Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol
Identifieur interne : 001703 ( Istex/Corpus ); précédent : 001702; suivant : 001704Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol
Auteurs : Angelika Buske-Kirschbaum ; Clemens Kirschbaum ; Helmuth Stierle ; Lea Jabaij ; Dirk HellhammerSource :
- Biological Psychology [ 0301-0511 ] ; 1994.
Abstract
There is growing evidence indicating that the immune function can be modified by classical conditioning techniques. This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK+ cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK+ cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.
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DOI: 10.1016/0301-0511(94)90035-3
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</title><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stierle, Helmuth" sort="Stierle, Helmuth" uniqKey="Stierle H" first="Helmuth" last="Stierle">Helmuth Stierle</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jabaij, Lea" sort="Jabaij, Lea" uniqKey="Jabaij L" first="Lea" last="Jabaij">Lea Jabaij</name><affiliation><mods:affiliation>Department of Clinical Immunology, University Hospital Utrecht, Utrecht, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AFB53E83A71A659EB22BE007A3516A4B2A8CBC81</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0301-0511(94)90035-3</idno><idno type="url">https://api.istex.fr/document/AFB53E83A71A659EB22BE007A3516A4B2A8CBC81/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001703</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001703</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</title><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stierle, Helmuth" sort="Stierle, Helmuth" uniqKey="Stierle H" first="Helmuth" last="Stierle">Helmuth Stierle</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jabaij, Lea" sort="Jabaij, Lea" uniqKey="Jabaij L" first="Lea" last="Jabaij">Lea Jabaij</name><affiliation><mods:affiliation>Department of Clinical Immunology, University Hospital Utrecht, Utrecht, Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name><affiliation><mods:affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Biological Psychology</title><title level="j" type="abbrev">BIOPSY</title><idno type="ISSN">0301-0511</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="143">143</biblScope><biblScope unit="page" to="155">155</biblScope></imprint><idno type="ISSN">0301-0511</idno></series><idno type="istex">AFB53E83A71A659EB22BE007A3516A4B2A8CBC81</idno><idno type="DOI">10.1016/0301-0511(94)90035-3</idno><idno type="PII">0301-0511(94)90035-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0301-0511</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is growing evidence indicating that the immune function can be modified by classical conditioning techniques. This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK+ cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK+ cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Angelika Buske-Kirschbaum</name><affiliations><json:string>Department of Psychology, University of Trier, D-54268 Trier, Germany</json:string></affiliations></json:item><json:item><name>Clemens Kirschbaum</name><affiliations><json:string>Department of Psychology, University of Trier, D-54268 Trier, Germany</json:string></affiliations></json:item><json:item><name>Helmuth Stierle</name><affiliations><json:string>Department of Psychology, University of Trier, D-54268 Trier, Germany</json:string></affiliations></json:item><json:item><name>Lea Jabaij</name><affiliations><json:string>Department of Clinical Immunology, University Hospital Utrecht, Utrecht, Netherlands</json:string></affiliations></json:item><json:item><name>Dirk Hellhammer</name><affiliations><json:string>Department of Psychology, University of Trier, D-54268 Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Conditioned immunomodulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Natural killer cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Discriminative learning</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Epinephrine</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>There is growing evidence indicating that the immune function can be modified by classical conditioning techniques. This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK+ cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK+ cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.</abstract><qualityIndicators><score>7.208</score><pdfVersion>1.2</pdfVersion><pdfPageSize>504 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1658</abstractCharCount><pdfWordCount>4304</pdfWordCount><pdfCharCount>30701</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>242</abstractWordCount></qualityIndicators><title>Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</title><pii><json:string>0301-0511(94)90035-3</json:string></pii><refBibs><json:item><author><json:item><name>R. Ader</name></json:item><json:item><name>N. 