Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry.
Identifieur interne : 000033 ( PubMed/Corpus ); précédent : 000032; suivant : 000034Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry.
Auteurs : Mark Kriegsmann ; Rémi Longuespée ; Petra Wandernoth ; Cristina Mohanu ; Katharina Lisenko ; Wilko Weichert ; Arne Warth ; Hendrik Dienemann ; Edwin De Pauw ; Tiemo Katzenberger ; Daniela Aust ; Gustavo Baretton ; Joerg Kriegsmann ; Rita CasadonteSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2016.
Abstract
In advanced tumor stages, diagnosis is frequently made from metastatic tumor tissue. In some cases, the identification of the tumor of origin may be difficult by histology alone. In this setting, immunohistochemical and molecular biological methods are often required. In a subset of tumors definite diagnosis cannot be achieved. Thus, additional new diagnostic methods are required for precise tumor subtyping. Mass spectrometric methods are of special interest for the discrimination of different tumor types. We investigated whether it is possible to discern adenocarcinomas of colon and lung using high-throughput imaging mass spectrometry on formalin-fixed paraffin-embedded tissue microarrays. 101 primary adenocarcinoma of the colon and 91 primary adenocarcinoma of the lung were used to train a Linear Discriminant Analysis model. Results were validated on an independent set of 116 colonic and 75 lung adenocarcinomas. In the validation cohort 109 of 116 patients with colonic and 67 of 75 patients with lung adenocarcinomas were correctly classified. The ability to define proteomic profiles capable to discern different tumor types promises a valuable tool in cancer diagnostics and might complement current approaches. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.
DOI: 10.1016/j.bbapap.2016.11.018
PubMed: 27939606
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Electronic address: r.longuespee@molekularpatho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Wandernoth, Petra" sort="Wandernoth, Petra" uniqKey="Wandernoth P" first="Petra" last="Wandernoth">Petra Wandernoth</name><affiliation><nlm:affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: petrawandernoth@gmx.de.</nlm:affiliation></affiliation></author><author><name sortKey="Mohanu, Cristina" sort="Mohanu, Cristina" uniqKey="Mohanu C" first="Cristina" last="Mohanu">Cristina Mohanu</name><affiliation><nlm:affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: cristinamohanu@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Lisenko, Katharina" sort="Lisenko, Katharina" uniqKey="Lisenko K" first="Katharina" last="Lisenko">Katharina Lisenko</name><affiliation><nlm:affiliation>Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Electronic address: Katharina.lisenko@med.uni-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Weichert, Wilko" sort="Weichert, Wilko" uniqKey="Weichert W" first="Wilko" last="Weichert">Wilko Weichert</name><affiliation><nlm:affiliation>Institute of Pathology, TU Munich, Munich, Germany. Electronic address: wilko.weichert@tum.de.</nlm:affiliation></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, Germany. Electronic address: arne.warth@med.uni-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Dienemann, Hendrik" sort="Dienemann, Hendrik" uniqKey="Dienemann H" first="Hendrik" last="Dienemann">Hendrik Dienemann</name><affiliation><nlm:affiliation>Department of Thoracic Surgery, Thoraxklinik at Heidelberg University, Heidelberg, Germany. Electronic address: hendrik.dienemann@thoraxklinik-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="De Pauw, Edwin" sort="De Pauw, Edwin" uniqKey="De Pauw E" first="Edwin" last="De Pauw">Edwin De Pauw</name><affiliation><nlm:affiliation>Mass Spectrometry Laboratory, Systems Biology and Chemical Biology, GIGA-Research, University of Liège, Belgium. Electronic address: e.depauw@ulg.ac.be.</nlm:affiliation></affiliation></author><author><name sortKey="Katzenberger, Tiemo" sort="Katzenberger, Tiemo" uniqKey="Katzenberger T" first="Tiemo" last="Katzenberger">Tiemo Katzenberger</name><affiliation><nlm:affiliation>Institute of Pathology, Hospital Aschaffenburg, Aschaffenburg, Germany. Electronic address: tiemo.katzenberger@klinikum-ab-alz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Aust, Daniela" sort="Aust, Daniela" uniqKey="Aust D" first="Daniela" last="Aust">Daniela Aust</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: daniela.aust@uniklinikum-dresden.de.</nlm:affiliation></affiliation></author><author><name sortKey="Baretton, Gustavo" sort="Baretton, Gustavo" uniqKey="Baretton G" first="Gustavo" last="Baretton">Gustavo Baretton</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: gustavo.baretton@uniklinikum-dresden.de.</nlm:affiliation></affiliation></author><author><name sortKey="Kriegsmann, Joerg" sort="Kriegsmann, Joerg" uniqKey="Kriegsmann J" first="Joerg" last="Kriegsmann">Joerg Kriegsmann</name><affiliation><nlm:affiliation>Proteopath GmbH, Trier, Germany; Center for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany. Electronic address: kriegsmann@patho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Casadonte, Rita" sort="Casadonte, Rita" uniqKey="Casadonte R" first="Rita" last="Casadonte">Rita Casadonte</name><affiliation><nlm:affiliation>Proteopath GmbH, Trier, Germany. Electronic address: r.casadonte@molekularpatho-trier.