Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder
Identifieur interne : 001045 ( Istex/Corpus ); précédent : 001044; suivant : 001046Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder
Auteurs : Kaixin Zhou ; Astrid Dempfle ; Mauricio Arcos-Burgos ; Steven C. Bakker ; Tobias Banaschewski ; Joseph Biederman ; Jan Buitelaar ; F. Xavier Castellanos ; Alysa Doyle ; Richard P. Ebstein ; Jenny Ekholm ; Paola Forabosco ; Barbara Franke ; Christine Freitag ; Susann Friedel ; Michael Gill ; Johannes Hebebrand ; Anke Hinney ; Christian Jacob ; Klaus Peter Lesch ; Sandra K. Loo ; Francisco Lopera ; James T. Mccracken ; James J. Mcgough ; Jobst Meyer ; Eric Mick ; Ana Miranda ; Maximilian Muenke1 ; Fernando Mulas ; Stanley F. Nelson ; T. Trang Nguyen ; Robert D. Oades ; Matthew N. Ogdie ; Juan David Palacio ; David Pineda ; Andreas Reif ; Tobias J. Renner ; Herbert Roeyers ; Marcel Romanos ; Aribert Rothenberger ; Helmut Sch Fer ; Joseph Sergeant ; Richard J. Sinke ; Susan L. Smalley ; Edmund Sonuga-Barke ; Hans-Christoph Steinhausen ; Emma Van Der Meulen ; Susanne Walitza ; Andreas Warnke ; Cathryn M. Lewis ; Stephen V. Faraone ; Philip AshersonSource :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2008-12-05.
English descriptors
Abstract
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/ajmg.b.30878
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Miller School of Medicine, University of Miami, Miami, Florida</mods:affiliation></affiliation><affiliation><mods:affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Bakker, Steven C" sort="Bakker, Steven C" uniqKey="Bakker S" first="Steven C." last="Bakker">Steven C. Bakker</name><affiliation><mods:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</mods:affiliation></affiliation></author><author><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Buitelaar, Jan" sort="Buitelaar, Jan" uniqKey="Buitelaar J" first="Jan" last="Buitelaar">Jan Buitelaar</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Castellanos, F Xavier" sort="Castellanos, F Xavier" uniqKey="Castellanos F" first="F. Xavier" last="Castellanos">F. Xavier Castellanos</name><affiliation><mods:affiliation>Child Study Center, New York University, New York, New York</mods:affiliation></affiliation></author><author><name sortKey="Doyle, Alysa" sort="Doyle, Alysa" uniqKey="Doyle A" first="Alysa" last="Doyle">Alysa Doyle</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P." last="Ebstein">Richard P. Ebstein</name><affiliation><mods:affiliation>Geha MHC, Petach‐Tikva, Israel</mods:affiliation></affiliation></author><author><name sortKey="Ekholm, Jenny" sort="Ekholm, Jenny" uniqKey="Ekholm J" first="Jenny" last="Ekholm">Jenny Ekholm</name><affiliation><mods:affiliation>Department of Human Genetics, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name><affiliation><mods:affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</mods:affiliation></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Freitag, Christine" sort="Freitag, Christine" uniqKey="Freitag C" first="Christine" last="Freitag">Christine Freitag</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Friedel, Susann" sort="Friedel, Susann" uniqKey="Friedel S" first="Susann" last="Friedel">Susann Friedel</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><mods:affiliation>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jacob, Christian" sort="Jacob, Christian" uniqKey="Jacob C" first="Christian" last="Jacob">Christian Jacob</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus Peter" last="Lesch">Klaus Peter Lesch</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loo, Sandra K" sort="Loo, Sandra K" uniqKey="Loo S" first="Sandra K." last="Loo">Sandra K. Loo</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Lopera, Francisco" sort="Lopera, Francisco" uniqKey="Lopera F" first="Francisco" last="Lopera">Francisco Lopera</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><mods:affiliation>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mick, Eric" sort="Mick, Eric" uniqKey="Mick E" first="Eric" last="Mick">Eric Mick</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Miranda, Ana" sort="Miranda, Ana" uniqKey="Miranda A" first="Ana" last="Miranda">Ana Miranda</name><affiliation><mods:affiliation>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Muenke1, Maximilian" sort="Muenke1, Maximilian" uniqKey="Muenke1 M" first="Maximilian" last="Muenke1">Maximilian Muenke1</name><affiliation><mods:affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Mulas, Fernando" sort="Mulas, Fernando" uniqKey="Mulas F" first="Fernando" last="Mulas">Fernando Mulas</name><affiliation><mods:affiliation>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Nelson, Stanley F" sort="Nelson, Stanley F" uniqKey="Nelson S" first="Stanley F." last="Nelson">Stanley F. Nelson</name><affiliation><mods:affiliation>Department of Human Genetics, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T. Trang" last="Nguyen">T. Trang Nguyen</name><affiliation><mods:affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name><affiliation><mods:affiliation>University Clinic for Child and Adolescent Psychiatry, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ogdie, Matthew N" sort="Ogdie, Matthew N" uniqKey="Ogdie M" first="Matthew N." last="Ogdie">Matthew N. Ogdie</name><affiliation><mods:affiliation>The Broad Institute, MIT, Cambridge, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Palacio, Juan David" sort="Palacio, Juan David" uniqKey="Palacio J" first="Juan David" last="Palacio">Juan David Palacio</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Pineda, David" sort="Pineda, David" uniqKey="Pineda D" first="David" last="Pineda">David Pineda</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name><affiliation><mods:affiliation>Ghent University, Dunantlaan, Ghent, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name><affiliation><mods:affiliation>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation><mods:affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sergeant, Joseph" sort="Sergeant, Joseph" uniqKey="Sergeant J" first="Joseph" last="Sergeant">Joseph Sergeant</name><affiliation><mods:affiliation>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sinke, Richard J" sort="Sinke, Richard J" uniqKey="Sinke R" first="Richard J." last="Sinke">Richard