Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects
Identifieur interne : 001369 ( Istex/Corpus ); précédent : 001368; suivant : 001370Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects
Auteurs : R. Deinzer ; C. Kirschbaum ; C. Gresele ; D. H. HellhammerSource :
- Physiology & Behavior [ 0031-9384 ] ; 1997.
English descriptors
Abstract
Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [t(13) = 3.11; p = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.
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DOI: 10.1016/S0031-9384(96)00465-9
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Kirschbaum</name><affiliation><mods:affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gresele, C" sort="Gresele, C" uniqKey="Gresele C" first="C." last="Gresele">C. Gresele</name><affiliation><mods:affiliation>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. 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Deinzer</name><affiliation><mods:affiliation>University of Düsseldorf, Institute for Medical Psychology, Moorenstr. 5, 40225 Düsseldorf, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: renate.deinzer@uni-duesseldorf.de</mods:affiliation></affiliation><affiliation><mods:affiliation>1 To whom requests for reprints should be addressed.</mods:affiliation></affiliation></author><author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name><affiliation><mods:affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gresele, C" sort="Gresele, C" uniqKey="Gresele C" first="C." last="Gresele">C. Gresele</name><affiliation><mods:affiliation>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name><affiliation><mods:affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Physiology & Behavior</title><title level="j" type="abbrev">PHB</title><idno type="ISSN">0031-9384</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="507">507</biblScope><biblScope unit="page" to="511">511</biblScope></imprint><idno type="ISSN">0031-9384</idno></series><idno type="istex">42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D</idno><idno type="DOI">10.1016/S0031-9384(96)00465-9</idno><idno type="PII">S0031-9384(96)00465-9</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-9384</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parachute jumping</term><term>Repeated stress</term><term>Salivary cortisol</term><term>h-CRH challenge</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [t(13) = 3.11; p = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>R. Deinzer,</name><affiliations><json:string>University of Düsseldorf, Institute for Medical Psychology, Moorenstr. 5, 40225 Düsseldorf, Germany</json:string><json:string>E-mail: renate.deinzer@uni-duesseldorf.de</json:string><json:string>1 To whom requests for reprints should be addressed.</json:string></affiliations></json:item><json:item><name>C. Kirschbaum</name><affiliations><json:string>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</json:string></affiliations></json:item><json:item><name>C. Gresele</name><affiliations><json:string>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</json:string></affiliations></json:item><json:item><name>D.H. Hellhammer</name><affiliations><json:string>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Repeated stress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Salivary cortisol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>h-CRH challenge</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parachute jumping</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [t(13) = 3.11; p = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.</abstract><qualityIndicators><score>6.534</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1581</abstractCharCount><pdfWordCount>3690</pdfWordCount><pdfCharCount>21439</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>237</abstractWordCount></qualityIndicators><title>Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</title><pii><json:string>S0031-9384(96)00465-9</json:string></pii><refBibs><json:item><author><json:item><name>A. Armario</name></json:item><json:item><name>J. Hidalgo</name></json:item><json:item><name>M. 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Psychol.</title></host><title>Mental task-induced strain and its after-effect assessed through variations in plasma cortisol levels</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>61</volume><pii><json:string>S0031-9384(00)X0026-1</json:string></pii><pages><last>511</last><first>507</first></pages><issn><json:string>0031-9384</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Physiology & Behavior</title><publicationDate>1997</publicationDate></host><categories><wos><json:string>social science</json:string><json:string>psychology, biological</json:string><json:string>science</json:string><json:string>behavioral sciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>psychology & cognitive sciences</json:string><json:string>behavioral science & comparative psychology</json:string></scienceMetrix></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1016/S0031-9384(96)00465-9</json:string></doi><id>42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D</id><score>1.2698138</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1997 Elsevier Science Inc.</p></availability><date>1997</date></publicationStmt><notesStmt><note type="content">Fig. 1: Individual cortisol profiles on stress (—) and control (-··-) days. Time of parachute jumps are indicated by vertical lines, time of h-CRH application (50 μg) by arrows. Subject numbers and gender are provided in the upper right corner of each graph. Note that the y-axis range of the first 3 graphs differs from that of the others.</note><note type="content">Fig. 2: Mean cortisol peaks and SEMs on the stress day and corresponding control day values. *** p < 0.001 for difference from the control day value.</note><note type="content">Fig. 3: Means ± SEMs of cortisol values before and after bolus injection of 50 μg h-CRH in the evening of the stress day and on a time-matched control day.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</title><author xml:id="author-1"><persName><forename type="first">R.</forename><surname>Deinzer,</surname></persName><email>renate.deinzer@uni-duesseldorf.de</email><affiliation>University of Düsseldorf, Institute for Medical Psychology, Moorenstr. 5, 40225 Düsseldorf, Germany</affiliation><affiliation>1 To whom requests for reprints should be addressed.</affiliation></author><author xml:id="author-2"><persName><forename type="first">C.</forename><surname>Kirschbaum</surname></persName><affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">C.</forename><surname>Gresele</surname></persName><affiliation>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">D.H.