The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder
Identifieur interne : 001839 ( Istex/Corpus ); précédent : 001838; suivant : 001840The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder
Auteurs : Chih-Chun Huang ; Yun-Hsuan Chang ; Sheng-Yu Lee ; Shiou-Lan Chen ; Shih-Heng Chen ; Chun-Hsien Chu ; San-Yuan Huang ; Nian-Sheng Tzeng ; I Hui Lee ; Tzung Lieh Yeh ; Yen Kuang Yang ; Ru-Band LuSource :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2012-07.
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Abstract
Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.
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DOI: 10.1002/ajmg.b.32055
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Chen</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chu, Chun Sien" sort="Chu, Chun Sien" uniqKey="Chu C" first="Chun-Hsien" last="Chu">Chun-Hsien Chu</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, San Uan" sort="Huang, San Uan" uniqKey="Huang S" first="San-Yuan" last="Huang">San-Yuan Huang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Tzeng, Nian Heng" sort="Tzeng, Nian Heng" uniqKey="Tzeng N" first="Nian-Sheng" last="Tzeng">Nian-Sheng Tzeng</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General 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Lu</name><affiliation><mods:affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E2C426AC2BB5BE540D1289D17BD413DCE77FD504</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1002/ajmg.b.32055</idno><idno type="url">https://api.istex.fr/document/E2C426AC2BB5BE540D1289D17BD413DCE77FD504/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001839</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder</title><author><name sortKey="Huang, Chih Hun" sort="Huang, Chih Hun" uniqKey="Huang C" first="Chih-Chun" last="Huang">Chih-Chun Huang</name><affiliation><mods:affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chang, Yun Suan" sort="Chang, Yun Suan" uniqKey="Chang Y" first="Yun-Hsuan" last="Chang">Yun-Hsuan Chang</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lee, Sheng U" sort="Lee, Sheng U" uniqKey="Lee S" first="Sheng-Yu" last="Lee">Sheng-Yu Lee</name><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Shiou An" sort="Chen, Shiou An" uniqKey="Chen S" first="Shiou-Lan" last="Chen">Shiou-Lan Chen</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Shih Eng" sort="Chen, Shih Eng" uniqKey="Chen S" first="Shih-Heng" last="Chen">Shih-Heng Chen</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chu, Chun Sien" sort="Chu, Chun Sien" uniqKey="Chu C" first="Chun-Hsien" last="Chu">Chun-Hsien Chu</name><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, San Uan" sort="Huang, San Uan" uniqKey="Huang S" first="San-Yuan" last="Huang">San-Yuan Huang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Tzeng, Nian Heng" sort="Tzeng, Nian Heng" uniqKey="Tzeng N" first="Nian-Sheng" last="Tzeng">Nian-Sheng Tzeng</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lee, I Hui" sort="Lee, I Hui" uniqKey="Lee I" first="I Hui" last="Lee">I Hui Lee</name><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Yeh, Tzung Lieh" sort="Yeh, Tzung Lieh" uniqKey="Yeh T" first="Tzung Lieh" last="Yeh">Tzung Lieh Yeh</name><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Yang, Yen Kuang" sort="Yang, Yen Kuang" uniqKey="Yang Y" first="Yen Kuang" last="Yang">Yen Kuang Yang</name><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><affiliation><mods:affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-07">2012-07</date><biblScope unit="volume">159B</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="501">501</biblScope><biblScope unit="page" to="507">507</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">E2C426AC2BB5BE540D1289D17BD413DCE77FD504</idno><idno type="DOI">10.1002/ajmg.b.32055</idno><idno type="ArticleID">AJMG32055</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BDNF</term><term>DRD2/ANKK1</term><term>bipolar disorders</term><term>genetic interaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Chih‐Chun Huang</name><affiliations><json:string>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Yun‐Hsuan Chang</name><affiliations><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Sheng‐Yu Lee</name><affiliations><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Shiou‐Lan Chen</name><affiliations><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Shih‐Heng Chen</name><affiliations><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Chun‐Hsien Chu</name><affiliations><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>San‐Yuan Huang</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Nian‐Sheng Tzeng</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>I Hui Lee</name><affiliations><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Tzung Lieh Yeh</name><affiliations><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Yen Kuang Yang</name><affiliations><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string></affiliations></json:item><json:item><name>Ru‐Band Lu</name><affiliations><json:string>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>BDNF</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bipolar disorders</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DRD2/ANKK1</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetic