A non-human primate system for large-scale genetic studies of complex traits
Identifieur interne : 000514 ( Ncbi/Checkpoint ); précédent : 000513; suivant : 000515A non-human primate system for large-scale genetic studies of complex traits
Auteurs : Anna J. Jasinska [États-Unis] ; Michelle K. Lin [États-Unis, Allemagne] ; Susan Service [États-Unis] ; Oi-Wa Choi [États-Unis] ; Joseph Deyoung [États-Unis] ; Olivera Grujic [États-Unis] ; Sit-Yee Kong [États-Unis] ; Yoon Jung [États-Unis] ; Mathew J. Jorgensen [États-Unis] ; Lynn A. Fairbanks [États-Unis] ; Trudy Turner [États-Unis] ; Rita M. Cantor [États-Unis] ; Jessica Wasserscheid [Canada] ; Ken Dewar [Canada] ; Wesley Warren [États-Unis] ; Richard K. Wilson [États-Unis] ; George Weinstock [États-Unis] ; J. David Jentsch [États-Unis] ; Nelson B. Freimer [États-Unis]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2012.
Abstract
Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (
Url:
DOI: 10.1093/hmg/dds160
PubMed: 22556363
PubMed Central: 3392106
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A non-human primate system for large-scale genetic studies of complex traits</title><author><name sortKey="Jasinska, Anna J" sort="Jasinska, Anna J" uniqKey="Jasinska A" first="Anna J." last="Jasinska">Anna J. Jasinska</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Michelle K" sort="Lin, Michelle K" uniqKey="Lin M" first="Michelle K." last="Lin">Michelle K. Lin</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neurobehavioral Genetics</addr-line>,<institution>Institute of Psychobiology, University of Trier</institution>,<addr-line>Johanniterufer 15, D-54290 Trier</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Service, Susan" sort="Service, Susan" uniqKey="Service S" first="Susan" last="Service">Susan Service</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Oi Wa" sort="Choi, Oi Wa" uniqKey="Choi O" first="Oi-Wa" last="Choi">Oi-Wa Choi</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deyoung, Joseph" sort="Deyoung, Joseph" uniqKey="Deyoung J" first="Joseph" last="Deyoung">Joseph Deyoung</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grujic, Olivera" sort="Grujic, Olivera" uniqKey="Grujic O" first="Olivera" last="Grujic">Olivera Grujic</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kong, Sit Yee" sort="Kong, Sit Yee" uniqKey="Kong S" first="Sit-Yee" last="Kong">Sit-Yee Kong</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Yoon" sort="Jung, Yoon" uniqKey="Jung Y" first="Yoon" last="Jung">Yoon Jung</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jorgensen, Mathew J" sort="Jorgensen, Mathew J" uniqKey="Jorgensen M" first="Mathew J." last="Jorgensen">Mathew J. Jorgensen</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Pathology</addr-line>,<institution>Section on Comparative Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fairbanks, Lynn A" sort="Fairbanks, Lynn A" uniqKey="Fairbanks L" first="Lynn A." last="Fairbanks">Lynn A. Fairbanks</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Trudy" sort="Turner, Trudy" uniqKey="Turner T" first="Trudy" last="Turner">Trudy Turner</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>University of Wisconsin-Milwaukee</institution>,<addr-line>Milwaukee, WI 53201</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cantor, Rita M" sort="Cantor, Rita M" uniqKey="Cantor R" first="Rita M." last="Cantor">Rita M. Cantor</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wasserscheid, Jessica" sort="Wasserscheid, Jessica" uniqKey="Wasserscheid J" first="Jessica" last="Wasserscheid">Jessica Wasserscheid</name><affiliation><nlm:aff id="af5"><addr-line>Research Institute of the McGill University Health Centre</addr-line>,<institution>McGill University and Génome Québec Innovation Centre</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Experimental Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, PQ</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dewar, Ken" sort="Dewar, Ken" uniqKey="Dewar K" first="Ken" last="Dewar">Ken Dewar</name><affiliation><nlm:aff id="af5"><addr-line>Research Institute of the McGill University Health Centre</addr-line>,<institution>McGill University and Génome Québec Innovation Centre</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Experimental Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, PQ</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Warren, Wesley" sort="Warren, Wesley" uniqKey="Warren W" first="Wesley" last="Warren">Wesley Warren</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Richard K" sort="Wilson, Richard K" uniqKey="Wilson R" first="Richard K." last="Wilson">Richard K. Wilson</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weinstock, George" sort="Weinstock, George" uniqKey="Weinstock G" first="George" last="Weinstock">George Weinstock</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jentsch, J David" sort="Jentsch, J David" uniqKey="Jentsch J" first="J. David" last="Jentsch">J. David Jentsch</name><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Psychology and Semel Institute for Neuroscience & Human Behavior</addr-line>,<institution>University