Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder
Identifieur interne : 001890 ( Istex/Corpus ); précédent : 001889; suivant : 001891Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder
Auteurs : Robert L. Findling ; Barbara L. Gracious ; Nora K. Mcnamara ; Eric A. Youngstrom ; Christine A. Demeter ; Lisa A. Branicky ; Joseph R. CalabreseSource :
- Bipolar Disorders [ 1398-5647 ] ; 2001-08.
English descriptors
- KwdEn :
Abstract
Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups.
Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained.
Results: The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.
Conclusions: These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.
Url:
DOI: 10.1034/j.1399-5618.2001.30405.x
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Mcnamara</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Youngstrom, Eric A" sort="Youngstrom, Eric A" uniqKey="Youngstrom E" first="Eric A" last="Youngstrom">Eric A. Youngstrom</name><affiliation><mods:affiliation>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</mods:affiliation></affiliation></author><author><name sortKey="Demeter, Christine A" sort="Demeter, Christine A" uniqKey="Demeter C" first="Christine A" last="Demeter">Christine A. Demeter</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Branicky, Lisa A" sort="Branicky, Lisa A" uniqKey="Branicky L" first="Lisa A" last="Branicky">Lisa A. Branicky</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R" last="Calabrese">Joseph R. Calabrese</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2D92CB9BAB14940EDA004A150E07B55FB5CD6076</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1034/j.1399-5618.2001.30405.x</idno><idno type="url">https://api.istex.fr/document/2D92CB9BAB14940EDA004A150E07B55FB5CD6076/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001890</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001890</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title><author><name sortKey="Findling, Robert L" sort="Findling, Robert L" uniqKey="Findling R" first="Robert L" last="Findling">Robert L. Findling</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Gracious, Barbara L" sort="Gracious, Barbara L" uniqKey="Gracious B" first="Barbara L" last="Gracious">Barbara L. Gracious</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Mcnamara, Nora K" sort="Mcnamara, Nora K" uniqKey="Mcnamara N" first="Nora K" last="Mcnamara">Nora K. Mcnamara</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Youngstrom, Eric A" sort="Youngstrom, Eric A" uniqKey="Youngstrom E" first="Eric A" last="Youngstrom">Eric A. Youngstrom</name><affiliation><mods:affiliation>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</mods:affiliation></affiliation></author><author><name sortKey="Demeter, Christine A" sort="Demeter, Christine A" uniqKey="Demeter C" first="Christine A" last="Demeter">Christine A. Demeter</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Branicky, Lisa A" sort="Branicky, Lisa A" uniqKey="Branicky L" first="Lisa A" last="Branicky">Lisa A. Branicky</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author><author><name sortKey="Calabrese, Joseph R" sort="Calabrese, Joseph R" uniqKey="Calabrese J" first="Joseph R" last="Calabrese">Joseph R. Calabrese</name><affiliation><mods:affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Bipolar Disorders</title><title level="j" type="abbrev">Bipolar Disorders</title><idno type="ISSN">1398-5647</idno><idno type="eISSN">1399-5618</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-08">2001-08</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="202">202</biblScope><biblScope unit="page" to="210">210</biblScope></imprint><idno type="ISSN">1398-5647</idno></series><idno type="istex">2D92CB9BAB14940EDA004A150E07B55FB5CD6076</idno><idno type="DOI">10.1034/j.1399-5618.2001.30405.x</idno><idno type="ArticleID">BDI030405</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1398-5647</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>adolescents</term><term>bipolar disorder</term><term>children</term><term>family history</term><term>life charting</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups.
Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained.
Results: The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.