J. Sinke</name><affiliation><mods:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Smalley, Susan L" sort="Smalley, Susan L" uniqKey="Smalley S" first="Susan L." last="Smalley">Susan L. Smalley</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Child Study Center, New York University, New York, New York</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</mods:affiliation></affiliation></author><author><name sortKey="Steinhausen, Hans Hristoph" sort="Steinhausen, Hans Hristoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Van Der Meulen, Emma" sort="Van Der Meulen, Emma" uniqKey="Van Der Meulen E" first="Emma" last="Van Der Meulen">Emma Van Der Meulen</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</mods:affiliation></affiliation></author><author><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B0F83818028A4010A3FEE7AA60DBB739E3DAB998</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/ajmg.b.30878</idno><idno type="url">https://api.istex.fr/document/B0F83818028A4010A3FEE7AA60DBB739E3DAB998/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001045</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001045</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder</title><author><name sortKey="Zhou, Kaixin" sort="Zhou, Kaixin" uniqKey="Zhou K" first="Kaixin" last="Zhou">Kaixin Zhou</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Dempfle, Astrid" sort="Dempfle, Astrid" uniqKey="Dempfle A" first="Astrid" last="Dempfle">Astrid Dempfle</name><affiliation><mods:affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Arcos Urgos, Mauricio" sort="Arcos Urgos, Mauricio" uniqKey="Arcos Urgos M" first="Mauricio" last="Arcos-Burgos">Mauricio Arcos-Burgos</name><affiliation><mods:affiliation>Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida</mods:affiliation></affiliation><affiliation><mods:affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Bakker, Steven C" sort="Bakker, Steven C" uniqKey="Bakker S" first="Steven C." last="Bakker">Steven C. Bakker</name><affiliation><mods:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</mods:affiliation></affiliation></author><author><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Buitelaar, Jan" sort="Buitelaar, Jan" uniqKey="Buitelaar J" first="Jan" last="Buitelaar">Jan Buitelaar</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Castellanos, F Xavier" sort="Castellanos, F Xavier" uniqKey="Castellanos F" first="F. Xavier" last="Castellanos">F. Xavier Castellanos</name><affiliation><mods:affiliation>Child Study Center, New York University, New York, New York</mods:affiliation></affiliation></author><author><name sortKey="Doyle, Alysa" sort="Doyle, Alysa" uniqKey="Doyle A" first="Alysa" last="Doyle">Alysa Doyle</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P." last="Ebstein">Richard P. Ebstein</name><affiliation><mods:affiliation>Geha MHC, Petach‐Tikva, Israel</mods:affiliation></affiliation></author><author><name sortKey="Ekholm, Jenny" sort="Ekholm, Jenny" uniqKey="Ekholm J" first="Jenny" last="Ekholm">Jenny Ekholm</name><affiliation><mods:affiliation>Department of Human Genetics, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name><affiliation><mods:affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</mods:affiliation></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation><mods:affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Freitag, Christine" sort="Freitag, Christine" uniqKey="Freitag C" first="Christine" last="Freitag">Christine Freitag</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Friedel, Susann" sort="Friedel, Susann" uniqKey="Friedel S" first="Susann" last="Friedel">Susann Friedel</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation><mods:affiliation>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jacob, Christian" sort="Jacob, Christian" uniqKey="Jacob C" first="Christian" last="Jacob">Christian Jacob</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus Peter" last="Lesch">Klaus Peter Lesch</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loo, Sandra K" sort="Loo, Sandra K" uniqKey="Loo S" first="Sandra K." last="Loo">Sandra K. Loo</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Lopera, Francisco" sort="Lopera, Francisco" uniqKey="Lopera F" first="Francisco" last="Lopera">Francisco Lopera</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><mods:affiliation>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mick, Eric" sort="Mick, Eric" uniqKey="Mick E" first="Eric" last="Mick">Eric Mick</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Miranda, Ana" sort="Miranda, Ana" uniqKey="Miranda A" first="Ana" last="Miranda">Ana Miranda</name><affiliation><mods:affiliation>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Muenke1, Maximilian" sort="Muenke1, Maximilian" uniqKey="Muenke1 M" first="Maximilian" last="Muenke1">Maximilian Muenke1</name><affiliation><mods:affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Mulas, Fernando" sort="Mulas, Fernando" uniqKey="Mulas F" first="Fernando" last="Mulas">Fernando Mulas</name><affiliation><mods:affiliation>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Nelson, Stanley F" sort="Nelson, Stanley F" uniqKey="Nelson S" first="Stanley F." last="Nelson">Stanley F. Nelson</name><affiliation><mods:affiliation>Department of Human Genetics, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T. Trang" last="Nguyen">T. Trang Nguyen</name><affiliation><mods:affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name><affiliation><mods:affiliation>University Clinic for Child and Adolescent Psychiatry, Essen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ogdie, Matthew N" sort="Ogdie, Matthew N" uniqKey="Ogdie M" first="Matthew N." last="Ogdie">Matthew N. Ogdie</name><affiliation><mods:affiliation>The Broad Institute, MIT, Cambridge, Massachusetts</mods:affiliation></affiliation></author><author><name sortKey="Palacio, Juan David" sort="Palacio, Juan David" uniqKey="Palacio J" first="Juan David" last="Palacio">Juan David Palacio</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Pineda, David" sort="Pineda, David" uniqKey="Pineda D" first="David" last="Pineda">David Pineda</name><affiliation><mods:affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</mods:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name><affiliation><mods:affiliation>Ghent