Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery
Identifieur interne : 001793 ( Main/Curation ); précédent : 001792; suivant : 001794Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery
Auteurs : Andrea Geiss [Allemagne] ; Nicolas Rohleder [Allemagne] ; Clemens Kirschbaum [Allemagne] ; Klaus Steinbach [Allemagne] ; Heinz W. Bauer [Allemagne] ; Fernand Anton [Allemagne, Luxembourg (pays)]Source :
- Pain : (Amsterdam) [ 0304-3959 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective, Homme.
English descriptors
- KwdEn :
- Adult, Catecholamine, Cytokine, Diskectomy (adverse effects), Female, Glucocorticoid, Human, Humans, Hydrocortisone, Hydrocortisone (blood), Hypothalamo-Hypophyseal System (physiology), Hypothalamohypophysoadrenal axis, Interleukin 6, Interleukin-6 (blood), Intervertebral Disc Displacement (blood), Intervertebral Disc Displacement (surgery), Intervertebral disk displacement, Male, Middle Aged, Pain, Pain Measurement (methods), Pain Threshold (physiology), Pain, Postoperative (blood), Pituitary-Adrenal System (physiology), Postoperative, Predictive Value of Tests, Preoperative, Prospective, Prospective Studies, Sensitivity, Sex, Stress, Treatment Failure.
- MESH :
- chemical , blood : Hydrocortisone, Interleukin-6.
- adverse effects : Diskectomy.
- blood : Intervertebral Disc Displacement, Pain, Postoperative.
- methods : Pain Measurement.
- physiology : Hypothalamo-Hypophyseal System, Pain Threshold, Pituitary-Adrenal System.
- surgery : Intervertebral Disc Displacement.
- Adult, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Treatment Failure.
Abstract
Patients with postoperative ongoing sciatic pain have been shown to exhibit reduced cortisol levels along with enhanced IL-6 levels. The aim of the present study was to clarify the relationship between a reduced cortisol secretion and enhanced cytokine levels by performing a prospective study on patients with disc herniation. Twenty-two patients were examined before and after their disc surgery. Twelve healthy, pain-free subjects matched for age, education and gender constituted the control group. The preoperative examinations included the assessment of the diurnal pattern of cortisol secretion and the feedback sensitivity of the hypothalamus-pituitary-adrenal (HPA) axis. Patients' subjective stress levels also were assessed during the preoperative examination. The diurnal pattern of cortisol secretion was again assessed during the postoperative examination. Furthermore, blood samples were collected to measure catecholamine, adrenocorticotropic hormone (ACTH)- and interleukin-6 (IL-6) levels before and after measuring the pressure pain thresholds (PPTs). An assessment of the sensitivity of circulating monocytes to the immunosuppressive effects of glucocorticoids was further included in the postoperative examinations. Failed back syndrome (FBS) patients (n=12) showed a reduced cortisol secretion in the morning hours and enhanced feedback sensitivity of the HPA axis. Furthermore, FBS patients displayed an increased in-vitro production of proinflammatory cytokines and a relative glucocorticoid resistance of pro-inflammatory cytokine producing monocytes as compared to non-FBS patients (n=10) and controls. After PPT measurement FBS patients exhibited an increased norepinephrine but decreased epinephrine response, together with lower ACTH levels and a four times higher plasma IL-6 response. These findings suggest that chronically stressed patients are at a higher risk for a poor surgical outcome as their reduced cortisol secretion promotes the postoperative ongoing synthesis of proinflammatory cytokines.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A49
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000445
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000812
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001959
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000715
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000715
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000715
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000191
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000191
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000191
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001766
Links to Exploration step
Pascal:05-0374222Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W." last="Bauer">Heinz W. Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Université du Luxembourg, 162A, avenue de la Faïbncerie</s1><s2>1511 Luxembourg</s2><s3>LUX</s3><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1511 Luxembourg</wicri:noRegion><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0374222</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0374222 INIST</idno><idno type="RBID">Pascal:05-0374222</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A49</idno><idno type="wicri:Area/PascalFrancis/Curation">000445</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000812</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000812</idno><idno type="wicri:doubleKey">0304-3959:2005:Geiss A:predicting:the:failure</idno><idno type="wicri:Area/Main/Merge">001959</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15733636</idno><idno type="wicri:Area/PubMed/Corpus">000715</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000715</idno><idno type="wicri:Area/PubMed/Curation">000715</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000715</idno><idno type="wicri:Area/PubMed/Checkpoint">000715</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000715</idno><idno type="wicri:Area/Ncbi/Merge">000191</idno><idno type="wicri:Area/Ncbi/Curation">000191</idno><idno type="wicri:Area/Ncbi/Checkpoint">000191</idno><idno type="wicri:doubleKey">0304-3959:2005:Geiss A:predicting:the:failure</idno><idno type="wicri:Area/Main/Merge">001766</idno><idno type="wicri:Area/Main/Curation">001793</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W." last="Bauer">Heinz W. Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Université du Luxembourg, 162A, avenue de la Faïbncerie</s1><s2>1511 Luxembourg</s2><s3>LUX</s3><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1511 Luxembourg</wicri:noRegion><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Pain : (Amsterdam)</title><title level="j" type="abbreviated">Pain : (Amst.)</title><idno type="ISSN">0304-3959</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Pain : (Amsterdam)</title><title level="j" type="abbreviated">Pain : (Amst.)</title><idno type="ISSN">0304-3959</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Catecholamine</term><term>Cytokine</term><term>Diskectomy (adverse effects)</term><term>Female</term><term>Glucocorticoid</term><term>Human</term><term>Humans</term><term>Hydrocortisone</term><term>Hydrocortisone (blood)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Hypothalamohypophysoadrenal axis</term><term>Interleukin 6</term><term>Interleukin-6 (blood)</term><term>Intervertebral Disc Displacement (blood)</term><term>Intervertebral Disc Displacement (surgery)</term><term>Intervertebral disk displacement</term><term>Male</term><term>Middle Aged</term><term>Pain</term><term>Pain Measurement (methods)</term><term>Pain Threshold (physiology)</term><term>Pain, Postoperative (blood)</term><term>Pituitary-Adrenal System (physiology)</term><term>Postoperative</term><term>Predictive Value of Tests</term><term>Preoperative</term><term>Prospective</term><term>Prospective Studies</term><term>Sensitivity</term><term>Sex</term><term>Stress</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hydrocortisone</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diskectomy</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Intervertebral Disc Displacement</term><term>Pain, Postoperative</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pain Measurement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pain Threshold</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Intervertebral Disc Displacement</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Treatment Failure</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prospective</term><term>Postopératoire</term><term>Douleur</term><term>Hydrocortisone</term><term>Interleukine 6</term><term>Cytokine</term><term>Sexe</term><term>Préopératoire</term><term>Hernie discale</term><term>Sensibilité</term><term>Stress</term><term>Catécholamine</term><term>Glucocorticoïde</term><term>Homme</term><term>Système hypothalamohypophysosurrénalien</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with postoperative ongoing sciatic pain have been shown to exhibit reduced cortisol levels along with enhanced IL-6 levels. The aim of the present study was to clarify the relationship between a reduced cortisol secretion and enhanced cytokine levels by performing a prospective study on patients with disc herniation. Twenty-two patients were examined before and after their disc surgery. Twelve healthy, pain-free subjects matched for age, education and gender constituted the control group. The preoperative examinations included the assessment of the diurnal pattern of cortisol secretion and the feedback sensitivity of the hypothalamus-pituitary-adrenal (HPA) axis. Patients' subjective stress levels also were assessed during the preoperative examination. The diurnal pattern of cortisol secretion was again assessed during the postoperative examination. Furthermore, blood samples were collected to measure catecholamine, adrenocorticotropic hormone (ACTH)- and interleukin-6 (IL-6) levels before and after measuring the pressure pain thresholds (PPTs). An assessment of the sensitivity of circulating monocytes to the immunosuppressive effects of glucocorticoids was further included in the postoperative examinations. Failed back syndrome (FBS) patients (n=12) showed a reduced cortisol secretion in the morning hours and enhanced feedback sensitivity of the HPA axis. Furthermore, FBS patients displayed an increased in-vitro production of proinflammatory cytokines and a relative glucocorticoid resistance of pro-inflammatory cytokine producing monocytes as compared to non-FBS patients (n=10) and controls. After PPT measurement FBS patients exhibited an increased norepinephrine but decreased epinephrine response, together with lower ACTH levels and a four times higher plasma IL-6 response. These findings suggest that chronically stressed patients are at a higher risk for a poor surgical outcome as their reduced cortisol secretion promotes the postoperative ongoing synthesis of proinflammatory cytokines.</div></front></TEI><double idat="0304-3959:2005:Geiss A:predicting:the:failure"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W." last="Bauer">Heinz W. Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Université du Luxembourg, 162A, avenue de la Faïbncerie</s1><s2>1511 Luxembourg</s2><s3>LUX</s3><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1511 Luxembourg</wicri:noRegion><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0374222</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0374222 INIST</idno><idno type="RBID">Pascal:05-0374222</idno><idno type="wicri:Area/PascalFrancis/Corpus">000A49</idno><idno type="wicri:Area/PascalFrancis/Curation">000445</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000812</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000812</idno><idno type="wicri:doubleKey">0304-3959:2005:Geiss A:predicting:the:failure</idno><idno type="wicri:Area/Main/Merge">001959</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Biological Psychology, Technical University of Dresden</s1><s2>01062 Dresden</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>01062 Dresden</wicri:noRegion><wicri:noRegion>Technical University of Dresden</wicri:noRegion><wicri:noRegion>01062 Dresden</wicri:noRegion></affiliation></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W." last="Bauer">Heinz W. Bauer</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</s1><s2>66709 Weiskirchen/Saarr</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>66709 Weiskirchen/Saarr</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion><wicri:noRegion>Klinik für Orthopädie und Sportmedizin der Hochwald Kliniken</wicri:noRegion></affiliation></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychobiology, University of Trier</s1><s2>54286 Trier</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>54286 Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Université du Luxembourg, 162A, avenue de la Faïbncerie</s1><s2>1511 Luxembourg</s2><s3>LUX</s3><sZ>6 aut.</sZ></inist:fA14><country>Luxembourg (pays)</country><wicri:noRegion>1511 Luxembourg</wicri:noRegion><orgName type="university">Université du Luxembourg</orgName><placeName><settlement type="city">Luxembourg</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Pain : (Amsterdam)</title><title level="j" type="abbreviated">Pain : (Amst.)</title><idno type="ISSN">0304-3959</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Pain : (Amsterdam)</title><title level="j" type="abbreviated">Pain : (Amst.)</title><idno type="ISSN">0304-3959</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Catecholamine</term><term>Cytokine</term><term>Glucocorticoid</term><term>Human</term><term>Hydrocortisone</term><term>Hypothalamohypophysoadrenal axis</term><term>Interleukin 6</term><term>Intervertebral disk displacement</term><term>Pain</term><term>Postoperative</term><term>Preoperative</term><term>Prospective</term><term>Sensitivity</term><term>Sex</term><term>Stress</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prospective</term><term>Postopératoire</term><term>Douleur</term><term>Hydrocortisone</term><term>Interleukine 6</term><term>Cytokine</term><term>Sexe</term><term>Préopératoire</term><term>Hernie discale</term><term>Sensibilité</term><term>Stress</term><term>Catécholamine</term><term>Glucocorticoïde</term><term>Homme</term><term>Système hypothalamohypophysosurrénalien</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with postoperative ongoing sciatic pain have been shown to exhibit reduced cortisol levels along with enhanced IL-6 levels. The aim of the present study was to clarify the relationship between a reduced cortisol secretion and enhanced cytokine levels by performing a prospective study on patients with disc herniation. Twenty-two patients were examined before and after their disc surgery. Twelve healthy, pain-free subjects matched for age, education and gender constituted the control group. The preoperative examinations included the assessment of the diurnal pattern of cortisol secretion and the feedback sensitivity of the hypothalamus-pituitary-adrenal (HPA) axis. Patients' subjective stress levels also were assessed during the preoperative examination. The diurnal pattern of cortisol secretion was again assessed during the postoperative examination. Furthermore, blood samples were collected to measure catecholamine, adrenocorticotropic hormone (ACTH)- and interleukin-6 (IL-6) levels before and after measuring the pressure pain thresholds (PPTs). An assessment of the sensitivity of circulating monocytes to the immunosuppressive effects of glucocorticoids was further included in the postoperative examinations. Failed back syndrome (FBS) patients (n=12) showed a reduced cortisol secretion in the morning hours and enhanced feedback sensitivity of the HPA axis. Furthermore, FBS patients displayed an increased in-vitro production of proinflammatory cytokines and a relative glucocorticoid resistance of pro-inflammatory cytokine producing monocytes as compared to non-FBS patients (n=10) and controls. After PPT measurement FBS patients exhibited an increased norepinephrine but decreased epinephrine response, together with lower ACTH levels and a four times higher plasma IL-6 response. These findings suggest that chronically stressed patients are at a higher risk for a poor surgical outcome as their reduced cortisol secretion promotes the postoperative ongoing synthesis of proinflammatory cytokines.</div></front></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery.</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychobiology, University of Trier, D-54286 Trier, Germany. andrea.geiss@orthop.gu.se</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychobiology, University of Trier, D-54286 Trier</wicri:regionArea><wicri:noRegion>54286 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W" last="Bauer">Heinz W. Bauer</name></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15733636</idno><idno type="pmid">15733636</idno><idno type="doi">10.1016/j.pain.2004.12.007</idno><idno type="wicri:Area/PubMed/Corpus">000715</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000715</idno><idno type="wicri:Area/PubMed/Curation">000715</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000715</idno><idno type="wicri:Area/PubMed/Checkpoint">000715</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000715</idno><idno type="wicri:Area/Ncbi/Merge">000191</idno><idno type="wicri:Area/Ncbi/Curation">000191</idno><idno type="wicri:Area/Ncbi/Checkpoint">000191</idno><idno type="wicri:doubleKey">0304-3959:2005:Geiss A:predicting:the:failure</idno><idno type="wicri:Area/Main/Merge">001766</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery.</title><author><name sortKey="Geiss, Andrea" sort="Geiss, Andrea" uniqKey="Geiss A" first="Andrea" last="Geiss">Andrea Geiss</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychobiology, University of Trier, D-54286 Trier, Germany. andrea.geiss@orthop.gu.se</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychobiology, University of Trier, D-54286 Trier</wicri:regionArea><wicri:noRegion>54286 Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Rohleder, Nicolas" sort="Rohleder, Nicolas" uniqKey="Rohleder N" first="Nicolas" last="Rohleder">Nicolas Rohleder</name></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name></author><author><name sortKey="Steinbach, Klaus" sort="Steinbach, Klaus" uniqKey="Steinbach K" first="Klaus" last="Steinbach">Klaus Steinbach</name></author><author><name sortKey="Bauer, Heinz W" sort="Bauer, Heinz W" uniqKey="Bauer H" first="Heinz W" last="Bauer">Heinz W. Bauer</name></author><author><name sortKey="Anton, Fernand" sort="Anton, Fernand" uniqKey="Anton F" first="Fernand" last="Anton">Fernand Anton</name></author></analytic><series><title level="j">Pain</title><idno type="ISSN">0304-3959</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Diskectomy (adverse effects)</term><term>Female</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Interleukin-6 (blood)</term><term>Intervertebral Disc Displacement (blood)</term><term>Intervertebral Disc Displacement (surgery)</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement (methods)</term><term>Pain Threshold (physiology)</term><term>Pain, Postoperative (blood)</term><term>Pituitary-Adrenal System (physiology)</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Treatment Failure</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Hydrocortisone</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diskectomy</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Intervertebral Disc Displacement</term><term>Pain, Postoperative</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Pain Measurement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pain Threshold</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Intervertebral Disc Displacement</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Treatment Failure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with postoperative ongoing sciatic pain have been shown to exhibit reduced cortisol levels along with enhanced IL-6 levels. The aim of the present study was to clarify the relationship between a reduced cortisol secretion and enhanced cytokine levels by performing a prospective study on patients with disc herniation. Twenty-two patients were examined before and after their disc surgery. Twelve healthy, pain-free subjects matched for age, education and gender constituted the control group. The preoperative examinations included the assessment of the diurnal pattern of cortisol secretion and the feedback sensitivity of the hypothalamus-pituitary-adrenal (HPA) axis. Patients' subjective stress levels also were assessed during the preoperative examination. The diurnal pattern of cortisol secretion was again assessed during the postoperative examination. Furthermore, blood samples were collected to measure catecholamine, adrenocorticotropic hormone (ACTH)- and interleukin-6 (IL-6) levels before and after measuring the pressure pain thresholds (PPTs). An assessment of the sensitivity of circulating monocytes to the immunosuppressive effects of glucocorticoids was further included in the postoperative examinations. Failed back syndrome (FBS) patients (n=12) showed a reduced cortisol secretion in the morning hours and enhanced feedback sensitivity of the HPA axis. Furthermore, FBS patients displayed an increased in-vitro production of proinflammatory cytokines and a relative glucocorticoid resistance of pro-inflammatory cytokine producing monocytes as compared to non-FBS patients (n=10) and controls. After PPT measurement FBS patients exhibited an increased norepinephrine but decreased epinephrine response, together with lower ACTH levels and a four times higher plasma IL-6 response. These findings suggest that chronically stressed patients are at a higher risk for a poor surgical outcome as their reduced cortisol secretion promotes the postoperative ongoing synthesis of proinflammatory cytokines.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001793 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001793 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Curation
|type= RBID
|clé= Pascal:05-0374222
|texte= Predicting the failure of disc surgery by a hypofunctional HPA axis: evidence from a prospective study on patients undergoing disc surgery
}}
| This area was generated with Dilib version V0.6.31. |  |