Conclusions: These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Robert L Findling</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item><json:item><name>Barbara L Gracious</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item><json:item><name>Nora K McNamara</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item><json:item><name>Eric A Youngstrom</name><affiliations><json:string>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</json:string></affiliations></json:item><json:item><name>Christine A Demeter</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item><json:item><name>Lisa A Branicky</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item><json:item><name>Joseph R Calabrese</name><affiliations><json:string>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>adolescents</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bipolar disorder</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>children</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>family history</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>life charting</value></json:item></subject><articleId><json:string>BDI030405</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups. Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained. Results: The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers. Conclusions: These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.</abstract><qualityIndicators><score>7.796</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1527</abstractCharCount><pdfWordCount>5835</pdfWordCount><pdfCharCount>37242</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>233</abstractWordCount></qualityIndicators><title>Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title><refBibs><json:item><author><json:item><name>EH Greves</name></json:item></author><host><volume>ii</volume><pages><last>826</last><first>824</first></pages><author></author><title>Lancet</title></host><title>Acute mania in a child of five years; recovery; remarks</title></json:item><json:item><author><json:item><name>J 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disorder</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>3</volume><publisherId><json:string>BDI</json:string></publisherId><pages><total>9</total><last>210</last><first>202</first></pages><issn><json:string>1398-5647</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1399-5618</json:string></eissn><title>Bipolar Disorders</title><doi><json:string>10.1111/(ISSN)1399-5618</json:string></doi></host><categories><wos><json:string>social science</json:string><json:string>psychiatry</json:string><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>psychiatry</json:string></scienceMetrix></categories><publicationDate>2001</publicationDate><copyrightDate>2001</copyrightDate><doi><json:string>10.1034/j.1399-5618.2001.30405.x</json:string></doi><id>2D92CB9BAB14940EDA004A150E07B55FB5CD6076</id><score>0.027839763</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/2D92CB9BAB14940EDA004A150E07B55FB5CD6076/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/2D92CB9BAB14940EDA004A150E07B55FB5CD6076/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/2D92CB9BAB14940EDA004A150E07B55FB5CD6076/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><availability><p>WILEY</p></availability><date>2001</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title><author xml:id="author-1"><persName><forename type="first">Robert L</forename><surname>Findling</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author><author xml:id="author-2"><persName><forename type="first">Barbara L</forename><surname>Gracious</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author><author xml:id="author-3"><persName><forename type="first">Nora K</forename><surname>McNamara</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author><author xml:id="author-4"><persName><forename type="first">Eric A</forename><surname>Youngstrom</surname></persName><affiliation>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</affiliation></author><author xml:id="author-5"><persName><forename type="first">Christine A</forename><surname>Demeter</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author><author xml:id="author-6"><persName><forename type="first">Lisa A</forename><surname>Branicky</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author><author xml:id="author-7"><persName><forename type="first">Joseph R</forename><surname>Calabrese</surname></persName><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation></author></analytic><monogr><title level="j">Bipolar Disorders</title><title level="j" type="abbrev">Bipolar Disorders</title><idno type="pISSN">1398-5647</idno><idno type="eISSN">1399-5618</idno><idno type="DOI">10.1111/(ISSN)1399-5618</idno><imprint><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-08"></date><biblScope unit="volume">3</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="202">202</biblScope><biblScope unit="page" to="210">210</biblScope></imprint></monogr><idno type="istex">2D92CB9BAB14940EDA004A150E07B55FB5CD6076</idno><idno type="DOI">10.1034/j.1399-5618.2001.30405.x</idno><idno type="ArticleID">BDI030405</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups.
Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained.
Results: The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.
