AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis
Identifieur interne : 001280 ( Istex/Corpus ); précédent : 001279; suivant : 001281AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis
Auteurs : E. Schmitt ; J. Kriegsmann ; R. Straub ; U. Müller-Ladner ; E. NeumannSource :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2013-06.
Abstract
Background The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology. Objectives Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium. Methods Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients. Results In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue. Conclusions The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases. Disclosure of Interest None Declared
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DOI: 10.1136/annrheumdis-2013-eular.2361
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title><author><name sortKey="Schmitt, E" sort="Schmitt, E" uniqKey="Schmitt E" first="E." last="Schmitt">E. Schmitt</name><affiliation><mods:affiliation>Justus-Liebig-University Of Giessen, Bad Nauheim</mods:affiliation></affiliation></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J." last="Kriegsmann">J. Kriegsmann</name><affiliation><mods:affiliation>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</mods:affiliation></affiliation></author><author><name sortKey="Straub, R" sort="Straub, R" uniqKey="Straub R" first="R." last="Straub">R. Straub</name><affiliation><mods:affiliation>Department of Internal Medicine I, University of Regensburg, Regensburg</mods:affiliation></affiliation></author><author><name sortKey="Muller Ladner, U" sort="Muller Ladner, U" uniqKey="Muller Ladner U" first="U." last="Müller-Ladner">U. Müller-Ladner</name><affiliation><mods:affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</mods:affiliation></affiliation></author><author><name sortKey="Neumann, E" sort="Neumann, E" uniqKey="Neumann E" first="E." last="Neumann">E. Neumann</name><affiliation><mods:affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9559FB1DDDEBEB99367D9371089E3DE0D0D257D1</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/annrheumdis-2013-eular.2361</idno><idno type="url">https://api.istex.fr/document/9559FB1DDDEBEB99367D9371089E3DE0D0D257D1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001280</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001280</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title><author><name sortKey="Schmitt, E" sort="Schmitt, E" uniqKey="Schmitt E" first="E." last="Schmitt">E. Schmitt</name><affiliation><mods:affiliation>Justus-Liebig-University Of Giessen, Bad Nauheim</mods:affiliation></affiliation></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J." last="Kriegsmann">J. Kriegsmann</name><affiliation><mods:affiliation>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</mods:affiliation></affiliation></author><author><name sortKey="Straub, R" sort="Straub, R" uniqKey="Straub R" first="R." last="Straub">R. Straub</name><affiliation><mods:affiliation>Department of Internal Medicine I, University of Regensburg, Regensburg</mods:affiliation></affiliation></author><author><name sortKey="Muller Ladner, U" sort="Muller Ladner, U" uniqKey="Muller Ladner U" first="U." last="Müller-Ladner">U. Müller-Ladner</name><affiliation><mods:affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</mods:affiliation></affiliation></author><author><name sortKey="Neumann, E" sort="Neumann, E" uniqKey="Neumann E" first="E." last="Neumann">E. Neumann</name><affiliation><mods:affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2013-06">2013-06</date><biblScope unit="volume">72</biblScope><biblScope unit="issue">Suppl 3</biblScope><biblScope unit="page" from="A797">A797</biblScope></imprint><idno type="ISSN">0003-4967</idno></series><idno type="istex">9559FB1DDDEBEB99367D9371089E3DE0D0D257D1</idno><idno type="DOI">10.1136/annrheumdis-2013-eular.2361</idno><idno type="href">annrheumdis-72-A797-2.pdf</idno><idno type="ArticleID">annrheumdis-2013-eular.2361</idno><idno type="local">annrheumdis;72/Suppl_3/A797-b</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology. Objectives Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium. Methods Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients. Results In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue. Conclusions The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases. Disclosure of Interest None Declared</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>E. Schmitt</name><affiliations><json:string>Justus-Liebig-University Of Giessen, Bad Nauheim</json:string></affiliations></json:item><json:item><name>J. Kriegsmann</name><affiliations><json:string>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</json:string></affiliations></json:item><json:item><name>R. Straub</name><affiliations><json:string>Department of Internal Medicine I, University of Regensburg, Regensburg</json:string></affiliations></json:item><json:item><name>U. Müller-Ladner</name><affiliations><json:string>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</json:string></affiliations></json:item><json:item><name>E. Neumann</name><affiliations><json:string>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</json:string></affiliations></json:item></author><articleId><json:string>annrheumdis-2013-eular.2361</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>Background The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology. Objectives Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium. Methods Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients. Results In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue. Conclusions The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases. Disclosure of Interest None Declared</abstract><qualityIndicators><score>6.378</score><pdfVersion>1.4</pdfVersion><pdfPageSize>594.72 x 