Elicitation of the immune response to p-phenytenediamine in allergic patients: the role of dose and exposure time
Identifieur interne : 000407 ( PascalFrancis/Checkpoint ); précédent : 000406; suivant : 000408Elicitation of the immune response to p-phenytenediamine in allergic patients: the role of dose and exposure time
Auteurs : C. Goebel [Allemagne] ; P.-J. Coenraads [Pays-Bas] ; H. Rothe [Allemagne] ; G. Kunze [Allemagne] ; M. Kock [Allemagne] ; H. Schlatter [Allemagne] ; G. F. Gerberick [Allemagne] ; B. Blömeke [Allemagne]Source :
- British journal of dermatology : (1951) [ 0007-0963 ] ; 2010.
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Abstract
Background Usage of hair dye products containing p-phenylenediamine (PPD) is a concern for PPD-allergic individuals. Objectives The present study investigates the role of dose and exposure time on elicitation of allergic contact dermatitis under conditions of permanent hair dyeing. Methods Elicitation responses after application of a typical hair dye product containing 2% PPD for 30 min followed by rinsing were analysed in 38 PPD-allergic individuals with a documented history of hair dye-related allergy. Skin binding experiments in vitro were performed to distinguish the dose available for elicitation from the dose applied. Results A positive reaction was elicited in 20 of 20 patients with grades ++ to +++ and 12 of 18 with grade + according to the classification of the International Contact Dermatitis Research Group. Under conditions of diagnostic patch testing (48 h exposure), the dose available for elicitation is more than 10-fold higher compared with the dose available for hair dyeing (30-min exposure, rinsing of product). Conclusions This investigation demonstrates that under simulated hair dye use conditions the actual exposure to PPD is more than an order of magnitude lower than under diagnostic patch testing, although sufficient to elicit a clearly noticeable reaction in 84% of PPD patch test-positive individuals.
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Schlatter</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Gerberick, G F" sort="Gerberick, G F" uniqKey="Gerberick G" first="G. F." last="Gerberick">G. F. Gerberick</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Blomeke, B" sort="Blomeke, B" uniqKey="Blomeke B" first="B." last="Blömeke">B. Blömeke</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Environmental Toxicology, Trier University, Am Wissenschaftspark 25-27</s1><s2>54296 Trier</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>Am Wissenschaftspark 25-27</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0038149</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 11-0038149 INIST</idno><idno type="RBID">Pascal:11-0038149</idno><idno type="wicri:Area/PascalFrancis/Corpus">000459</idno><idno type="wicri:Area/PascalFrancis/Curation">000884</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000407</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000407</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Elicitation of the immune response to p-phenytenediamine in allergic patients: the role of dose and exposure time</title><author><name sortKey="Goebel, C" sort="Goebel, C" uniqKey="Goebel C" first="C." last="Goebel">C. Goebel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P.-J." last="Coenraads">P.-J. Coenraads</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Dermatology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Rothe, H" sort="Rothe, H" uniqKey="Rothe H" first="H." last="Rothe">H. Rothe</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Kunze, G" sort="Kunze, G" uniqKey="Kunze G" first="G." last="Kunze">G. Kunze</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Kock, M" sort="Kock, M" uniqKey="Kock M" first="M." last="Kock">M. Kock</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Schlatter, H" sort="Schlatter, H" uniqKey="Schlatter H" first="H." last="Schlatter">H. Schlatter</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Gerberick, G F" sort="Gerberick, G F" uniqKey="Gerberick G" first="G. F." last="Gerberick">G. F. Gerberick</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Blomeke, B" sort="Blomeke, B" uniqKey="Blomeke B" first="B." last="Blömeke">B. Blömeke</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Environmental Toxicology, Trier University, Am Wissenschaftspark 25-27</s1><s2>54296 Trier</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>Am Wissenschaftspark 25-27</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allergy</term><term>Contact dermatitis</term><term>Dermatology</term><term>Dose</term><term>Exposure time</term><term>Hair</term><term>Hair (head)</term><term>Human</term><term>Immune response</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Allergie</term><term>Dermatite de contact</term><term>Réponse immune</term><term>Dose</term><term>Temps exposition</term><term>Homme</term><term>Poil</term><term>Cheveu</term><term>Dermatologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Allergie</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Usage of hair dye products containing p-phenylenediamine (PPD) is a concern for PPD-allergic individuals. Objectives The present study investigates the role of dose and exposure time on elicitation of allergic contact dermatitis under conditions of permanent hair dyeing. Methods Elicitation responses after application of a typical hair dye product containing 2% PPD for 30 min followed by rinsing were analysed in 38 PPD-allergic individuals with a documented history of hair dye-related allergy. Skin binding experiments in vitro were performed to distinguish the dose available for elicitation from the dose applied. Results A positive reaction was elicited in 20 of 20 patients with grades ++ to +++ and 12 of 18 with grade + according to the classification of the International Contact Dermatitis Research Group. Under conditions of diagnostic patch testing (48 h exposure), the dose available for elicitation is more than 10-fold higher compared with the dose available for hair dyeing (30-min exposure, rinsing of product). Conclusions This investigation demonstrates that under simulated hair dye use conditions the actual exposure to PPD is more than an order of magnitude lower than under diagnostic patch testing, although sufficient to elicit a clearly noticeable reaction in 84% of PPD patch test-positive individuals.