Conclusions: These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>adolescents</term></item><item><term>bipolar disorder</term></item><item><term>children</term></item><item><term>family history</term></item><item><term>life charting</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/2D92CB9BAB14940EDA004A150E07B55FB5CD6076/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Munksgaard International Publishers</publisherName><publisherLoc>Copenhagen</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-5618</doi><issn type="print">1398-5647</issn><issn type="electronic">1399-5618</issn><idGroup><id type="product" value="BDI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="BIPOLAR DISORDERS">Bipolar Disorders</title><title type="short">Bipolar Disorders</title></titleGroup></publicationMeta><publicationMeta level="part" position="08004"><doi origin="wiley">10.1111/bdi.2001.3.issue-4</doi><numberingGroup><numbering type="journalVolume" number="3">3</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2001-08">August 2001</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0020200" status="forIssue"><doi origin="wiley">10.1034/j.1399-5618.2001.30405.x</doi><idGroup><id type="unit" value="BDI030405"></id><id type="supplier" value="bdi1o163"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2008-07-07"></event><event type="publishedOnlineFinalForm" date="2008-07-07"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-16"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-25"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="202">202</numbering><numbering type="pageLast" number="210">210</numbering></numberingGroup><correspondenceTo>Corresponding author: Robert L Findling, MD, Director, Child & Adolescent Psychiatry, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106‐5080, USA. Fax: +1 216 844 5883; e‐mail: <email>robert.findling@uhhs.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BDI.BDI030405.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 12 March 2001 Accepted 24 April 2001</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="50"></count><count type="linksPubMed" number="30"></count><count type="linksCrossRef" number="1"></count></countGroup><titleGroup><title type="main">Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title><title type="shortAuthors">Findling et al.</title><title type="short">Pediatric bipolar I disorder</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a0"><personName><givenNames>Robert L</givenNames><familyName>Findling</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a0"><personName><givenNames>Barbara L</givenNames><familyName>Gracious</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a0"><personName><givenNames>Nora K</givenNames><familyName>McNamara</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Eric A</givenNames><familyName>Youngstrom</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a0"><personName><givenNames>Christine A</givenNames><familyName>Demeter</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a0"><personName><givenNames>Lisa A</givenNames><familyName>Branicky</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a0"><personName><givenNames>Joseph R</givenNames><familyName>Calabrese</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a0"><unparsedAffiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</unparsedAffiliation></affiliation><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">adolescents</keyword><keyword xml:id="k2">bipolar disorder</keyword><keyword xml:id="k3">children</keyword><keyword xml:id="k4">family history</keyword><keyword xml:id="k5">life charting</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p> <i><b>Objectives:</b></i> The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups.
<i><b>Method:</b></i> Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained.
<i><b>Results:</b></i> The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.
<i><b>Conclusions:</b></i> These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pediatric bipolar I disorder</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Rapid, continuous cycling and psychiatric co‐morbidity in pediatric bipolar I disorder</title></titleInfo><name type="personal"><namePart type="given">Robert L</namePart><namePart type="family">Findling</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara L</namePart><namePart type="family">Gracious</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nora K</namePart><namePart type="family">McNamara</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric A</namePart><namePart type="family">Youngstrom</namePart><affiliation>Department of Psychology, Case Western Reserve University, Cleveland, OH, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine A</namePart><namePart type="family">Demeter</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lisa A</namePart><namePart type="family">Branicky</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph R</namePart><namePart type="family">Calabrese</namePart><affiliation>Department of Psychiatry, University Hospitals of Cleveland/Case Western Reserve University School of Medicine,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Munksgaard International Publishers</publisher><place><placeTerm type="text">Copenhagen</placeTerm></place><dateIssued encoding="w3cdtf">2001-08</dateIssued><edition>Received 12 March 2001 Accepted 24 April 2001</edition><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">50</extent></physicalDescription><abstract lang="en">Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP‐I) as it occurs in children and adolescents and to assess whether the manifestations of BP‐I were similar in both age groups.
Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP‐I were included in this study. The diagnosis of BP‐I was established for these youths based on the results of a semi‐structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters’ illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co‐morbidities and parental psychopathology were also obtained.
Results: The clinical presentation of BP‐I was similar in children and adolescents. Youths meeting diagnostic criteria for BP‐I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP‐I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter‐episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.
Conclusions: These data suggest that the presentation of juvenile BP‐I is a cyclic and valid clinical condition with manifestations on a continuum with the later‐onset forms of this illness.</abstract><subject lang="en"><genre>keywords</genre><topic>adolescents</topic><topic>bipolar disorder</topic><topic>children</topic><topic>family history</topic><topic>life charting</topic></subject><relatedItem type="host"><titleInfo><title>Bipolar Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Bipolar Disorders</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1398-5647</identifier><identifier type="eISSN">1399-5618</identifier><identifier type="DOI">10.1111/(ISSN)1399-5618</identifier><identifier type="PublisherID">BDI</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>202</start><end>210</end><total>9</total></extent></part></relatedItem><identifier type="istex">2D92CB9BAB14940EDA004A150E07B55FB5CD6076</identifier><identifier type="DOI">10.1034/j.1399-5618.2001.30405.x</identifier><identifier type="ArticleID">BDI030405</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Munksgaard International Publishers</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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