Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances
Identifieur interne : 000C13 ( Istex/Corpus ); précédent : 000C12; suivant : 000C14Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances
Auteurs : Claudia Skazik ; Silke Grannemann ; Liane Wilbers ; Hans F. Merk ; Pieter-Jan Coenraads ; Sebastian Breuer ; Brunhilde BlömekeSource :
- Contact Dermatitis [ 0105-1873 ] ; 2008-10.
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Abstract
Background: Patch tests to p‐phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross‐reactivity.
Url:
DOI: 10.1111/j.1600-0536.2008.01416.x
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ISTEX:11B4B495771EECF8B0F66D3A07F1B7D9F938C002Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title><author><name sortKey="Skazik, Claudia" sort="Skazik, Claudia" uniqKey="Skazik C" first="Claudia" last="Skazik">Claudia Skazik</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grannemann, Silke" sort="Grannemann, Silke" uniqKey="Grannemann S" first="Silke" last="Grannemann">Silke Grannemann</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wilbers, Liane" sort="Wilbers, Liane" uniqKey="Wilbers L" first="Liane" last="Wilbers">Liane Wilbers</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation></author><author><name sortKey="Merk, Hans F" sort="Merk, Hans F" uniqKey="Merk H" first="Hans F." last="Merk">Hans F. Merk</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation></author><author><name sortKey="Coenraads, Pieter An" sort="Coenraads, Pieter An" uniqKey="Coenraads P" first="Pieter-Jan" last="Coenraads">Pieter-Jan Coenraads</name><affiliation><mods:affiliation>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Breuer, Sebastian" sort="Breuer, Sebastian" uniqKey="Breuer S" first="Sebastian" last="Breuer">Sebastian Breuer</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Blomeke, Brunhilde" sort="Blomeke, Brunhilde" uniqKey="Blomeke B" first="Brunhilde" last="Blömeke">Brunhilde Blömeke</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: bloemeke@uni‐trier.de</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:11B4B495771EECF8B0F66D3A07F1B7D9F938C002</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1600-0536.2008.01416.x</idno><idno type="url">https://api.istex.fr/document/11B4B495771EECF8B0F66D3A07F1B7D9F938C002/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C13</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title><author><name sortKey="Skazik, Claudia" sort="Skazik, Claudia" uniqKey="Skazik C" first="Claudia" last="Skazik">Claudia Skazik</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grannemann, Silke" sort="Grannemann, Silke" uniqKey="Grannemann S" first="Silke" last="Grannemann">Silke Grannemann</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Wilbers, Liane" sort="Wilbers, Liane" uniqKey="Wilbers L" first="Liane" last="Wilbers">Liane Wilbers</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation></author><author><name sortKey="Merk, Hans F" sort="Merk, Hans F" uniqKey="Merk H" first="Hans F." last="Merk">Hans F. Merk</name><affiliation><mods:affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</mods:affiliation></affiliation></author><author><name sortKey="Coenraads, Pieter An" sort="Coenraads, Pieter An" uniqKey="Coenraads P" first="Pieter-Jan" last="Coenraads">Pieter-Jan Coenraads</name><affiliation><mods:affiliation>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Breuer, Sebastian" sort="Breuer, Sebastian" uniqKey="Breuer S" first="Sebastian" last="Breuer">Sebastian Breuer</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Blomeke, Brunhilde" sort="Blomeke, Brunhilde" uniqKey="Blomeke B" first="Brunhilde" last="Blömeke">Brunhilde Blömeke</name><affiliation><mods:affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: bloemeke@uni‐trier.de</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Contact Dermatitis</title><idno type="ISSN">0105-1873</idno><idno type="eISSN">1600-0536</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-10">2008-10</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="203">203</biblScope><biblScope unit="page" to="211">211</biblScope></imprint><idno type="ISSN">0105-1873</idno></series><idno type="istex">11B4B495771EECF8B0F66D3A07F1B7D9F938C002</idno><idno type="DOI">10.1111/j.1600-0536.2008.01416.x</idno><idno type="ArticleID">COD1416</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-1873</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>T‐cell clones</term><term>Vβ analysis</term><term>cross‐reaction</term><term>delayed‐type hypersensitivity</term><term>para‐amino compounds</term><term>p‐phenylenediamine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: Patch tests to p‐phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross‐reactivity.