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Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions

Identifieur interne : 000740 ( PascalFrancis/Corpus ); précédent : 000739; suivant : 000741

Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions

Auteurs : Nathalie Grova ; Henri Schroeder ; Sophie Farinelle ; Emmanuel Prodhomme ; Anne Valley ; Claude P. Muller

Source :

RBID : Pascal:09-0021305

Descripteurs français

English descriptors

Abstract

Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg-1 day-1, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg-1 B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg-1) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A06       @3 SUP1
A08 01  1  ENG  @1 Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
A09 01  1  ENG  @1 Halogenated Persistent Organic Pollutants - Dioxin 2005 Toronto
A11 01  1    @1 GROVA (Nathalie)
A11 02  1    @1 SCHROEDER (Henri)
A11 03  1    @1 FARINELLE (Sophie)
A11 04  1    @1 PRODHOMME (Emmanuel)
A11 05  1    @1 VALLEY (Anne)
A11 06  1    @1 MULLER (Claude P.)
A12 01  1    @1 ALAEE (Mehran) @9 ed.
A12 02  1    @1 ARSENAULT (Gilles) @9 ed.
A12 03  1    @1 PARROTT (Joanne) @9 ed.
A12 04  1    @1 REINER (Eric J.) @9 ed.
A14 01      @1 Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102 @2 1011 Luxembourg @3 LUX @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut.
A14 02      @1 Neurosciences Comportementales, URAFPA. INRA UC340, Nancy Université, BP 239 @2 54506 Vandoeuvre les Nancy @3 FRA @Z 2 aut. @Z 5 aut.
A14 03      @1 Department of Immunology, The Graduate School of Psychobiology, University of Trier @2 54290 Trier @3 DEU @Z 6 aut.
A15 01      @1 Water Science and Technology Branch, Environmental Canada @2 Burlington @3 CAN @Z 1 aut. @Z 3 aut.
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A15 03      @1 Laboratory Services Branch, Ontario Ministry of Environment @2 Toronto @3 CAN @Z 4 aut.
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C01 01    ENG  @0 Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg-1 day-1, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg-1 B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg-1) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.
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Format Inist (serveur)

NO : PASCAL 09-0021305 INIST
ET : Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
AU : GROVA (Nathalie); SCHROEDER (Henri); FARINELLE (Sophie); PRODHOMME (Emmanuel); VALLEY (Anne); MULLER (Claude P.); ALAEE (Mehran); ARSENAULT (Gilles); PARROTT (Joanne); REINER (Eric J.)
AF : Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102/1011 Luxembourg/Luxembourg (1 aut., 3 aut., 4 aut., 6 aut.); Neurosciences Comportementales, URAFPA. INRA UC340, Nancy Université, BP 239/54506 Vandoeuvre les Nancy/France (2 aut., 5 aut.); Department of Immunology, The Graduate School of Psychobiology, University of Trier/54290 Trier/Allemagne (6 aut.); Water Science and Technology Branch, Environmental Canada/Burlington/Canada (1 aut., 3 aut.); Wellington Laboratories/Guelph/Canada (2 aut.); Laboratory Services Branch, Ontario Ministry of Environment/Toronto/Canada (4 aut.)
DT : Publication en série; Congrès; Niveau analytique
SO : Chemosphere : (Oxford); ISSN 0045-6535; Coden CMSHAF; Royaume-Uni; Da. 2008; Vol. 73; No. SUP1; S295-S302; Bibl. 3/4 p.
LA : Anglais
EA : Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg-1 day-1, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg-1 B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg-1) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.
CC : 002B03L06
FD : Benzo pyrène; Subaigu; Benzo[a]pyrène; Comportement; Animal adulte; Souris; NMDA; Angoisse anxiété; Récepteur NMDA; Gène; Encéphale; Récepteur glutamate; Sousunité; Sang; Composé aromatique polycyclique; Hydrocarbure; Mécanisme action; Toxicité
FG : Rodentia; Mammalia; Vertebrata; Polluant organique persistant; Composé organique; Affect affectivité
ED : Benzopyrene; Subacute; Behavior; Adult animal; Mouse; NMDA; Anxiety; NMDA receptor; Gene; Encephalon; Glutamate receptor; Subunit; Blood; Polycyclic aromatic compound; Hydrocarbon; Mechanism of action; Toxicity
EG : Rodentia; Mammalia; Vertebrata; Persistent organic pollutant; Organic compounds; Affect affectivity
SD : Benzopireno; Subagudo; Conducta; Animal adulto; Ratón; NMDA; Angustia ansiedad; Receptor NMDA; Gen; Encéfalo; Receptor glutámato; Subunitad; Sangre; Compuesto aromático policíclico; Hidrocarburo; Mecanismo acción; Toxicidad
LO : INIST-15565.354000185279380450
ID : 09-0021305

