Percutaneous Isolated Hepatic Perfusion as a Treatment for Isolated Hepatic Metastases of Uveal Melanoma: Patient Outcome and Safety in a Multi-centre Study.
Identifieur interne : 000013 ( PubMed/Checkpoint ); précédent : 000012; suivant : 000014Percutaneous Isolated Hepatic Perfusion as a Treatment for Isolated Hepatic Metastases of Uveal Melanoma: Patient Outcome and Safety in a Multi-centre Study.
Auteurs : Thomas J. Vogl [Allemagne] ; Silvia A. Koch [Allemagne] ; Gösta Lotz [Allemagne] ; Bernhard Gebauer [Allemagne] ; Winfried Willinek [Allemagne] ; Christoph Engelke [Allemagne] ; Roland Brüning [Allemagne] ; Martin Zeile [Allemagne] ; Frank Wacker [Allemagne] ; Arndt Vogel [Allemagne] ; Boris Radeleff [Allemagne] ; Jan-Erik Scholtz [Allemagne]Source :
- Cardiovascular and interventional radiology [ 1432-086X ] ; 2017.
Abstract
Percutaneous isolated hepatic perfusion (PIHP) with Melphalan has been developed as a treatment for patients with isolated hepatic metastases of uveal melanoma. We discuss patient outcome and safety in a retrospective multi-centre study.
DOI: 10.1007/s00270-017-1588-2
PubMed: 28144756
Affiliations:
- Allemagne
- Bade-Wurtemberg, Basse-Saxe, Berlin, District de Darmstadt, District de Karlsruhe, Hambourg, Hesse (Land)
- Berlin, Francfort-sur-le-Main, Göttingen, Hambourg, Hanovre, Heidelberg
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Vogl</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Koch, Silvia A" sort="Koch, Silvia A" uniqKey="Koch S" first="Silvia A" last="Koch">Silvia A. Koch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Lotz, Gosta" sort="Lotz, Gosta" uniqKey="Lotz G" first="Gösta" last="Lotz">Gösta Lotz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Intensive-Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country 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wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende gGmbH, An der Lutter 24, 37075, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende gGmbH, An der Lutter 24, 37075, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Bruning, Roland" sort="Bruning, Roland" uniqKey="Bruning R" first="Roland" last="Brüning">Roland Brüning</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Zeile, Martin" sort="Zeile, Martin" uniqKey="Zeile M" first="Martin" last="Zeile">Martin Zeile</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Wacker, Frank" sort="Wacker, Frank" uniqKey="Wacker F" first="Frank" last="Wacker">Frank Wacker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Vogel, Arndt" sort="Vogel, Arndt" uniqKey="Vogel A" first="Arndt" last="Vogel">Arndt Vogel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Radeleff, Boris" sort="Radeleff, Boris" uniqKey="Radeleff B" first="Boris" last="Radeleff">Boris Radeleff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Voßstraße 2, 69115, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Voßstraße 2, 69115, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Scholtz, Jan Erik" sort="Scholtz, Jan Erik" uniqKey="Scholtz J" first="Jan-Erik" last="Scholtz">Jan-Erik Scholtz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. janerikscholtz@gmail.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28144756</idno><idno type="pmid">28144756</idno><idno type="doi">10.1007/s00270-017-1588-2</idno><idno type="wicri:Area/PubMed/Corpus">000014</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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Vogl</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Koch, Silvia A" sort="Koch, Silvia A" uniqKey="Koch S" first="Silvia A" last="Koch">Silvia A. Koch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Lotz, Gosta" sort="Lotz, Gosta" uniqKey="Lotz G" first="Gösta" last="Lotz">Gösta Lotz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology, Intensive-Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology, Intensive-Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Gebauer, Bernhard" sort="Gebauer, Bernhard" uniqKey="Gebauer B" first="Bernhard" last="Gebauer">Bernhard Gebauer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Campus Charité Mitte, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Campus Charité Mitte, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Willinek, Winfried" sort="Willinek, Winfried" uniqKey="Willinek W" first="Winfried" last="Willinek">Winfried Willinek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Brüderkrankenhaus