Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress
Identifieur interne : 000B47 ( Main/Merge ); précédent : 000B46; suivant : 000B48Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress
Auteurs : Marion Tegethoff [Suisse, Allemagne] ; Jean-Sébastien Raul [France] ; Carole Jamey [France] ; MEHDI BEN KHELIL [France] ; Bertrand Ludes [France] ; Gunther Meinlschmidt [Suisse]Source :
- Biological psychology [ 0301-0511 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Easily accessible biomarkers for fetal stress biology are lacking. We here explore whether quantification of major fetal steroids, dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEAS), with liquid chromatography/tandem mass spectrometry in infant nails is a tool to assess fetal stress biology in response to maternal stressful life events during pregnancy. Sufficient nail (≥1 mg) was available from 80 infants (93% of those providing samples). The concentration of DHEA, but not DHEAS, was increased in infants of mothers with stressful life events during pregnancy (DHEA: F1,41 = 6.105, P = 0.018; DHEAS: F1,77 = 0.767, P=0.384). DHEA concentrations were not related to maternal stress before pregnancy (F1,41 =0.010, P=0.922). Infant nail DHEA may be a fetal biological correlate of intrauterine exposure to maternal stress. The method promises the first non-invasive retrospective biomarker for intrauterine stress biology, opening new ways for research and clinical applications in fetal medicine, endocrinology, obstetrics, gynecology, and for understanding the developmental origins of health and disease.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000402
- to stream PascalFrancis, to step Corpus: 000483
- to stream PascalFrancis, to step Curation: 000946
- to stream PascalFrancis, to step Checkpoint: 000314
Links to Exploration step
Pascal:11-0344758Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress</title>
<author><name sortKey="Tegethoff, Marion" sort="Tegethoff, Marion" uniqKey="Tegethoff M" first="Marion" last="Tegethoff">Marion Tegethoff</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Clinical Psychology and Psychiatry, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, Johanniterufer 15</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Johanniterufer 15</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raul, Jean Sebastien" sort="Raul, Jean Sebastien" uniqKey="Raul J" first="Jean-Sébastien" last="Raul">Jean-Sébastien Raul</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jamey, Carole" sort="Jamey, Carole" uniqKey="Jamey C" first="Carole" last="Jamey">Carole Jamey</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mehdi Ben Khelil" sort="Mehdi Ben Khelil" uniqKey="Mehdi Ben Khelil" last="Mehdi Ben Khelil">MEHDI BEN KHELIL</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ludes, Bertrand" sort="Ludes, Bertrand" uniqKey="Ludes B" first="Bertrand" last="Ludes">Bertrand Ludes</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>National Centre of Competence in Research "Swiss Etiological Study of Adjustment and Mental Health (sesam)</s1>
<s2>Birmannsgasse 4055</s2>
<s3>CHE</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>National Centre of Competence in Research "Swiss Etiological Study of Adjustment and Mental Health (sesam)</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0344758</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0344758 INIST</idno>
<idno type="RBID">Pascal:11-0344758</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000402</idno>
<idno type="stanalyst">FRANCIS 11-0344758 INIST</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000483</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000946</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000314</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000314</idno>
<idno type="wicri:doubleKey">0301-0511:2011:Tegethoff M:dehydroepiandrosterone:in:nails</idno>
<idno type="wicri:Area/Main/Merge">000B47</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress</title>
<author><name sortKey="Tegethoff, Marion" sort="Tegethoff, Marion" uniqKey="Tegethoff M" first="Marion" last="Tegethoff">Marion Tegethoff</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Clinical Psychology and Psychiatry, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, Johanniterufer 15</s1>
<s2>54290 Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<wicri:noRegion>Johanniterufer 15</wicri:noRegion>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raul, Jean Sebastien" sort="Raul, Jean Sebastien" uniqKey="Raul J" first="Jean-Sébastien" last="Raul">Jean-Sébastien Raul</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jamey, Carole" sort="Jamey, Carole" uniqKey="Jamey C" first="Carole" last="Jamey">Carole Jamey</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mehdi Ben Khelil" sort="Mehdi Ben Khelil" uniqKey="Mehdi Ben Khelil" last="Mehdi Ben Khelil">MEHDI BEN KHELIL</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ludes, Bertrand" sort="Ludes, Bertrand" uniqKey="Ludes B" first="Bertrand" last="Ludes">Bertrand Ludes</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Institute of Legal Medicine, University of Strasbourg, 11 rue Humann</s1>