interaction</value></json:item></subject><articleId><json:string>AJMG32055</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</abstract><qualityIndicators><score>7.628</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1526</abstractCharCount><pdfWordCount>5277</pdfWordCount><pdfCharCount>34463</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>219</abstractWordCount></qualityIndicators><title>The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder</title><refBibs><json:item><author><json:item><name>HS Akiskal</name></json:item></author><host><volume>21</volume><pages><last>11</last><first>3</first></pages><issue>Spec No 6</issue><author></author><title>Encephale</title></host><title>The bipolar spectrum: Research and clinical perspectives</title></json:item><json:item><author><json:item><name>HS Akiskal</name></json:item></author><host><volume>73</volume><pages><last>5</last><first>1</first></pages><issue>1–2</issue><author></author><title>J Affect Disord</title></host><title>Validating ‘hard’ and ‘soft’ phenotypes within the bipolar spectrum: Continuity or discontinuity</title></json:item><json:item><author><json:item><name>HS Akiskal</name></json:item><json:item><name>O Pinto</name></json:item></author><host><volume>22</volume><pages><last>534</last><first>517</first></pages><issue>3</issue><author></author><title>Psychiatr Clin North Am</title></host><title>The evolving bipolar spectrum. 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disorder</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2012 Wiley Periodicals, Inc.</p></availability><date>2012</date></publicationStmt><notesStmt><note type="content">*Conflicts of interest: The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.</note><note type="content">*How to Cite this Article: Huang C‐C, Chang Y‐H, Lee S‐Y, Chen S‐L, Chen S‐H, Chu C‐H, Huang S‐Y, Tzeng N‐S, Lee IH, Yeh TL, Yang YK, Lu R‐B. 2012. 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Am J Med Genet Part B 159B:501–507.</note><note>Taiwan National Health Research Institute - No. NHRI‐EX99‐9738NI;</note><note>Taiwan National Science Council - No. NSC98‐2627‐B‐006‐017; No. NSC99‐2627‐B‐006‐015;</note><note>National Cheng Kung University Project</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder</title><author xml:id="author-1"><persName><forename type="first">Chih‐Chun</forename><surname>Huang</surname></persName><affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation></author><author xml:id="author-2"><persName><forename type="first">Yun‐Hsuan</forename><surname>Chang</surname></persName><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-3"><persName><forename type="first">Sheng‐Yu</forename><surname>Lee</surname></persName><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-4"><persName><forename type="first">Shiou‐Lan</forename><surname>Chen</surname></persName><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-5"><persName><forename type="first">Shih‐Heng</forename><surname>Chen</surname></persName><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-6"><persName><forename type="first">Chun‐Hsien</forename><surname>Chu</surname></persName><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-7"><persName><forename type="first">San‐Yuan</forename><surname>Huang</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</affiliation></author><author xml:id="author-8"><persName><forename type="first">Nian‐Sheng</forename><surname>Tzeng</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</affiliation></author><author xml:id="author-9"><persName><forename type="first">I Hui</forename><surname>Lee</surname></persName><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-10"><persName><forename type="first">Tzung Lieh</forename><surname>Yeh</surname></persName><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-11"><persName><forename type="first">Yen Kuang</forename><surname>Yang</surname></persName><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation></author><author xml:id="author-12"><persName><forename type="first">Ru‐Band</forename><surname>Lu</surname></persName><affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</affiliation></author></analytic><monogr><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="pISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><idno type="DOI">10.1002/(ISSN)1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-07"></date><biblScope unit="volume">159B</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="501">501</biblScope><biblScope unit="page" to="507">507</biblScope></imprint></monogr><idno type="istex">E2C426AC2BB5BE540D1289D17BD413DCE77FD504</idno><idno type="DOI">10.1002/ajmg.b.32055</idno><idno type="ArticleID">AJMG32055</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2012</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>BDNF</term></item><item><term>bipolar disorders</term></item><item><term>DRD2/ANKK1</term></item><item><term>genetic interaction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-10-04">Received</change><change when="2012-04-04">Registration</change><change when="2012-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E2C426AC2BB5BE540D1289D17BD413DCE77FD504/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1552-485X</doi><issn type="print">1552-4841</issn><issn type="electronic">1552-485X</issn><idGroup><id type="product" value="AJMG"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="AMERICAN JOURNAL OF MEDICAL GENETICS PART B: NEUROPSYCHIATRIC GENETICS">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title type="short">Am. J. Med. Genet.