Trier, Nordallee 1, 54292, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Brüderkrankenhaus Trier, Nordallee 1, 54292, Trier</wicri:regionArea><wicri:noRegion>54292, Trier</wicri:noRegion><wicri:noRegion>54292, Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Engelke, Christoph" sort="Engelke, Christoph" uniqKey="Engelke C" first="Christoph" last="Engelke">Christoph Engelke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende gGmbH, An der Lutter 24, 37075, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende gGmbH, An der Lutter 24, 37075, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Bruning, Roland" sort="Bruning, Roland" uniqKey="Bruning R" first="Roland" last="Brüning">Roland Brüning</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Zeile, Martin" sort="Zeile, Martin" uniqKey="Zeile M" first="Martin" last="Zeile">Martin Zeile</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Wacker, Frank" sort="Wacker, Frank" uniqKey="Wacker F" first="Frank" last="Wacker">Frank Wacker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Vogel, Arndt" sort="Vogel, Arndt" uniqKey="Vogel A" first="Arndt" last="Vogel">Arndt Vogel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Radeleff, Boris" sort="Radeleff, Boris" uniqKey="Radeleff B" first="Boris" last="Radeleff">Boris Radeleff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Voßstraße 2, 69115, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Voßstraße 2, 69115, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Scholtz, Jan Erik" sort="Scholtz, Jan Erik" uniqKey="Scholtz J" first="Jan-Erik" last="Scholtz">Jan-Erik Scholtz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. janerikscholtz@gmail.com.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><series><title level="j">Cardiovascular and interventional radiology</title><idno type="eISSN">1432-086X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Percutaneous isolated hepatic perfusion (PIHP) with Melphalan has been developed as a treatment for patients with isolated hepatic metastases of uveal melanoma. We discuss patient outcome and safety in a retrospective multi-centre study.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28144756</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>01</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-086X</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Cardiovascular and interventional radiology</Title><ISOAbbreviation>Cardiovasc Intervent Radiol</ISOAbbreviation></Journal><ArticleTitle>Percutaneous Isolated Hepatic Perfusion as a Treatment for Isolated Hepatic Metastases of Uveal Melanoma: Patient Outcome and Safety in a Multi-centre Study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00270-017-1588-2</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Percutaneous isolated hepatic perfusion (PIHP) with Melphalan has been developed as a treatment for patients with isolated hepatic metastases of uveal melanoma. We discuss patient outcome and safety in a retrospective multi-centre study.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Between 2012 and 2016 18 patients with un-resectable isolated hepatic metastases of uveal melanoma received single or repeated PIHP with Melphalan (n = 35) at seven sites. Progression-free time, overall survival time (OS) and tumour response by means of RECIST 1.1 criteria were evaluated. Peri- and post-procedural adverse events (AE) were registered. Patients' life quality was assessed using four-point scale questionnaires.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 18 patients, initial PIHP treatment resulted in partial response (PR) in eight, stable disease (SD) in seven and progressive disease (PD) in three cases. Nine patients underwent second PIHP with PR in eight cases and PD in one case. Six patients were evaluated after third PIHP with PR in five patients and SD in one patient. Two patients received fourth PIHP with PD in both cases. Median OS was 9.6 months (range 1.6-41.0 months). Median progression-free survival time was 12.4 months (range 0.9-41.0 months) with 1-year survival of 44%. Most common post-procedural AE grade 3 and 4 were temporary leukopenia (n = 11) and thrombocytopenia (n = 8). Patients' self-assessments showed good ratings for overall health and quality of life with only slight changes after PIHP, and a high degree of satisfaction with PIHP treatment.