</forename><surname>Hellhammer</surname></persName><affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</affiliation></author></analytic><monogr><title level="j">Physiology & Behavior</title><title level="j" type="abbrev">PHB</title><idno type="pISSN">0031-9384</idno><idno type="PII">S0031-9384(00)X0026-1</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">61</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="507">507</biblScope><biblScope unit="page" to="511">511</biblScope></imprint></monogr><idno type="istex">42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D</idno><idno type="DOI">10.1016/S0031-9384(96)00465-9</idno><idno type="PII">S0031-9384(96)00465-9</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [t(13) = 3.11; p = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Repeated stress</term></item><item><term>Salivary cortisol</term></item><item><term>h-CRH challenge</term></item><item><term>Parachute jumping</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity><istex:entity SYSTEM="gr3" NDATA="IMAGE" name="gr3"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>PHB</jid><aid>2557</aid><ce:pii>S0031-9384(96)00465-9</ce:pii><ce:doi>10.1016/S0031-9384(96)00465-9</ce:doi><ce:copyright year="1997" type="full-transfer">Elsevier Science Inc.</ce:copyright></item-info><head><ce:title>Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</ce:title><ce:author-group><ce:author><ce:indexed-name>Deinzer</ce:indexed-name><ce:given-name>R.</ce:given-name><ce:surname>Deinzer,</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:indexed-name>Kirschbaum</ce:indexed-name><ce:given-name>C.</ce:given-name><ce:surname>Kirschbaum</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:indexed-name>Gresele</ce:indexed-name><ce:given-name>C.</ce:given-name><ce:surname>Gresele</ce:surname><ce:cross-ref refid="AFF3">c</ce:cross-ref></ce:author><ce:author><ce:indexed-name>Hellhammer</ce:indexed-name><ce:given-name>D.H.</ce:given-name><ce:surname>Hellhammer</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>University of Düsseldorf, Institute for Medical Psychology, Moorenstr. 5, 40225 Düsseldorf, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>E-mail: renate.deinzer@uni-duesseldorf.de</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>To whom requests for reprints should be addressed.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="7" month="3" year="1996"></ce:date-received><ce:date-accepted day="12" month="9" year="1996"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [<ce:italic>t</ce:italic>(13) = 3.11; <ce:italic>p</ce:italic> = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Repeated stress</ce:text></ce:keyword><ce:keyword><ce:text>Salivary cortisol</ce:text></ce:keyword><ce:keyword><ce:text>h-CRH challenge</ce:text></ce:keyword><ce:keyword><ce:text>Parachute jumping</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Adrenocortical Responses to Repeated Parachute Jumping and Subsequent h-CRH Challenge in Inexperienced Healthy Subjects</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Deinzer,</namePart><affiliation>University of Düsseldorf, Institute for Medical Psychology, Moorenstr. 5, 40225 Düsseldorf, Germany</affiliation><affiliation>E-mail: renate.deinzer@uni-duesseldorf.de</affiliation><affiliation>1 To whom requests for reprints should be addressed.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Kirschbaum</namePart><affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gresele</namePart><affiliation>University of Kiel, Institute for Psychology, 24098 Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.H.</namePart><namePart type="family">Hellhammer</namePart><affiliation>University of Trier, Department of Clinical and Physiological Psychology, 54296 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Deinzer, R., C. Kirschbaum, C. Gresele and D. H. Hellhammer. Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects. Physiol Behav 61(4) 507–511, 1997.—The present study examined the adrenocortical response to 3 consecutive parachute jumps and a poststress h-CRH challenge. Fifteen participants in a parachute-jumping course took saliva samples for later cortisol analysis every 20 min throughout the day, when they accomplished their very first 3 parachute jumps and throughout a control day. The effects of an h-CRH challenge on salivary cortisol were assessed in the evening of the jumping day and on a control day. Parachute jumping induced 3 distinct highly significant adrenocortical responses. The respective cortisol increases for the first, second, and third jump were 39.4 ± 26.5 nmol/l, 31.4 ± 21.4 nmol/l, and 16.5 ± 11.9 nmol/l. Cortisol responses to the first and second jump did not differ but the response to the third jump was significantly reduced [t(13) = 3.11; p = 0.008]. Two groups of subjects were identified, “decreasers,” whose response decreased from one to the other jump, and “increasers,” whose response remained unchanged or increased. The magnitude of the preceding cortisol response of decreasers exceeded that of increasers significantly by about 30 nmol. The mean adrenocortical effects of the poststress h-CRH challenge and the time-matched challenge on a control day did not differ although, in 4 subjects, the poststress adrenocortical reponse to h-CRH was completely suppressed.</abstract><note type="content">Fig. 1: Individual cortisol profiles on stress (—) and control (-··-) days. Time of parachute jumps are indicated by vertical lines, time of h-CRH application (50 μg) by arrows. Subject numbers and gender are provided in the upper right corner of each graph. Note that the y-axis range of the first 3 graphs differs from that of the others.</note><note type="content">Fig. 2: Mean cortisol peaks and SEMs on the stress day and corresponding control day values. *** p < 0.001 for difference from the control day value.</note><note type="content">Fig. 3: Means ± SEMs of cortisol values before and after bolus injection of 50 μg h-CRH in the evening of the stress day and on a time-matched control day.</note><subject lang="en"><genre>Keywords</genre><topic>Repeated stress</topic><topic>Salivary cortisol</topic><topic>h-CRH challenge</topic><topic>Parachute jumping</topic></subject><relatedItem type="host"><titleInfo><title>Physiology & Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PHB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199704</dateIssued></originInfo><identifier type="ISSN">0031-9384</identifier><identifier type="PII">S0031-9384(00)X0026-1</identifier><part><date>199704</date><detail type="volume"><number>61</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>477</start><end>632</end></extent><extent unit="pages"><start>507</start><end>511</end></extent></part></relatedItem><identifier type="istex">42E8380D1A6FBA2B8E2D99B4303DB5B6F846820D</identifier><identifier type="DOI">10.1016/S0031-9384(96)00465-9</identifier><identifier type="PII">S0031-9384(96)00465-9</identifier><accessCondition type="use and reproduction" contentType="copyright">©1997 Elsevier Science Inc.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science Inc., ©1997</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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