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Pascal:09-0021305

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<term>Animal adulte</term>
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<div type="abstract" xml:lang="en">Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg
<sup>-1</sup>
day
<sup>-1</sup>
, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg
<sup>-1</sup>
B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg
<sup>-1</sup>
) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.</div>
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<s0>Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg
<sup>-1</sup>
day
<sup>-1</sup>
, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg
<sup>-1</sup>
B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg
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<s5>62</s5>
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<s2>NA</s2>
<s5>62</s5>
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<s2>NA</s2>
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<fA30 i1="01" i2="1" l="ENG">
<s1>International Symposium on halogenated environmental organic pollutants and POPs (Dioxin 2005)</s1>
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<NO>PASCAL 09-0021305 INIST</NO>
<ET>Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions</ET>
<AU>GROVA (Nathalie); SCHROEDER (Henri); FARINELLE (Sophie); PRODHOMME (Emmanuel); VALLEY (Anne); MULLER (Claude P.); ALAEE (Mehran); ARSENAULT (Gilles); PARROTT (Joanne); REINER (Eric J.)</AU>
<AF>Institute of Immunology, Laboratoire National de Santé, 20A Rue Auguste Lumière, P.O. Box 1102/1011 Luxembourg/Luxembourg (1 aut., 3 aut., 4 aut., 6 aut.); Neurosciences Comportementales, URAFPA. INRA UC340, Nancy Université, BP 239/54506 Vandoeuvre les Nancy/France (2 aut., 5 aut.); Department of Immunology, The Graduate School of Psychobiology, University of Trier/54290 Trier/Allemagne (6 aut.); Water Science and Technology Branch, Environmental Canada/Burlington/Canada (1 aut., 3 aut.); Wellington Laboratories/Guelph/Canada (2 aut.); Laboratory Services Branch, Ontario Ministry of Environment/Toronto/Canada (4 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Chemosphere : (Oxford); ISSN 0045-6535; Coden CMSHAF; Royaume-Uni; Da. 2008; Vol. 73; No. SUP1; S295-S302; Bibl. 3/4 p.</SO>
<LA>Anglais</LA>
<EA>Abnormal glutamatergic transmission caused by modulation of N-methyl-D-aspartate (NMDA) receptors was demonstrated in animal models chronically exposed to various organic micropollutants. Recent developments in neurobiology have implicated these receptors in the regulation of anxiety. In order to investigate anxiety-related effects of benzo[a]pyrene (B[a]P), Balb/c mice were sub-acutely exposed to B[a]P (0.02-200 mg kg
<sup>-1</sup>
day
<sup>-1</sup>
, 10 days, i.p.). Their performance was tested in the elevated-plus maze and the hole-board apparatus and the NMDA receptor expression genes (NR1, 2A and 2B subunits) was measured in eight brain regions. Mice treated with 20-200mg kg
<sup>-1</sup>
B[a]P showed a disproportionate accumulation of B[a]P and its metabolites (in particular, the toxic 7,8-diol-B[a]P) in the blood and even more in the brain. These mice were less anxious than controls in the hole-board test and the elevated-plus maze. This observation was associated with an overexpression of the NMDA NR1 receptor gene and concomitant decreases of the NR2A and NR2B subunits expression in the hippocampus, the hypothalamus and the cerebellum. In the temporal cortex, a significant dose-related decrease of NR2A was observed whereas the other subunits remained unchanged. In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg
<sup>-1</sup>
) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions.</EA>
<CC>002B03L06</CC>
<FD>Benzo pyrène; Subaigu; Benzo[a]pyrène; Comportement; Animal adulte; Souris; NMDA; Angoisse anxiété; Récepteur NMDA; Gène; Encéphale; Récepteur glutamate; Sousunité; Sang; Composé aromatique polycyclique; Hydrocarbure; Mécanisme action; Toxicité</FD>
<FG>Rodentia; Mammalia; Vertebrata; Polluant organique persistant; Composé organique; Affect affectivité</FG>
<ED>Benzopyrene; Subacute; Behavior; Adult animal; Mouse; NMDA; Anxiety; NMDA receptor; Gene; Encephalon; Glutamate receptor; Subunit; Blood; Polycyclic aromatic compound; Hydrocarbon; Mechanism of action; Toxicity</ED>
<EG>Rodentia; Mammalia; Vertebrata; Persistent organic pollutant; Organic compounds; Affect affectivity</EG>
<SD>Benzopireno; Subagudo; Conducta; Animal adulto; Ratón; NMDA; Angustia ansiedad; Receptor NMDA; Gen; Encéfalo; Receptor glutámato; Subunitad; Sangre; Compuesto aromático policíclico; Hidrocarburo; Mecanismo acción; Toxicidad</SD>
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   |type=    RBID
   |clé=     Pascal:09-0021305
   |texte=   Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
}}
Wicri

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