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This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK+ cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK+ cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Conditioned immunomodulation</term></item><item><term>Natural killer cells</term></item><item><term>Discriminative learning</term></item><item><term>Epinephrine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/AFB53E83A71A659EB22BE007A3516A4B2A8CBC81/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BIOPSY</jid><aid>94900353</aid><ce:pii>0301-0511(94)90035-3</ce:pii><ce:doi>10.1016/0301-0511(94)90035-3</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</ce:title><ce:author-group><ce:author><ce:given-name>Angelika</ce:given-name><ce:surname>Buske-Kirschbaum</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Clemens</ce:given-name><ce:surname>Kirschbaum</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Helmuth</ce:given-name><ce:surname>Stierle</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Lea</ce:given-name><ce:surname>Jabaij</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Dirk</ce:given-name><ce:surname>Hellhammer</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Psychology, University of Trier, D-54268 Trier, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Clinical Immunology, University Hospital Utrecht, Utrecht, Netherlands</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author.</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>There is growing evidence indicating that the immune function can be modified by classical conditioning techniques. This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK<ce:sup>+</ce:sup> cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK<ce:sup>+</ce:sup> cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Conditioned immunomodulation</ce:text></ce:keyword><ce:keyword><ce:text>Natural killer cells</ce:text></ce:keyword><ce:keyword><ce:text>Discriminative learning</ce:text></ce:keyword><ce:keyword><ce:text>Epinephrine</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Conditioned manipulation of natural killer (NK) cells in humans using a discriminative learning protocol</title></titleInfo><name type="personal"><namePart type="given">Angelika</namePart><namePart type="family">Buske-Kirschbaum</namePart><affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</affiliation><description>Corresponding author.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clemens</namePart><namePart type="family">Kirschbaum</namePart><affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helmuth</namePart><namePart type="family">Stierle</namePart><affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lea</namePart><namePart type="family">Jabaij</namePart><affiliation>Department of Clinical Immunology, University Hospital Utrecht, Utrecht, Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk</namePart><namePart type="family">Hellhammer</namePart><affiliation>Department of Psychology, University of Trier, D-54268 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">There is growing evidence indicating that the immune function can be modified by classical conditioning techniques. This phenomenon, initially explored in animals, is further documented by studies providing evidence that the human immune response can also be influenced by classical conditioning processes. In the present study, we tested the hypothesis that human immune parameters can be modulated by discriminative learning processes. Using a classical discriminative conditioning design, healthy volunteers were provided with a CS + (sherbet sweet/white noise), which was repeatedly paired with an injection of epinephrine (unconditioned stimulus, US). After epinephrine injections (0.2 mg subcutaneously), a transient increase of natural killer (NK) cell activity (unconditioned response, UR) could be observed. A second stimulus complex (herbal sweet/auditory stimulus, conditioned stimulus, CS −) remained without reinforcement. After repeated presentation of the stimuli, re-exposure of the CS + on the test trial 1 resulted in a significantly increased number of NK positive (NK+ cells and in slightly elevated NK cell activity. No alteration of NK cells, however, could be observed after presentation of the CS −. A second re-exposure of the CS + on test trial 3, again resulted in a marked increase of NK+ cell number as well as in significantly elevated NK cell activity. The data presented here extend previous observations of conditioned alteration of immune responses in humans and indicate that the human organism might be able to react differentially to external stimuli, which have been associated with different immunological consequences.</abstract><subject><genre>Keywords</genre><topic>Conditioned immunomodulation</topic><topic>Natural killer cells</topic><topic>Discriminative learning</topic><topic>Epinephrine</topic></subject><relatedItem type="host"><titleInfo><title>Biological Psychology</title></titleInfo><titleInfo type="abbreviated"><title>BIOPSY</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199410</dateIssued></originInfo><identifier type="ISSN">0301-0511</identifier><identifier type="PII">S0301-0511(00)X0122-6</identifier><part><date>199410</date><detail type="volume"><number>38</number><caption>vol.</caption></detail><detail type="issue"><number>2–3</number><caption>no.</caption></detail><extent unit="issue pages"><start>95</start><end>222</end></extent><extent unit="pages"><start>143</start><end>155</end></extent></part></relatedItem><identifier type="istex">AFB53E83A71A659EB22BE007A3516A4B2A8CBC81</identifier><identifier type="DOI">10.1016/0301-0511(94)90035-3</identifier><identifier type="PII">0301-0511(94)90035-3</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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