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Claudia Skazik</name><affiliations><json:string>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</json:string><json:string>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</json:string></affiliations></json:item><json:item><name>Silke Grannemann</name><affiliations><json:string>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</json:string></affiliations></json:item><json:item><name>Liane Wilbers</name><affiliations><json:string>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</json:string></affiliations></json:item><json:item><name>Hans F. Merk</name><affiliations><json:string>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</json:string></affiliations></json:item><json:item><name>Pieter‐Jan Coenraads</name><affiliations><json:string>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</json:string></affiliations></json:item><json:item><name>Sebastian Breuer</name><affiliations><json:string>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</json:string></affiliations></json:item><json:item><name>Brunhilde Blömeke</name><affiliations><json:string>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</json:string><json:string>E-mail: bloemeke@uni‐trier.de</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cross‐reaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>delayed‐type hypersensitivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>para‐amino compounds</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>p‐phenylenediamine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>T‐cell clones</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Vβ analysis</value></json:item></subject><articleId><json:string>COD1416</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.825</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 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sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1111/j.1600-0536.2008.01416.x</json:string></doi><id>11B4B495771EECF8B0F66D3A07F1B7D9F938C002</id><score>1.2096095</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/11B4B495771EECF8B0F66D3A07F1B7D9F938C002/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/11B4B495771EECF8B0F66D3A07F1B7D9F938C002/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/11B4B495771EECF8B0F66D3A07F1B7D9F938C002/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard</p></availability><date>2008</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title><author xml:id="author-1"><persName><forename type="first">Claudia</forename><surname>Skazik</surname></persName><note type="biography">Note: Present address: Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany</note><note type="biography">These authors contributed equally to this work.</note><affiliation>Note: Present address: Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany</affiliation><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Silke</forename><surname>Grannemann</surname></persName><note type="biography">These authors contributed equally to this work.</note><affiliation>These authors contributed equally to this work.</affiliation><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Liane</forename><surname>Wilbers</surname></persName><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation></author><author xml:id="author-4"><persName><forename type="first">Hans F.</forename><surname>Merk</surname></persName><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation></author><author xml:id="author-5"><persName><forename type="first">Pieter‐Jan</forename><surname>Coenraads</surname></persName><affiliation>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</affiliation></author><author xml:id="author-6"><persName><forename type="first">Sebastian</forename><surname>Breuer</surname></persName><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">Brunhilde</forename><surname>Blömeke</surname></persName><email>bloemeke@uni‐trier.de</email><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation></author></analytic><monogr><title level="j">Contact Dermatitis</title><idno type="pISSN">0105-1873</idno><idno type="eISSN">1600-0536</idno><idno type="DOI">10.1111/(ISSN)1600-0536</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-10"></date><biblScope unit="volume">59</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="203">203</biblScope><biblScope unit="page" to="211">211</biblScope></imprint></monogr><idno type="istex">11B4B495771EECF8B0F66D3A07F1B7D9F938C002</idno><idno type="DOI">10.1111/j.1600-0536.2008.01416.x</idno><idno type="ArticleID">COD1416</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background: Patch tests to p‐phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross‐reactivity.</p></abstract><abstract><p>Objectives: In order to understand the health risks associated with cross‐reactivity, we studied cross‐reactivity of eight chemicals in vitro by measurement of T‐cell proliferation of peripheral blood mononuclear cells (PBMC), T‐cell lines (TCL), and T‐cell clones (TCC) of subjects with a positive patch test result to PPD.</p></abstract><abstract><p>Patients/Methods: We studied PBMC from 13 patients and were able to generate TCL from seven and TCC from four patients. Their proliferative responses to the chemicals were estimated.