Autonomic cardiovascular regulation in obesity
Identifieur interne : 000017 ( PascalFrancis/Curation ); précédent : 000016; suivant : 000018Autonomic cardiovascular regulation in obesity
Auteurs : K. Laederach-Hofmann [Suisse] ; L. Mussgay [Allemagne] ; H. Ruddel [Allemagne]Source :
- Journal of endocrinology [ 0022-0795 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Obese persons suffer from an increased mortality risk supposedly due to cardiovascular disorders related to either continuously lowered parasympathetic or altered sympathetic activation. Our cross-sectional correlation study establishes the relationship between obesity and autonomic regulation as well as salivary cortisol levels. Three patient cohorts were sampled, covering ranges of body mass index (BMI) of 27-32 (n=17), 33-39 (n=13) and above 40 kg/m2(n=12), and stratified for age, sex and menopausal status. Autonomic cardiovascular regulation was assessed by use of heart rate variability and continuous blood pressure recordings. Spectral analytical calculation (discrete Fourier transformation) yields indices of sympathetic and parasympathetic activation and baroreflex sensitivity. Morning salivary cortisol was concurrently collected. Contrary to expectation, BMI and waist/hip ratio (WHR) were inversely correlated with sympathetic activity. This was true for resting conditions (r=-0.48, P<0.001; r=-0.33, P<0.05 for BMI and WHR respectively) and for mental challenge (r=-0.42, P<0.01 for BMI). Resting baroreflex sensitivity was strongly related to the degree of obesity at rest (BMI: r=-0.35, P<0.05) and for mental challenge (r=-0.53, P<0.001). Salivary cortisol correlated significantly with waist circumference (r=-0.34, P=0.05). With increasing weight, no overstimulation was found but a depression in sympathetic and parasympathetic activity together with a significant reduction in baroreflex functioning and in salivary cortisol levels.
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Mussgay</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Trier, Center for Psychobiological and Psychosomatic Research, Department of Behavioral Medicine, St-Franziska-Stift</s1><s2>Bad Kreuznach</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Ruddel, H" sort="Ruddel, H" uniqKey="Ruddel H" first="H." last="Ruddel">H. Ruddel</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Trier, Center for Psychobiological and Psychosomatic Research, Department of Behavioral Medicine, St-Franziska-Stift</s1><s2>Bad Kreuznach</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0106447</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0106447 INIST</idno><idno type="RBID">Pascal:00-0106447</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F52</idno><idno type="wicri:Area/PascalFrancis/Curation">000017</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Autonomic cardiovascular regulation in obesity</title><author><name sortKey="Laederach Hofmann, K" sort="Laederach Hofmann, K" uniqKey="Laederach Hofmann K" first="K." last="Laederach-Hofmann">K. Laederach-Hofmann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Unit of Psychosomatic and Psychosocial Medicine, University of Berne</s1><s3>CHE</s3><sZ>1 aut.</sZ></inist:fA14><country>Suisse</country></affiliation></author><author><name sortKey="Mussgay, L" sort="Mussgay, L" uniqKey="Mussgay L" first="L." last="Mussgay">L. Mussgay</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Trier, Center for Psychobiological and Psychosomatic Research, Department of Behavioral Medicine, St-Franziska-Stift</s1><s2>Bad Kreuznach</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author><author><name sortKey="Ruddel, H" sort="Ruddel, H" uniqKey="Ruddel H" first="H." last="Ruddel">H. Ruddel</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Trier, Center for Psychobiological and Psychosomatic Research, Department of Behavioral Medicine, St-Franziska-Stift</s1><s2>Bad Kreuznach</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country></affiliation></author></analytic><series><title level="j" type="main">Journal of endocrinology</title><title level="j" type="abbreviated">J. endocrinol.</title><idno type="ISSN">0022-0795</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of endocrinology</title><title level="j" type="abbreviated">J. endocrinol.</title><idno type="ISSN">0022-0795</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arterial pressure</term><term>Autonomic nervous system</term><term>Cardiovascular control</term><term>Cohort study</term><term>Complication</term><term>Heart rate</term><term>Human</term><term>Obesity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux autonome</term><term>Contrôle cardiovasculaire</term><term>Rythme cardiaque</term><term>Pression artérielle</term><term>Complication</term><term>Etude cohorte</term><term>Obésité</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Obese persons suffer from an increased mortality risk supposedly due to cardiovascular disorders related to either continuously lowered parasympathetic or altered sympathetic activation. Our cross-sectional correlation study establishes the relationship between obesity and autonomic regulation as well as salivary cortisol levels. Three patient cohorts were sampled, covering ranges of body mass index (BMI) of 27-32 (n=17), 33-39 (n=13) and above 40 kg/m<sup>2</sup>(n=12), and stratified for age, sex and menopausal status. Autonomic cardiovascular regulation was assessed by use of heart rate variability and continuous blood pressure recordings. Spectral analytical calculation (discrete Fourier transformation) yields indices of sympathetic and parasympathetic activation and baroreflex sensitivity. Morning salivary cortisol was concurrently collected. Contrary to expectation, BMI and waist/hip ratio (WHR) were inversely correlated with sympathetic activity. This was true for resting conditions (r=-0.48, P<0.001; r=-0.33, P<0.05 for BMI and WHR respectively) and for mental challenge (r=-0.42, P<0.01 for BMI). Resting baroreflex sensitivity was strongly related to the degree of obesity at rest (BMI: r=-0.35, P<0.05) and for mental challenge (r=-0.53, P<0.001). Salivary cortisol correlated significantly with waist circumference (r=-0.34, P=0.05). 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