Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.
Identifieur interne : 000275 ( Ncbi/Merge ); précédent : 000274; suivant : 000276Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.
Auteurs : Robert Kumsta [Allemagne] ; Sonja Entringer ; Jan W. Koper ; Elisabeth F C. Van Rossum ; Dirk H. Hellhammer ; Stefan WüstSource :
- Biological psychiatry [ 0006-3223 ] ; 2007.
English descriptors
- KwdEn :
- Adaptation, Physiological (genetics), Adaptation, Psychological, Adrenocorticotropic Hormone (blood), Adrenocorticotropic Hormone (drug effects), Adult, Analysis of Variance, Contraceptives, Oral (pharmacology), Ethinyl Estradiol (pharmacology), Female, Genetic Variation, Haplotypes, Humans, Hydrocortisone (metabolism), Hypothalamo-Hypophyseal System (drug effects), Hypothalamo-Hypophyseal System (physiology), Linkage Disequilibrium, Male, Pituitary-Adrenal System (drug effects), Pituitary-Adrenal System (physiology), Polymorphism, Genetic, Receptors, Glucocorticoid (genetics), Reference Values, Saliva (metabolism), Sex Factors, Stress, Psychological (genetics), Stress, Psychological (metabolism).
- MESH :
- chemical , blood : Adrenocorticotropic Hormone.
- chemical , drug effects : Adrenocorticotropic Hormone.
- drug effects : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- genetics : Adaptation, Physiological, Receptors, Glucocorticoid, Stress, Psychological.
- chemical , metabolism : Hydrocortisone, Saliva, Stress, Psychological.
- chemical , pharmacology : Contraceptives, Oral, Ethinyl Estradiol.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- Adaptation, Psychological, Adult, Analysis of Variance, Female, Genetic Variation, Haplotypes, Humans, Linkage Disequilibrium, Male, Polymorphism, Genetic, Reference Values, Sex Factors.
Abstract
Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease.
DOI: 10.1016/j.biopsych.2007.04.013
PubMed: 17716631
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Koper</name></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17716631</idno><idno type="pmid">17716631</idno><idno type="doi">10.1016/j.biopsych.2007.04.013</idno><idno type="wicri:Area/PubMed/Corpus">000640</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000640</idno><idno type="wicri:Area/PubMed/Curation">000640</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000640</idno><idno type="wicri:Area/PubMed/Checkpoint">000640</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000640</idno><idno type="wicri:Area/Ncbi/Merge">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.</title><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychobiology, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychobiology, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name></author><author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W" last="Koper">Jan W. Koper</name></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></author></analytic><series><title level="j">Biological psychiatry</title><idno type="ISSN">0006-3223</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term><term>Adaptation, Psychological</term><term>Adrenocorticotropic Hormone (blood)</term><term>Adrenocorticotropic Hormone (drug effects)</term><term>Adult</term><term>Analysis of Variance</term><term>Contraceptives, Oral (pharmacology)</term><term>Ethinyl Estradiol (pharmacology)</term><term>Female</term><term>Genetic Variation</term><term>Haplotypes</term><term>Humans</term><term>Hydrocortisone (metabolism)</term><term>Hypothalamo-Hypophyseal System (drug effects)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Linkage Disequilibrium</term><term>Male</term><term>Pituitary-Adrenal System (drug effects)</term><term>Pituitary-Adrenal System (physiology)</term><term>Polymorphism, Genetic</term><term>Receptors, Glucocorticoid (genetics)</term><term>Reference Values</term><term>Saliva (metabolism)</term><term>Sex Factors</term><term>Stress, Psychological (genetics)</term><term>Stress, Psychological (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Adrenocorticotropic Hormone</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term><term>Receptors, Glucocorticoid</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term><term>Saliva</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Contraceptives, Oral</term><term>Ethinyl Estradiol</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Genetic Variation</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Male</term><term>Polymorphism, Genetic</term><term>Reference Values</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17716631</PMID><DateCreated><Year>2007</Year><Month>10</Month><Day>05</Day></DateCreated><DateCompleted><Year>2007</Year><Month>11</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0006-3223</ISSN><JournalIssue CitedMedium="Print"><Volume>62</Volume><Issue>8</Issue><PubDate><Year>2007</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Biological psychiatry</Title><ISOAbbreviation>Biol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.</ArticleTitle><Pagination><MedlinePgn>863-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We investigated 206 healthy subjects and assessed associations between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and hypothalamic-pituitary-adrenal (HPA) axis responses to psychosocial stress (Trier Social Stress Test, TSST) and glucocorticoid sensitivity measured by a dexamethasone suppression test (DST).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Male 9beta AG carriers displayed the highest adrenocorticotropic hormone (ACTH) and total cortisol TSST responses (for ACTH: main effect genotype p = .02) whereas male BclI GG carriers showed diminished responses. Remarkably, the BclI GG genotype in women (all using oral contraceptives) was associated with the highest total cortisol TSST responses, resulting in a significant sex by genotype interaction (p = .03). Following the DST, male 9beta AG carriers had elevated ACTH levels (sex by genotype interaction p = .03).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We observed significant sex specific associations between GR gene polymorphisms and HPA axis responses to psychosocial stress as well as GC sensitivity. These findings support the relevance of GR gene polymorphisms in HPA axis regulation. Genetic variations of the GR might constitute a risk factor in development of HPA axis related disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumsta</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Psychobiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Entringer</LastName><ForeName>Sonja</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Koper</LastName><ForeName>Jan W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>van Rossum</LastName><ForeName>Elisabeth F C</ForeName><Initials>EF</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Dirk H</ForeName><Initials>DH</Initials></Author><Author ValidYN="Y"><LastName>Wüst</LastName><ForeName>Stefan</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>08</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Psychiatry</MedlineTA><NlmUniqueID>0213264</NlmUniqueID><ISSNLinking>0006-3223</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003276">Contraceptives, Oral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497713">NR3C1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011965">Receptors, Glucocorticoid</NameOfSubstance></Chemical><Chemical><RegistryNumber>423D2T571U</RegistryNumber><NameOfSubstance UI="D004997">Ethinyl Estradiol</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000223" MajorTopicYN="N">Adaptation, Psychological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000324" MajorTopicYN="N">Adrenocorticotropic Hormone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003276" MajorTopicYN="N">Contraceptives, Oral</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004997" MajorTopicYN="N">Ethinyl Estradiol</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011965" MajorTopicYN="N">Receptors, Glucocorticoid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2006</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>04</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>12</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17716631</ArticleId><ArticleId IdType="pii">S0006-3223(07)00331-9</ArticleId><ArticleId IdType="doi">10.1016/j.biopsych.2007.04.013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W" last="Koper">Jan W. Koper</name><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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