University, Dunantlaan, Ghent, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name><affiliation><mods:affiliation>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation><mods:affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sergeant, Joseph" sort="Sergeant, Joseph" uniqKey="Sergeant J" first="Joseph" last="Sergeant">Joseph Sergeant</name><affiliation><mods:affiliation>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sinke, Richard J" sort="Sinke, Richard J" uniqKey="Sinke R" first="Richard J." last="Sinke">Richard J. Sinke</name><affiliation><mods:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Smalley, Susan L" sort="Smalley, Susan L" uniqKey="Smalley S" first="Susan L." last="Smalley">Susan L. Smalley</name><affiliation><mods:affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Child Study Center, New York University, New York, New York</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</mods:affiliation></affiliation></author><author><name sortKey="Steinhausen, Hans Hristoph" sort="Steinhausen, Hans Hristoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Van Der Meulen, Emma" sort="Van Der Meulen, Emma" uniqKey="Van Der Meulen E" first="Emma" last="Van Der Meulen">Emma Van Der Meulen</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation><mods:affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><affiliation><mods:affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</mods:affiliation></affiliation></author><author><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><affiliation><mods:affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-05">2008-12-05</date><biblScope unit="volume">147B</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1392">1392</biblScope><biblScope unit="page" to="1398">1398</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">B0F83818028A4010A3FEE7AA60DBB739E3DAB998</idno><idno type="DOI">10.1002/ajmg.b.30878</idno><idno type="ArticleID">AJMG30878</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADHD</term><term>GSMA</term><term>linkage</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Kaixin Zhou</name><affiliations><json:string>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</json:string></affiliations></json:item><json:item><name>Astrid Dempfle</name><affiliations><json:string>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Mauricio Arcos‐Burgos</name><affiliations><json:string>Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida</json:string><json:string>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Steven C. Bakker</name><affiliations><json:string>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</json:string></affiliations></json:item><json:item><name>Tobias Banaschewski</name><affiliations><json:string>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</json:string></affiliations></json:item><json:item><name>Joseph Biederman</name><affiliations><json:string>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</json:string></affiliations></json:item><json:item><name>Jan Buitelaar</name><affiliations><json:string>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>F. Xavier Castellanos</name><affiliations><json:string>Child Study Center, New York University, New York, New York</json:string></affiliations></json:item><json:item><name>Alysa Doyle</name><affiliations><json:string>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</json:string></affiliations></json:item><json:item><name>Richard P. Ebstein</name><affiliations><json:string>Geha MHC, Petach‐Tikva, Israel</json:string></affiliations></json:item><json:item><name>Jenny Ekholm</name><affiliations><json:string>Department of Human Genetics, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Paola Forabosco</name><affiliations><json:string>Department of Medical and Molecular Genetics, King's College London, London, UK</json:string><json:string>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</json:string></affiliations></json:item><json:item><name>Barbara Franke</name><affiliations><json:string>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</json:string><json:string>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Christine Freitag</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</json:string></affiliations></json:item><json:item><name>Susann Friedel</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</json:string></affiliations></json:item><json:item><name>Michael Gill</name><affiliations><json:string>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</json:string></affiliations></json:item><json:item><name>Johannes Hebebrand</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</json:string></affiliations></json:item><json:item><name>Anke Hinney</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</json:string></affiliations></json:item><json:item><name>Christian Jacob</name><affiliations><json:string>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Klaus Peter Lesch</name><affiliations><json:string>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Sandra K. Loo</name><affiliations><json:string>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Francisco Lopera</name><affiliations><json:string>Neurosciences Group, University of Antioquia, Medellín, Colombia</json:string></affiliations></json:item><json:item><name>James T. McCracken</name><affiliations><json:string>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>James J. McGough</name><affiliations><json:string>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Jobst Meyer</name><affiliations><json:string>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</json:string></affiliations></json:item><json:item><name>Eric Mick</name><affiliations><json:string>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</json:string></affiliations></json:item><json:item><name>Ana Miranda</name><affiliations><json:string>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</json:string></affiliations></json:item><json:item><name>Maximilian Muenke1</name><affiliations><json:string>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Fernando Mulas</name><affiliations><json:string>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</json:string></affiliations></json:item><json:item><name>Stanley F. Nelson</name><affiliations><json:string>Department of Human Genetics, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>T.Trang