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">PIHP with Melphalan proved to be a relatively safe, minimal-invasive and repeatable treatment for patients with non-resectable hepatic metastases of uveal melanoma.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vogl</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koch</LastName><ForeName>Silvia A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lotz</LastName><ForeName>Gösta</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Intensive-Care Medicine and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gebauer</LastName><ForeName>Bernhard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Campus Charité Mitte, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willinek</LastName><ForeName>Winfried</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Brüderkrankenhaus Trier, Nordallee 1, 54292, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engelke</LastName><ForeName>Christoph</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Evangelisches Krankenhaus Göttingen-Weende gGmbH, An der Lutter 24, 37075, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brüning</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeile</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Asklepios Klinik Barmbek, Rübenkamp 220, 22291, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wacker</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vogel</LastName><ForeName>Arndt</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Radeleff</LastName><ForeName>Boris</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Voßstraße 2, 69115, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scholtz</LastName><ForeName>Jan-Erik</ForeName><Initials>JE</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4631-6126</Identifier><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. janerikscholtz@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge StreetSuite 400, Boston, MA, 02141, USA. janerikscholtz@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cardiovasc Intervent Radiol</MedlineTA><NlmUniqueID>8003538</NlmUniqueID><ISSNLinking>0174-1551</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chemosaturation</Keyword><Keyword MajorTopicYN="N">Liver metastases</Keyword><Keyword MajorTopicYN="N">Melphalan</Keyword><Keyword MajorTopicYN="N">Percutaneous isolated hepatic perfusion</Keyword><Keyword MajorTopicYN="N">Uveal melanoma</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28144756</ArticleId><ArticleId IdType="doi">10.1007/s00270-017-1588-2</ArticleId><ArticleId IdType="pii">10.1007/s00270-017-1588-2</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Berlin</li><li>District de Darmstadt</li><li>District de Karlsruhe</li><li>Hambourg</li><li>Hesse (Land)</li></region><settlement><li>Berlin</li><li>Francfort-sur-le-Main</li><li>Göttingen</li><li>Hambourg</li><li>Hanovre</li><li>Heidelberg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Vogl, Thomas J" sort="Vogl, Thomas J" uniqKey="Vogl T" first="Thomas J" last="Vogl">Thomas J. Vogl</name></region><name sortKey="Bruning, Roland" sort="Bruning, Roland" uniqKey="Bruning R" first="Roland" last="Brüning">Roland Brüning</name><name sortKey="Engelke, Christoph" sort="Engelke, Christoph" uniqKey="Engelke C" first="Christoph" last="Engelke">Christoph Engelke</name><name sortKey="Gebauer, Bernhard" sort="Gebauer, Bernhard" uniqKey="Gebauer B" first="Bernhard" last="Gebauer">Bernhard Gebauer</name><name sortKey="Koch, Silvia A" sort="Koch, Silvia A" uniqKey="Koch S" first="Silvia A" last="Koch">Silvia A. Koch</name><name sortKey="Lotz, Gosta" sort="Lotz, Gosta" uniqKey="Lotz G" first="Gösta" last="Lotz">Gösta Lotz</name><name sortKey="Radeleff, Boris" sort="Radeleff, Boris" uniqKey="Radeleff B" first="Boris" last="Radeleff">Boris Radeleff</name><name sortKey="Scholtz, Jan Erik" sort="Scholtz, Jan Erik" uniqKey="Scholtz J" first="Jan-Erik" last="Scholtz">Jan-Erik Scholtz</name><name sortKey="Vogel, Arndt" sort="Vogel, Arndt" uniqKey="Vogel A" first="Arndt" last="Vogel">Arndt Vogel</name><name sortKey="Wacker, Frank" sort="Wacker, Frank" uniqKey="Wacker F" first="Frank" last="Wacker">Frank Wacker</name><name sortKey="Willinek, Winfried" sort="Willinek, Winfried" uniqKey="Willinek W" first="Winfried" last="Willinek">Winfried Willinek</name><name sortKey="Zeile, Martin" sort="Zeile, Martin" uniqKey="Zeile M" first="Martin" last="Zeile">Martin Zeile</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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