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27939606</idno><idno type="pmid">27939606</idno><idno type="doi">10.1016/j.bbapap.2016.11.018</idno><idno type="wicri:Area/PubMed/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000033</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry.</title><author><name sortKey="Kriegsmann, Mark" sort="Kriegsmann, Mark" uniqKey="Kriegsmann M" first="Mark" last="Kriegsmann">Mark Kriegsmann</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: mark.kriegsmann@med.uni-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Longuespee, Remi" sort="Longuespee, Remi" uniqKey="Longuespee R" first="Rémi" last="Longuespée">Rémi Longuespée</name><affiliation><nlm:affiliation>Proteopath GmbH, Trier, Germany. Electronic address: r.longuespee@molekularpatho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Wandernoth, Petra" sort="Wandernoth, Petra" uniqKey="Wandernoth P" first="Petra" last="Wandernoth">Petra Wandernoth</name><affiliation><nlm:affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: petrawandernoth@gmx.de.</nlm:affiliation></affiliation></author><author><name sortKey="Mohanu, Cristina" sort="Mohanu, Cristina" uniqKey="Mohanu C" first="Cristina" last="Mohanu">Cristina Mohanu</name><affiliation><nlm:affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: cristinamohanu@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Lisenko, Katharina" sort="Lisenko, Katharina" uniqKey="Lisenko K" first="Katharina" last="Lisenko">Katharina Lisenko</name><affiliation><nlm:affiliation>Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Electronic address: Katharina.lisenko@med.uni-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Weichert, Wilko" sort="Weichert, Wilko" uniqKey="Weichert W" first="Wilko" last="Weichert">Wilko Weichert</name><affiliation><nlm:affiliation>Institute of Pathology, TU Munich, Munich, Germany. Electronic address: wilko.weichert@tum.de.</nlm:affiliation></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, Germany. Electronic address: arne.warth@med.uni-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="Dienemann, Hendrik" sort="Dienemann, Hendrik" uniqKey="Dienemann H" first="Hendrik" last="Dienemann">Hendrik Dienemann</name><affiliation><nlm:affiliation>Department of Thoracic Surgery, Thoraxklinik at Heidelberg University, Heidelberg, Germany. Electronic address: hendrik.dienemann@thoraxklinik-heidelberg.de.</nlm:affiliation></affiliation></author><author><name sortKey="De Pauw, Edwin" sort="De Pauw, Edwin" uniqKey="De Pauw E" first="Edwin" last="De Pauw">Edwin De Pauw</name><affiliation><nlm:affiliation>Mass Spectrometry Laboratory, Systems Biology and Chemical Biology, GIGA-Research, University of Liège, Belgium. Electronic address: e.depauw@ulg.ac.be.</nlm:affiliation></affiliation></author><author><name sortKey="Katzenberger, Tiemo" sort="Katzenberger, Tiemo" uniqKey="Katzenberger T" first="Tiemo" last="Katzenberger">Tiemo Katzenberger</name><affiliation><nlm:affiliation>Institute of Pathology, Hospital Aschaffenburg, Aschaffenburg, Germany. Electronic address: tiemo.katzenberger@klinikum-ab-alz.de.</nlm:affiliation></affiliation></author><author><name sortKey="Aust, Daniela" sort="Aust, Daniela" uniqKey="Aust D" first="Daniela" last="Aust">Daniela Aust</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: daniela.aust@uniklinikum-dresden.de.</nlm:affiliation></affiliation></author><author><name sortKey="Baretton, Gustavo" sort="Baretton, Gustavo" uniqKey="Baretton G" first="Gustavo" last="Baretton">Gustavo Baretton</name><affiliation><nlm:affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: gustavo.baretton@uniklinikum-dresden.de.</nlm:affiliation></affiliation></author><author><name sortKey="Kriegsmann, Joerg" sort="Kriegsmann, Joerg" uniqKey="Kriegsmann J" first="Joerg" last="Kriegsmann">Joerg Kriegsmann</name><affiliation><nlm:affiliation>Proteopath GmbH, Trier, Germany; Center for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany. Electronic address: kriegsmann@patho-trier.de.</nlm:affiliation></affiliation></author><author><name sortKey="Casadonte, Rita" sort="Casadonte, Rita" uniqKey="Casadonte R" first="Rita" last="Casadonte">Rita Casadonte</name><affiliation><nlm:affiliation>Proteopath GmbH, Trier, Germany. Electronic address: r.casadonte@molekularpatho-trier.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In advanced tumor stages, diagnosis is frequently made from metastatic tumor tissue. In some cases, the identification of the tumor of origin may be difficult by histology alone. In this setting, immunohistochemical and molecular biological methods are often required. In a subset of tumors definite diagnosis cannot be achieved. Thus, additional new diagnostic methods are required for precise tumor subtyping. Mass spectrometric methods are of special interest for the discrimination of different tumor types. We investigated whether it is possible to discern adenocarcinomas of colon and lung using high-throughput imaging mass spectrometry on formalin-fixed paraffin-embedded tissue microarrays. 101 primary adenocarcinoma of the colon and 91 primary adenocarcinoma of the lung were used to train a Linear Discriminant Analysis model. Results were validated on an independent set of 116 colonic and 75 lung adenocarcinomas. In the validation cohort 109 of 116 patients with colonic and 67 of 75 patients with lung adenocarcinomas were correctly classified. The ability to define proteomic profiles capable to discern different tumor types promises a valuable tool in cancer diagnostics and might complement current approaches. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27939606</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>12</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2016</Year><Month>Dec</Month><Day>08</Day></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim. Biophys. Acta</ISOAbbreviation></Journal><ArticleTitle>Typing of colon and lung adenocarcinoma by high throughput imaging mass spectrometry.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S1570-9639(16)30257-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbapap.2016.11.018</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">In advanced tumor stages, diagnosis is frequently made from metastatic tumor tissue. In some cases, the identification of the tumor of origin may be difficult by histology alone. In this setting, immunohistochemical and molecular biological methods are often required. In a subset of tumors definite diagnosis cannot be achieved. Thus, additional new diagnostic methods are required for precise tumor subtyping. Mass spectrometric methods are of special interest for the discrimination of different tumor types. We investigated whether it is possible to discern adenocarcinomas of colon and lung using high-throughput imaging mass spectrometry on formalin-fixed paraffin-embedded tissue microarrays. 101 primary adenocarcinoma of the colon and 91 primary adenocarcinoma of the lung were used to train a Linear Discriminant Analysis model. Results were validated on an independent set of 116 colonic and 75 lung adenocarcinomas. In the validation cohort 109 of 116 patients with colonic and 67 of 75 patients with lung adenocarcinomas were correctly classified. The ability to define proteomic profiles capable to discern different tumor types promises a valuable tool in cancer diagnostics and might complement current approaches. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kriegsmann</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: mark.kriegsmann@med.uni-heidelberg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Longuespée</LastName><ForeName>Rémi</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Proteopath GmbH, Trier, Germany. Electronic address: r.longuespee@molekularpatho-trier.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wandernoth</LastName><ForeName>Petra</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: petrawandernoth@gmx.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohanu</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Molecular Pathology Trier, Trier, Germany. Electronic address: cristinamohanu@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lisenko</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Electronic address: Katharina.lisenko@med.uni-heidelberg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weichert</LastName><ForeName>Wilko</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Institute of Pathology, TU Munich, Munich, Germany. Electronic address: wilko.weichert@tum.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warth</LastName><ForeName>Arne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research, Germany. Electronic address: arne.warth@med.uni-heidelberg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dienemann</LastName><ForeName>Hendrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Thoracic Surgery, Thoraxklinik at Heidelberg University, Heidelberg, Germany. Electronic address: hendrik.dienemann@thoraxklinik-heidelberg.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Pauw</LastName><ForeName>Edwin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Mass Spectrometry Laboratory, Systems Biology and Chemical Biology, GIGA-Research, University of Liège, Belgium. Electronic address: e.depauw@ulg.ac.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katzenberger</LastName><ForeName>Tiemo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Pathology, Hospital Aschaffenburg, Aschaffenburg, Germany. Electronic address: tiemo.katzenberger@klinikum-ab-alz.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aust</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: daniela.aust@uniklinikum-dresden.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baretton</LastName><ForeName>Gustavo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany. Electronic address: gustavo.baretton@uniklinikum-dresden.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kriegsmann</LastName><ForeName>Joerg</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Proteopath GmbH, Trier, Germany; Center for Histology, Cytology and Molecular Diagnostics Trier, Trier, Germany. Electronic address: kriegsmann@patho-trier.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casadonte</LastName><ForeName>Rita</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Proteopath GmbH, Trier, Germany. Electronic address: r.casadonte@molekularpatho-trier.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biochim Biophys Acta</MedlineTA><NlmUniqueID>0217513</NlmUniqueID><ISSNLinking>0006-3002</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adenocarcinoma</Keyword><Keyword MajorTopicYN="N">Colon</Keyword><Keyword MajorTopicYN="N">Imaging mass spectrometry</Keyword><Keyword MajorTopicYN="N">Lung</Keyword><Keyword MajorTopicYN="N">MALDI</Keyword><Keyword MajorTopicYN="N">Tumor-typing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27939606</ArticleId><ArticleId IdType="pii">S1570-9639(16)30257-6</ArticleId><ArticleId IdType="doi">10.1016/j.bbapap.2016.11.018</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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