Dual HER2-blockade with pertuzumab and trastuzumab in HER2-positive early breast cancer: a subanalysis of data from the randomized phase III GeparSepto trial.
Identifieur interne : 000150 ( Main/Exploration ); précédent : 000149; suivant : 000151Dual HER2-blockade with pertuzumab and trastuzumab in HER2-positive early breast cancer: a subanalysis of data from the randomized phase III GeparSepto trial.
Auteurs : S. Loibl [Allemagne] ; C. Jackisch [Allemagne] ; A. Schneeweiss [Allemagne] ; S. Schmatloch [Allemagne] ; B. Aktas [Allemagne] ; C. Denkert [Allemagne] ; H. Wiebringhaus [Allemagne] ; S. Kümmel [Allemagne] ; M. Warm [Allemagne] ; S. Paepke [Allemagne] ; M. Just [Allemagne] ; C. Hanusch [Allemagne] ; J. Hackmann ; J-U Blohmer [Allemagne] ; M. Clemens [Allemagne] ; S Dan Costa [Allemagne] ; B. Gerber [Allemagne] ; K. Engels [Allemagne] ; V. Nekljudova [Allemagne] ; G. Von Minckwitz [Allemagne] ; M. Untch [Allemagne]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2016.
Abstract
The neoadjuvant phase III GeparSepto study showed that substituting nab-paclitaxel for standard solvent-based paclitaxel significantly improved the pathologic complete response (pCR) rate achieved with a sequential neoadjuvant chemotherapy regimen of paclitaxel, epirubicin and cyclophosphamide for high-risk primary breast cancer. Recent trials demonstrated that in HER2+ breast cancer pCR can be increased by using pertuzumab in addition to trastuzumab and chemotherapy. The present analysis focuses on efficacy and safety data from the subset of patients with HER2+ tumors from the GeparSepto trial (n=396) in comparison to the HER2- cohort.
DOI: 10.1093/annonc/mdw610
PubMed: 27831502
Affiliations:
- Allemagne
- Bade-Wurtemberg, Bavière, Berlin, District de Cologne, District de Haute-Bavière, District de Karlsruhe, Rhénanie-du-Nord-Westphalie, Saxe-Anhalt
- Berlin, Cologne, Heidelberg, Magdebourg, Munich
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Paepke</name><affiliation wicri:level="3"><nlm:affiliation>Women's Clinic, Klinikum rechts der Isar der TU München, Klinik und Poliklinik für Frauenheilkunde, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinikum rechts der Isar der TU München, Klinik und Poliklinik für Frauenheilkunde, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Just, M" sort="Just, M" uniqKey="Just M" first="M" last="Just">M. 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Hackmann</name><affiliation><nlm:affiliation>Breast Unit, Marien Hospital Witten, Witten.</nlm:affiliation><wicri:noCountry code="subField">Witten</wicri:noCountry></affiliation></author><author><name sortKey="Blohmer, J U" sort="Blohmer, J U" uniqKey="Blohmer J" first="J-U" last="Blohmer">J-U Blohmer</name><affiliation wicri:level="3"><nlm:affiliation>Women's Clinic, Klinik für Gynäkologie am Campus Charité Mitte, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinik für Gynäkologie am Campus Charité Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Clemens, M" sort="Clemens, M" uniqKey="Clemens M" first="M" last="Clemens">M. Clemens</name><affiliation wicri:level="1"><nlm:affiliation>Women's Clinic, Klinikum Mutterhaus der Borromäerinnen, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinikum Mutterhaus der Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Costa, S Dan" sort="Costa, S Dan" uniqKey="Costa S" first="S Dan" last="Costa">S Dan Costa</name><affiliation wicri:level="3"><nlm:affiliation>Gynecology, Universitäts-Frauenklinik, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynecology, Universitäts-Frauenklinik, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Gerber, B" sort="Gerber, B" uniqKey="Gerber B" first="B" last="Gerber">B. Gerber</name><affiliation wicri:level="1"><nlm:affiliation>Women's Clinic, Universitäts-Frauenklinik, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Universitäts-Frauenklinik, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Engels, K" sort="Engels, K" uniqKey="Engels