Latanoprost eye drops increase concentration of glycosaminoglycans in posterior rabbit sclera.
Identifieur interne : 000167 ( Ncbi/Merge ); précédent : 000166; suivant : 000168Latanoprost eye drops increase concentration of glycosaminoglycans in posterior rabbit sclera.
Auteurs : Klaus Trier [Danemark] ; S Ren Munk Ribel-MadsenSource :
- Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [ 1080-7683 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Cornea (drug effects), Cornea (metabolism), Female, Glycosaminoglycans (metabolism), Instillation, Drug, Ophthalmic Solutions, Prostaglandins F, Synthetic (administration & dosage), Prostaglandins F, Synthetic (pharmacokinetics), Prostaglandins F, Synthetic (pharmacology), Rabbits, Sclera (drug effects), Sclera (metabolism), Spectrophotometry, Uronic Acids (analysis).
- MESH :
- chemical , administration & dosage : Prostaglandins F, Synthetic.
- chemical , analysis : Uronic Acids.
- chemical , metabolism : Glycosaminoglycans.
- drug effects : Cornea, Sclera.
- metabolism : Cornea, Sclera.
- chemical , pharmacokinetics : Prostaglandins F, Synthetic.
- chemical , pharmacology : Prostaglandins F, Synthetic.
- Animals, Female, Instillation, Drug, Ophthalmic Solutions, Rabbits, Spectrophotometry.
Abstract
Glycosaminoglycans are important components of ocular tissues such as the sclera. The pressure reducing effect of a new antiglaucoma drug, latanoprost, is based on an increase in the uveo-scleral outflow by way of modulation of the intracellular matrix of the ciliary body. The purpose of the study was to test the effect of latanoprost on the content of glycosaminoglycans in rabbit cornea and sclera.
DOI: 10.1089/1080768041223648
PubMed: 15279723
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pubmed:15279723Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Latanoprost eye drops increase concentration of glycosaminoglycans in posterior rabbit sclera.</title><author><name sortKey="Trier, Klaus" sort="Trier, Klaus" uniqKey="Trier K" first="Klaus" last="Trier">Klaus Trier</name><affiliation wicri:level="1"><nlm:affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark. ktrier@dadlnet.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Trier Eye Clinic and Research Laboratories, Hellerup</wicri:regionArea><wicri:noRegion>Hellerup</wicri:noRegion></affiliation></author><author><name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15279723</idno><idno type="pmid">15279723</idno><idno type="doi">10.1089/1080768041223648</idno><idno type="wicri:Area/PubMed/Corpus">000740</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000740</idno><idno type="wicri:Area/PubMed/Curation">000740</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000740</idno><idno type="wicri:Area/PubMed/Checkpoint">000740</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000740</idno><idno type="wicri:Area/Ncbi/Merge">000167</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Latanoprost eye drops increase concentration of glycosaminoglycans in posterior rabbit sclera.</title><author><name sortKey="Trier, Klaus" sort="Trier, Klaus" uniqKey="Trier K" first="Klaus" last="Trier">Klaus Trier</name><affiliation wicri:level="1"><nlm:affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark. ktrier@dadlnet.dk</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Trier Eye Clinic and Research Laboratories, Hellerup</wicri:regionArea><wicri:noRegion>Hellerup</wicri:noRegion></affiliation></author><author><name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name></author></analytic><series><title level="j">Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics</title><idno type="ISSN">1080-7683</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cornea (drug effects)</term><term>Cornea (metabolism)</term><term>Female</term><term>Glycosaminoglycans (metabolism)</term><term>Instillation, Drug</term><term>Ophthalmic Solutions</term><term>Prostaglandins F, Synthetic (administration & dosage)</term><term>Prostaglandins F, Synthetic (pharmacokinetics)</term><term>Prostaglandins F, Synthetic (pharmacology)</term><term>Rabbits</term><term>Sclera (drug effects)</term><term>Sclera (metabolism)</term><term>Spectrophotometry</term><term>Uronic Acids (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Prostaglandins F, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Uronic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glycosaminoglycans</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cornea</term><term>Sclera</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cornea</term><term>Sclera</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Prostaglandins F, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Prostaglandins F, Synthetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Instillation, Drug</term><term>Ophthalmic Solutions</term><term>Rabbits</term><term>Spectrophotometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glycosaminoglycans are important components of ocular tissues such as the sclera. The pressure reducing effect of a new antiglaucoma drug, latanoprost, is based on an increase in the uveo-scleral outflow by way of modulation of the intracellular matrix of the ciliary body. The purpose of the study was to test the effect of latanoprost on the content of glycosaminoglycans in rabbit cornea and sclera.