UnivTrevesV1, Main, Curation, bibRecord, 001789

Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma

Identifieur interne : 001789 ( Main/Curation ); précédent : 001788; suivant : 001790

Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma

Auteurs : Agnieszka Korfel [Allemagne] ; Peter Martus [Allemagne] ; Mohammad R. Nowrousian [Allemagne] ; Dieter K. Hossfeld [Allemagne] ; Heinz Kirchen [Allemagne] ; Joachim Brücher [Allemagne] ; Matthias Stelljes [Allemagne] ; Josef Birkmann [Allemagne] ; Christian Peschel [Allemagne] ; Rita Pasold [Allemagne] ; Lars Fischer [Allemagne] ; Kristoph Jahnke [Allemagne] ; Eckhard Thiel [Allemagne]

Source :

British journal of haematology [ 0007-1048 ] ; 2005.

RBID : Pascal:05-0444007

Descripteurs français

Pascal (Inist)
- Chimiothérapie, Traitement, Anticancéreux, Lymphome, Facteur prédictif, Survie, Radiothérapie, Primaire, Système nerveux central, Toxicité, Hématologie.

English descriptors

KwdEn :
- Antineoplastic agent, Central nervous system, Chemotherapy, Hematology, Lymphoma, Predictive factor, Primary, Radiotherapy, Survival, Toxicity, Treatment.

Abstract

The majority of the available data on primary central nervous system lymphoma (PCNSL) derive from small unicentric or oligocentric studies. In this multicentre study, we evaluated the response, survival and toxicity in PCNSL patients after carmustine, methotrexate 1.5 g/m², procarbazine and dexamethasone (BMPD) chemotherapy and searched for prognostic factors. Fifty-six patients received the BMPD protocol (dexamethasone was given only in course 1). The overall complete response rate to chemotherapy was 61% (34/56). Ten complete responders received whole-brain irradiation and 24 were not irradiated. Responders to chemotherapy had. significantly longer median overall survival than non-responders (18.2 vs. 9.9 months, P = 0.02). Median survival was significantly longer at institutions accruing at least four patients than at those with fewer patients (31.5 vs. 9.5 months, P = 0.03).

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Le document en format XML

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<author><name sortKey="Thiel, Eckhard" sort="Thiel, Eckhard" uniqKey="Thiel E" first="Eckhard" last="Thiel">Eckhard Thiel</name>
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<placeName><region type="land" nuts="3">Berlin</region>
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<series><title level="j" type="main">British journal of haematology</title>
<title level="j" type="abbreviated">Br. j. haematol.</title>
<idno type="ISSN">0007-1048</idno>
<imprint><date when="2005">2005</date>
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<seriesStmt><title level="j" type="main">British journal of haematology</title>
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<idno type="ISSN">0007-1048</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term>
<term>Central nervous system</term>
<term>Chemotherapy</term>
<term>Hematology</term>
<term>Lymphoma</term>
<term>Predictive factor</term>
<term>Primary</term>
<term>Radiotherapy</term>
<term>Survival</term>
<term>Toxicity</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term>
<term>Traitement</term>
<term>Anticancéreux</term>
<term>Lymphome</term>
<term>Facteur prédictif</term>
<term>Survie</term>
<term>Radiothérapie</term>
<term>Primaire</term>
<term>Système nerveux central</term>
<term>Toxicité</term>
<term>Hématologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The majority of the available data on primary central nervous system lymphoma (PCNSL) derive from small unicentric or oligocentric studies. In this multicentre study, we evaluated the response, survival and toxicity in PCNSL patients after carmustine, methotrexate 1.5 g/m<sup>2</sup>
, procarbazine and dexamethasone (BMPD) chemotherapy and searched for prognostic factors. Fifty-six patients received the BMPD protocol (dexamethasone was given only in course 1). The overall complete response rate to chemotherapy was 61% (34/56). Ten complete responders received whole-brain irradiation and 24 were not irradiated. Responders to chemotherapy had. significantly longer median overall survival than non-responders (18.2 vs. 9.9 months, P = 0.02). Median survival was significantly longer at institutions accruing at least four patients than at those with fewer patients (31.5 vs. 9.5 months, P = 0.03).</div>
</front>
</TEI>
</record>

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   |type=    RBID
   |clé=     Pascal:05-0444007
   |texte=   Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma
}}

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	Serveur d'exploration sur l'Université de Trèves
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Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma

Response to chemotherapy and treating institution predict survival in primary central nervous system lymphoma

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