of California, Los Angeles</institution>,<addr-line>CA 90095</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22556363</idno><idno type="pmc">3392106</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392106</idno><idno type="RBID">PMC:3392106</idno><idno type="doi">10.1093/hmg/dds160</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000112</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000112</idno><idno type="wicri:Area/Pmc/Curation">000112</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000112</idno><idno type="wicri:Area/Pmc/Checkpoint">000119</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000119</idno><idno type="wicri:Area/Ncbi/Merge">000514</idno><idno type="wicri:Area/Ncbi/Curation">000514</idno><idno type="wicri:Area/Ncbi/Checkpoint">000514</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A non-human primate system for large-scale genetic studies of complex traits</title><author><name sortKey="Jasinska, Anna J" sort="Jasinska, Anna J" uniqKey="Jasinska A" first="Anna J." last="Jasinska">Anna J. Jasinska</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Michelle K" sort="Lin, Michelle K" uniqKey="Lin M" first="Michelle K." last="Lin">Michelle K. Lin</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Neurobehavioral Genetics</addr-line>,<institution>Institute of Psychobiology, University of Trier</institution>,<addr-line>Johanniterufer 15, D-54290 Trier</addr-line>,<country>Germany</country>,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Service, Susan" sort="Service, Susan" uniqKey="Service S" first="Susan" last="Service">Susan Service</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Oi Wa" sort="Choi, Oi Wa" uniqKey="Choi O" first="Oi-Wa" last="Choi">Oi-Wa Choi</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deyoung, Joseph" sort="Deyoung, Joseph" uniqKey="Deyoung J" first="Joseph" last="Deyoung">Joseph Deyoung</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grujic, Olivera" sort="Grujic, Olivera" uniqKey="Grujic O" first="Olivera" last="Grujic">Olivera Grujic</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kong, Sit Yee" sort="Kong, Sit Yee" uniqKey="Kong S" first="Sit-Yee" last="Kong">Sit-Yee Kong</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Yoon" sort="Jung, Yoon" uniqKey="Jung Y" first="Yoon" last="Jung">Yoon Jung</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jorgensen, Mathew J" sort="Jorgensen, Mathew J" uniqKey="Jorgensen M" first="Mathew J." last="Jorgensen">Mathew J. Jorgensen</name><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Pathology</addr-line>,<institution>Section on Comparative Medicine, Wake Forest School of Medicine</institution>,<addr-line>Winston-Salem, NC 27157</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fairbanks, Lynn A" sort="Fairbanks, Lynn A" uniqKey="Fairbanks L" first="Lynn A." last="Fairbanks">Lynn A. Fairbanks</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Trudy" sort="Turner, Trudy" uniqKey="Turner T" first="Trudy" last="Turner">Trudy Turner</name><affiliation wicri:level="1"><nlm:aff id="af4"><institution>University of Wisconsin-Milwaukee</institution>,<addr-line>Milwaukee, WI 53201</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cantor, Rita M" sort="Cantor, Rita M" uniqKey="Cantor R" first="Rita M." last="Cantor">Rita M. Cantor</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wasserscheid, Jessica" sort="Wasserscheid, Jessica" uniqKey="Wasserscheid J" first="Jessica" last="Wasserscheid">Jessica Wasserscheid</name><affiliation><nlm:aff id="af5"><addr-line>Research Institute of the McGill University Health Centre</addr-line>,<institution>McGill University and Génome Québec Innovation Centre</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Experimental Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, PQ</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dewar, Ken" sort="Dewar, Ken" uniqKey="Dewar K" first="Ken" last="Dewar">Ken Dewar</name><affiliation><nlm:aff id="af5"><addr-line>Research Institute of the McGill University Health Centre</addr-line>,<institution>McGill University and Génome Québec Innovation Centre</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Human Genetics</addr-line></nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Experimental Medicine</addr-line>,<institution>McGill University</institution>,<addr-line>Montreal, PQ</addr-line>,<country>Canada</country><addr-line>H3A 1A1</addr-line>,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Warren, Wesley" sort="Warren, Wesley" uniqKey="Warren W" first="Wesley" last="Warren">Wesley Warren</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Richard K" sort="Wilson, Richard K" uniqKey="Wilson R" first="Richard K." last="Wilson">Richard K. Wilson</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weinstock, George" sort="Weinstock, George" uniqKey="Weinstock G" first="George" last="Weinstock">George Weinstock</name><affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af8"><institution>The Genome Institute at Washington University</institution>,<addr-line>St Louis, MO 