Nguyen</name><affiliations><json:string>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Robert D. Oades</name><affiliations><json:string>University Clinic for Child and Adolescent Psychiatry, Essen, Germany</json:string></affiliations></json:item><json:item><name>Matthew N. Ogdie</name><affiliations><json:string>The Broad Institute, MIT, Cambridge, Massachusetts</json:string></affiliations></json:item><json:item><name>Juan David Palacio</name><affiliations><json:string>Neurosciences Group, University of Antioquia, Medellín, Colombia</json:string></affiliations></json:item><json:item><name>David Pineda</name><affiliations><json:string>Neurosciences Group, University of Antioquia, Medellín, Colombia</json:string></affiliations></json:item><json:item><name>Andreas Reif</name><affiliations><json:string>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Tobias J. Renner</name><affiliations><json:string>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Herbert Roeyers</name><affiliations><json:string>Ghent University, Dunantlaan, Ghent, Belgium</json:string></affiliations></json:item><json:item><name>Marcel Romanos</name><affiliations><json:string>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Aribert Rothenberger</name><affiliations><json:string>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</json:string></affiliations></json:item><json:item><name>Helmut Schäfer</name><affiliations><json:string>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</json:string></affiliations></json:item><json:item><name>Joseph Sergeant</name><affiliations><json:string>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Richard J. Sinke</name><affiliations><json:string>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</json:string></affiliations></json:item><json:item><name>Susan L. Smalley</name><affiliations><json:string>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</json:string><json:string>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Edmund Sonuga‐Barke</name><affiliations><json:string>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</json:string><json:string>Child Study Center, New York University, New York, New York</json:string><json:string>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</json:string></affiliations></json:item><json:item><name>Hans‐Christoph Steinhausen</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>Emma van der Meulen</name><affiliations><json:string>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</json:string></affiliations></json:item><json:item><name>Susanne Walitza</name><affiliations><json:string>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Andreas Warnke</name><affiliations><json:string>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</json:string></affiliations></json:item><json:item><name>Cathryn M Lewis</name><affiliations><json:string>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</json:string><json:string>Department of Medical and Molecular Genetics, King's College London, London, UK</json:string></affiliations></json:item><json:item><name>Stephen V. Faraone</name><affiliations><json:string>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</json:string><json:string>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</json:string></affiliations></json:item><json:item><name>Philip Asherson</name><affiliations><json:string>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</json:string><json:string>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ADHD</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>GSMA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>linkage</value></json:item></subject><articleId><json:string>AJMG30878</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. 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disorder</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2008 Wiley‐Liss, Inc.</p></availability><date>2008</date></publicationStmt><notesStmt><note type="content">*Please cite this article as follows: Zhou K, Dempfle A, Arcos‐Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar J, Castellanos FX, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muenke1 M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner TJ, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga‐Barke E, Steinhausen H.‐C, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P. 2008. Meta‐Analysis of Genome‐Wide Linkage Scans of Attention Deficit Hyperactivity Disorder. Am J Med Genet Part B 147B:1392–1398.</note><note>NIH - No. R01HD37694; No. R01MH62873;</note><note>NIMH - No. MH058277; No. MH071852;</note><note>Academy of Finland (Ekholm)</note><note>MRC - No. G0400960;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder</title><author xml:id="author-1"><persName><forename type="first">Kaixin</forename><surname>Zhou</surname></persName><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation></author><author xml:id="author-2"><persName><forename type="first">Astrid</forename><surname>Dempfle</surname></persName><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Mauricio</forename><surname>Arcos‐Burgos</surname></persName><affiliation>Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida</affiliation><affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</affiliation></author><author xml:id="author-4"><persName><forename type="first">Steven C.</forename><surname>Bakker</surname></persName><affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation></author><author xml:id="author-5"><persName><forename type="first">Tobias</forename><surname>Banaschewski</surname></persName><affiliation>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">Joseph</forename><surname>Biederman</surname></persName><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation></author><author xml:id="author-7"><persName><forename type="first">Jan</forename><surname>Buitelaar</surname></persName><affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</affiliation></author><author xml:id="author-8"><persName><forename type="first">F. Xavier</forename><surname>Castellanos</surname></persName><affiliation>Child Study Center, New York University, New York, New York</affiliation></author><author xml:id="author-9"><persName><forename type="first">Alysa</forename><surname>Doyle</surname></persName><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation></author><author xml:id="author-10"><persName><forename type="first">Richard P.