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Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.

Identifieur interne : 000275 ( PubMed/Checkpoint ); précédent : 000274; suivant : 000276

Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.

Auteurs : B. Blömeke [Allemagne] ; L M Pot ; P-J Coenraads ; J. Hennen ; M. Kock ; C. Goebel

Source :

RBID : pubmed:25234507

English descriptors

Abstract

The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.

DOI: 10.1111/bjd.13412
PubMed: 25234507


Affiliations:


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pubmed:25234507

Le document en format XML

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<title xml:lang="en">Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.</title>
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<name sortKey="Blomeke, B" sort="Blomeke, B" uniqKey="Blomeke B" first="B" last="Blömeke">B. Blömeke</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Environmental Toxicology, University Trier, Universitätsring 15,, 54296, Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<name sortKey="Pot, L M" sort="Pot, L M" uniqKey="Pot L" first="L M" last="Pot">L M Pot</name>
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<name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P-J" last="Coenraads">P-J Coenraads</name>
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<name sortKey="Hennen, J" sort="Hennen, J" uniqKey="Hennen J" first="J" last="Hennen">J. Hennen</name>
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<name sortKey="Kock, M" sort="Kock, M" uniqKey="Kock M" first="M" last="Kock">M. Kock</name>
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<name sortKey="Goebel, C" sort="Goebel, C" uniqKey="Goebel C" first="C" last="Goebel">C. Goebel</name>
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<name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P-J" last="Coenraads">P-J Coenraads</name>
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<name sortKey="Kock, M" sort="Kock, M" uniqKey="Kock M" first="M" last="Kock">M. Kock</name>
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<title level="j">The British journal of dermatology</title>
<idno type="eISSN">1365-2133</idno>
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<term>Cross Reactions (immunology)</term>
<term>Dermatitis, Allergic Contact (immunology)</term>
<term>Female</term>
<term>Forearm</term>
<term>Hair Dyes (adverse effects)</term>
<term>Humans</term>
<term>Male</term>
<term>Patch Tests</term>
<term>Phenylenediamines (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en">
<term>Hair Dyes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Cross Reactions</term>
<term>Dermatitis, Allergic Contact</term>
<term>Phenylenediamines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Female</term>
<term>Forearm</term>
<term>Humans</term>
<term>Male</term>
<term>Patch Tests</term>
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<front>
<div type="abstract" xml:lang="en">The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.</div>
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<Year>2015</Year>
<Month>04</Month>
<Day>01</Day>
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<DateCompleted>
<Year>2015</Year>
<Month>12</Month>
<Day>28</Day>
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<Year>2015</Year>
<Month>04</Month>
<Day>01</Day>
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<ISSN IssnType="Electronic">1365-2133</ISSN>
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<Volume>172</Volume>
<Issue>4</Issue>
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<Year>2015</Year>
<Month>Apr</Month>
</PubDate>
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<Title>The British journal of dermatology</Title>
<ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation>
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<ArticleTitle>Cross-elicitation responses to 2-methoxymethyl-p-phenylenediamine under hair dye use conditions in p-phenylenediamine-allergic individuals.</ArticleTitle>
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<MedlinePgn>976-80</MedlinePgn>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The factors influencing elicitation responses in individuals allergic to p-phenylenediamine (PPD) in hair dyes are not well understood.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Investigation of the elicitation response to the new, less-sensitizing PPD alternative 2-methoxymethyl-p-phenylenediamine (ME-PPD) under simulated hair dye use conditions.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The cross-elicitation response to ME-PPD (2% in a hair dye test product for 30 min on forearm then rinsing) was analysed at days 2 and 3 in 30 PPD-allergic individuals with diagnostic patch test grades +, ++ or +++ according to the classification of the International Contact Dermatitis Research Group.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Cross-reactivity to the ME-PPD-containing hair dye test product was elicited in nine of 30 subjects (30%), while 70% were negative. Cross-reactivity was elicited in two of four cases with grade +++, three of 10 with grade ++ and four of 16 with grade +. Under identical conditions, PPD was previously found to elicit a response in 21 of 27 PPD-allergic individuals. In 18 of these 21 individuals, either the strength of the cross-elicitation response to ME-PPD was decreased or no response occurred.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Under simulated hair dye use conditions, a significantly lower degree of cross-elicitation to ME-PPD (30%) was observed than previously reported for PPD (32 of 38, 84%). Additionally, a decreased cross-elicitation strength was observed across all three patch test grades, likely reflecting the reduced skin-sensitization properties of ME-PPD. Consequently, careful dermatological evaluation is required to assess cross-reactivity to ME-PPD in patients allergic to hair dyes.</AbstractText>
<CopyrightInformation>© 2014 British Association of Dermatologists.</CopyrightInformation>
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<NameOfSubstance UI="C587181">2-methoxymethyl-p-phenylenediamine</NameOfSubstance>
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<NameOfSubstance UI="D006202">Hair Dyes</NameOfSubstance>
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<NameOfSubstance UI="D010655">Phenylenediamines</NameOfSubstance>
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<RegistryNumber>U770QIT64J</RegistryNumber>
<NameOfSubstance UI="C029728">4-phenylenediamine</NameOfSubstance>
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