</p></abstract><abstract><p>Results: Concurrent reactions to these compounds on the polyclonal and monoclonal level were found. A restricted T‐cell receptor (TCR) Vβ16‐usage was observed (5/8 clones). A detailed analysis of 34 TCL showed broad cross‐reactivity (64.7%) between PPD, p‐toluenediamine, Bandrowski’s Base, and p‐aminoazobenzene. More restricted patterns were found in 8.8%, which responded only to compounds with two or three benzene rings, whereas 26.5% of the clones reacted specifically only to one compound.</p></abstract><abstract><p>Conclusion: More than 60% of the clones showed a broad cross‐reactivity pattern. Hence, clinically observed cross‐reactivity between different para‐amino compounds can be based on a TCR recognizing similar epitopes of these compounds with low specificity.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>cross‐reaction</term></item><item><term>delayed‐type hypersensitivity</term></item><item><term>para‐amino compounds</term></item><item><term>p‐phenylenediamine</term></item><item><term>T‐cell clones</term></item><item><term>Vβ analysis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/11B4B495771EECF8B0F66D3A07F1B7D9F938C002/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0536</doi><issn type="print">0105-1873</issn><issn type="electronic">1600-0536</issn><idGroup><id type="product" value="COD"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="CONTACT DERMATITIS">Contact Dermatitis</title></titleGroup></publicationMeta><publicationMeta level="part" position="10004"><doi origin="wiley">10.1111/cod.2008.59.issue-4</doi><numberingGroup><numbering type="journalVolume" number="59">59</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2008-10">October 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="2" status="forIssue"><doi origin="wiley">10.1111/j.1600-0536.2008.01416.x</doi><idGroup><id type="unit" value="COD1416"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1"><i>Original Articles</i></title></titleGroup><copyright>© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard</copyright><eventGroup><event type="firstOnline" date="2008-09-30"></event><event type="publishedOnlineFinalForm" date="2008-09-30"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:HeaderRef result:HeaderRef" date="2010-07-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="203">203</numbering><numbering type="pageLast" number="211">211</numbering></numberingGroup><correspondenceTo><i>Brunhilde Blömeke
Department of Environmental Toxicology
University Trier
Am Wissenschaftspark 25‐27
54296 Trier
Germany
Tel: 49 651 201 3781
Fax: 49 651 201 3780
e‐mail: </i><email normalForm="bloemeke@uni-trier.de">bloemeke@uni‐trier.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:COD.COD1416.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 13 May 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="0"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Reactivity of <i>in vitro </i>activated human T lymphocytes to <i>p</i>‐phenylenediamine and related substances</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2" noteRef="#fn1 #fn2"><personName><givenNames>Claudia</givenNames><familyName>Skazik</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2" noteRef="#fn2"><personName><givenNames>Silke</givenNames><familyName>Grannemann</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Liane</givenNames><familyName>Wilbers</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Hans F.</givenNames><familyName>Merk</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a3"><personName><givenNames>Pieter‐Jan</givenNames><familyName>Coenraads</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Sebastian</givenNames><familyName>Breuer</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2" corresponding="yes"><personName><givenNames>Brunhilde</givenNames><familyName>Blömeke</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="NL"><unparsedAffiliation>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cross‐reaction</keyword><keyword xml:id="k2">delayed‐type hypersensitivity</keyword><keyword xml:id="k3">para‐amino compounds</keyword><keyword xml:id="k4"><i>p</i>‐phenylenediamine</keyword><keyword xml:id="k5">T‐cell clones</keyword><keyword xml:id="k6">Vβ analysis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> Patch tests to <i>p</i>‐phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross‐reactivity.</p><p><b>Objectives: </b> In order to understand the health risks associated with cross‐reactivity, we studied cross‐reactivity of eight chemicals <i>in vitro </i>by measurement of T‐cell proliferation of peripheral blood mononuclear cells (PBMC), T‐cell lines (TCL), and T‐cell clones (TCC) of subjects with a positive patch test result to PPD.</p><p><b>Patients/Methods: </b> We studied PBMC from 13 patients and were able to generate TCL from seven and TCC from four patients. Their proliferative responses to the chemicals were estimated.