</forename><surname>Ebstein</surname></persName><affiliation>Geha MHC, Petach‐Tikva, Israel</affiliation></author><author xml:id="author-11"><persName><forename type="first">Jenny</forename><surname>Ekholm</surname></persName><affiliation>Department of Human Genetics, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-12"><persName><forename type="first">Paola</forename><surname>Forabosco</surname></persName><affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</affiliation><affiliation>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</affiliation></author><author xml:id="author-13"><persName><forename type="first">Barbara</forename><surname>Franke</surname></persName><affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</affiliation><affiliation>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation></author><author xml:id="author-14"><persName><forename type="first">Christine</forename><surname>Freitag</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</affiliation></author><author xml:id="author-15"><persName><forename type="first">Susann</forename><surname>Friedel</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation></author><author xml:id="author-16"><persName><forename type="first">Michael</forename><surname>Gill</surname></persName><affiliation>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</affiliation></author><author xml:id="author-17"><persName><forename type="first">Johannes</forename><surname>Hebebrand</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation></author><author xml:id="author-18"><persName><forename type="first">Anke</forename><surname>Hinney</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation></author><author xml:id="author-19"><persName><forename type="first">Christian</forename><surname>Jacob</surname></persName><affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-20"><persName><forename type="first">Klaus Peter</forename><surname>Lesch</surname></persName><affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-21"><persName><forename type="first">Sandra K.</forename><surname>Loo</surname></persName><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-22"><persName><forename type="first">Francisco</forename><surname>Lopera</surname></persName><affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</affiliation></author><author xml:id="author-23"><persName><forename type="first">James T.</forename><surname>McCracken</surname></persName><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-24"><persName><forename type="first">James J.</forename><surname>McGough</surname></persName><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-25"><persName><forename type="first">Jobst</forename><surname>Meyer</surname></persName><affiliation>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</affiliation></author><author xml:id="author-26"><persName><forename type="first">Eric</forename><surname>Mick</surname></persName><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation></author><author xml:id="author-27"><persName><forename type="first">Ana</forename><surname>Miranda</surname></persName><affiliation>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</affiliation></author><author xml:id="author-28"><persName><forename type="first">Maximilian</forename><surname>Muenke1</surname></persName><affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</affiliation></author><author xml:id="author-29"><persName><forename type="first">Fernando</forename><surname>Mulas</surname></persName><affiliation>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</affiliation></author><author xml:id="author-30"><persName><forename type="first">Stanley F.</forename><surname>Nelson</surname></persName><affiliation>Department of Human Genetics, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-31"><persName><forename type="first">T.Trang</forename><surname>Nguyen</surname></persName><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author xml:id="author-32"><persName><forename type="first">Robert D.</forename><surname>Oades</surname></persName><affiliation>University Clinic for Child and Adolescent Psychiatry, Essen, Germany</affiliation></author><author xml:id="author-33"><persName><forename type="first">Matthew N.</forename><surname>Ogdie</surname></persName><affiliation>The Broad Institute, MIT, Cambridge, Massachusetts</affiliation></author><author xml:id="author-34"><persName><forename type="first">Juan David</forename><surname>Palacio</surname></persName><affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</affiliation></author><author xml:id="author-35"><persName><forename type="first">David</forename><surname>Pineda</surname></persName><affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</affiliation></author><author xml:id="author-36"><persName><forename type="first">Andreas</forename><surname>Reif</surname></persName><affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-37"><persName><forename type="first">Tobias J.</forename><surname>Renner</surname></persName><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-38"><persName><forename type="first">Herbert</forename><surname>Roeyers</surname></persName><affiliation>Ghent University, Dunantlaan, Ghent, Belgium</affiliation></author><author xml:id="author-39"><persName><forename type="first">Marcel</forename><surname>Romanos</surname></persName><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-40"><persName><forename type="first">Aribert</forename><surname>Rothenberger</surname></persName><affiliation>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</affiliation></author><author xml:id="author-41"><persName><forename type="first">Helmut</forename><surname>Schäfer</surname></persName><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</affiliation></author><author xml:id="author-42"><persName><forename type="first">Joseph</forename><surname>Sergeant</surname></persName><affiliation>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</affiliation></author><author xml:id="author-43"><persName><forename type="first">Richard J.</forename><surname>Sinke</surname></persName><affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation></author><author xml:id="author-44"><persName><forename type="first">Susan L.