Exploring the genetic link between RLS and ADHD
Identifieur interne : 001082 ( Main/Merge ); précédent : 001081; suivant : 001083Exploring the genetic link between RLS and ADHD
Auteurs : B. G. Schimmelmann [Allemagne] ; S. Friedel [Allemagne] ; T. T. Nguyen [Allemagne] ; S. Sauer [Allemagne] ; C. I. Ganz Vogel [Allemagne] ; K. Konrad [Allemagne] ; C. Wilhelm [Allemagne] ; J. Sinzig [Allemagne] ; T. J. Renner [Allemagne] ; M. Romanos [Allemagne] ; H. Palmason [Allemagne] ; A. Dempfle [Allemagne] ; S. Walitza [Allemagne, Suisse] ; C. Freitag [Allemagne] ; J. Meyer [Allemagne] ; M. Linder [Allemagne] ; H. Sch Fer [Allemagne] ; A. Warnke [Allemagne] ; K. P. Lesch [Allemagne] ; B. Herpertz-Dahlman [Allemagne] ; A. Hinney [Allemagne] ; J. Hebebrand [Allemagne]Source :
- Journal of psychiatric research [ 0022-3956 ] ; 2009.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique.
English descriptors
Abstract
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood onset. Clinical and biological evidence points to shared common central nervous system (CNS) pathology of ADHD and restless legs syndrome (RLS). It was hypothesized that variants previously found to be associated with RLS in two large genome-wide association studies (GWA), will also be associated with ADHD. SNPs located in MEIS1 (rs2300478), BTBD9 (rs9296249, rs3923809, rs6923737), and MAP2K5 (rs12593813, rs4489954) as well as three SNPs tagging the identified haplotype in MEIS1 (rs6710341, rs12469063, rs4544423) were genotyped in a well characterized German sample of 224 families comprising one or more affected sibs (386 children) and both parents. We found no evidence for preferential transmission of the hypothesized variants to ADHD. Subsequent analyses elicited nominal significant association with haplotypes consisting of the three SNPs in BTBD9 (χ2 =14.8, df = 7, nominal p = 0.039). According to exploratory post hoc analyses, the major contribution to this finding came from the A-A-A-haplotype with a haplotype-wise nominal p-value of 0.009. However, this result did not withstand correction for multiple testing. In view of our results, RLS risk alleles may have a lower effect on ADHD than on RLS or may not be involved in ADHD. The negative findings may additionally result from genetic heterogeneity of ADHD, i.e. risk alleles for RLS may only be relevant for certain subtypes of ADHD. Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD.
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Wilhelm</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Technical University of Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Sinzig, J" sort="Sinzig, J" uniqKey="Sinzig J" first="J." last="Sinzig">J. Sinzig</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Child and Adolescent Psychiatry, University of Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University of Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Renner, T J" sort="Renner, T J" uniqKey="Renner T" first="T. J." last="Renner">T. J. Renner</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Romanos, M" sort="Romanos, M" uniqKey="Romanos M" first="M." last="Romanos">M. Romanos</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Palmason, H" sort="Palmason, H" uniqKey="Palmason H" first="H." last="Palmason">H. Palmason</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurobehavioral Genetics, University of Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Dempfle, A" sort="Dempfle, A" uniqKey="Dempfle A" first="A." last="Dempfle">A. Dempfle</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Walitza, S" sort="Walitza, S" uniqKey="Walitza S" first="S." last="Walitza">S. Walitza</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Child and Adolescent Psychiatry, University of Zürich</s1><s3>CHE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Freitag, C" sort="Freitag, C" uniqKey="Freitag C" first="C." last="Freitag">C. Freitag</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Child and Adolescent Psychiatry, Saarland University Hospital</s1><s2>Homburg</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Saarland University Hospital</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, J" sort="Meyer, J" uniqKey="Meyer J" first="J." last="Meyer">J. Meyer</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurobehavioral Genetics, University of Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Linder, M" sort="Linder, M" uniqKey="Linder M" first="M." last="Linder">M. Linder</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child and Adolescent Psychiatry, Bezirksklinik Regensburg</s1><s2>Regensburg</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Bezirksklinik Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Warnke, A" sort="Warnke, A" uniqKey="Warnke A" first="A." last="Warnke">A. Warnke</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K. P." last="Lesch">K. P. Lesch</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Psychiatry and Psychotherapy, Julius-Maximilians-University Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Herpertz Dahlman, B" sort="Herpertz Dahlman, B" uniqKey="Herpertz Dahlman B" first="B." last="Herpertz-Dahlman">B. Herpertz-Dahlman</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Technical University of Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Hinney, A" sort="Hinney, A" uniqKey="Hinney