyer, Velia Isabel" sort="Huelsmeyer, Velia Isabel" uniqKey="Huelsmeyer V" first="Velia-Isabel" last="Huelsmeyer">Velia-Isabel Huelsmeyer</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schenk, Henning" sort="Schenk, Henning" uniqKey="Schenk H" first="Henning" last="Schenk">Henning Schenk</name><affiliation><nlm:affiliation>Neurology Service, Tierklinik Lueneburg, Lueneburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gandini, Gualtiero" sort="Gandini, Gualtiero" uniqKey="Gandini G" first="Gualtiero" last="Gandini">Gualtiero Gandini</name><affiliation><nlm:affiliation>Department of Veterinary Medical Science, University of Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gnirs, Kirsten" sort="Gnirs, Kirsten" uniqKey="Gnirs K" first="Kirsten" last="Gnirs">Kirsten Gnirs</name><affiliation><nlm:affiliation>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blot, Stephane" sort="Blot, Stephane" uniqKey="Blot S" first="Stéphane" last="Blot">Stéphane Blot</name><affiliation><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jeandel, Aurelien" sort="Jeandel, Aurelien" uniqKey="Jeandel A" first="Aurélien" last="Jeandel">Aurélien Jeandel</name><affiliation><nlm:affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</nlm:affiliation></affiliation></author><author><name sortKey="Baroni, Massimo" sort="Baroni, Massimo" uniqKey="Baroni M" first="Massimo" last="Baroni">Massimo Baroni</name><affiliation><nlm:affiliation>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Loderstedt, Shenja" sort="Loderstedt, Shenja" uniqKey="Loderstedt S" first="Shenja" last="Loderstedt">Shenja Loderstedt</name><affiliation><nlm:affiliation>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Abbiati, Gianluca" sort="Abbiati, Gianluca" uniqKey="Abbiati G" first="Gianluca" last="Abbiati">Gianluca Abbiati</name><affiliation><nlm:affiliation>Clinica Veterinaria Malpensa, Samarate, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Leithaeuser, Carola" sort="Leithaeuser, Carola" uniqKey="Leithaeuser C" first="Carola" last="Leithaeuser">Carola Leithaeuser</name><affiliation><nlm:affiliation>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Sabine" sort="Schulze, Sabine" uniqKey="Schulze S" first="Sabine" last="Schulze">Sabine Schulze</name><affiliation><nlm:affiliation>Small Animal Clinic Fuerstenwalde, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kornberg, Marion" sort="Kornberg, Marion" uniqKey="Kornberg M" first="Marion" last="Kornberg">Marion Kornberg</name><affiliation><nlm:affiliation>Small Animal Clinic Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lowrie, Mark" sort="Lowrie, Mark" uniqKey="Lowrie M" first="Mark" last="Lowrie">Mark Lowrie</name><affiliation><nlm:affiliation>Dovecote Veterinary Hospital, Castle Donington, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Matiasek, Kaspar" sort="Matiasek, Kaspar" uniqKey="Matiasek K" first="Kaspar" last="Matiasek">Kaspar Matiasek</name><affiliation><nlm:affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: kaspar.matiasek@neuropathologie.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neuromuscular disorders : NMD</title><idno type="eISSN">1873-2364</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent views on Guillain-Barré syndrome (GBS) question the accuracy of classification into axonal and demyelinating subtypes that represent convergent neurophysiological phenotypes rather than immunological targets. Instead it has been proposed to clarify the primarily affected fibre subunit in nerve biopsies. As nerve biopsies rarely are part of routine work-up in human patients we evaluated tissues taken from companion animals affected by GBS-like polyradiculoneuropathy to screen for distribution of immune cells, targeted fibre components and segregating non-inflammatory lesions. We identified that immune responses were directed either at Schmidt-Lanterman clefts, the paranode-node complex or both. Based on infiltrative and non-inflammatory changes, four subtypes and/or stages were distinguished, some of which indicate localisation of primary target antigens while others represent convergent late stage pictures, as a consequence to epitope spreading. The impact of histological subtyping onto clinical management and prognosis remains to be evaluated in future clinical trials. Natural development and clinical manifestation of large animal dysimmune neuropathy may reflect human Guillain-Barré syndrome more accurately than experimental models and therefore provide complementary clues for translational research.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27743643</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>16</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2364</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Neuromuscular disorders : NMD</Title><ISOAbbreviation>Neuromuscul. Disord.</ISOAbbreviation></Journal><ArticleTitle>Nodo-paranodopathy, internodopathy and cleftopathy: Target-based reclassification of Guillain-Barré-like immune-mediated polyradiculoneuropathies in dogs and cats.