Allostatic load, perceived stress, and health: a prospective study in two age groups.
Identifieur interne : 000184 ( Ncbi/Curation ); précédent : 000183; suivant : 000185Allostatic load, perceived stress, and health: a prospective study in two age groups.
Auteurs : J. Hellhammer [Allemagne] ; W. Schlotz ; A A Stone ; K M Pirke ; D. HellhammerSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Aged, Aging (physiology), Depression (epidemiology), Depression (psychology), Female, Fibrinogen (metabolism), Health, Humans, Hydrocortisone (deficiency), Hydrocortisone (metabolism), Hypothalamo-Hypophyseal System (physiology), Male, Pituitary-Adrenal System (physiology), Saliva (metabolism), Seasons, Stress, Psychological (complications), Stress, Psychological (physiopathology).
- MESH :
- chemical , deficiency : Hydrocortisone.
- chemical , metabolism : Fibrinogen, Hydrocortisone.
- complications : Stress, Psychological.
- epidemiology : Depression.
- metabolism : Saliva.
- physiology : Aging, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- physiopathology : Stress, Psychological.
- psychology : Depression.
- Adult, Aged, Female, Health, Humans, Male, Seasons.
Abstract
Overactivity of the hypothalamus-pituitary-adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress-related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1-year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.
DOI: 10.1196/annals.1314.002
PubMed: 15677392
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Hellhammer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychobiology, Trier University, D-54290 Trier, Germany. juliane.hellhammer@uni-trier.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychobiology, Trier University, D-54290 Trier</wicri:regionArea><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>54290 Trier</wicri:noRegion><wicri:noRegion>D-54290 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Schlotz, W" sort="Schlotz, W" uniqKey="Schlotz W" first="W" last="Schlotz">W. Schlotz</name></author><author><name sortKey="Stone, A A" sort="Stone, A A" uniqKey="Stone A" first="A A" last="Stone">A A Stone</name></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name></author><author><name sortKey="Hellhammer, D" sort="Hellhammer, D" uniqKey="Hellhammer D" first="D" last="Hellhammer">D. 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However, there may be other stress-related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1-year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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