<s2>67085 Strasbourg</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Missionsstrasse 60/62</s1>
<s2>4055 Basel</s2>
<s3>CHE</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4055 Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>National Centre of Competence in Research "Swiss Etiological Study of Adjustment and Mental Health (sesam)</s1>
<s2>Birmannsgasse 4055</s2>
<s3>CHE</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>National Centre of Competence in Research "Swiss Etiological Study of Adjustment and Mental Health (sesam)</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Biological psychology</title>
<title level="j" type="abbreviated">Biol. psychol.</title>
<idno type="ISSN">0301-0511</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Biological psychology</title>
<title level="j" type="abbreviated">Biol. psychol.</title>
<idno type="ISSN">0301-0511</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological marker</term>
<term>Dehydroepiandrosterone</term>
<term>Exposure</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Hypothalamus</term>
<term>Infant</term>
<term>Pituitary gland</term>
<term>Prenatal</term>
<term>Steroid</term>
<term>Stress</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Déhydroépiandrostérone</term>
<term>Marqueur biologique</term>
<term>Stress</term>
<term>Prénatal</term>
<term>Hypothalamus</term>
<term>Hypophyse</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Exposition</term>
<term>Stéroïde</term>
<term>Nourrisson</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Easily accessible biomarkers for fetal stress biology are lacking. We here explore whether quantification of major fetal steroids, dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEAS), with liquid chromatography/tandem mass spectrometry in infant nails is a tool to assess fetal stress biology in response to maternal stressful life events during pregnancy. Sufficient nail (≥1 mg) was available from 80 infants (93% of those providing samples). The concentration of DHEA, but not DHEAS, was increased in infants of mothers with stressful life events during pregnancy (DHEA: F<sub>1,41</sub>
= 6.105, P = 0.018; DHEAS: F<sub>1,77</sub>
= 0.767, P<sub>=</sub>
0.384). DHEA concentrations were not related to maternal stress before pregnancy (F<sub>1,41</sub>
=0.010, P<sub>=</sub>
0.922). Infant nail DHEA may be a fetal biological correlate of intrauterine exposure to maternal stress. The method promises the first non-invasive retrospective biomarker for intrauterine stress biology, opening new ways for research and clinical applications in fetal medicine, endocrinology, obstetrics, gynecology, and for understanding the developmental origins of health and disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Suisse</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Grand Est</li>
<li>Rhénanie-Palatinat</li>
</region>
<settlement><li>Strasbourg</li>
<li>Trèves (Allemagne)</li>
</settlement>
<orgName><li>Université de Trèves</li>
</orgName>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Tegethoff, Marion" sort="Tegethoff, Marion" uniqKey="Tegethoff M" first="Marion" last="Tegethoff">Marion Tegethoff</name>
</noRegion>
<name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name>
<name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name>
<name sortKey="Meinlschmidt, Gunther" sort="Meinlschmidt, Gunther" uniqKey="Meinlschmidt G" first="Gunther" last="Meinlschmidt">Gunther Meinlschmidt</name>
<name sortKey="Tegethoff, Marion" sort="Tegethoff, Marion" uniqKey="Tegethoff M" first="Marion" last="Tegethoff">Marion Tegethoff</name>
</country>
<country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Tegethoff, Marion" sort="Tegethoff, Marion" uniqKey="Tegethoff M" first="Marion" last="Tegethoff">Marion Tegethoff</name>
</region>
</country>
<country name="France"><region name="Grand Est"><name sortKey="Raul, Jean Sebastien" sort="Raul, Jean Sebastien" uniqKey="Raul J" first="Jean-Sébastien" last="Raul">Jean-Sébastien Raul</name>
</region>
<name sortKey="Jamey, Carole" sort="Jamey, Carole" uniqKey="Jamey C" first="Carole" last="Jamey">Carole Jamey</name>
<name sortKey="Ludes, Bertrand" sort="Ludes, Bertrand" uniqKey="Ludes B" first="Bertrand" last="Ludes">Bertrand Ludes</name>
<name sortKey="Mehdi Ben Khelil" sort="Mehdi Ben Khelil" uniqKey="Mehdi Ben Khelil" last="Mehdi Ben Khelil">MEHDI BEN KHELIL</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B47 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000B47 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Rhénanie |area= UnivTrevesV1 |flux= Main |étape= Merge |type= RBID |clé= Pascal:11-0344758 |texte= Dehydroepiandrosterone in nails of infants: A potential biomarker of intrauterine responses to maternal stress }}
![]() | This area was generated with Dilib version V0.6.31. | ![]() |