Proteomic investigation of human cystic echinococcosis in the liver.
Identifieur interne : 000011 ( Main/Exploration ); précédent : 000010; suivant : 000012Proteomic investigation of human cystic echinococcosis in the liver.
Auteurs : Rémi Longuespée [Allemagne] ; Rita Casadonte [Allemagne] ; Mark Kriegsmann [Allemagne] ; Petra Wandernoth [Allemagne] ; Katharina Lisenko [Allemagne] ; Gabriel Mazzucchelli [Belgique] ; Michael Becker [Allemagne] ; Jörg Kriegsmann [Allemagne]Source :
- Molecular and biochemical parasitology [ 1872-9428 ] ; 2017.
Abstract
Cystic echinococcosis (CE) is a pandemic infectious disease caused by the tapeworm Echinococcus granulosus that forms cysts in different organs such as lungs and liver. Imaging examination and serological tests have some drawbacks such as low sensitivity. In this study, we used an up-to-date workflow of laser microdissection-based microproteomics and matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry in order to depict the proteomic pattern of CE in the liver. This investigation revealed specific markers of a parasitic cyst in liver. This proteomic pattern could facilitate diagnosis of CE in the future.
DOI: 10.1016/j.molbiopara.2016.12.002
PubMed: 27986452
Affiliations:
- Allemagne, Belgique
- Bade-Wurtemberg, Brême (Land), District de Karlsruhe, Province de Liège
- Brême, Heidelberg, Liège
- Université de Liège
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Le document en format XML
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Molecular Pathology Trier, Max Planck Strasse 17, 54296 Trier, Germany; MVZ for Histology, Cytology and Molecular Diagnostics Trier, Max Planck Strasse 5, 54296 Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Proteopath GmbH, Trier, Max Planck Strasse 17, 54296 Trier, Germany; Molecular Pathology Trier, Max Planck Strasse 17, 54296 Trier, Germany; MVZ for Histology, Cytology and Molecular Diagnostics Trier, Max Planck Strasse 5, 54296 Trier</wicri:regionArea><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular and biochemical parasitology</title><idno type="eISSN">1872-9428</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cystic echinococcosis (CE) is a pandemic infectious disease caused by the tapeworm Echinococcus granulosus that forms cysts in different organs such as lungs and liver. Imaging examination and serological tests have some drawbacks such as low sensitivity. In this study, we used an up-to-date workflow of laser microdissection-based microproteomics and matrix-assisted laser desorption/ionization time-of-flight imaging mass spectrometry in order to depict the proteomic pattern of CE in the liver. This investigation revealed specific markers of a parasitic cyst in liver. This proteomic pattern could facilitate diagnosis of CE in the future.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li></country><region><li>Bade-Wurtemberg</li><li>Brême (Land)</li><li>District de Karlsruhe</li><li>Province de Liège</li></region><settlement><li>Brême</li><li>Heidelberg</li><li>Liège</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Longuespee, Remi" sort="Longuespee, Remi" uniqKey="Longuespee R" first="Rémi" last="Longuespée">Rémi Longuespée</name></region><name sortKey="Becker, Michael" sort="Becker, Michael" uniqKey="Becker M" first="Michael" last="Becker">Michael Becker</name><name sortKey="Casadonte, Rita" sort="Casadonte, Rita" uniqKey="Casadonte R" first="Rita" last="Casadonte">Rita Casadonte</name><name sortKey="Kriegsmann, Jorg" sort="Kriegsmann, Jorg" uniqKey="Kriegsmann J" first="Jörg" last="Kriegsmann">Jörg Kriegsmann</name><name sortKey="Kriegsmann, Mark" sort="Kriegsmann, Mark" uniqKey="Kriegsmann M" first="Mark" last="Kriegsmann">Mark Kriegsmann</name><name sortKey="Lisenko, Katharina" sort="Lisenko, Katharina" uniqKey="Lisenko K" first="Katharina" last="Lisenko">Katharina Lisenko</name><name sortKey="Wandernoth, Petra" sort="Wandernoth, Petra" uniqKey="Wandernoth P" first="Petra" last="Wandernoth">Petra Wandernoth</name></country><country name="Belgique"><region name="Province de Liège"><name sortKey="Mazzucchelli, Gabriel" sort="Mazzucchelli, Gabriel" uniqKey="Mazzucchelli G" first="Gabriel" last="Mazzucchelli">Gabriel Mazzucchelli</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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