Heroin reduces startle and cortisol response in opioid‐maintained heroin‐dependent patients
Identifieur interne : 000A14 ( Main/Merge ); précédent : 000A13; suivant : 000A15Heroin reduces startle and cortisol response in opioid‐maintained heroin‐dependent patients
Auteurs : Marc Walter [Suisse] ; Gerhard A. Wiesbeck ; Bigna Degen ; Jürgen Albrich ; Monika Oppel ; André Schulz [Allemagne] ; Hartmut Sch Chinger [Allemagne] ; Kenneth M. Dürsteler-Macfarland [Suisse]Source :
- Addiction Biology [ 1355-6215 ] ; 2011-01.
English descriptors
- KwdEn :
Abstract
Heroin dependence (HD) is a chronic relapsing brain disorder characterized by a compulsion to seek and use heroin. Stress is seen as a key factor for heroin use. Methadone maintenance and the prescription of pharmaceutical heroin [diacetylmorphine (DAM)] are established treatments for HD in several countries. The present study examined whether DAM‐maintained patients and methadone‐maintained patients differ from healthy controls in startle reflex and cortisol levels. Fifty‐seven participants, 19 of each group matched for age, sex and smoking status, completed a startle session which included the presentation of 24 bursts of white noise while eye‐blink responses to startling noises were recorded. Salivary cortisol was collected three times after awakening, before, during and after the startle session. DAM was administered before the experiment, while methadone was administered afterwards. Both heroin‐dependent patient groups exhibited significantly smaller startle responses than healthy controls (P < 0.05). Whereas the cortisol levels after awakening did not differ across the three groups, the experimental cortisol levels were significantly lower in DAM‐maintained patients, who received their opioid before the experiment, than in methadone‐maintained patients and healthy controls (P < 0.0001). Opioid maintenance treatment for HD is associated with reduced startle responses. Acute DAM administration may suppress cortisol levels, and DAM maintenance treatment may represent an effective alternative to methadone in stress‐sensitive, heroin‐dependent patients.
Url:
DOI: 10.1111/j.1369-1600.2010.00205.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001334
- to stream Istex, to step Curation: 001222
- to stream Istex, to step Checkpoint: 000196
Links to Exploration step
ISTEX:725D9AC2FEA74912EA3F388412BE268B132AF636Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heroin reduces startle and cortisol response in opioid‐maintained heroin‐dependent patients</title>
<author><name sortKey="Walter, Marc" sort="Walter, Marc" uniqKey="Walter M" first="Marc" last="Walter">Marc Walter</name>
</author>
<author><name sortKey="Wiesbeck, Gerhard A" sort="Wiesbeck, Gerhard A" uniqKey="Wiesbeck G" first="Gerhard A." last="Wiesbeck">Gerhard A. Wiesbeck</name>
</author>
<author><name sortKey="Degen, Bigna" sort="Degen, Bigna" uniqKey="Degen B" first="Bigna" last="Degen">Bigna Degen</name>
</author>
<author><name sortKey="Albrich, Jurgen" sort="Albrich, Jurgen" uniqKey="Albrich J" first="Jürgen" last="Albrich">Jürgen Albrich</name>
</author>
<author><name sortKey="Oppel, Monika" sort="Oppel, Monika" uniqKey="Oppel M" first="Monika" last="Oppel">Monika Oppel</name>
</author>
<author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name>
</author>
<author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name>
</author>
<author><name sortKey="Dursteler Acfarland, Kenneth M" sort="Dursteler Acfarland, Kenneth M" uniqKey="Dursteler Acfarland K" first="Kenneth M." last="Dürsteler-Macfarland">Kenneth M. Dürsteler-Macfarland</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:725D9AC2FEA74912EA3F388412BE268B132AF636</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1111/j.1369-1600.2010.00205.x</idno>
<idno type="url">https://api.istex.fr/document/725D9AC2FEA74912EA3F388412BE268B132AF636/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001334</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001334</idno>
<idno type="wicri:Area/Istex/Curation">001222</idno>
<idno type="wicri:Area/Istex/Checkpoint">000196</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000196</idno>
<idno type="wicri:doubleKey">1355-6215:2011:Walter M:heroin:reduces:startle</idno>
<idno type="wicri:Area/Main/Merge">000A14</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Heroin reduces startle and cortisol response in opioid‐maintained heroin‐dependent patients</title>