</forename><surname>Smalley</surname></persName><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><affiliation>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation></author><author xml:id="author-45"><persName><forename type="first">Edmund</forename><surname>Sonuga‐Barke</surname></persName><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>Child Study Center, New York University, New York, New York</affiliation><affiliation>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</affiliation></author><author xml:id="author-46"><persName><forename type="first">Hans‐Christoph</forename><surname>Steinhausen</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</affiliation></author><author xml:id="author-47"><persName><forename type="first">Emma</forename><surname>van der Meulen</surname></persName><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation></author><author xml:id="author-48"><persName><forename type="first">Susanne</forename><surname>Walitza</surname></persName><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-49"><persName><forename type="first">Andreas</forename><surname>Warnke</surname></persName><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation></author><author xml:id="author-50"><persName><forename type="first">Cathryn M</forename><surname>Lewis</surname></persName><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</affiliation></author><author xml:id="author-51"><persName><forename type="first">Stephen V.</forename><surname>Faraone</surname></persName><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation><affiliation>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</affiliation></author><author xml:id="author-52"><persName><forename type="first">Philip</forename><surname>Asherson</surname></persName><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</affiliation></author></analytic><monogr><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="pISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><idno type="DOI">10.1002/(ISSN)1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-05"></date><biblScope unit="volume">147B</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1392">1392</biblScope><biblScope unit="page" to="1398">1398</biblScope></imprint></monogr><idno type="istex">B0F83818028A4010A3FEE7AA60DBB739E3DAB998</idno><idno type="DOI">10.1002/ajmg.b.30878</idno><idno type="ArticleID">AJMG30878</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>ADHD</term></item><item><term>GSMA</term></item><item><term>linkage</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-05-30">Received</change><change when="2008-08-28">Registration</change><change when="2008-12-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B0F83818028A4010A3FEE7AA60DBB739E3DAB998/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1552-485X</doi><issn type="print">1552-4841</issn><issn type="electronic">1552-485X</issn><idGroup><id type="product" value="AJMG"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="AMERICAN JOURNAL OF MEDICAL GENETICS PART B: NEUROPSYCHIATRIC GENETICS">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title type="short">Am. J. Med. Genet.</title></titleGroup><selfCitationGroup><citation type="ancestor" xml:id="cit1"><journalTitle>American Journal of Medical Genetics</journalTitle><accessionId ref="info:x-wiley/issn/01487299">0148-7299</accessionId><accessionId ref="info:x-wiley/issn/10968628">1096-8628</accessionId><pubYear year="2004">2004</pubYear></citation></selfCitationGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/ajmg.b.v147b:8</doi><titleGroup><title type="specialIssueTitle">Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd</title></titleGroup><numberingGroup><numbering type="journalVolume" number="147">147B</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2008-12-05">5 December 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ajmg.b.30878</doi><idGroup><id type="unit" value="AJMG30878"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title><title type="tocHeading2">Genome‐wide Linkage Studies of ADHD</title></titleGroup><copyright ownership="publisher">Copyright © 2008 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2008-05-30"></event><event type="manuscriptAccepted" date="2008-08-28"></event><event type="publishedOnlineEarlyUnpaginated" date="2008-11-05"></event><event type="firstOnline" date="2008-11-05"></event><event type="publishedOnlineFinalForm" date="2008-11-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-05-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">1392</numbering><numbering type="pageLast">1398</numbering></numberingGroup><correspondenceTo>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AJMG.AJMG30878.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="5097"></count></countGroup><titleGroup><title type="main" xml:lang="en">Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder<link href="#fn1"></link></title><title type="short" xml:lang="en">Attention Deficit Hyperactivity Disorder</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Kaixin</givenNames><familyName>Zhou</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Astrid</givenNames><familyName>Dempfle</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Mauricio</givenNames><familyName>Arcos‐Burgos</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Steven C.</givenNames><familyName>Bakker</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Tobias</givenNames><familyName>Banaschewski</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Joseph</givenNames><familyName>Biederman</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Jan</givenNames><familyName>Buitelaar</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af9"><personName><givenNames>F. 