K" first="K" last="Engels">K. Engels</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Zentrum für Pathologie, Zytologie und Molekularpathologie Neuss, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pathology, Zentrum für Pathologie, Zytologie und Molekularpathologie Neuss</wicri:regionArea><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion></affiliation></author><author><name sortKey="Nekljudova, V" sort="Nekljudova, V" uniqKey="Nekljudova V" first="V" last="Nekljudova">V. Nekljudova</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group Neu-Isenburg</wicri:regionArea></affiliation></author><author><name sortKey="Von Minckwitz, G" sort="Von Minckwitz, G" uniqKey="Von Minckwitz G" first="G" last="Von Minckwitz">G. Von Minckwitz</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group Neu-Isenburg</wicri:regionArea></affiliation></author><author><name sortKey="Untch, M" sort="Untch, M" uniqKey="Untch M" first="M" last="Untch">M. 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Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group Neu-Isenburg, Germany; sibylle.loibl@gbg.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>German Breast Group Neu-Isenburg</wicri:regionArea></affiliation></author><author><name sortKey="Jackisch, C" sort="Jackisch, C" uniqKey="Jackisch C" first="C" last="Jackisch">C. Jackisch</name><affiliation wicri:level="1"><nlm:affiliation>Obstetrics & Gynecology, Sana Klinikum, Offenbach, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Obstetrics & Gynecology, Sana Klinikum, Offenbach</wicri:regionArea><wicri:noRegion>Offenbach</wicri:noRegion><wicri:noRegion>Offenbach</wicri:noRegion><wicri:noRegion>Offenbach</wicri:noRegion></affiliation></author><author><name sortKey="Schneeweiss, A" sort="Schneeweiss, A" uniqKey="Schneeweiss A" first="A" last="Schneeweiss">A. Schneeweiss</name><affiliation wicri:level="3"><nlm:affiliation>National Center for Tumor Diseases, University Hospital, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University Hospital, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schmatloch, S" sort="Schmatloch, S" uniqKey="Schmatloch S" first="S" last="Schmatloch">S. Schmatloch</name><affiliation wicri:level="1"><nlm:affiliation>Elisabeth-Krankenhaus Kassel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Elisabeth-Krankenhaus Kassel</wicri:regionArea></affiliation></author><author><name sortKey="Aktas, B" sort="Aktas, B" uniqKey="Aktas B" first="B" last="Aktas">B. Aktas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecology & Obstetrics, University Women's Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology & Obstetrics, University Women's Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University Hospital Charité, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Hospital Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wiebringhaus, H" sort="Wiebringhaus, H" uniqKey="Wiebringhaus H" first="H" last="Wiebringhaus">H. Wiebringhaus</name><affiliation wicri:level="1"><nlm:affiliation>Gynecology, St. Barbara-Klinik Hamm-Heessen, Hamm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynecology, St. Barbara-Klinik Hamm-Heessen, Hamm</wicri:regionArea><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion><wicri:noRegion>Hamm</wicri:noRegion></affiliation></author><author><name sortKey="Kummel, S" sort="Kummel, S" uniqKey="Kummel S" first="S" last="Kümmel">S. Kümmel</name><affiliation wicri:level="1"><nlm:affiliation>Breast Unit, interdisziplinäres Brustzentrum an den Kliniken Essen-Mitte, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Breast Unit, interdisziplinäres Brustzentrum an den Kliniken Essen-Mitte, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Warm, M" sort="Warm, M" uniqKey="Warm M" first="M" last="Warm">M. Warm</name><affiliation wicri:level="3"><nlm:affiliation>Breast Unit, Brustzentrum im Krankenhaus Köln-Holweide, Köln, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Breast