841.68 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>2531</abstractCharCount><pdfWordCount>1378</pdfWordCount><pdfCharCount>9246</pdfCharCount><pdfPageCount>1</pdfPageCount><abstractWordCount>364</abstractWordCount></qualityIndicators><title>AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title><genre><json:string>abstract</json:string></genre><host><volume>72</volume><publisherId><json:string>ard</json:string></publisherId><pages><first>A797</first></pages><issn><json:string>0003-4967</json:string></issn><issue>Suppl 3</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-2060</json:string></eissn><title>Annals of the Rheumatic Diseases</title></host><categories><wos><json:string>science</json:string><json:string>rheumatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>arthritis & rheumatology</json:string></scienceMetrix></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1136/annrheumdis-2013-eular.2361</json:string></doi><id>9559FB1DDDEBEB99367D9371089E3DE0D0D257D1</id><score>0.31473735</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/9559FB1DDDEBEB99367D9371089E3DE0D0D257D1/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/9559FB1DDDEBEB99367D9371089E3DE0D0D257D1/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9559FB1DDDEBEB99367D9371089E3DE0D0D257D1/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><availability><p>© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</p></availability><date>2013</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title><author xml:id="author-1"><persName><forename type="first">E.</forename><surname>Schmitt</surname></persName><affiliation>Justus-Liebig-University Of Giessen, Bad Nauheim</affiliation></author><author xml:id="author-2"><persName><forename type="first">J.</forename><surname>Kriegsmann</surname></persName><affiliation>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</affiliation></author><author xml:id="author-3"><persName><forename type="first">R.</forename><surname>Straub</surname></persName><affiliation>Department of Internal Medicine I, University of Regensburg, Regensburg</affiliation></author><author xml:id="author-4"><persName><forename type="first">U.</forename><surname>Müller-Ladner</surname></persName><affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">E.</forename><surname>Neumann</surname></persName><affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</affiliation></author></analytic><monogr><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="pISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2013-06"></date><biblScope unit="volume">72</biblScope><biblScope unit="issue">Suppl 3</biblScope><biblScope unit="page" from="A797">A797</biblScope></imprint></monogr><idno type="istex">9559FB1DDDEBEB99367D9371089E3DE0D0D257D1</idno><idno type="DOI">10.1136/annrheumdis-2013-eular.2361</idno><idno type="href">annrheumdis-72-A797-2.pdf</idno><idno type="ArticleID">annrheumdis-2013-eular.2361</idno><idno type="local">annrheumdis;72/Suppl_3/A797-b</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology. Objectives Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium. Methods Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients. Results In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue. Conclusions The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases. Disclosure of Interest None Declared</p></abstract></profileDesc><revisionDesc><change when="2013-06">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-19">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9559FB1DDDEBEB99367D9371089E3DE0D0D257D1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">annrheumdis</journal-id><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-id journal-id-type="publisher-id">ard</journal-id><journal-title>Annals of the Rheumatic Diseases</journal-title><abbrev-journal-title abbrev-type="publisher">Ann Rheum Dis</abbrev-journal-title><abbrev-journal-title>Ann Rheum Dis</abbrev-journal-title><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">annrheumdis-2013-eular.2361</article-id><article-id pub-id-type="doi">10.1136/annrheumdis-2013-eular.2361</article-id><article-id pub-id-type="other">annrheumdis;72/Suppl_3/A797-b</article-id><article-id pub-id-type="other">annrheumdis;annrheumdis-2013-eular.2361</article-id><article-id pub-id-type="other">A797.2</article-id><article-id pub-id-type="other">annrheumdis-2013-eular.2361</article-id><article-categories><subj-group subj-group-type="heading"><subject>Abstracts accepted for publication</subject><subj-group subj-group-type="heading"><subject>Cytokines and inflammatory mediators</subject></subj-group></subj-group></article-categories><title-group><article-title>AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Schmitt</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="AF00001"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kriegsmann</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="AF00002"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Straub</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="AF00003"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Müller-Ladner</surname><given-names>U.</given-names></name><xref ref-type="aff" rid="AF00004"><sup>4</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Neumann</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="AF00004"><sup>4</sup></xref></contrib></contrib-group><aff id="AF00001"><sup>1</sup>Justus-Liebig-University Of Giessen, Bad Nauheim</aff><aff id="AF00002"><sup>2</sup>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</aff><aff id="AF00003"><sup>3</sup>Department of Internal Medicine I, University of Regensburg, Regensburg</aff><aff id="AF00004"><sup>4</sup>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</aff><pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><volume>72</volume><volume-id pub-id-type="other">72</volume-id><volume-id pub-id-type="other">72</volume-id><issue>Suppl 3</issue><issue-id pub-id-type="other">annrheumdis;72/Suppl_3</issue-id><issue-id pub-id-type="other" content-type="supplement">Suppl_3</issue-id><issue-id pub-id-type="other">72/Suppl_3</issue-id><issue-title>Annual European Congress of Rheumatology EULAR abstracts 2013, 12–15 June 2013, Spain</issue-title><fpage seq="2">A797</fpage><permissions><copyright-statement>© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="annrheumdis-72-A797-2.pdf"></self-uri><abstract><sec><title>Background</title><p>The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology.