Pain sensitivity, cerebral laterality, and negative affect
Identifieur interne : 001039 ( Istex/Corpus ); précédent : 001038; suivant : 001040Pain sensitivity, cerebral laterality, and negative affect
Auteurs : Paul Pauli ; Georg Wiedemann ; Matthias NickolaSource :
- Pain [ 0304-3959 ] ; 1999.
Abstract
The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.
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DOI: 10.1016/S0304-3959(98)00231-0
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Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</mods:affiliation></affiliation></author><author><name sortKey="Wiedemann, Georg" sort="Wiedemann, Georg" uniqKey="Wiedemann G" first="Georg" last="Wiedemann">Georg Wiedemann</name><affiliation><mods:affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Nickola, Matthias" sort="Nickola, Matthias" uniqKey="Nickola M" first="Matthias" last="Nickola">Matthias Nickola</name><affiliation><mods:affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:00884A4F7EE6C7F0EE1173A895D613E522BD57EF</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0304-3959(98)00231-0</idno><idno type="url">https://api.istex.fr/document/00884A4F7EE6C7F0EE1173A895D613E522BD57EF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001039</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001039</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Pain sensitivity, cerebral laterality, and negative affect</title><author><name sortKey="Pauli, Paul" sort="Pauli, Paul" uniqKey="Pauli P" first="Paul" last="Pauli">Paul Pauli</name><affiliation><mods:affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</mods:affiliation></affiliation></author><author><name sortKey="Wiedemann, Georg" sort="Wiedemann, Georg" uniqKey="Wiedemann G" first="Georg" last="Wiedemann">Georg Wiedemann</name><affiliation><mods:affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Nickola, Matthias" sort="Nickola, Matthias" uniqKey="Nickola M" first="Matthias" last="Nickola">Matthias Nickola</name><affiliation><mods:affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pain</title><title level="j" type="abbrev">PAIN</title><idno type="ISSN">0304-3959</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="359">359</biblScope><biblScope unit="page" to="364">364</biblScope></imprint><idno type="ISSN">0304-3959</idno></series><idno type="istex">00884A4F7EE6C7F0EE1173A895D613E522BD57EF</idno><idno type="DOI">10.1016/S0304-3959(98)00231-0</idno><idno type="PII">S0304-3959(98)00231-0</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Paul Pauli</name><affiliations><json:string>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</json:string><json:string>Corresponding author. Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</json:string></affiliations></json:item><json:item><name>Georg Wiedemann</name><affiliations><json:string>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Matthias Nickola</name><affiliations><json:string>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</json:string><json:string>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Pain sensitivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cerebral laterality</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Affect</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Depression</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.</abstract><qualityIndicators><score>5.78</score><pdfVersion>1.2</pdfVersion><pdfPageSize>593 x 793 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1355</abstractCharCount><pdfWordCount>3524</pdfWordCount><pdfCharCount>22420</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>188</abstractWordCount></qualityIndicators><title>Pain sensitivity, cerebral laterality, and negative affect</title><pii><json:string>S0304-3959(98)00231-0</json:string></pii><refBibs><json:item><author><json:item><name>A.T Beck</name></json:item><json:item><name>R.A Steer</name></json:item><json:item><name>M.G Garbin</name></json:item></author><host><volume>8</volume><pages><last>100</last><first>77</first></pages><author></author><title>Clin. 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Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</affiliation></author><author xml:id="author-2"><persName><forename type="first">Georg</forename><surname>Wiedemann</surname></persName><affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Matthias</forename><surname>Nickola</surname></persName><affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</affiliation><affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</affiliation></author></analytic><monogr><title level="j">Pain</title><title level="j" type="abbrev">PAIN</title><idno type="pISSN">0304-3959</idno><idno type="PII">S0304-3959(00)X0049-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">80</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="359">359</biblScope><biblScope unit="page" to="364">364</biblScope></imprint></monogr><idno type="istex">00884A4F7EE6C7F0EE1173A895D613E522BD57EF</idno><idno type="DOI">10.1016/S0304-3959(98)00231-0</idno><idno type="PII">S0304-3959(98)00231-0</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Pain sensitivity</term></item><item><term>Cerebral laterality</term></item><item><term>Affect</term></item><item><term>Depression</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1998-10-12">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/00884A4F7EE6C7F0EE1173A895D613E522BD57EF/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity><istex:entity