Two consecutive fatal cases of acute myocardial infarction caused by free floating thrombus in the ascending aorta and review of literature.
Identifieur interne : 001389 ( Main/Merge ); précédent : 001388; suivant : 001390Two consecutive fatal cases of acute myocardial infarction caused by free floating thrombus in the ascending aorta and review of literature.
Auteurs : M. Knoess [Allemagne] ; M. Otto ; T. Kracht ; P. NeisSource :
- Forensic science international [ 1872-6283 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aorta (pathology), Aortic Diseases (complications), Aortic Diseases (pathology), Coronary Stenosis (pathology), Coronary Vessels (pathology), Fatal Outcome, Female, Forensic Pathology, Humans, Multiple Sclerosis (complications), Myocardial Infarction (etiology), Myocardial Infarction (pathology), Pregnancy, Pregnancy Complications, Cardiovascular (pathology), Thrombosis (complications), Thrombosis (pathology).
- MESH :
- complications : Aortic Diseases, Multiple Sclerosis, Thrombosis.
- etiology : Myocardial Infarction.
- pathology : Aorta, Aortic Diseases, Coronary Stenosis, Coronary Vessels, Myocardial Infarction, Pregnancy Complications, Cardiovascular, Thrombosis.
- Adult, Fatal Outcome, Female, Forensic Pathology, Humans, Pregnancy.
Abstract
Free floating thrombus in the ascending aorta is an uncommon source of acute myocardial infarction. We report on two cases of young women who died of acute myocardial infarction caused by a free floating thrombus in the sinus of Valsalva obstructing the coronary arteries' ostia. The first case reports on a 30-year-old pregnant woman who anamnestically had episodes with short loss of consciousness and weakness. The second case presents a 37-year-old woman suffering from multiple sclerosis with no previous history of thrombotic events. The review of literature revealed a predominance of women (eight females and three males). Interestingly, the coronary arteries bear no preference concerning the right (RCA) or left coronary artery (LCA) being more often occluded by a free floating thrombus. Especially, younger women (mean age 45.5 years, range 30-59 years) with no history of cardiac symptoms and without atherosclerotic changes seem to be predispositioned. The hypothesis that thrombus formation in cases without plaque disruption may depend on an endothelial erosion which seems to be more common in younger women and promoted by a hyperthrombogenic state is supported by our two cases. A comprehensive literature search revealed, that these are the first two reports on a free floating thrombus being the cause of fatal acute myocardial infarction in a pregnant woman, respectively, a woman suffering from multiple sclerosis.
DOI: 10.1016/j.forsciint.2006.08.025
PubMed: 17010548
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Knoess</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Pathology, Moltkestrasse 32, 54292 Trier, Germany. drknoess@aol.com</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Pathology, Moltkestrasse 32, 54292 Trier</wicri:regionArea><wicri:noRegion>54292 Trier</wicri:noRegion><wicri:noRegion>54292 Trier</wicri:noRegion><wicri:noRegion>54292 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name></author><author><name sortKey="Kracht, T" sort="Kracht, T" uniqKey="Kracht T" first="T" last="Kracht">T. Kracht</name></author><author><name sortKey="Neis, P" sort="Neis, P" uniqKey="Neis P" first="P" last="Neis">P. 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We report on two cases of young women who died of acute myocardial infarction caused by a free floating thrombus in the sinus of Valsalva obstructing the coronary arteries' ostia. The first case reports on a 30-year-old pregnant woman who anamnestically had episodes with short loss of consciousness and weakness. The second case presents a 37-year-old woman suffering from multiple sclerosis with no previous history of thrombotic events. The review of literature revealed a predominance of women (eight females and three males). Interestingly, the coronary arteries bear no preference concerning the right (RCA) or left coronary artery (LCA) being more often occluded by a free floating thrombus. Especially, younger women (mean age 45.5 years, range 30-59 years) with no history of cardiac symptoms and without atherosclerotic changes seem to be predispositioned. The hypothesis that thrombus formation in cases without plaque disruption may depend on an endothelial erosion which seems to be more common in younger women and promoted by a hyperthrombogenic state is supported by our two cases. A comprehensive literature search revealed, that these are the first two reports on a free floating thrombus being the cause of fatal acute myocardial infarction in a pregnant woman, respectively, a woman suffering from multiple sclerosis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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