</p><p><b>Results: </b> Concurrent reactions to these compounds on the polyclonal and monoclonal level were found. A restricted T‐cell receptor (TCR) Vβ16‐usage was observed (5/8 clones). A detailed analysis of 34 TCL showed broad cross‐reactivity (64.7%) between PPD, <i>p</i>‐toluenediamine, Bandrowski’s Base, and <i>p</i>‐aminoazobenzene. More restricted patterns were found in 8.8%, which responded only to compounds with two or three benzene rings, whereas 26.5% of the clones reacted specifically only to one compound.</p><p><b>Conclusion: </b> More than 60% of the clones showed a broad cross‐reactivity pattern. Hence, clinically observed cross‐reactivity between different para‐amino compounds can be based on a TCR recognizing similar epitopes of these compounds with low specificity.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p> Present address: Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany</p></note><note xml:id="fn2"><label><sup>†</sup></label><p> These authors contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Reactivity of in vitro activated human T lymphocytes to p‐phenylenediamine and related substances</title></titleInfo><name type="personal"><namePart type="given">Claudia</namePart><namePart type="family">Skazik</namePart><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation><description>Note: Present address: Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany</description><description>These authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Silke</namePart><namePart type="family">Grannemann</namePart><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation><description>These authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Liane</namePart><namePart type="family">Wilbers</namePart><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans F.</namePart><namePart type="family">Merk</namePart><affiliation>Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pieter‐Jan</namePart><namePart type="family">Coenraads</namePart><affiliation>Department of Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sebastian</namePart><namePart type="family">Breuer</namePart><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brunhilde</namePart><namePart type="family">Blömeke</namePart><affiliation>Department of Environmental Toxicology, University of Trier, 54296 Trier, Germany</affiliation><affiliation>E-mail: bloemeke@uni‐trier.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-10</dateIssued><edition>Accepted for publication 13 May 2008</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">2</extent><extent unit="references">35</extent></physicalDescription><abstract>Background: Patch tests to p‐phenylenediamine (PPD) and related substances often show concurrent reactions that can be attributed to separate sensitization or cross‐reactivity.</abstract><abstract>Objectives: In order to understand the health risks associated with cross‐reactivity, we studied cross‐reactivity of eight chemicals in vitro by measurement of T‐cell proliferation of peripheral blood mononuclear cells (PBMC), T‐cell lines (TCL), and T‐cell clones (TCC) of subjects with a positive patch test result to PPD.</abstract><abstract>Patients/Methods: We studied PBMC from 13 patients and were able to generate TCL from seven and TCC from four patients. Their proliferative responses to the chemicals were estimated.</abstract><abstract>Results: Concurrent reactions to these compounds on the polyclonal and monoclonal level were found. A restricted T‐cell receptor (TCR) Vβ16‐usage was observed (5/8 clones). A detailed analysis of 34 TCL showed broad cross‐reactivity (64.7%) between PPD, p‐toluenediamine, Bandrowski’s Base, and p‐aminoazobenzene. More restricted patterns were found in 8.8%, which responded only to compounds with two or three benzene rings, whereas 26.5% of the clones reacted specifically only to one compound.</abstract><abstract>Conclusion: More than 60% of the clones showed a broad cross‐reactivity pattern. Hence, clinically observed cross‐reactivity between different para‐amino compounds can be based on a TCR recognizing similar epitopes of these compounds with low specificity.</abstract><subject lang="en"><genre>keywords</genre><topic>cross‐reaction</topic><topic>delayed‐type hypersensitivity</topic><topic>para‐amino compounds</topic><topic>p‐phenylenediamine</topic><topic>T‐cell clones</topic><topic>Vβ analysis</topic></subject><relatedItem type="host"><titleInfo><title>Contact Dermatitis</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0105-1873</identifier><identifier type="eISSN">1600-0536</identifier><identifier type="DOI">10.1111/(ISSN)1600-0536</identifier><identifier type="PublisherID">COD</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>203</start><end>211</end><total>9</total></extent></part></relatedItem><identifier type="istex">11B4B495771EECF8B0F66D3A07F1B7D9F938C002</identifier><identifier type="DOI">10.1111/j.1600-0536.2008.01416.x</identifier><identifier type="ArticleID">COD1416</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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