UnivTrevesV1, Main, Merge, bibRecord, 001084

Endogenous cortisol suppression with metyrapone enhances acoustic startle in healthy subjects

Identifieur interne : 001084 ( Main/Merge ); précédent : 001083; suivant : 001085

Endogenous cortisol suppression with metyrapone enhances acoustic startle in healthy subjects

Auteurs : Sonja Roemer [Allemagne] ; Frauke Nees [Allemagne] ; Steffen Richter [Allemagne] ; Terry D. Blumenthal [États-Unis] ; Hartmut Sch Chinger [Allemagne]

Source :

Hormones and behavior : (Print) [ 0018-506X ] ; 2009.

RBID : Pascal:09-0116093

Descripteurs français

Pascal (Inist)
- Endogène, Hydrocortisone, Métyrapone, Individu sain, Court terme, Habituation, Homme, Antiinflammatoire, Produit diagnostic.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiinflammatory agent, Diagnostic agent, Endogenous, Habituation, Healthy subject, Human, Hydrocortisone, Metyrapone, Short term.

Abstract

Previous human studies have shown that excess cortisol sufficient to fully occupy central nervous system (CNS) corticosteroid receptors may reduce startle eye blink. The present study tested whether cortisol depletion and the resulting reduction in activity of CNS corticosteroid receptors has the opposite effect. In a single-blind, placebo-controlled, randomized study, eye blink EMG responses to 105 dB acoustic startle stimuli were assessed in 25 healthy subjects who received oral metyrapone (1500 mg) to suppress endogenous cortisol production, while 24 controls received oral placebo. As expected, metyrapone significantly reduced salivary cortisol, indicating effective endogenous cortisol suppression. Startle eye blink responses were significantly increased in the metyrapone group. Short-term habituation of the startle reflex was not different between groups. Our results suggest that startle is enhanced during depletion of cortisol. This effect may be mediated by CNS mechanisms controlling cortisol feedback.

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Pascal:09-0116093

Le document en format XML

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<front><div type="abstract" xml:lang="en">Previous human studies have shown that excess cortisol sufficient to fully occupy central nervous system (CNS) corticosteroid receptors may reduce startle eye blink. The present study tested whether cortisol depletion and the resulting reduction in activity of CNS corticosteroid receptors has the opposite effect. In a single-blind, placebo-controlled, randomized study, eye blink EMG responses to 105 dB acoustic startle stimuli were assessed in 25 healthy subjects who received oral metyrapone (1500 mg) to suppress endogenous cortisol production, while 24 controls received oral placebo. As expected, metyrapone significantly reduced salivary cortisol, indicating effective endogenous cortisol suppression. Startle eye blink responses were significantly increased in the metyrapone group. Short-term habituation of the startle reflex was not different between groups. Our results suggest that startle is enhanced during depletion of cortisol. This effect may be mediated by CNS mechanisms controlling cortisol feedback.</div>
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Endogenous cortisol suppression with metyrapone enhances acoustic startle in healthy subjects

Endogenous cortisol suppression with metyrapone enhances acoustic startle in healthy subjects

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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