The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
Identifieur interne : 000272 ( Ncbi/Merge ); précédent : 000271; suivant : 000273The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
Auteurs : Nick Butz [Allemagne] ; Stefan A. Müller [Allemagne] ; Karl-Heinz Treutner [Allemagne] ; Michail Anurov [Russie] ; Svetlana Titkova [Russie] ; Alexander P. Oettinger [Russie] ; Volker Schumpelick [Allemagne]Source :
- BMC Surgery [ 1471-2482 ] ; 2007.
Abstract
The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.
In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.
The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm2, in the NaCl+Blood-group (n = 10) 147,68 mm2. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm2, in the PhL+Blood-group (n = 9) 11,95 mm2. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).
Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.
Url:
DOI: 10.1186/1471-2482-7-14
PubMed: 17651501
PubMed Central: 1945018
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PMC:1945018Le document en format XML
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<series><title level="j">BMC Surgery</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.</p>
</sec>
<sec><title>Results</title>
<p>The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm<sup>2</sup>
, in the NaCl+Blood-group (n = 10) 147,68 mm<sup>2</sup>
. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm<sup>2</sup>
, in the PhL+Blood-group (n = 9) 11,95 mm<sup>2</sup>
. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).</p>
</sec>
<sec><title>Conclusion</title>
<p>Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Surg</journal-id>
<journal-title>BMC Surgery</journal-title>
<issn pub-type="epub">1471-2482</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17651501</article-id>
<article-id pub-id-type="pmc">1945018</article-id>
<article-id pub-id-type="publisher-id">1471-2482-7-14</article-id>
<article-id pub-id-type="doi">10.1186/1471-2482-7-14</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions</article-title>
</title-group>
<contrib-group><contrib id="A1" corresp="yes" contrib-type="author"><name><surname>Butz</surname>
<given-names>Nick</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>Nbutz@ukaachen.de</email>
</contrib>
<contrib id="A2" contrib-type="author"><name><surname>Müller</surname>
<given-names>Stefan A</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>stefan.mueller@mutterhaus.de</email>
</contrib>
<contrib id="A3" contrib-type="author"><name><surname>Treutner</surname>
<given-names>Karl-Heinz</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>treutner@park-klinik.com</email>
</contrib>
<contrib id="A4" contrib-type="author"><name><surname>Anurov</surname>
<given-names>Michail</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>anurov@ints.ru</email>
</contrib>
<contrib id="A5" contrib-type="author"><name><surname>Titkova</surname>
<given-names>Svetlana</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>titkova@ints.ru</email>
</contrib>
<contrib id="A6" contrib-type="author"><name><surname>Oettinger</surname>
<given-names>Alexander P</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>oett@rsmu.ru</email>
</contrib>
<contrib id="A7" contrib-type="author"><name><surname>Schumpelick</surname>
<given-names>Volker</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>vschumpelick@ukaachen.de</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Department of Surgery, Medical Faculty Rhenish-Westphalian Technical University, Aachen, Germany</aff>
<aff id="I2"><label>2</label>
Department of Surgery I, Klinikum Mutterhaus der Borromäerinnen, Trier, Germany</aff>
<aff id="I3"><label>3</label>
Abdominal Center, Park-Klinik Weissensee, Berlin, Germany</aff>
<aff id="I4"><label>4</label>
Joint Institute for Surgical Research Russian Medical State University, Moscow, Russia</aff>
<pub-date pub-type="collection"><year>2007</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>7</month>
<year>2007</year>
</pub-date>
<volume>7</volume>
<fpage>14</fpage>
<lpage>14</lpage>
<ext-link ext-link-type="uri" xlink:href="http://www.biomedcentral.com/1471-2482/7/14"></ext-link>
<history><date date-type="received"><day>24</day>
<month>2</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>25</day>
<month>7</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2007 Butz et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>Butz et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0"></ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
<pmc-comment>
Butz
Nick
Nbutz@ukaachen.de
The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
2007 BMC Surgery 7(1): 14-. (2007) 1471-2482(2007)7:1<14> urn:ISSN:1471-2482 </pmc-comment>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>The formation of adhesions following abdominal surgery is a well known problem. In previous studies we demonstrated the efficacy and safety of intraperitoneally applied phospholipids in order to prevent adhesion formation. This study evaluates the influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.</p>
</sec>
<sec><title>Results</title>
<p>The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm<sup>2</sup>
, in the NaCl+Blood-group (n = 10) 147,68 mm<sup>2</sup>
. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm<sup>2</sup>
, in the PhL+Blood-group (n = 9) 11,95 mm<sup>2</sup>
. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).</p>
</sec>
<sec><title>Conclusion</title>
<p>Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Russie</li>
</country>
<region><li>Berlin</li>
<li>District de Cologne</li>
<li>District fédéral central</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
<li>Berlin</li>
<li>Moscou</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Butz, Nick" sort="Butz, Nick" uniqKey="Butz N" first="Nick" last="Butz">Nick Butz</name>
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<name sortKey="Muller, Stefan A" sort="Muller, Stefan A" uniqKey="Muller S" first="Stefan A" last="Müller">Stefan A. Müller</name>
<name sortKey="Schumpelick, Volker" sort="Schumpelick, Volker" uniqKey="Schumpelick V" first="Volker" last="Schumpelick">Volker Schumpelick</name>
<name sortKey="Treutner, Karl Heinz" sort="Treutner, Karl Heinz" uniqKey="Treutner K" first="Karl-Heinz" last="Treutner">Karl-Heinz Treutner</name>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Anurov, Michail" sort="Anurov, Michail" uniqKey="Anurov M" first="Michail" last="Anurov">Michail Anurov</name>
</region>
<name sortKey="Oettinger, Alexander P" sort="Oettinger, Alexander P" uniqKey="Oettinger A" first="Alexander P" last="Oettinger">Alexander P. Oettinger</name>
<name sortKey="Titkova, Svetlana" sort="Titkova, Svetlana" uniqKey="Titkova S" first="Svetlana" last="Titkova">Svetlana Titkova</name>
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