SYSTEM="gr2" NDATA="IMAGE" name="gr2"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PAIN</jid><aid>3828</aid><ce:pii>S0304-3959(98)00231-0</ce:pii><ce:doi>10.1016/S0304-3959(98)00231-0</ce:doi><ce:copyright year="1999" type="other">International Association for the Study of Pain</ce:copyright></item-info><head><ce:title>Pain sensitivity, cerebral laterality, and negative affect</ce:title><ce:author-group><ce:author><ce:given-name>Paul</ce:given-name><ce:surname>Pauli</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref><ce:cross-ref refid="CORR1">*</ce:cross-ref></ce:author><ce:author><ce:given-name>Georg</ce:given-name><ce:surname>Wiedemann</ce:surname><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:author><ce:given-name>Matthias</ce:given-name><ce:surname>Nickola</ce:surname><ce:cross-ref refid="AFF1">a</ce:cross-ref><ce:cross-ref refid="AFF2">b</ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</ce:textfn></ce:affiliation><ce:correspondence id="CORR1"><ce:label>*</ce:label><ce:text>Corresponding author. Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</ce:text></ce:correspondence></ce:author-group><ce:date-received day="13" month="7" year="1998"></ce:date-received><ce:date-revised day="12" month="10" year="1998"></ce:date-revised><ce:date-accepted day="27" month="10" year="1998"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Pain sensitivity</ce:text></ce:keyword><ce:keyword><ce:text>Cerebral laterality</ce:text></ce:keyword><ce:keyword><ce:text>Affect</ce:text></ce:keyword><ce:keyword><ce:text>Depression</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Pain sensitivity, cerebral laterality, and negative affect</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Pain sensitivity, cerebral laterality, and negative affect</title></titleInfo><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Pauli</namePart><affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</affiliation><affiliation>Corresponding author. Tel.: +49-7071-297-4513; fax: +49-7071-295-956; e-mail: paul.pauli@uni-tuebingen.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georg</namePart><namePart type="family">Wiedemann</namePart><affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthias</namePart><namePart type="family">Nickola</namePart><affiliation>Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstr. 29, D-72074 Tübingen, Germany</affiliation><affiliation>University Hospital of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 22, D-72076 Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateModified encoding="w3cdtf">1998-10-12</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The right hemisphere is assumed to play a unique role for pain sensitivity and negative affect. Pressure pain thresholds were assessed daily in eight right-handed participants over a 6-week period in order to obtain reliable measures of pain sensitivity unaffected by situational influences. In an additional session, cerebral laterality was assessed with behavioral and an EEG measures. Psychometric measures were used to examine emotionality (depression, neuroticism). Pain thresholds were lower on the left compared with the right hand, and pain thresholds increased within the first 3-measurement weeks. Enhanced pain sensitivity as reflected in weekly pain threshold was associated with a increased right frontal compared with left frontal brain activity as indicated by EEG, with a left-visual field advantage in the perception of emotional faces, and with increased negative affect (depression, neuroticism). In addition, a significant positive correlation between a relatively increased right frontal brain activity and depression was found. Correlations between pain thresholds and `non-emotional' laterality measures (central or parietal EEG asymmetry, dichotic consonant-vocal-recall test) were not significant. We conclude that a right frontal brain hyperactivity might be a biological marker for enhanced pain sensitivity and negative affect.</abstract><note type="content">Fig. 1: Weekly pressure pain thresholds (PPT) assessed over 6 weeks at the dorsal side of the middle phalanx of the left and right middle fingers.</note><note type="content">Fig. 2: Associations between weekly pain thresholds during week 6 and laterality scores as assessed by the emotional faces tests (EFT; RT measure), or asymmetry in frontal brain activity (alpha power) during the eyes closed phases.</note><note type="content">Table 1: Correlations between pain thresholds and laterality scores</note><subject><genre>Keywords</genre><topic>Pain sensitivity</topic><topic>Cerebral laterality</topic><topic>Affect</topic><topic>Depression</topic></subject><relatedItem type="host"><titleInfo><title>Pain</title></titleInfo><titleInfo type="abbreviated"><title>PAIN</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19990301</dateIssued></originInfo><identifier type="ISSN">0304-3959</identifier><identifier type="PII">S0304-3959(00)X0049-8</identifier><part><date>19990301</date><detail type="volume"><number>80</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>452</end></extent><extent unit="pages"><start>359</start><end>364</end></extent></part></relatedItem><identifier type="istex">00884A4F7EE6C7F0EE1173A895D613E522BD57EF</identifier><identifier type="DOI">10.1016/S0304-3959(98)00231-0</identifier><identifier type="PII">S0304-3959(98)00231-0</identifier><accessCondition type="use and reproduction" contentType="copyright">©1999 International Association for the Study of Pain</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>International Association for the Study of Pain, ©1999</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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