Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.
Identifieur interne : 000275 ( PubMed/Checkpoint ); précédent : 000274; suivant : 000276Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.
Auteurs : B. Blömeke [Allemagne] ; L M Pot ; P-J Coenraads ; J. Hennen ; M. Kock ; C. GoebelSource :
- The British journal of dermatology [ 1365-2133 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Hair Dyes.
- immunology : Cross Reactions, Dermatitis, Allergic Contact, Phenylenediamines.
- Female, Forearm, Humans, Male, Patch Tests.
Abstract
The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.
DOI: 10.1111/bjd.13412
PubMed: 25234507
Affiliations:
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pubmed:25234507Le document en format XML
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<author><name sortKey="Pot, L M" sort="Pot, L M" uniqKey="Pot L" first="L M" last="Pot">L M Pot</name>
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<series><title level="j">The British journal of dermatology</title>
<idno type="eISSN">1365-2133</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cross Reactions (immunology)</term>
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<term>Female</term>
<term>Forearm</term>
<term>Hair Dyes (adverse effects)</term>
<term>Humans</term>
<term>Male</term>
<term>Patch Tests</term>
<term>Phenylenediamines (immunology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Hair Dyes</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cross Reactions</term>
<term>Dermatitis, Allergic Contact</term>
<term>Phenylenediamines</term>
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<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Forearm</term>
<term>Humans</term>
<term>Male</term>
<term>Patch Tests</term>
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<front><div type="abstract" xml:lang="en">The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.</div>
</front>
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<DateCreated><Year>2015</Year>
<Month>04</Month>
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<Title>The British journal of dermatology</Title>
<ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation>
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<ArticleTitle>Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.</ArticleTitle>
<Pagination><MedlinePgn>976-80</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Investigation of the elicitation response to the new, less-sensitizing PPD alternative 2-methoxymethyl-p-phenylenediamine (ME-PPD) under simulated hair dye use conditions.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The cross-elicitation response to ME-PPD (2% in a hair dye test product for 30 min on forearm then rinsing) was analysed at days 2 and 3 in 30 PPD-allergic individuals with diagnostic patch test grades +, ++ or +++ according to the classification of the International Contact Dermatitis Research Group.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Cross-reactivity to the ME-PPD-containing hair dye test product was elicited in nine of 30 subjects (30%), while 70% were negative. Cross-reactivity was elicited in two of four cases with grade +++, three of 10 with grade ++ and four of 16 with grade +. Under identical conditions, PPD was previously found to elicit a response in 21 of 27 PPD-allergic individuals. In 18 of these 21 individuals, either the strength of the cross-elicitation response to ME-PPD was decreased or no response occurred.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Under simulated hair dye use conditions, a significantly lower degree of cross-elicitation to ME-PPD (30%) was observed than previously reported for PPD (32 of 38, 84%). Additionally, a decreased cross-elicitation strength was observed across all three patch test grades, likely reflecting the reduced skin-sensitization properties of ME-PPD. Consequently, careful dermatological evaluation is required to assess cross-reactivity to ME-PPD in patients allergic to hair dyes.</AbstractText>
<CopyrightInformation>© 2014 British Association of Dermatologists.</CopyrightInformation>
</Abstract>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C587181">2-methoxymethyl-p-phenylenediamine</NameOfSubstance>
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<NameOfSubstance UI="D006202">Hair Dyes</NameOfSubstance>
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<NameOfSubstance UI="D010655">Phenylenediamines</NameOfSubstance>
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<NameOfSubstance UI="C029728">4-phenylenediamine</NameOfSubstance>
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