A" first="A." last="Hinney">A. Hinney</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0314293</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0314293 INIST</idno><idno type="RBID">Pascal:09-0314293</idno><idno type="wicri:Area/PascalFrancis/Corpus">000673</idno><idno type="stanalyst">FRANCIS 09-0314293 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000758</idno><idno type="wicri:Area/PascalFrancis/Curation">000733</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000526</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000526</idno><idno type="wicri:doubleKey">0022-3956:2009:Schimmelmann B:exploring:the:genetic</idno><idno type="wicri:Area/Main/Merge">001082</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Exploring the genetic link between RLS and ADHD</title><author><name sortKey="Schimmelmann, B G" sort="Schimmelmann, B G" uniqKey="Schimmelmann B" first="B. G." last="Schimmelmann">B. G. Schimmelmann</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Friedel, S" sort="Friedel, S" uniqKey="Friedel S" first="S." last="Friedel">S. Friedel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, T T" sort="Nguyen, T T" uniqKey="Nguyen T" first="T. T." last="Nguyen">T. T. Nguyen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Sauer, S" sort="Sauer, S" uniqKey="Sauer S" first="S." last="Sauer">S. Sauer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Max Planck Institute for Molecular Genetics, Otto Warburg Laboratory</s1><s2>Berlin</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Ganz Vogel, C I" sort="Ganz Vogel, C I" uniqKey="Ganz Vogel C" first="C. I." last="Ganz Vogel">C. I. Ganz Vogel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Konrad, K" sort="Konrad, K" uniqKey="Konrad K" first="K." last="Konrad">K. Konrad</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Technical University of Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Wilhelm, C" sort="Wilhelm, C" uniqKey="Wilhelm C" first="C." last="Wilhelm">C. Wilhelm</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Technical University of Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Sinzig, J" sort="Sinzig, J" uniqKey="Sinzig J" first="J." last="Sinzig">J. Sinzig</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Child and Adolescent Psychiatry, University of Cologne</s1><s2>Cologne</s2><s3>DEU</s3><sZ>8 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>University of Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Renner, T J" sort="Renner, T J" uniqKey="Renner T" first="T. J." last="Renner">T. J. Renner</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Romanos, M" sort="Romanos, M" uniqKey="Romanos M" first="M." last="Romanos">M. Romanos</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Palmason, H" sort="Palmason, H" uniqKey="Palmason H" first="H." last="Palmason">H. Palmason</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurobehavioral Genetics, University of Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Dempfle, A" sort="Dempfle, A" uniqKey="Dempfle A" first="A." last="Dempfle">A. Dempfle</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Walitza, S" sort="Walitza, S" uniqKey="Walitza S" first="S." last="Walitza">S. Walitza</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Child and Adolescent Psychiatry, University of Zürich</s1><s3>CHE</s3><sZ>13 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Freitag, C" sort="Freitag, C" uniqKey="Freitag C" first="C." last="Freitag">C. Freitag</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Child and Adolescent Psychiatry, Saarland University Hospital</s1><s2>Homburg</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Saarland University Hospital</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, J" sort="Meyer, J" uniqKey="Meyer J" first="J." last="Meyer">J. Meyer</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Neurobehavioral Genetics, University of Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Linder, M" sort="Linder, M" uniqKey="Linder M" first="M." last="Linder">M. Linder</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Child and Adolescent Psychiatry, Bezirksklinik Regensburg</s1><s2>Regensburg</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Bezirksklinik Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Warnke, A" sort="Warnke, A" uniqKey="Warnke A" first="A." last="Warnke">A. Warnke</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, Julius-Maximilians-University Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Julius-Maximilians-University Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K. P." last="Lesch">K. P. Lesch</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Psychiatry and Psychotherapy, Julius-Maximilians-University Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>19 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Herpertz Dahlman, B" sort="Herpertz Dahlman, B" uniqKey="Herpertz Dahlman B" first="B." last="Herpertz-Dahlman">B. Herpertz-Dahlman</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Technical University of Aachen</s1><s2>Aachen</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Hinney, A" sort="Hinney, A" uniqKey="Hinney A" first="A." last="Hinney">A. Hinney</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Child and Adolescent Psychiatry and -Psychotherapy, University of Duisburg-Essen, LVR Klinikun Essen, Virchowstr. 174</s1><s2>45147 Essen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>21 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>Virchowstr. 