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15279723</PMID><DateCreated><Year>2004</Year><Month>07</Month><Day>28</Day></DateCreated><DateCompleted><Year>2004</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1080-7683</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>3</Issue><PubDate><Year>2004</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics</Title><ISOAbbreviation>J Ocul Pharmacol Ther</ISOAbbreviation></Journal><ArticleTitle>Latanoprost eye drops increase concentration of glycosaminoglycans in posterior rabbit sclera.</ArticleTitle><Pagination><MedlinePgn>185-8</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Glycosaminoglycans are important components of ocular tissues such as the sclera. The pressure reducing effect of a new antiglaucoma drug, latanoprost, is based on an increase in the uveo-scleral outflow by way of modulation of the intracellular matrix of the ciliary body. The purpose of the study was to test the effect of latanoprost on the content of glycosaminoglycans in rabbit cornea and sclera.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Twelve rabbits were studied. Six rabbits were treated for 12 weeks with latanoprost eye drops and 6 with hydroxypropylmethylcellulose, dextran 70 eye drops for control. Samples were taken from cornea and anterior, lateral, and posterior sclera. Glycosaminoglycans were determined quantitatively by spectrophotometry (uronic acids).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A significant increase in the concentration of uronic acids was found in all three localisations of sclera from latanoprost-treated animals. The increase was 26%, 24%, and 20% in anterior, lateral, and posterior sclera, respectively.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Long-term treatment with latanoprost induces biochemical changes in sclera. The results indicate that topically applied latanoprost reaches the posterior parts of the rabbit eye.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Trier</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Trier Eye Clinic and Research Laboratories, Hellerup, Denmark. ktrier@dadlnet.dk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ribel-Madsen</LastName><ForeName>Søren Munk</ForeName><Initials>SM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Ocul Pharmacol Ther</MedlineTA><NlmUniqueID>9511091</NlmUniqueID><ISSNLinking>1080-7683</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006025">Glycosaminoglycans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009883">Ophthalmic Solutions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011461">Prostaglandins F, Synthetic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014574">Uronic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C020341">glucosaminoglycans</NameOfSubstance></Chemical><Chemical><RegistryNumber>6Z5B6HVF6O</RegistryNumber><NameOfSubstance UI="C072042">latanoprost</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003315" MajorTopicYN="N">Cornea</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006025" MajorTopicYN="N">Glycosaminoglycans</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007322" MajorTopicYN="N">Instillation, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009883" MajorTopicYN="N">Ophthalmic Solutions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011461" MajorTopicYN="N">Prostaglandins F, Synthetic</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012590" MajorTopicYN="N">Sclera</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013053" MajorTopicYN="N">Spectrophotometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014574" MajorTopicYN="N">Uronic Acids</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>7</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>12</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>7</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15279723</ArticleId><ArticleId IdType="doi">10.1089/1080768041223648</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey="Ribel Madsen, S Ren Munk" sort="Ribel Madsen, S Ren Munk" uniqKey="Ribel Madsen S" first="S Ren Munk" last="Ribel-Madsen">S Ren Munk Ribel-Madsen</name></noCountry><country name="Danemark"><noRegion><name sortKey="Trier, Klaus" sort="Trier, Klaus" uniqKey="Trier K" first="Klaus" last="Trier">Klaus Trier</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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