Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload
Identifieur interne : 000E95 ( PascalFrancis/Checkpoint ); précédent : 000E94; suivant : 000E96Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload
Auteurs : P. Schulz [Allemagne] ; C. Kirschbaum [Allemagne] ; J. Prüssner [Allemagne] ; D. Hellhammer [Allemagne]Source :
- Stress medicine [ 0748-8386 ] ; 1998.
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Abstract
The present study investigated the association between chronic stress and cortisol changes during the first hour after awakening in the morning. According to results of a pilot study, it was hypothesized that chronically stressed subjects would show a more enhanced and prolonged increase of cortisol level after awakening compared to non-stressed subjects. In 100 subjects, chronic stress was assessed twice with a 1-week interval between measures and cortisol was repeatedly measured during the first hour of awakening on 3 consecutive days. Results showed that chronically stressed subjects had a significantly larger increase in cortisol (+15.5 nmol/l) compared to unstressed subjects (+9.1 nmol/l). Further analysis indicated a significant sex difference with larger increases in chronically stressed women (+16.5 nmol/l) compared to stressed men (+11.8 nmol/l). From these data we conclude that a repeated measurement of free cortisol in response to awakening should be considered a possible biological correlate of chronic stress. Possible causes, consequences and clinical relevance of this hypercortisolism in chronically stressed subjects are briefly discussed.
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Further analysis indicated a significant sex difference with larger increases in chronically stressed women (+16.5 nmol/l) compared to stressed men (+11.8 nmol/l). From these data we conclude that a repeated measurement of free cortisol in response to awakening should be considered a possible biological correlate of chronic stress. 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Schulz</name></region><name sortKey="Hellhammer, D" sort="Hellhammer, D" uniqKey="Hellhammer D" first="D." last="Hellhammer">D. Hellhammer</name><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name><name sortKey="Prussner, J" sort="Prussner, J" uniqKey="Prussner J" first="J." last="Prüssner">J. Prüssner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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