Synovial immunopathology in haemochromatosis arthropathy
Identifieur interne : 001935 ( Istex/Curation ); précédent : 001934; suivant : 001936Synovial immunopathology in haemochromatosis arthropathy
Auteurs : Gisela Ruiz Heiland [Allemagne] ; Elmar Aigner [Autriche] ; Tomáš Dallos [Allemagne, Slovaquie] ; Enijad Sahinbegovic [Allemagne] ; Veit Krenn [Allemagne] ; Christoph Thaler [Autriche] ; Günter Weiss [Autriche] ; Jörg H. Distler [Allemagne] ; Christian Datz [Autriche] ; Georg Schett [Allemagne] ; Jochen Zwerina [Allemagne]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2010-06.
Abstract
Background Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis. The pathophysiology of musculoskeletal involvement is, however, unclear. Objective To analyse synovial tissue obtained at surgery from patients with HH arthropathy and compare it qualitatively and quantitatively with specimens from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods Synovial tissue from 15 patients with HH, 20 with RA and 39 with OA was obtained during surgery. A synovitis grading system was used to determine the severity of synovial inflammation. Using immunohistochemistry, synovial neovascularisation and infiltration of macrophages, neutrophils and lymphocytes were quantitatively assessed. Results Synovitis in HH arthropathy largely resembles OA with mild infiltration of mononuclear cells and lymphocytes, formation of synovial microvessels and a low degree of synovial hyperplasia. While many features of HH arthropathy are reminiscent of OA, macrophage and especially neutrophil invasion is clearly more prominent in HH arthropathy than in primary OA and mimics features of RA. This finding was observed particularly in synovial tissue of HH samples with marked haemosiderin deposition. Discussion The histological picture of the synovium in HH arthropathy largely resembles a process reminiscent of OA. Neutrophil invasion is, however, markedly increased in HH arthropathy, especially in joints with iron deposition. Accumulation of neutrophils may be crucial for the production of matrix enzymes, which enables cartilage degradation and more rapidly progressive articular damage.
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DOI: 10.1136/ard.2009.120204
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xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>2nd Department of Paediatrics, Medical Faculty, Comenius University in Bratislava, Bratislava, Slovakia</mods:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>2nd Department of Paediatrics, Medical Faculty, Comenius University in Bratislava, Bratislava</wicri:regionArea></affiliation></author><author><name sortKey="Sahinbegovic, Enijad" sort="Sahinbegovic, Enijad" uniqKey="Sahinbegovic E" first="Enijad" last="Sahinbegovic">Enijad Sahinbegovic</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Krenn, Veit" sort="Krenn, Veit" uniqKey="Krenn V" first="Veit" last="Krenn">Veit Krenn</name><affiliation wicri:level="1"><mods:affiliation>Institute of Pathology, Trier, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Trier</wicri:regionArea></affiliation></author><author><name sortKey="Thaler, Christoph" sort="Thaler, Christoph" uniqKey="Thaler C" first="Christoph" last="Thaler">Christoph Thaler</name><affiliation wicri:level="1"><mods:affiliation>Department of Orthopedic Surgery, Medical University of Salzburg, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Orthopedic Surgery, Medical University of Salzburg</wicri:regionArea></affiliation></author><author><name sortKey="Weiss, Gunter" sort="Weiss, Gunter" uniqKey="Weiss G" first="Günter" last="Weiss">Günter Weiss</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine, Medical University of Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Medical University of Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Distler, Jorg H" sort="Distler, Jorg H" uniqKey="Distler J" first="Jörg H" last="Distler">Jörg H. Distler</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Datz, Christian" sort="Datz, Christian" uniqKey="Datz C" first="Christian" last="Datz">Christian Datz</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine, Hospital Oberndorf, Salzburg, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Internal Medicine, Hospital Oberndorf, Salzburg</wicri:regionArea></affiliation></author><author><name sortKey="Schett, Georg" sort="Schett, Georg" uniqKey="Schett G" first="Georg" last="Schett">Georg Schett</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Zwerina, Jochen" sort="Zwerina, Jochen" uniqKey="Zwerina J" first="Jochen" last="Zwerina">Jochen Zwerina</name><affiliation wicri:level="1"><mods:affiliation>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2010-06">2010-06</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1214">1214</biblScope></imprint><idno type="ISSN">0003-4967</idno></series><idno type="istex">C182C4ECA47D86A51F936CFE3979BC240A9B4845</idno><idno type="DOI">10.1136/ard.2009.120204</idno><idno type="href">annrheumdis-69-1214.pdf</idno><idno type="ArticleID">annrheumdis120204</idno><idno type="PMID">19933745</idno><idno type="local">annrheumdis;69/6/1214</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis. The pathophysiology of musculoskeletal involvement is, however, unclear. Objective To analyse synovial tissue obtained at surgery from patients with HH arthropathy and compare it qualitatively and quantitatively with specimens from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods Synovial tissue from 15 patients with HH, 20 with RA and 39 with OA was obtained during surgery. A synovitis grading system was used to determine the severity of synovial inflammation. Using immunohistochemistry, synovial neovascularisation and infiltration of macrophages, neutrophils and lymphocytes were quantitatively assessed. Results Synovitis in HH arthropathy largely resembles OA with mild infiltration of mononuclear cells and lymphocytes, formation of synovial microvessels and a low degree of synovial hyperplasia. While many features of HH arthropathy are reminiscent of OA, macrophage and especially neutrophil invasion is clearly more prominent in HH arthropathy than in primary OA and mimics features of RA. This finding was observed particularly in synovial tissue of HH samples with marked haemosiderin deposition. Discussion The histological picture of the synovium in HH arthropathy largely resembles a process reminiscent of OA. Neutrophil invasion is, however, markedly increased in HH arthropathy, especially in joints with iron deposition. Accumulation of neutrophils may be crucial for the production of matrix enzymes, which enables cartilage degradation and more rapidly progressive articular damage.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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