</title></titleGroup><selfCitationGroup><citation type="ancestor" xml:id="cit1"><journalTitle>American Journal of Medical Genetics</journalTitle><accessionId ref="info:x-wiley/issn/01487299">0148-7299</accessionId><accessionId ref="info:x-wiley/issn/10968628">1096-8628</accessionId><pubYear year="2004">2004</pubYear></citation></selfCitationGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/ajmg.b.v159b.5</doi><numberingGroup><numbering type="journalVolume" number="159">159B</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2012-07">July 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="40" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ajmg.b.32055</doi><idGroup><id type="unit" value="AJMG32055"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2012 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2011-10-04"></event><event type="manuscriptAccepted" date="2012-04-04"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.1.5 mode:FullText" date="2012-06-05"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-04-18"></event><event type="firstOnline" date="2012-04-18"></event><event type="publishedOnlineFinalForm" date="2012-06-05"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">501</numbering><numbering type="pageLast">507</numbering></numberingGroup><correspondenceTo>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AJMG.AJMG32055.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="75"></count><count type="wordTotal" number="6818"></count></countGroup><titleGroup><title type="main" xml:lang="en">The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder<link href="#fn1"></link><link href="#fn2"></link></title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Chih‐Chun</givenNames><familyName>Huang</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Yun‐Hsuan</givenNames><familyName>Chang</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Sheng‐Yu</givenNames><familyName>Lee</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Shiou‐Lan</givenNames><familyName>Chen</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Shih‐Heng</givenNames><familyName>Chen</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Chun‐Hsien</givenNames><familyName>Chu</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af7"><personName><givenNames>San‐Yuan</givenNames><familyName>Huang</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Nian‐Sheng</givenNames><familyName>Tzeng</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>I Hui</givenNames><familyName>Lee</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af2 #af3 #af5"><personName><givenNames>Tzung Lieh</givenNames><familyName>Yeh</familyName></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af2 #af3 #af5 #af6"><personName><givenNames>Yen Kuang</givenNames><familyName>Yang</familyName></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af1 #af2 #af3 #af4 #af5 #af6" corresponding="yes"><personName><givenNames>Ru‐Band</givenNames><familyName>Lu</familyName></personName><contactDetails><email>rblu@mail.ncku.edu.tw</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="TW" type="organization"><unparsedAffiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="TW" type="organization"><unparsedAffiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="TW" type="organization"><unparsedAffiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="TW" type="organization"><unparsedAffiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="TW" type="organization"><unparsedAffiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="TW" type="organization"><unparsedAffiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="TW" type="organization"><unparsedAffiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><i>BDNF</i></keyword><keyword xml:id="kwd2">bipolar disorders</keyword><keyword xml:id="kwd3"><i>DRD2/ANKK1</i></keyword><keyword xml:id="kwd4">genetic interaction</keyword></keywordGroup><fundingInfo><fundingAgency>Taiwan National Health Research Institute</fundingAgency><fundingNumber>NHRI‐EX99‐9738NI</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Taiwan National Science Council</fundingAgency><fundingNumber>NSC98‐2627‐B‐006‐017</fundingNumber><fundingNumber>NSC99‐2627‐B‐006‐015</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Cheng Kung University Project</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (<i>DRD2/ANKK1</i>), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (<i>BDNF</i>) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the <i>BDNF</i> and <i>DRD2/ANKK1</i> genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the <i>BDNF</i> and <i>DRD2/ANKK1 Taq1A</i> polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the <i>BDNF</i> Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the <i>BDNF</i> Val66Met polymorphism and A1/A2 genotype of <i>DRD2/ANKK1 Taq1A</i> polymorphism was found only in BP‐II patients. We provide initial evidence that the <i>BDNF</i> Val66Me and <i>DRD2/ANKK1 Taq1A</i> polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Conflicts of interest: The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.</p></note><note xml:id="fn2"><p>How to Cite this Article: Huang C‐C, Chang Y‐H, Lee S‐Y, Chen S‐L, Chen S‐H, Chu C‐H, Huang S‐Y, Tzeng N‐S, Lee IH, Yeh TL, Yang YK, Lu R‐B. 2012. The Interaction Between BDNF and DRD2 in Bipolar II Disorder but not in Bipolar I Disorder. Am J Med Genet Part B 159B:501–507.