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[Endoprosthesis failure in the ankle joint : Histopathological diagnostics and classification].

Identifieur interne : 000043 ( PubMed/Checkpoint ); précédent : 000042; suivant : 000044

[Endoprosthesis failure in the ankle joint : Histopathological diagnostics and classification].

Auteurs : S. Müller [Allemagne] ; M. Walther [Allemagne] ; A. Röser [Allemagne] ; V. Krenn [Allemagne]

Source :

RBID : pubmed:28004128

Abstract

Endoprostheses of the ankle joint show higher revision rates of 3.29 revisions per 100 component years. The aims of this study were the application and modification of the consensus classification of the synovia-like interface membrane (SLIM) for periprosthetic failure of the ankle joint, the etiological clarification of periprosthetic pseudocysts and a detailed measurement of proliferative activity (Ki67) in the region of osteolysis.

DOI: 10.1007/s00132-016-3372-4
PubMed: 28004128


Affiliations:


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pubmed:28004128

Le document en format XML

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<nlm:affiliation>Zentrum für Histologie, Zytologie und molekulare Diagnostik, Max-Planck-Straße 5, 54296, Trier, Deutschland. s.mueller@patho-trier.de.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<title xml:lang="en">[Endoprosthesis failure in the ankle joint : Histopathological diagnostics and classification].</title>
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<nlm:affiliation>Zentrum für Histologie, Zytologie und molekulare Diagnostik, Max-Planck-Straße 5, 54296, Trier, Deutschland. s.mueller@patho-trier.de.</nlm:affiliation>
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<name sortKey="Walther, M" sort="Walther, M" uniqKey="Walther M" first="M" last="Walther">M. Walther</name>
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<nlm:affiliation>Schön-Klinik München-Harlaching, München, Deutschland.</nlm:affiliation>
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<nlm:affiliation>Zentrum für Histologie, Zytologie und molekulare Diagnostik, Max-Planck-Straße 5, 54296, Trier, Deutschland.</nlm:affiliation>
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<title level="j">Der Orthopade</title>
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<div type="abstract" xml:lang="en">Endoprostheses of the ankle joint show higher revision rates of 3.29 revisions per 100 component years. The aims of this study were the application and modification of the consensus classification of the synovia-like interface membrane (SLIM) for periprosthetic failure of the ankle joint, the etiological clarification of periprosthetic pseudocysts and a detailed measurement of proliferative activity (Ki67) in the region of osteolysis.</div>
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<Month>12</Month>
<Day>22</Day>
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<Year>2016</Year>
<Month>12</Month>
<Day>23</Day>
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<Year>2016</Year>
<Month>Dec</Month>
<Day>21</Day>
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<Title>Der Orthopade</Title>
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<ArticleTitle>[Endoprosthesis failure in the ankle joint : Histopathological diagnostics and classification].</ArticleTitle>
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<AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Endoprostheses of the ankle joint show higher revision rates of 3.29 revisions per 100 component years. The aims of this study were the application and modification of the consensus classification of the synovia-like interface membrane (SLIM) for periprosthetic failure of the ankle joint, the etiological clarification of periprosthetic pseudocysts and a detailed measurement of proliferative activity (Ki67) in the region of osteolysis.</AbstractText>
<AbstractText Label="MATERIAL AND METHOD" NlmCategory="METHODS">Tissue samples from 159 patients were examined according to the criteria of the standardized consensus classification. Of these, 117 cases were derived from periprosthetic membranes of the ankle. The control group included 42 tissue specimens from the hip and knee joints. Particle identification and characterization were carried out using the particle algorithm. An immunohistochemical examination with Ki67 proliferation was performed in all cases of ankle pseudocysts and 19 control cases.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The consensus classification of SLIM is transferrable to endoprosthetic failure of the ankle joint. Periprosthetic pseudocysts with the histopathological characteristics of the appropriate SLIM subtype were detectable in 39 cases of ankle joint endoprostheses (33.3%). The mean value of the Ki67 index was 14% and showed an increased proliferation rate in periprosthetic pseudocysts of the ankle (p-value 0.02037).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In periprosthetic pseudocysts an above average higher detection rate of type 1 SLIM induced by abrasion (51.3%) with an increased Ki67 proliferation fraction (p-value 0.02037) was found, which can be interpreted as local destructive intraosseus synovialitis. This can be the reason for formation of pseudocystic osteolysis caused by high mechanical stress in ankle endoprostheses. A simplified diagnostic classification scoring system of dysfunctional endoprostheses of the ankle is proposed for collation of periprosthetic pseudocysts, ossifications and the Ki67 proliferation fraction.</AbstractText>
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<VernacularTitle>Endoprothesenversagen im oberen Sprunggelenk : Histopathologische Diagnostik und Klassifikation.</VernacularTitle>
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<Keyword MajorTopicYN="N">Periprosthetic pseudocysts</Keyword>
<Keyword MajorTopicYN="N">Prosthesis failure</Keyword>
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