<author><name sortKey="Walter, Marc" sort="Walter, Marc" uniqKey="Walter M" first="Marc" last="Walter">Marc Walter</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Suisse</country>
</affiliation>
</author>
<author><name sortKey="Wiesbeck, Gerhard A" sort="Wiesbeck, Gerhard A" uniqKey="Wiesbeck G" first="Gerhard A." last="Wiesbeck">Gerhard A. Wiesbeck</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Degen, Bigna" sort="Degen, Bigna" uniqKey="Degen B" first="Bigna" last="Degen">Bigna Degen</name>
<affiliation></affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Albrich, Jurgen" sort="Albrich, Jurgen" uniqKey="Albrich J" first="Jürgen" last="Albrich">Jürgen Albrich</name>
<affiliation></affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Oppel, Monika" sort="Oppel, Monika" uniqKey="Oppel M" first="Monika" last="Oppel">Monika Oppel</name>
<affiliation></affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychobiology, Department of Clinical Physiology, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychobiology, Department of Clinical Physiology, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Dursteler Acfarland, Kenneth M" sort="Dursteler Acfarland, Kenneth M" uniqKey="Dursteler Acfarland K" first="Kenneth M." last="Dürsteler-Macfarland">Kenneth M. Dürsteler-Macfarland</name>
<affiliation></affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Suisse</country>
<wicri:regionArea>Psychiatric University Hospital, Division of Substance Use Disorders, University of Zurich</wicri:regionArea>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
<orgName type="university">Université de Zurich</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Addiction Biology</title>
<idno type="ISSN">1355-6215</idno>
<idno type="eISSN">1369-1600</idno>
<imprint><publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2011-01">2011-01</date>
<biblScope unit="volume">16</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="145">145</biblScope>
<biblScope unit="page" to="151">151</biblScope>
</imprint>
<idno type="ISSN">1355-6215</idno>
</series>
<idno type="istex">725D9AC2FEA74912EA3F388412BE268B132AF636</idno>
<idno type="DOI">10.1111/j.1369-1600.2010.00205.x</idno>
<idno type="ArticleID">ADB205</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1355-6215</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cortisol</term>
<term>diacetylmorphine</term>
<term>heroin dependence</term>
<term>methadone</term>
<term>startle reflex</term>
<term>stress</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Heroin dependence (HD) is a chronic relapsing brain disorder characterized by a compulsion to seek and use heroin. Stress is seen as a key factor for heroin use. Methadone maintenance and the prescription of pharmaceutical heroin [diacetylmorphine (DAM)] are established treatments for HD in several countries. The present study examined whether DAM‐maintained patients and methadone‐maintained patients differ from healthy controls in startle reflex and cortisol levels. Fifty‐seven participants, 19 of each group matched for age, sex and smoking status, completed a startle session which included the presentation of 24 bursts of white noise while eye‐blink responses to startling noises were recorded. Salivary cortisol was collected three times after awakening, before, during and after the startle session. DAM was administered before the experiment, while methadone was administered afterwards. Both heroin‐dependent patient groups exhibited significantly smaller startle responses than healthy controls (P < 0.05). Whereas the cortisol levels after awakening did not differ across the three groups, the experimental cortisol levels were significantly lower in DAM‐maintained patients, who received their opioid before the experiment, than in methadone‐maintained patients and healthy controls (P < 0.0001). Opioid maintenance treatment for HD is associated with reduced startle responses. Acute DAM administration may suppress cortisol levels, and DAM maintenance treatment may represent an effective alternative to methadone in stress‐sensitive, heroin‐dependent patients.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000A14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Rhénanie |area= UnivTrevesV1 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:725D9AC2FEA74912EA3F388412BE268B132AF636 |texte= Heroin reduces startle and cortisol response in opioid‐maintained heroin‐dependent patients }}
![]() | This area was generated with Dilib version V0.6.31. | ![]() |