Systematic examination of the signal area precision of a single quadrupole enhanced low mass option (ELMO) TSQ™ mass spectrometer
Identifieur interne : 001912 ( Istex/Corpus ); précédent : 001911; suivant : 001913Systematic examination of the signal area precision of a single quadrupole enhanced low mass option (ELMO) TSQ™ mass spectrometer
Auteurs : Klaus Fischer ; Susanne Höffler ; Axel MeyerSource :
- Rapid Communications in Mass Spectrometry [ 0951-4198 ] ; 2006-08-30.
Abstract
To examine the precision of the signal area response of an enhanced low mass option (ELMO) MSQ™ mass spectrometer, operated in the negative electrospray ionization (ESI) mode, extended tests were performed, using flow injection analysis mass spectrometry (FIA‐MS). Analytes were nitrate, nitrite, malonic acid, and D,L‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. Copyright © 2006 John Wiley & Sons, Ltd.
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DOI: 10.1002/rcm.2611
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Mass Spectrom.</title><idno type="ISSN">0951-4198</idno><idno type="eISSN">1097-0231</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2006-08-30">2006-08-30</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2419">2419</biblScope><biblScope unit="page" to="2426">2426</biblScope></imprint><idno type="ISSN">0951-4198</idno></series><idno type="istex">3F2A781E16B068587718AF69D7C5000956D28B9B</idno><idno type="DOI">10.1002/rcm.2611</idno><idno type="ArticleID">RCM2611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-4198</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the precision of the signal area response of an enhanced low mass option (ELMO) MSQ™ mass spectrometer, operated in the negative electrospray ionization (ESI) mode, extended tests were performed, using flow injection analysis mass spectrometry (FIA‐MS). Analytes were nitrate, nitrite, malonic acid, and D,L‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. Copyright © 2006 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Klaus Fischer</name><affiliations><json:string>University of Trier, Faculty VI – Geography and Geosciences, Department of Analytical and Ecological Chemistry, Behringstr. 21, 54296 Trier, Germany</json:string><json:string>University of Trier, Faculty VI – Geography/Geosciences, Department of Analytical and Ecological Chemistry, Behringstr. 21, 54296 Trier, Germany.</json:string></affiliations></json:item><json:item><name>Susanne Höffler</name></json:item><json:item><name>Axel Meyer</name></json:item></author><articleId><json:string>RCM2611</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>To examine the precision of the signal area response of an enhanced low mass option (ELMO) MSQ™ mass spectrometer, operated in the negative electrospray ionization (ESI) mode, extended tests were performed, using flow injection analysis mass spectrometry (FIA‐MS). Analytes were nitrate, nitrite, malonic acid, and D,L‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. 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Chromatogr. A</title></host></json:item><json:item><host><author></author><title>Slingsby RW, Schnute WC. Poster presentation 17th Int. 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Analytes were nitrate, nitrite, malonic acid, and D,L‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. Copyright © 2006 John Wiley & Sons, Ltd.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-04-07">Received</change><change when="2006-06-14">Registration</change><change when="2006-08-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/3F2A781E16B068587718AF69D7C5000956D28B9B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1097-0231</doi><issn type="print">0951-4198</issn><issn type="electronic">1097-0231</issn><idGroup><id type="product" value="RCM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="RAPID COMMUNICATIONS IN MASS SPECTROMETRY">Rapid Communications in Mass Spectrometry</title><title type="subtitle">An International Journal Devoted to the Rapid Dissemination of Up‐to‐the‐Minute Research in Mass Spectrometry</title><title type="short">Rapid Commun. 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Analytes were nitrate, nitrite, malonic acid, and <sc>D,L</sc>‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. Copyright © 2006 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Systematic examination of the signal area precision of a single quadrupole enhanced low mass option (ELMO) TSQ™ mass spectrometer</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Examination of the signal area precision of an ELMO TSQ™</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Systematic examination of the signal area precision of a single quadrupole enhanced low mass option (ELMO) TSQ™ mass spectrometer</title></titleInfo><name type="personal"><namePart type="given">Klaus</namePart><namePart type="family">Fischer</namePart><affiliation>University of Trier, Faculty VI – Geography and Geosciences, Department of Analytical and Ecological Chemistry, Behringstr. 21, 54296 Trier, Germany</affiliation><affiliation>University of Trier, Faculty VI – Geography/Geosciences, Department of Analytical and Ecological Chemistry, Behringstr. 21, 54296 Trier, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susanne</namePart><namePart type="family">Höffler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Axel</namePart><namePart type="family">Meyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-08-30</dateIssued><dateCaptured encoding="w3cdtf">2006-04-07</dateCaptured><dateValid encoding="w3cdtf">2006-06-14</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">6</extent><extent unit="references">19</extent></physicalDescription><abstract lang="en">To examine the precision of the signal area response of an enhanced low mass option (ELMO) MSQ™ mass spectrometer, operated in the negative electrospray ionization (ESI) mode, extended tests were performed, using flow injection analysis mass spectrometry (FIA‐MS). Analytes were nitrate, nitrite, malonic acid, and D,L‐mandelic acid. Composition and concentration of injected samples, application of an ASRS anion suppressor and of the cone wash unit, methanol addition to the FIA flow medium, and the voltage bias of the hexapole transfer lens were test variables. Individual test cycles comprised up to 90 injections, processed within 20 h. With a few exceptions the signal response tended to decline over time leading to a loss of more than 80% of the initial signal area in extreme cases. A hexapole radio‐frequency (RF) voltage bias of −0.3 V led to an overall low detector response and to high losses of sensitivity over time. Other correlations between the insufficient signal reproducibility and FIA‐MS operating conditions could not be established. The test scheme gave hints how to localize the cause of the mass spectrometer malfunction. The repetition of the test scheme after remedying the detected electronic default demonstrated that relative standard deviations less than 5% can be achieved for a sequence of 30 injections if methanol is added to the FIA flow medium and if a suppressor is used. Based on these findings a recommendation is formulated to supplement current test schemes for instrument performance verification by a detector response precision criterion. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><relatedItem type="host"><titleInfo><title>Rapid Communications in Mass Spectrometry</title><subTitle>An International Journal Devoted to the Rapid Dissemination of Up‐to‐the‐Minute Research in Mass Spectrometry</subTitle></titleInfo><titleInfo type="abbreviated"><title>Rapid Commun. Mass Spectrom.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0951-4198</identifier><identifier type="eISSN">1097-0231</identifier><identifier type="DOI">10.1002/(ISSN)1097-0231</identifier><identifier type="PublisherID">RCM</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2419</start><end>2426</end><total>8</total></extent></part></relatedItem><identifier type="istex">3F2A781E16B068587718AF69D7C5000956D28B9B</identifier><identifier type="DOI">10.1002/rcm.2611</identifier><identifier type="ArticleID">RCM2611</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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