63108</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jentsch, J David" sort="Jentsch, J David" uniqKey="Jentsch J" first="J. David" last="Jentsch">J. David Jentsch</name><affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Psychology and Semel Institute for Neuroscience & Human Behavior</addr-line>,<institution>University of California, Los Angeles</institution>,<addr-line>CA 90095</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Center for Neurobehavioral Genetics</addr-line>,<institution>Semel Institute for Neuroscience & Human Behavior, University of California</institution>,<addr-line>Los Angeles, CA 90095</addr-line>,<country>USA</country>,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Non-human primates provide genetic model systems biologically intermediate between humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (<italic>Chlorocebus aethiops sabaeus</italic>) are genetically homogeneous and large enough to permit well-powered genetic mapping studies of quantitative traits relevant to human health, including expression quantitative trait loci (eQTL). Previous transcriptome-wide investigation in an extended vervet pedigree identified 29 heritable transcripts for which levels of expression in peripheral blood correlate strongly with expression levels in the brain. Quantitative trait linkage analysis using 261 microsatellite markers identified significant (<italic>n</italic> = 8) and suggestive (<italic>n</italic> = 4) linkages for 12 of these transcripts, including both <italic>cis</italic>- and <italic>trans</italic>-eQTL. Seven transcripts, located on different chromosomes, showed maximum linkage to markers in a single region of vervet chromosome 9; this observation suggests the possibility of a master <italic>trans</italic>-regulator locus in this region. For one <italic>cis</italic>-eQTL (at <italic>B3GALTL</italic>, beta-1,3-glucosyltransferase), we conducted follow-up single nucleotide polymorphism genotyping and fine-scale association analysis in a sample of unrelated Caribbean vervets, localizing this eQTL to a region of <200 kb. These results suggest the value of pedigree and population samples of the Caribbean vervet for linkage and association mapping studies of quantitative traits. The imminent whole genome sequencing of many of these vervet samples will enhance the power of such investigations by providing a comprehensive catalog of genetic variation.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Jasinska, Anna J" sort="Jasinska, Anna J" uniqKey="Jasinska A" first="Anna J." last="Jasinska">Anna J. Jasinska</name></noRegion><name sortKey="Cantor, Rita M" sort="Cantor, Rita M" uniqKey="Cantor R" first="Rita M." last="Cantor">Rita M. Cantor</name><name sortKey="Choi, Oi Wa" sort="Choi, Oi Wa" uniqKey="Choi O" first="Oi-Wa" last="Choi">Oi-Wa Choi</name><name sortKey="Deyoung, Joseph" sort="Deyoung, Joseph" uniqKey="Deyoung J" first="Joseph" last="Deyoung">Joseph Deyoung</name><name sortKey="Fairbanks, Lynn A" sort="Fairbanks, Lynn A" uniqKey="Fairbanks L" first="Lynn A." last="Fairbanks">Lynn A. Fairbanks</name><name sortKey="Freimer, Nelson B" sort="Freimer, Nelson B" uniqKey="Freimer N" first="Nelson B." last="Freimer">Nelson B. Freimer</name><name sortKey="Grujic, Olivera" sort="Grujic, Olivera" uniqKey="Grujic O" first="Olivera" last="Grujic">Olivera Grujic</name><name sortKey="Jentsch, J David" sort="Jentsch, J David" uniqKey="Jentsch J" first="J. David" last="Jentsch">J. David Jentsch</name><name sortKey="Jorgensen, Mathew J" sort="Jorgensen, Mathew J" uniqKey="Jorgensen M" first="Mathew J." last="Jorgensen">Mathew J. Jorgensen</name><name sortKey="Jung, Yoon" sort="Jung, Yoon" uniqKey="Jung Y" first="Yoon" last="Jung">Yoon Jung</name><name sortKey="Kong, Sit Yee" sort="Kong, Sit Yee" uniqKey="Kong S" first="Sit-Yee" last="Kong">Sit-Yee Kong</name><name sortKey="Lin, Michelle K" sort="Lin, Michelle K" uniqKey="Lin M" first="Michelle K." last="Lin">Michelle K. Lin</name><name sortKey="Service, Susan" sort="Service, Susan" uniqKey="Service S" first="Susan" last="Service">Susan Service</name><name sortKey="Turner, Trudy" sort="Turner, Trudy" uniqKey="Turner T" first="Trudy" last="Turner">Trudy Turner</name><name sortKey="Warren, Wesley" sort="Warren, Wesley" uniqKey="Warren W" first="Wesley" last="Warren">Wesley Warren</name><name sortKey="Weinstock, George" sort="Weinstock, George" uniqKey="Weinstock G" first="George" last="Weinstock">George Weinstock</name><name sortKey="Wilson, Richard K" sort="Wilson, Richard K" uniqKey="Wilson R" first="Richard K." last="Wilson">Richard K. Wilson</name></country><country name="Allemagne"><noRegion><name sortKey="Lin, Michelle K" sort="Lin, Michelle K" uniqKey="Lin M" first="Michelle K." last="Lin">Michelle K. Lin</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Wasserscheid, Jessica" sort="Wasserscheid, Jessica" uniqKey="Wasserscheid J" first="Jessica" last="Wasserscheid">Jessica Wasserscheid</name></noRegion><name sortKey="Dewar, Ken" sort="Dewar, Ken" uniqKey="Dewar K" first="Ken" last="Dewar">Ken Dewar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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