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UK</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="IT" type="organization"><unparsedAffiliation>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="NL" type="organization"><unparsedAffiliation>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af15" countryCode="DE" type="organization"><unparsedAffiliation>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af16" countryCode="DE" type="organization"><unparsedAffiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af17" countryCode="IE" type="organization"><unparsedAffiliation>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</unparsedAffiliation></affiliation><affiliation xml:id="af18" countryCode="DE" type="organization"><unparsedAffiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af19" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</unparsedAffiliation></affiliation><affiliation xml:id="af20" countryCode="CO" type="organization"><unparsedAffiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</unparsedAffiliation></affiliation><affiliation xml:id="af21" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af22" countryCode="ES" type="organization"><unparsedAffiliation>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af23" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af24" countryCode="DE" type="organization"><unparsedAffiliation>University Clinic for Child and Adolescent Psychiatry, Essen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af25" countryCode="US" type="organization"><unparsedAffiliation>The Broad Institute, MIT, Cambridge, Massachusetts</unparsedAffiliation></affiliation><affiliation xml:id="af26" countryCode="DE" type="organization"><unparsedAffiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af27" countryCode="BE" type="organization"><unparsedAffiliation>Ghent University, Dunantlaan, Ghent, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="af28" countryCode="DE" type="organization"><unparsedAffiliation>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af29" countryCode="NL" type="organization"><unparsedAffiliation>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af30" countryCode="US" type="organization"><unparsedAffiliation>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</unparsedAffiliation></affiliation><affiliation xml:id="af31" countryCode="GB" type="organization"><unparsedAffiliation>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</unparsedAffiliation></affiliation><affiliation xml:id="af32" countryCode="CH" type="organization"><unparsedAffiliation>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af33" countryCode="NL" type="organization"><unparsedAffiliation>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af34" countryCode="US" type="organization"><unparsedAffiliation>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">ADHD</keyword><keyword xml:id="kwd2">GSMA</keyword><keyword xml:id="kwd3">linkage</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>R01HD37694</fundingNumber><fundingNumber>R01MH62873</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIMH</fundingAgency><fundingNumber>MH058277</fundingNumber><fundingNumber>MH071852</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Academy of Finland (Ekholm)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>MRC</fundingAgency><fundingNumber>G0400960</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (<i>P</i><sub>SR</sub> = 0.00034, <i>P</i><sub>OR</sub> = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Please cite this article as follows: Zhou K, Dempfle A, Arcos‐Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar J, Castellanos FX, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muenke1 M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner TJ, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga‐Barke E, Steinhausen H.‐C, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P. 2008. Meta‐Analysis of Genome‐Wide Linkage Scans of Attention Deficit Hyperactivity Disorder. Am J Med Genet Part B 147B:1392–1398.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Attention Deficit Hyperactivity Disorder</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder</title></titleInfo><name type="personal"><namePart type="given">Kaixin</namePart><namePart type="family">Zhou</namePart><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Astrid</namePart><namePart type="family">Dempfle</namePart><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mauricio</namePart><namePart type="family">Arcos‐Burgos</namePart><affiliation>Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida</affiliation><affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Steven C.</namePart><namePart type="family">Bakker</namePart><affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tobias</namePart><namePart type="family">Banaschewski</namePart><affiliation>Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Biederman</namePart><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Buitelaar</namePart><affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. Xavier</namePart><namePart type="family">Castellanos</namePart><affiliation>Child Study Center, New York University, New York, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alysa</namePart><namePart type="family">Doyle</namePart><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard P.</namePart><namePart type="family">Ebstein</namePart><affiliation>Geha MHC, Petach‐Tikva, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jenny</namePart><namePart type="family">Ekholm</namePart><affiliation>Department of Human Genetics, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paola</namePart><namePart type="family">Forabosco</namePart><affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</affiliation><affiliation>Istituto di Genetica delle Popolazioni—CNR, Alghero, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Franke</namePart><affiliation>Department of Psychiatry, Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Nijmegen, The Netherlands</affiliation><affiliation>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Freitag</namePart><affiliation>Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susann</namePart><namePart type="family">Friedel</namePart><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael</namePart><namePart type="family">Gill</namePart><affiliation>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Johannes</namePart><namePart type="family">Hebebrand</namePart><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anke</namePart><namePart type="family">Hinney</namePart><affiliation>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Jacob</namePart><affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Klaus Peter</namePart><namePart type="family">Lesch</namePart><affiliation>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandra K.