Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men.
Identifieur interne : 001287 ( Main/Exploration ); précédent : 001286; suivant : 001288Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men.
Auteurs : Claudia Buss [Allemagne] ; Catherine Lord ; Mehereen Wadiwalla ; Dirk H. Hellhammer ; Sonia J. Lupien ; Michael J. Meaney ; Jens C. PruessnerSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Hippocampus.
- embryology : Hippocampus, Stress, Physiological.
- Adult, Birth Weight, Child, Child Rearing, Embryonic Development, Female, Humans, Magnetic Resonance Imaging, Male, Mothers, Prognosis, Risk Factors, Sex Factors.
Abstract
Smaller hippocampal volume is associated with psychiatric disorders. Variations in hippocampal volume are discussed as both a consequence of the neurotoxic effects of stress and as a pre-existing condition leading to increased vulnerability for cognitive and emotional impairments. To investigate whether early experience can account for variability in hippocampal volume in adulthood (vulnerability hypothesis), we assessed the relationship between birth weight and hippocampal volume in 44 subjects. The reported quality of maternal care in early childhood, as evaluated by the Parental Bonding Inventory, was used as index of the quality of the postnatal environment. Hippocampal volume was assessed from magnetic resonance images using a manual segmentation protocol. We show that birth weight significantly predicts hippocampal volume in adulthood only in female subjects reporting low maternal care. The results suggest that the postnatal environment modulates the neurodevelopmental consequences of prenatal risk and that this effect is sex-specific.
DOI: 10.1523/JNEUROSCI.3252-06.2007
PubMed: 17344396
Affiliations:
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Le document en format XML
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Hellhammer</name></author><author><name sortKey="Lupien, Sonia J" sort="Lupien, Sonia J" uniqKey="Lupien S" first="Sonia J" last="Lupien">Sonia J. Lupien</name></author><author><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name></author><author><name sortKey="Pruessner, Jens C" sort="Pruessner, Jens C" uniqKey="Pruessner J" first="Jens C" last="Pruessner">Jens C. Pruessner</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Birth Weight</term><term>Child</term><term>Child Rearing</term><term>Embryonic Development</term><term>Female</term><term>Hippocampus (anatomy & histology)</term><term>Hippocampus (embryology)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mothers</term><term>Prognosis</term><term>Risk Factors</term><term>Sex Factors</term><term>Stress, Physiological (embryology)</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Hippocampus</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Birth Weight</term><term>Child</term><term>Child Rearing</term><term>Embryonic Development</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mothers</term><term>Prognosis</term><term>Risk Factors</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Smaller hippocampal volume is associated with psychiatric disorders. Variations in hippocampal volume are discussed as both a consequence of the neurotoxic effects of stress and as a pre-existing condition leading to increased vulnerability for cognitive and emotional impairments. To investigate whether early experience can account for variability in hippocampal volume in adulthood (vulnerability hypothesis), we assessed the relationship between birth weight and hippocampal volume in 44 subjects. The reported quality of maternal care in early childhood, as evaluated by the Parental Bonding Inventory, was used as index of the quality of the postnatal environment. Hippocampal volume was assessed from magnetic resonance images using a manual segmentation protocol. We show that birth weight significantly predicts hippocampal volume in adulthood only in female subjects reporting low maternal care. The results suggest that the postnatal environment modulates the neurodevelopmental consequences of prenatal risk and that this effect is sex-specific.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><name sortKey="Lord, Catherine" sort="Lord, Catherine" uniqKey="Lord C" first="Catherine" last="Lord">Catherine Lord</name><name sortKey="Lupien, Sonia J" sort="Lupien, Sonia J" uniqKey="Lupien S" first="Sonia J" last="Lupien">Sonia J. Lupien</name><name sortKey="Meaney, Michael J" sort="Meaney, Michael J" uniqKey="Meaney M" first="Michael J" last="Meaney">Michael J. Meaney</name><name sortKey="Pruessner, Jens C" sort="Pruessner, Jens C" uniqKey="Pruessner J" first="Jens C" last="Pruessner">Jens C. Pruessner</name><name sortKey="Wadiwalla, Mehereen" sort="Wadiwalla, Mehereen" uniqKey="Wadiwalla M" first="Mehereen" last="Wadiwalla">Mehereen Wadiwalla</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Buss, Claudia" sort="Buss, Claudia" uniqKey="Buss C" first="Claudia" last="Buss">Claudia Buss</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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