Starvation-induced hyperactivity in the rat: The role of endocrine and neurotransmitter changes
Identifieur interne : 002C07 ( Main/Exploration ); précédent : 002C06; suivant : 002C08Starvation-induced hyperactivity in the rat: The role of endocrine and neurotransmitter changes
Auteurs : K. M. Pirke [Allemagne] ; A. Broocks [Allemagne] ; T. Wilckens [Allemagne] ; R. Marquard [Allemagne] ; U. Schweiger [Allemagne]Source :
- Neuroscience and Biobehavioral Reviews [ 0149-7634 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Activité animale, Androgène, Anorexie mentale, Article synthèse, Catécholamine, Corticostérone, Dopamine, Encéphale, Glucocorticoïde, Hormone stéroïde sexuelle, Hormone surrénalienne, Hormone testiculaire, Hyperactivité, Hypothalamus, Jeûne alimentaire prolongé, Modèle animal, Neuromédiateur, Noradrénaline, Poids corporel, Rat, Système nerveux central, Sérotonine, Testostérone, Trouble comportement alimentaire.
English descriptors
- KwdEn :
- Adrenal hormone, Androgen, Animal activity, Animal model, Animals, Anorexia nervosa, Body weight, Brain (vertebrata), Catecholamine, Central nervous system, Corticosterone, Dopamine, Eating disorder, Endocrine Glands (physiopathology), Estrus, Female, Glucocorticoid, Hyperactivity, Hypothalamus, Male, Motor Activity (physiology), Neuromediator, Neurotransmitter Agents (physiology), Norepinephrine, Rat, Rats, Review, Serotonin, Sex steroid hormone, Starvation, Starvation (physiopathology), Starvation (psychology), Testicular hormone, Testosterone.
- MESH :
- chemical , physiology : Neurotransmitter Agents.
- physiology : Motor Activity.
- physiopathology : Endocrine Glands, Starvation.
- psychology : Starvation.
- Animals, Female, Male, Rats.
Abstract
Semistarved rats develop high running wheel activity. This running activity induces increased norepinephrine, dopamine, and serotonin turnover in the hypothalamus. Corticosterone in plasma becomes increased while luteinizing hormone and testosterone are suppressed. In female rats cyclic gonadal function is suppressed. Running activity in the semistarved rats can be suppressed specifically by serotonin 1-c-agonists and by α2-adrenoceptor agonists. This animal model is helpful in the understanding of the combined effects of starvation and hyperactivity, which are observed in many patients with anorexia nervosa. The observation of the serotonergic system might help to develop a pharmacological treatment of hyperactivity in anorectic patients.
Url:
DOI: 10.1016/S0149-7634(05)80012-0
Affiliations:
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M." last="Pirke">K. M. Pirke</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Psychobiology and Psychosomatic Research, Department of Psychoendocrinology, University of Trier, Building D, Box 3825, 5500 Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Requests for reprints should be addressed to K.M. Pirke, Center of Psychobiology and Psychosomatic Research, Department of Psychoendocrinology, University of Trier, Building D, Box 3825, 5500 Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Broocks, A" sort="Broocks, A" uniqKey="Broocks A" first="A." last="Broocks">A. Broocks</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Psychobiology and Psychosomatic Research, Department of Psychoendocrinology, University of Trier, Building D, Box 3825, 5500 Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Psychobiology and Psychosomatic Research, Department of Psychoendocrinology, University of Trier, Building D, Box 3825, 5500 Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Marquard, R" sort="Marquard, R" uniqKey="Marquard R" first="R." last="Marquard">R. Marquard</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Psychobiology and Psychosomatic Research, Department of Psychoendocrinology, University of Trier, Building D, Box 3825, 5500 Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institute for Psychiatry, Division of Psychoneuroendocrinology, Kraepelinstr. 10, 8000 Munich 40</wicri:regionArea><wicri:noRegion>8000 Munich 40</wicri:noRegion><wicri:noRegion>8000 Munich 40</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience and Biobehavioral Reviews</title><title level="j" type="abbrev">NBR</title><idno type="ISSN">0149-7634</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="287">287</biblScope><biblScope unit="page" to="294">294</biblScope></imprint><idno type="ISSN">0149-7634</idno></series><idno type="istex">0FE58D2BC76E27E5AB2A3C55BFF928D66923B2FD</idno><idno type="DOI">10.1016/S0149-7634(05)80012-0</idno><idno type="PII">S0149-7634(05)80012-0</idno><idno type="ArticleID">05800120</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0149-7634</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal hormone</term><term>Androgen</term><term>Animal activity</term><term>Animal model</term><term>Animals</term><term>Anorexia nervosa</term><term>Body weight</term><term>Brain (vertebrata)</term><term>Catecholamine</term><term>Central nervous system</term><term>Corticosterone</term><term>Dopamine</term><term>Eating disorder</term><term>Endocrine Glands (physiopathology)</term><term>Estrus</term><term>Female</term><term>Glucocorticoid</term><term>Hyperactivity</term><term>Hypothalamus</term><term>Male</term><term>Motor Activity (physiology)</term><term>Neuromediator</term><term>Neurotransmitter Agents (physiology)</term><term>Norepinephrine</term><term>Rat</term><term>Rats</term><term>Review</term><term>Serotonin</term><term>Sex steroid hormone</term><term>Starvation</term><term>Starvation (physiopathology)</term><term>Starvation (psychology)</term><term>Testicular hormone</term><term>Testosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Neurotransmitter Agents</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Endocrine Glands</term><term>Starvation</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Starvation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Activité animale</term><term>Androgène</term><term>Anorexie mentale</term><term>Article synthèse</term><term>Catécholamine</term><term>Corticostérone</term><term>Dopamine</term><term>Encéphale</term><term>Glucocorticoïde</term><term>Hormone stéroïde sexuelle</term><term>Hormone surrénalienne</term><term>Hormone testiculaire</term><term>Hyperactivité</term><term>Hypothalamus</term><term>Jeûne alimentaire prolongé</term><term>Modèle animal</term><term>Neuromédiateur</term><term>Noradrénaline</term><term>Poids corporel</term><term>Rat</term><term>Système nerveux central</term><term>Sérotonine</term><term>Testostérone</term><term>Trouble comportement alimentaire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Semistarved rats develop high running wheel activity. This running activity induces increased norepinephrine, dopamine, and serotonin turnover in the hypothalamus. Corticosterone in plasma becomes increased while luteinizing hormone and testosterone are suppressed. In female rats cyclic gonadal function is suppressed. Running activity in the semistarved rats can be suppressed specifically by serotonin 1-c-agonists and by α2-adrenoceptor agonists. This animal model is helpful in the understanding of the combined effects of starvation and hyperactivity, which are observed in many patients with anorexia nervosa. The observation of the serotonergic system might help to develop a pharmacological treatment of hyperactivity in anorectic patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name></region><name sortKey="Broocks, A" sort="Broocks, A" uniqKey="Broocks A" first="A." last="Broocks">A. Broocks</name><name sortKey="Marquard, R" sort="Marquard, R" uniqKey="Marquard R" first="R." last="Marquard">R. Marquard</name><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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