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0007-0963</s0></fA01><fA02 i1="01"><s0>BJDEAZ</s0></fA02><fA03 i2="1"><s0>Br. j. dermatol. : (1951)</s0></fA03><fA05><s2>163</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Elicitation of the immune response to p-phenytenediamine in allergic patients: the role of dose and exposure time</s1></fA08><fA11 i1="01" i2="1"><s1>GOEBEL (C.)</s1></fA11><fA11 i1="02" i2="1"><s1>COENRAADS (P.-J.)</s1></fA11><fA11 i1="03" i2="1"><s1>ROTHE (H.)</s1></fA11><fA11 i1="04" i2="1"><s1>KUNZE (G.)</s1></fA11><fA11 i1="05" i2="1"><s1>KOCK (M.)</s1></fA11><fA11 i1="06" i2="1"><s1>SCHLATTER (H.)</s1></fA11><fA11 i1="07" i2="1"><s1>GERBERICK (G. F.)</s1></fA11><fA11 i1="08" i2="1"><s1>BLÖMEKE (B.)</s1></fA11><fA14 i1="01"><s1>The Procter & Gamble Company, Central Product Safety</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Dermatology, University Medical Center Groningen, University of Groningen</s1><s2>Groningen</s2><s3>NLD</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Environmental Toxicology, Trier University, Am Wissenschaftspark 25-27</s1><s2>54296 Trier</s2><s3>DEU</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1205-1211</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>1043</s2><s5>354000194013640100</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>36 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0038149</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>British journal of dermatology : (1951)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background Usage of hair dye products containing p-phenylenediamine (PPD) is a concern for PPD-allergic individuals. Objectives The present study investigates the role of dose and exposure time on elicitation of allergic contact dermatitis under conditions of permanent hair dyeing. Methods Elicitation responses after application of a typical hair dye product containing 2% PPD for 30 min followed by rinsing were analysed in 38 PPD-allergic individuals with a documented history of hair dye-related allergy. Skin binding experiments in vitro were performed to distinguish the dose available for elicitation from the dose applied. Results A positive reaction was elicited in 20 of 20 patients with grades ++ to +++ and 12 of 18 with grade + according to the classification of the International Contact Dermatitis Research Group. Under conditions of diagnostic patch testing (48 h exposure), the dose available for elicitation is more than 10-fold higher compared with the dose available for hair dyeing (30-min exposure, rinsing of product). Conclusions This investigation demonstrates that under simulated hair dye use conditions the actual exposure to PPD is more than an order of magnitude lower than under diagnostic patch testing, although sufficient to elicit a clearly noticeable reaction in 84% of PPD patch test-positive individuals.</s0></fC01><fC02 i1="01" i2="X"><s0>002B08</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Allergie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Allergy</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Alergia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Dermatite de contact</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Contact dermatitis</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Dermatitis de contacto</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Réponse immune</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Immune response</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Respuesta inmune</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dose</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dose</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Dosis</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Temps exposition</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Exposure time</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Tiempo exposición</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Homme</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Human</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Hombre</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Poil</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Hair</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Pelo</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Cheveu</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Hair (head)</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Cabello</s0><s5>14</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Dermatologie</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Dermatology</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Dermatología</s0><s5>15</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Immunopathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Immunopathology</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Inmunopatología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de la peau</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Skin disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Piel patología</s0><s5>38</s5></fC07><fN21><s1>024</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>District de Darmstadt</li><li>Groningue (province)</li><li>Hesse (Land)</li></region><settlement><li>Darmstadt</li><li>Groningue</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Goebel, C" sort="Goebel, C" uniqKey="Goebel C" first="C." last="Goebel">C. Goebel</name></region><name sortKey="Blomeke, B" sort="Blomeke, B" uniqKey="Blomeke B" first="B." last="Blömeke">B. Blömeke</name><name sortKey="Gerberick, G F" sort="Gerberick, G F" uniqKey="Gerberick G" first="G. F." last="Gerberick">G. F. Gerberick</name><name sortKey="Kock, M" sort="Kock, M" uniqKey="Kock M" first="M." last="Kock">M. Kock</name><name sortKey="Kunze, G" sort="Kunze, G" uniqKey="Kunze G" first="G." last="Kunze">G. Kunze</name><name sortKey="Rothe, H" sort="Rothe, H" uniqKey="Rothe H" first="H." last="Rothe">H. Rothe</name><name sortKey="Schlatter, H" sort="Schlatter, H" uniqKey="Schlatter H" first="H." last="Schlatter">H. Schlatter</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Coenraads, P J" sort="Coenraads, P J" uniqKey="Coenraads P" first="P.-J." last="Coenraads">P.-J. Coenraads</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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