Unit, Brustzentrum im Krankenhaus Köln-Holweide, Köln</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Paepke, S" sort="Paepke, S" uniqKey="Paepke S" first="S" last="Paepke">S. Paepke</name><affiliation wicri:level="3"><nlm:affiliation>Women's Clinic, Klinikum rechts der Isar der TU München, Klinik und Poliklinik für Frauenheilkunde, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinikum rechts der Isar der TU München, Klinik und Poliklinik für Frauenheilkunde, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Just, M" sort="Just, M" uniqKey="Just M" first="M" last="Just">M. Just</name><affiliation wicri:level="1"><nlm:affiliation>Oncology, Onkologische Schwerpunktpraxis Bielefeld, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Oncology, Onkologische Schwerpunktpraxis Bielefeld</wicri:regionArea><wicri:noRegion>Onkologische Schwerpunktpraxis Bielefeld</wicri:noRegion><wicri:noRegion>Onkologische Schwerpunktpraxis Bielefeld</wicri:noRegion><wicri:noRegion>Onkologische Schwerpunktpraxis Bielefeld</wicri:noRegion></affiliation></author><author><name sortKey="Hanusch, C" sort="Hanusch, C" uniqKey="Hanusch C" first="C" last="Hanusch">C. Hanusch</name><affiliation wicri:level="3"><nlm:affiliation>Women's Clinic, Klinikum zum Roten Kreuz, München, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinikum zum Roten Kreuz, München</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hackmann, J" sort="Hackmann, J" uniqKey="Hackmann J" first="J" last="Hackmann">J. Hackmann</name><affiliation><nlm:affiliation>Breast Unit, Marien Hospital Witten, Witten.</nlm:affiliation><wicri:noCountry code="subField">Witten</wicri:noCountry></affiliation></author><author><name sortKey="Blohmer, J U" sort="Blohmer, J U" uniqKey="Blohmer J" first="J-U" last="Blohmer">J-U Blohmer</name><affiliation wicri:level="3"><nlm:affiliation>Women's Clinic, Klinik für Gynäkologie am Campus Charité Mitte, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinik für Gynäkologie am Campus Charité Mitte, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Clemens, M" sort="Clemens, M" uniqKey="Clemens M" first="M" last="Clemens">M. Clemens</name><affiliation wicri:level="1"><nlm:affiliation>Women's Clinic, Klinikum Mutterhaus der Borromäerinnen, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Klinikum Mutterhaus der Borromäerinnen, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Costa, S Dan" sort="Costa, S Dan" uniqKey="Costa S" first="S Dan" last="Costa">S Dan Costa</name><affiliation wicri:level="3"><nlm:affiliation>Gynecology, Universitäts-Frauenklinik, Magdeburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynecology, Universitäts-Frauenklinik, Magdeburg</wicri:regionArea><placeName><region type="land" nuts="2">Saxe-Anhalt</region><settlement type="city">Magdebourg</settlement></placeName></affiliation></author><author><name sortKey="Gerber, B" sort="Gerber, B" uniqKey="Gerber B" first="B" last="Gerber">B. Gerber</name><affiliation wicri:level="1"><nlm:affiliation>Women's Clinic, Universitäts-Frauenklinik, Rostock, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Women's Clinic, Universitäts-Frauenklinik, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Engels, K" sort="Engels, K" uniqKey="Engels K" first="K" last="Engels">K. Engels</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Zentrum für Pathologie, Zytologie und Molekularpathologie Neuss, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pathology, Zentrum für Pathologie, Zytologie und Molekularpathologie Neuss</wicri:regionArea><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion><wicri:noRegion>Zytologie und Molekularpathologie Neuss</wicri:noRegion></affiliation></author><author><name sortKey="Nekljudova, V" sort="Nekljudova, V" uniqKey="Nekljudova V" first="V" last="Nekljudova">V. Nekljudova</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group Neu-Isenburg</wicri:regionArea></affiliation></author><author><name