</p></sec><sec><title>Objectives</title><p>Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium.</p></sec><sec><title>Methods</title><p>Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients.</p></sec><sec><title>Results</title><p>In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue.</p></sec><sec><title>Conclusions</title><p>The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases.</p></sec><sec><title>Disclosure of Interest</title><p>None Declared</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>AB0038 Adipokine expression in synovial tissue from patients with psoriatic arthritis</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Schmitt</namePart><affiliation>Justus-Liebig-University Of Giessen, Bad Nauheim</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Kriegsmann</namePart><affiliation>Department of Molecular Pathology, Center for Histology, Cytology and Molecular Diagnostics, Trier</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Straub</namePart><affiliation>Department of Internal Medicine I, University of Regensburg, Regensburg</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Müller-Ladner</namePart><affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Neumann</namePart><affiliation>Department of Internal Medicine and Rheumatology, Justus-Liebig-University Of Giessen, Bad Nauheim, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><dateIssued encoding="w3cdtf">2013-06</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background The pathophysiology of psoriatic arthritis (PsA) is not as well understood as for rheumatoid arthritis (RA), and the distinction between both diseases is often difficult. However, both diseases are characterized by synovial alterations within the affected joints and the central involvement of pro-inflammatory factors. Adipokines such as adiponectin, visfatin/PBEF and resistin have recently been identified as signaling molecules with substantial immunomodulatory potential. These adipokines are increased in RA synovium and exert a pro-inflammatory impact on central cells of RA pathophysiology. Objectives Therefore, the synovial adipokine expression of adiponectin, visfatin/PBEF and resistin was evaluated in PsA synovium. Methods Synovial tissues from affected joints of PsA patients were stained with hematoxylin/eosin. Immunohistochemical staining against fibroblasts (vimentin), macrophages (CD16), T cells (CD3), B cells (CD20), vessels (collagen type IV) as well as against adiponectin, visfatin/PBEF and resistin were performed in serial sections. Additionally, adipokine expression was compared to the expression pattern of RA patients. Results In the majority of patients, the synovial tissue from PsA showed no hyperplasia of the lining layer in comparison to RA. 71% of the synovial tissue showed a high expression of Visfatin/PBEF. However resistin was less detectable in PsA lining layer, 71% showed a low resistin secretion. In comparison to RA, resistin expression was lower in PsA whereas visfatin/PBEF was comparable. In contrast to RA, the expression of adiponectin in the lining layer was completely absent in most PsA patients. 86 % of the samples showed moderate adiponectin signals, which were mainly located in the sublining in vessels showing a strong expression in PsA. In RA, the sublining showed adiponectin expression in the vessels but also by connective tissue cells. Resistin and visfatin/PBEF were detectable in the sublining and comparable between RA and PsA tissues. Adiponectin was expressed in inflammatory infiltrates in RA. However, this pattern was not present in PsA tissue. Conclusions The synovial membranes from PsA and RA show clear differences to those of RA-affected joints and are in part reflected by the adipokine expression. Specifically, adiponectin is more prominent in the RA than in the PsA lining layer. Adipokines may therefore play different roles in inflammatory processes operative in these chronic rheumatic diseases. Disclosure of Interest None Declared</abstract><relatedItem type="host"><titleInfo><title>Annals of the Rheumatic Diseases</title></titleInfo><titleInfo type="abbreviated"><title>Ann Rheum Dis</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0003-4967</identifier><identifier type="eISSN">1468-2060</identifier><identifier type="PublisherID">ard</identifier><identifier type="PublisherID-hwp">annrheumdis</identifier><identifier type="PublisherID-nlm-ta">Ann Rheum Dis</identifier><part><date>2013</date><detail type="title"><title>Annual European Congress of Rheumatology EULAR abstracts 2013, 12–15 June 2013, Spain</title></detail><detail type="volume"><caption>vol.</caption><number>72</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 3</number></detail><extent unit="pages"><start>A797</start></extent></part></relatedItem><identifier type="istex">9559FB1DDDEBEB99367D9371089E3DE0D0D257D1</identifier><identifier type="DOI">10.1136/annrheumdis-2013-eular.2361</identifier><identifier type="href">annrheumdis-72-A797-2.pdf</identifier><identifier type="ArticleID">annrheumdis-2013-eular.2361</identifier><identifier type="local">annrheumdis;72/Suppl_3/A797-b</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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