Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being
Identifieur interne : 001B63 ( Istex/Corpus ); précédent : 001B62; suivant : 001B64Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being
Auteurs : Oliver T. Wolf ; Ewald Naumann ; Dirk H. Hellhammer ; Clemens KirschbaumSource :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 1998-09.
Abstract
Background. In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted. Methods. In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented. Results. Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood. Conclusions. A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood.
Url:
DOI: 10.1093/gerona/53A.5.M385
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title><author><name sortKey="Wolf, Oliver T" sort="Wolf, Oliver T" uniqKey="Wolf O" first="Oliver T." last="Wolf">Oliver T. Wolf</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name><affiliation><mods:affiliation>department of Psychology, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B0647B524B606438D1113EE72C75B916E80787CF</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1093/gerona/53A.5.M385</idno><idno type="url">https://api.istex.fr/document/B0647B524B606438D1113EE72C75B916E80787CF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B63</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title><author><name sortKey="Wolf, Oliver T" sort="Wolf, Oliver T" uniqKey="Wolf O" first="Oliver T." last="Wolf">Oliver T. Wolf</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name><affiliation><mods:affiliation>department of Psychology, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title><idno type="ISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><publisher>The Gerontological Society of America</publisher><date type="published" when="1998-09">1998-09</date><biblScope unit="volume">53A</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="M385">M385</biblScope><biblScope unit="page" to="M390">M390</biblScope></imprint><idno type="ISSN">1079-5006</idno></series><idno type="istex">B0647B524B606438D1113EE72C75B916E80787CF</idno><idno type="DOI">10.1093/gerona/53A.5.M385</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1079-5006</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted. Methods. In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented. Results. Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood. Conclusions. A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Oliver T. Wolf</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</json:string></affiliations></json:item><json:item><name>Ewald Naumann</name><affiliations><json:string>department of Psychology, University of Trier, Trier Germany</json:string></affiliations></json:item><json:item><name>Dirk H. Hellhammer</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</json:string></affiliations></json:item><json:item><name>Clemens Kirschbaum</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</json:string></affiliations></json:item></author><subject><json:item><value>Articles</value></json:item></subject><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Background. In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted. Methods. In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented. Results. Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood. Conclusions. A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. 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test</title><publicationDate>1996</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>53A</volume><publisherId><json:string>gerona</json:string></publisherId><pages><last>M390</last><first>M385</first></pages><issn><json:string>1079-5006</json:string></issn><issue>5</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1758-535X</json:string></eissn><title>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title></host><categories><wos><json:string>social science</json:string><json:string>gerontology</json:string><json:string>science</json:string><json:string>geriatrics & gerontology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>public health & health services</json:string><json:string>gerontology</json:string></scienceMetrix></categories><publicationDate>1998</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1093/gerona/53A.5.M385</json:string></doi><id>B0647B524B606438D1113EE72C75B916E80787CF</id><score>1.6560897</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B0647B524B606438D1113EE72C75B916E80787CF/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B0647B524B606438D1113EE72C75B916E80787CF/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B0647B524B606438D1113EE72C75B916E80787CF/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The Gerontological Society of America</publisher><availability><p>© 1998 by The Gerontological Society of America</p></availability><date>1998</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title><author xml:id="author-1"><persName><forename type="first">Oliver T.</forename><surname>Wolf</surname></persName><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Ewald</forename><surname>Naumann</surname></persName><affiliation>department of Psychology, University of Trier, Trier Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Dirk H.</forename><surname>Hellhammer</surname></persName><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">Clemens</forename><surname>Kirschbaum</surname></persName><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation></author></analytic><monogr><title level="j">The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title><idno type="pISSN">1079-5006</idno><idno type="eISSN">1758-535X</idno><imprint><publisher>The Gerontological Society of America</publisher><date type="published" when="1998-09"></date><biblScope unit="volume">53A</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="M385">M385</biblScope><biblScope unit="page" to="M390">M390</biblScope></imprint></monogr><idno type="istex">B0647B524B606438D1113EE72C75B916E80787CF</idno><idno type="DOI">10.1093/gerona/53A.5.M385</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><abstract><p>Background. In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted. Methods. In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented. Results. Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood. Conclusions. A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood.</p></abstract><textClass><keywords scheme="keyword"><list><item><term>Articles</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998-09">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B0647B524B606438D1113EE72C75B916E80787CF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">gerona</journal-id><journal-id journal-id-type="publisher-id">gerona</journal-id><journal-title>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</journal-title><issn pub-type="ppub">1079-5006</issn><issn pub-type="epub">1758-535X</issn><publisher><publisher-name>The Gerontological Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/gerona/53A.5.M385</article-id><article-categories><subj-group subj-group-type="heading"><subject>Journal of Gerontology: Medical Sciences</subject></subj-group><subj-group><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wolf</surname><given-names>Oliver T.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Naumann</surname><given-names>Ewald</given-names></name><xref ref-type="aff" rid="au2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hellhammer</surname><given-names>Dirk H.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kirschbaum</surname><given-names>Clemens</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref></contrib><aff id="au1"><label>1</label><institution>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier</institution> <addr-line>Germany</addr-line></aff><aff id="au2"><label>2</label><institution>department of Psychology, University of Trier, Trier</institution> <addr-line>Germany</addr-line></aff></contrib-group><pub-date pub-type="ppub"><month>9</month><year>1998</year></pub-date><volume>53A</volume><issue>5</issue><fpage>M385</fpage><lpage>M390</lpage><history><date date-type="received"><day>07</day><month>7</month><year>1997</year></date><date date-type="accepted"><day>18</day><month>12</month><year>1997</year></date></history><copyright-statement>© 1998 by The Gerontological Society of America</copyright-statement><copyright-year>1998</copyright-year><abstract><p><bold><italic>Background.</italic></bold></p><p>In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted.</p><p><bold><italic>Methods.</italic></bold></p><p>In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented.</p><p><bold><italic>Results.</italic></bold></p><p>Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood.</p><p><bold><italic>Conclusions.</italic></bold></p><p>A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being</title></titleInfo><name type="personal"><namePart type="given">Oliver T.</namePart><namePart type="family">Wolf</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ewald</namePart><namePart type="family">Naumann</namePart><affiliation>department of Psychology, University of Trier, Trier Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk H.</namePart><namePart type="family">Hellhammer</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clemens</namePart><namePart type="family">Kirschbaum</namePart><affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><topic>Articles</topic></subject><originInfo><publisher>The Gerontological Society of America</publisher><dateIssued encoding="w3cdtf">1998-09</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background. In humans, concentrations of the adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decline with age. Results from studies in rodents have suggested that DHEA administration can improve memory performance as well as neuronal plasticity. However, a first study from our laboratory could not demonstrate beneficial effects of DHEA substitution on cognitive performance and well-being in elderly subjects. To further evaluate whether DHEA replacement has effects on the central nervous system, an experiment using eventrelated potentials (ERPs) was conducted. Methods. In this placebo-controlled crossover study, 17 elderly men (mean age, 71.1 ± 1.7 yr; range 59–81 yr) took placebo or DHEA (50 mg/day) for 2 weeks (double blind). After each treatment period subjects participated in an auditory oddball paradigm with three oddball blocks. In the first two blocks subjects had to count the rare tone silently, whereas, in the third block they had to press a button. In addition, memory tests assessing visual, spatial, and semantic memory as well as questionnaires on psychological and physical well-being were presented. Results. Baseline DHEAS levels were lower compared with young adults. After 2-week DHEA replacement, DHEAS levels rose 5-fold to levels observed in young men. DHEA substitution modulated the P3 component of the ERPs, which reflects information updating in short-term memory. P3 amplitude was increased after DHEA administration, and only selectively in the second oddball block. DHEA did not influence P3 latency. Moreover, DHEA did not enhance memory or mood. Conclusions. A 2-week DHEA replacement in elderly men results in changes in electrophysiological indices of central nervous system stimulus processing if the task is performed repeatedly. However, these effects do not appear to be strong enough to improve memory or mood.</abstract><relatedItem type="host"><titleInfo><title>The Journals of Gerontology Series A: Biological Sciences and Medical Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1079-5006</identifier><identifier type="eISSN">1758-535X</identifier><identifier type="PublisherID">gerona</identifier><identifier type="PublisherID-hwp">gerona</identifier><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>53A</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>M385</start><end>M390</end></extent></part></relatedItem><identifier type="istex">B0647B524B606438D1113EE72C75B916E80787CF</identifier><identifier type="DOI">10.1093/gerona/53A.5.M385</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1998 by The Gerontological Society of America</accessCondition><recordInfo><recordContentSource>OUP</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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