</ArticleTitle><Pagination><MedlinePgn>825-836</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0960-8966(16)30100-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nmd.2016.08.015</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">Recent views on Guillain-Barré syndrome (GBS) question the accuracy of classification into axonal and demyelinating subtypes that represent convergent neurophysiological phenotypes rather than immunological targets. Instead it has been proposed to clarify the primarily affected fibre subunit in nerve biopsies. As nerve biopsies rarely are part of routine work-up in human patients we evaluated tissues taken from companion animals affected by GBS-like polyradiculoneuropathy to screen for distribution of immune cells, targeted fibre components and segregating non-inflammatory lesions. We identified that immune responses were directed either at Schmidt-Lanterman clefts, the paranode-node complex or both. Based on infiltrative and non-inflammatory changes, four subtypes and/or stages were distinguished, some of which indicate localisation of primary target antigens while others represent convergent late stage pictures, as a consequence to epitope spreading. The impact of histological subtyping onto clinical management and prognosis remains to be evaluated in future clinical trials. Natural development and clinical manifestation of large animal dysimmune neuropathy may reflect human Guillain-Barré syndrome more accurately than experimental models and therefore provide complementary clues for translational research.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosati</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matiasek</LastName><ForeName>Lara</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Neurology Referral Service, Tierklinik Haar, Haar, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corlazzoli</LastName><ForeName>Daniele</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cappello</LastName><ForeName>Rodolfo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>North Downs Specialist Referrals, Bletchingley, Surrey, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porcarelli</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Clinica Veterinaria Roma Sud, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harcourt-Brown</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Section of Neurology, Langford Veterinary Services, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jurina</LastName><ForeName>Konrad</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garosi</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Neurology Referral Service, Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flegel</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Neurology Unit, Department of Small Animal Medicine, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quitt</LastName><ForeName>Pia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molin</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huelsmeyer</LastName><ForeName>Velia-Isabel</ForeName><Initials>VI</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität, München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schenk</LastName><ForeName>Henning</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Neurology Service, Tierklinik Lueneburg, Lueneburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gandini</LastName><ForeName>Gualtiero</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Veterinary Medical Science, University of Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gnirs</LastName><ForeName>Kirsten</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blot</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeandel</LastName><ForeName>Aurélien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Neurologie, Ecole Nationale Vétérinaire d'Alfort, University of Paris Est, Maisons Alfort, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baroni</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinica Veterinaria Valdinievole, Monsummano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loderstedt</LastName><ForeName>Shenja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Section of Neurology, Clinic of Small Animal Medicine, University of Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abbiati</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Clinica Veterinaria Malpensa, Samarate, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leithaeuser</LastName><ForeName>Carola</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Small Animal Clinic Magunna-Magunna-Nickel, Norderstedt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulze</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Small Animal Clinic Fuerstenwalde, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kornberg</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Small Animal Clinic Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lowrie</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dovecote Veterinary Hospital, Castle Donington, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matiasek</LastName><ForeName>Kaspar</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section of Clinical & Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: kaspar.matiasek@neuropathologie.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuromuscul Disord</MedlineTA><NlmUniqueID>9111470</NlmUniqueID><ISSNLinking>0960-8966</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Canine</Keyword><Keyword MajorTopicYN="N">Coonhound paralysis</Keyword><Keyword MajorTopicYN="N">Feline</Keyword><Keyword MajorTopicYN="N">Immune-mediated</Keyword><Keyword MajorTopicYN="N">Peripheral nerve</Keyword><Keyword MajorTopicYN="N">Polyneuritis</Keyword><Keyword MajorTopicYN="N">Polyradiculoneuritis</Keyword><Keyword MajorTopicYN="N">Subtype</Keyword><Keyword MajorTopicYN="N">Teasing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27743643</ArticleId><ArticleId IdType="pii">S0960-8966(16)30100-6</ArticleId><ArticleId IdType="doi">10.1016/j.nmd.2016.08.015</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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