174</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of psychiatric research</title><title level="j" type="abbreviated">J. psychiatr. res.</title><idno type="ISSN">0022-3956</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of psychiatric research</title><title level="j" type="abbreviated">J. psychiatr. res.</title><idno type="ISSN">0022-3956</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Attention disorder with hyperactivity</term><term>Genetics</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Génétique</term><term>Trouble déficitaire de l'attention avec hyperactivité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Attention deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder of childhood onset. Clinical and biological evidence points to shared common central nervous system (CNS) pathology of ADHD and restless legs syndrome (RLS). It was hypothesized that variants previously found to be associated with RLS in two large genome-wide association studies (GWA), will also be associated with ADHD. SNPs located in MEIS1 (rs2300478), BTBD9 (rs9296249, rs3923809, rs6923737), and MAP2K5 (rs12593813, rs4489954) as well as three SNPs tagging the identified haplotype in MEIS1 (rs6710341, rs12469063, rs4544423) were genotyped in a well characterized German sample of 224 families comprising one or more affected sibs (386 children) and both parents. We found no evidence for preferential transmission of the hypothesized variants to ADHD. Subsequent analyses elicited nominal significant association with haplotypes consisting of the three SNPs in BTBD9 (χ<sup>2</sup> =1<sub>4</sub>.8, df = 7, nominal p = 0.039). According to exploratory post hoc analyses, the major contribution to this finding came from the A-A-A-haplotype with a haplotype-wise nominal p-value of 0.009. However, this result did not withstand correction for multiple testing. In view of our results, RLS risk alleles may have a lower effect on ADHD than on RLS or may not be involved in ADHD. The negative findings may additionally result from genetic heterogeneity of ADHD, i.e. risk alleles for RLS may only be relevant for certain subtypes of ADHD. Genes relevant to RLS remain interesting candidates for ADHD; particularly BTBD9 needs further study, as it has been related to iron storage, a potential pathophysiological link between RLS and certain subtypes of ADHD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Bavière</li><li>Berlin</li><li>Canton de Zurich</li><li>District de Basse-Franconie</li><li>District de Cologne</li><li>District de Giessen</li><li>Hesse (Land)</li><li>Rhénanie-Palatinat</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li><li>Berlin</li><li>Marbourg</li><li>Trèves (Allemagne)</li><li>Wurtzbourg</li><li>Zurich</li></settlement><orgName><li>Université de Trèves</li><li>Université de Zurich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Schimmelmann, B G" sort="Schimmelmann, B G" uniqKey="Schimmelmann B" first="B. G." last="Schimmelmann">B. G. Schimmelmann</name></noRegion><name sortKey="Dempfle, A" sort="Dempfle, A" uniqKey="Dempfle A" first="A." last="Dempfle">A. Dempfle</name><name sortKey="Freitag, C" sort="Freitag, C" uniqKey="Freitag C" first="C." last="Freitag">C. Freitag</name><name sortKey="Friedel, S" sort="Friedel, S" uniqKey="Friedel S" first="S." last="Friedel">S. Friedel</name><name sortKey="Ganz Vogel, C I" sort="Ganz Vogel, C I" uniqKey="Ganz Vogel C" first="C. I." last="Ganz Vogel">C. I. Ganz Vogel</name><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><name sortKey="Herpertz Dahlman, B" sort="Herpertz Dahlman, B" uniqKey="Herpertz Dahlman B" first="B." last="Herpertz-Dahlman">B. Herpertz-Dahlman</name><name sortKey="Hinney, A" sort="Hinney, A" uniqKey="Hinney A" first="A." last="Hinney">A. Hinney</name><name sortKey="Konrad, K" sort="Konrad, K" uniqKey="Konrad K" first="K." last="Konrad">K. Konrad</name><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K. P." last="Lesch">K. P. Lesch</name><name sortKey="Linder, M" sort="Linder, M" uniqKey="Linder M" first="M." last="Linder">M. Linder</name><name sortKey="Meyer, J" sort="Meyer, J" uniqKey="Meyer J" first="J." last="Meyer">J. Meyer</name><name sortKey="Nguyen, T T" sort="Nguyen, T T" uniqKey="Nguyen T" first="T. T." last="Nguyen">T. T. Nguyen</name><name sortKey="Palmason, H" sort="Palmason, H" uniqKey="Palmason H" first="H." last="Palmason">H. Palmason</name><name sortKey="Renner, T J" sort="Renner, T J" uniqKey="Renner T" first="T. J." last="Renner">T. J. Renner</name><name sortKey="Romanos, M" sort="Romanos, M" uniqKey="Romanos M" first="M." last="Romanos">M. Romanos</name><name sortKey="Sauer, S" sort="Sauer, S" uniqKey="Sauer S" first="S." last="Sauer">S. Sauer</name><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><name sortKey="Sinzig, J" sort="Sinzig, J" uniqKey="Sinzig J" first="J." last="Sinzig">J. Sinzig</name><name sortKey="Walitza, S" sort="Walitza, S" uniqKey="Walitza S" first="S." last="Walitza">S. Walitza</name><name sortKey="Warnke, A" sort="Warnke, A" uniqKey="Warnke A" first="A." last="Warnke">A. Warnke</name><name sortKey="Wilhelm, C" sort="Wilhelm, C" uniqKey="Wilhelm C" first="C." last="Wilhelm">C. Wilhelm</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Walitza, S" sort="Walitza, S" uniqKey="Walitza S" first="S." last="Walitza">S. Walitza</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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