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The interaction between BDNF and DRD2 in Bipolar II disorder but not in bipolar i disorder</title></titleInfo><name type="personal"><namePart type="given">Chih‐Chun</namePart><namePart type="family">Huang</namePart><affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yun‐Hsuan</namePart><namePart type="family">Chang</namePart><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sheng‐Yu</namePart><namePart type="family">Lee</namePart><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shiou‐Lan</namePart><namePart type="family">Chen</namePart><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shih‐Heng</namePart><namePart type="family">Chen</namePart><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chun‐Hsien</namePart><namePart type="family">Chu</namePart><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">San‐Yuan</namePart><namePart type="family">Huang</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nian‐Sheng</namePart><namePart type="family">Tzeng</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I Hui</namePart><namePart type="family">Lee</namePart><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tzung Lieh</namePart><namePart type="family">Yeh</namePart><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yen Kuang</namePart><namePart type="family">Yang</namePart><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ru‐Band</namePart><namePart type="family">Lu</namePart><affiliation>Department of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Division of Clinical Psychology, Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Addiction Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Institute of Behavioral Medicine, Institute of Allied Health Sciences, Department of Psychiatry College of Medicine and Hospital, National Cheng Kung University 138 Sheng‐Li Road, Tainan 70428, Taiwan.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2012-07</dateIssued><dateCaptured encoding="w3cdtf">2011-10-04</dateCaptured><dateValid encoding="w3cdtf">2012-04-04</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">75</extent><extent unit="words">6818</extent></physicalDescription><abstract lang="en">Bipolar I (BP‐I) and bipolar II (BP‐II) disorders are the two most common subtypes of bipolar disorder. However, most studies have not differentiated bipolar disorder into BP‐I and BP‐II groups, for which the underlying etiology differentiating these two subtypes remains unclear. The genetic association between both subtypes is essential for improving our understanding. The dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1), one of the dopaminergic pathways, as well as the brain‐derived neurotrophic factor (BDNF) gene, were reported as candidate genes in the etiology of bipolar disorder. Therefore, we examined the contribution of the BDNF and DRD2/ANKK1 genes and their interaction to the differentiation of BP‐I and BP‐II. Seven hundred ninety‐two participants were recruited: 208 with BP‐I, 329 with BP‐II, and 255 healthy controls. The genotypes of the BDNF and DRD2/ANKK1 Taq1A polymorphisms were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A significant main effect for the Val/Val genotype of the BDNF Val66Met polymorphism predicted BP‐II patients. The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP‐II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP‐II disorder and that BP‐I and BP‐II are genetically distinct. © 2012 Wiley Periodicals, Inc.</abstract><note type="content">*Conflicts of interest: The authors of this paper do not have any commercial associations that might pose a conflict of interest in connection with this manuscript.</note><note type="content">*How to Cite this Article: Huang C‐C, Chang Y‐H, Lee S‐Y, Chen S‐L, Chen S‐H, Chu C‐H, Huang S‐Y, Tzeng N‐S, Lee IH, Yeh TL, Yang YK, Lu R‐B. 2012. The Interaction Between BDNF and DRD2 in Bipolar II Disorder but not in Bipolar I Disorder. Am J Med Genet Part B 159B:501–507.</note><note type="funding">Taiwan National Health Research Institute - No. NHRI‐EX99‐9738NI; </note><note type="funding">Taiwan National Science Council - No. NSC98‐2627‐B‐006‐017; No. NSC99‐2627‐B‐006‐015; </note><note type="funding">National Cheng Kung University Project</note><subject lang="en"><genre>keywords</genre><topic>BDNF</topic><topic>bipolar disorders</topic><topic>DRD2/ANKK1</topic><topic>genetic interaction</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Med. Genet.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1552-4841</identifier><identifier type="eISSN">1552-485X</identifier><identifier type="DOI">10.1002/(ISSN)1552-485X</identifier><identifier type="PublisherID">AJMG</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>159B</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>501</start><end>507</end><total>7</total></extent></part></relatedItem><relatedItem type="preceding"><titleInfo><title>American Journal of Medical Genetics</title></titleInfo><identifier type="ISSN">0148-7299</identifier><identifier type="ISSN">1096-8628</identifier><part><date point="end">2004</date></part></relatedItem><identifier type="istex">E2C426AC2BB5BE540D1289D17BD413DCE77FD504</identifier><identifier type="DOI">10.1002/ajmg.b.32055</identifier><identifier type="ArticleID">AJMG32055</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2012 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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