sortKey="Von Minckwitz, G" sort="Von Minckwitz, G" uniqKey="Von Minckwitz G" first="G" last="Von Minckwitz">G. Von Minckwitz</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group Neu-Isenburg</wicri:regionArea></affiliation></author><author><name sortKey="Untch, M" sort="Untch, M" uniqKey="Untch M" first="M" last="Untch">M. Untch</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecology and Obstetrics, HELIOS Klinikum Berlin-Buch, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynecology and Obstetrics, HELIOS Klinikum Berlin-Buch, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neoadjuvant phase III GeparSepto study showed that substituting nab-paclitaxel for standard solvent-based paclitaxel significantly improved the pathologic complete response (pCR) rate achieved with a sequential neoadjuvant chemotherapy regimen of paclitaxel, epirubicin and cyclophosphamide for high-risk primary breast cancer. Recent trials demonstrated that in HER2+ breast cancer pCR can be increased by using pertuzumab in addition to trastuzumab and chemotherapy. The present analysis focuses on efficacy and safety data from the subset of patients with HER2+ tumors from the GeparSepto trial (n=396) in comparison to the HER2- cohort.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Berlin</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe-Anhalt</li></region><settlement><li>Berlin</li><li>Cologne</li><li>Heidelberg</li><li>Magdebourg</li><li>Munich</li></settlement></list><tree><noCountry><name sortKey="Hackmann, J" sort="Hackmann, J" uniqKey="Hackmann J" first="J" last="Hackmann">J. Hackmann</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Loibl, S" sort="Loibl, S" uniqKey="Loibl S" first="S" last="Loibl">S. Loibl</name></noRegion><name sortKey="Aktas, B" sort="Aktas, B" uniqKey="Aktas B" first="B" last="Aktas">B. Aktas</name><name sortKey="Blohmer, J U" sort="Blohmer, J U" uniqKey="Blohmer J" first="J-U" last="Blohmer">J-U Blohmer</name><name sortKey="Clemens, M" sort="Clemens, M" uniqKey="Clemens M" first="M" last="Clemens">M. Clemens</name><name sortKey="Costa, S Dan" sort="Costa, S Dan" uniqKey="Costa S" first="S Dan" last="Costa">S Dan Costa</name><name sortKey="Denkert, C" sort="Denkert, C" uniqKey="Denkert C" first="C" last="Denkert">C. Denkert</name><name sortKey="Engels, K" sort="Engels, K" uniqKey="Engels K" first="K" last="Engels">K. Engels</name><name sortKey="Gerber, B" sort="Gerber, B" uniqKey="Gerber B" first="B" last="Gerber">B. Gerber</name><name sortKey="Hanusch, C" sort="Hanusch, C" uniqKey="Hanusch C" first="C" last="Hanusch">C. Hanusch</name><name sortKey="Jackisch, C" sort="Jackisch, C" uniqKey="Jackisch C" first="C" last="Jackisch">C. Jackisch</name><name sortKey="Just, M" sort="Just, M" uniqKey="Just M" first="M" last="Just">M. Just</name><name sortKey="Kummel, S" sort="Kummel, S" uniqKey="Kummel S" first="S" last="Kümmel">S. Kümmel</name><name sortKey="Nekljudova, V" sort="Nekljudova, V" uniqKey="Nekljudova V" first="V" last="Nekljudova">V. Nekljudova</name><name sortKey="Paepke, S" sort="Paepke, S" uniqKey="Paepke S" first="S" last="Paepke">S. Paepke</name><name sortKey="Schmatloch, S" sort="Schmatloch, S" uniqKey="Schmatloch S" first="S" last="Schmatloch">S. Schmatloch</name><name sortKey="Schneeweiss, A" sort="Schneeweiss, A" uniqKey="Schneeweiss A" first="A" last="Schneeweiss">A. Schneeweiss</name><name sortKey="Untch, M" sort="Untch, M" uniqKey="Untch M" first="M" last="Untch">M. Untch</name><name sortKey="Von Minckwitz, G" sort="Von Minckwitz, G" uniqKey="Von Minckwitz G" first="G" last="Von Minckwitz">G. Von Minckwitz</name><name sortKey="Warm, M" sort="Warm, M" uniqKey="Warm M" first="M" last="Warm">M. Warm</name><name sortKey="Wiebringhaus, H" sort="Wiebringhaus, H" uniqKey="Wiebringhaus H" first="H" last="Wiebringhaus">H. Wiebringhaus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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