</namePart><namePart type="family">Loo</namePart><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francisco</namePart><namePart type="family">Lopera</namePart><affiliation>Neurosciences Group, University of Antioquia, Medellín, Colombia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James T.</namePart><namePart type="family">McCracken</namePart><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James J.</namePart><namePart type="family">McGough</namePart><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jobst</namePart><namePart type="family">Meyer</namePart><affiliation>Department of Neurobehavioral Genetics, University of Trier, Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric</namePart><namePart type="family">Mick</namePart><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ana</namePart><namePart type="family">Miranda</namePart><affiliation>Department of Developmental and Educational Psychology, University of Valencia, Valencia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maximilian</namePart><namePart type="family">Muenke1</namePart><affiliation>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fernando</namePart><namePart type="family">Mulas</namePart><affiliation>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stanley F.</namePart><namePart type="family">Nelson</namePart><affiliation>Department of Human Genetics, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.Trang</namePart><namePart type="family">Nguyen</namePart><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University 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type="personal"><namePart type="given">Marcel</namePart><namePart type="family">Romanos</namePart><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aribert</namePart><namePart type="family">Rothenberger</namePart><affiliation>Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helmut</namePart><namePart type="family">Schäfer</namePart><affiliation>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joseph</namePart><namePart type="family">Sergeant</namePart><affiliation>Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Richard J.</namePart><namePart type="family">Sinke</namePart><affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susan L.</namePart><namePart type="family">Smalley</namePart><affiliation>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><affiliation>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edmund</namePart><namePart type="family">Sonuga‐Barke</namePart><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>Child Study Center, New York University, New York, New York</affiliation><affiliation>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans‐Christoph</namePart><namePart type="family">Steinhausen</namePart><affiliation>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emma</namePart><namePart type="family">van der Meulen</namePart><affiliation>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susanne</namePart><namePart type="family">Walitza</namePart><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Warnke</namePart><affiliation>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Cathryn M</namePart><namePart type="family">Lewis</namePart><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>Department of Medical and Molecular Genetics, King's College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen V.</namePart><namePart type="family">Faraone</namePart><affiliation>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts</affiliation><affiliation>Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Philip</namePart><namePart type="family">Asherson</namePart><affiliation>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK</affiliation><affiliation>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF, UK.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-12-05</dateIssued><dateCaptured encoding="w3cdtf">2008-05-30</dateCaptured><dateValid encoding="w3cdtf">2008-08-28</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">28</extent><extent unit="words">5097</extent></physicalDescription><abstract lang="en">Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.</abstract><note type="content">*Please cite this article as follows: Zhou K, Dempfle A, Arcos‐Burgos M, Bakker SC, Banaschewski T, Biederman J, Buitelaar J, Castellanos FX, Doyle A, Ebstein RP, Ekholm J, Forabosco P, Franke B, Freitag C, Friedel S, Gill M, Hebebrand J, Hinney A, Jacob C, Lesch KP, Loo SK, Lopera F, McCracken JT, McGough JJ, Meyer J, Mick E, Miranda A, Muenke1 M, Mulas F, Nelson SF, Nguyen TT, Oades RD, Ogdie MN, Palacio JD, Pineda D, Reif A, Renner TJ, Roeyers H, Romanos M, Rothenberger A, Schäfer H, Sergeant J, Sinke RJ, Smalley SL, Sonuga‐Barke E, Steinhausen H.‐C, van der Meulen E, Walitza S, Warnke A, Lewis CM, Faraone SV, Asherson P. 2008. Meta‐Analysis of Genome‐Wide Linkage Scans of Attention Deficit Hyperactivity Disorder. Am J Med Genet Part B 147B:1392–1398.</note><note type="funding">NIH - No. R01HD37694; No. R01MH62873; </note><note type="funding">NIMH - No. MH058277; No. MH071852; </note><note type="funding">Academy of Finland (Ekholm)</note><note type="funding">MRC - No. G0400960; </note><subject lang="en"><genre>keywords</genre><topic>ADHD</topic><topic>GSMA</topic><topic>linkage</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Med. Genet.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1552-4841</identifier><identifier type="eISSN">1552-485X</identifier><identifier type="DOI">10.1002/(ISSN)1552-485X</identifier><identifier type="PublisherID">AJMG</identifier><part><date>2008</date><detail type="title"><title>Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd</title></detail><detail type="volume"><caption>vol.</caption><number>147B</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1392</start><end>1398</end><total>7</total></extent></part></relatedItem><relatedItem type="preceding"><titleInfo><title>American Journal of Medical Genetics</title></titleInfo><identifier type="ISSN">0148-7299</identifier><identifier type="ISSN">1096-8628</identifier><part><date point="end">2004</date></part></relatedItem><identifier type="istex">B0F83818028A4010A3FEE7AA60DBB739E3DAB998</identifier><identifier type="DOI">10.1002/ajmg.b.30878</identifier><identifier type="ArticleID">AJMG30878</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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