Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication
Identifieur interne : 000B65 ( Istex/Corpus ); précédent : 000B64; suivant : 000B66Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication
Auteurs : Clemens Kirschbaum ; Karl-Martin Pirke ; Dirk H. HellhammerSource :
- Psychoneuroendocrinology [ 0306-4530 ] ; 1995.
Abstract
In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (n = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.
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DOI: 10.1016/0306-4530(94)00078-O
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ISTEX:5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</title><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: Kirschba@Pcmail.uni.tirer.de</mods:affiliation></affiliation></author><author><name sortKey="Pirke, Karl Martin" sort="Pirke, Karl Martin" uniqKey="Pirke K" first="Karl-Martin" last="Pirke">Karl-Martin Pirke</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0306-4530(94)00078-O</idno><idno type="url">https://api.istex.fr/document/5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B65</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</title><author><name sortKey="Kirschbaum, Clemens" sort="Kirschbaum, Clemens" uniqKey="Kirschbaum C" first="Clemens" last="Kirschbaum">Clemens Kirschbaum</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: Kirschba@Pcmail.uni.tirer.de</mods:affiliation></affiliation></author><author><name sortKey="Pirke, Karl Martin" sort="Pirke, Karl Martin" uniqKey="Pirke K" first="Karl-Martin" last="Pirke">Karl-Martin Pirke</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Psychoneuroendocrinology</title><title level="j" type="abbrev">PNEC</title><idno type="ISSN">0306-4530</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="509">509</biblScope><biblScope unit="page" to="514">514</biblScope></imprint><idno type="ISSN">0306-4530</idno></series><idno type="istex">5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509</idno><idno type="DOI">10.1016/0306-4530(94)00078-O</idno><idno type="PII">0306-4530(94)00078-O</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-4530</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (n = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Clemens Kirschbaum</name><affiliations><json:string>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</json:string><json:string>E-mail: Kirschba@Pcmail.uni.tirer.de</json:string></affiliations></json:item><json:item><name>Karl-martin Pirke</name><affiliations><json:string>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</json:string></affiliations></json:item><json:item><name>Dirk H. Hellhammer</name><affiliations><json:string>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Cortisol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Contraceptive pill</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Humans</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Laboratory stressor</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Affect</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sex steroids</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (n = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.</abstract><qualityIndicators><score>4.654</score><pdfVersion>1.3</pdfVersion><pdfPageSize>468 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1193</abstractCharCount><pdfWordCount>2554</pdfWordCount><pdfCharCount>17084</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>175</abstractWordCount></qualityIndicators><title>Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</title><pii><json:string>0306-4530(94)00078-O</json:string></pii><refBibs><json:item><author><json:item><name>B. Allolio</name></json:item><json:item><name>U. Deuβ</name></json:item><json:item><name>D. Kaulen</name></json:item><json:item><name>G. Feltes</name></json:item><json:item><name>P. 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Hellhammer, University of trier, Universitaetsring 15, D-54286 Trier, Germany</affiliation><affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</affiliation></author></analytic><monogr><title level="j">Psychoneuroendocrinology</title><title level="j" type="abbrev">PNEC</title><idno type="pISSN">0306-4530</idno><idno type="PII">S0306-4530(00)X0007-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="509">509</biblScope><biblScope unit="page" to="514">514</biblScope></imprint></monogr><idno type="istex">5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509</idno><idno type="DOI">10.1016/0306-4530(94)00078-O</idno><idno type="PII">0306-4530(94)00078-O</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (n = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Cortisol</term></item><item><term>Contraceptive pill</term></item><item><term>Humans</term></item><item><term>Laboratory stressor</term></item><item><term>Affect</term></item><item><term>Sex steroids</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PNEC</jid><aid>9400078O</aid><ce:pii>0306-4530(94)00078-O</ce:pii><ce:doi>10.1016/0306-4530(94)00078-O</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Article</ce:textfn></ce:dochead><ce:title>Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</ce:title><ce:author-group><ce:author><ce:given-name>Clemens</ce:given-name><ce:surname>Kirschbaum</ce:surname><ce:e-address>Kirschba@Pcmail.uni.tirer.de</ce:e-address></ce:author><ce:author><ce:given-name>Karl-martin</ce:given-name><ce:surname>Pirke</ce:surname></ce:author><ce:author><ce:given-name>Dirk H.</ce:given-name><ce:surname>Hellhammer</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address correspondence and reprint requests to: Prof. Dr. D.H. Hellhammer, University of trier, Universitaetsring 15, D-54286 Trier, Germany</ce:text></ce:correspondence></ce:author-group><ce:date-received day="10" month="6" year="1994"></ce:date-received><ce:date-accepted day="4" month="10" year="1994"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; <ce:italic>n</ce:italic> = 28) and in control women (<ce:italic>n</ce:italic> = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (<ce:italic>n</ce:italic> = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Cortisol</ce:text></ce:keyword><ce:keyword><ce:text>Contraceptive pill</ce:text></ce:keyword><ce:keyword><ce:text>Humans</ce:text></ce:keyword><ce:keyword><ce:text>Laboratory stressor</ce:text></ce:keyword><ce:keyword><ce:text>Affect</ce:text></ce:keyword><ce:keyword><ce:text>Sex steroids</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication</title></titleInfo><name type="personal"><namePart type="given">Clemens</namePart><namePart type="family">Kirschbaum</namePart><affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</affiliation><affiliation>E-mail: Kirschba@Pcmail.uni.tirer.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karl-martin</namePart><namePart type="family">Pirke</namePart><affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk H.</namePart><namePart type="family">Hellhammer</namePart><affiliation>Center for Psychobiology and Psychosomatic Research, University of Trier, Germany</affiliation><description>Address correspondence and reprint requests to: Prof. Dr. D.H. Hellhammer, University of trier, Universitaetsring 15, D-54286 Trier, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29). While no significant differences in baseline levels were observed, altered adrenocortical responses were found in OC users. These women showed significantly attenuated cortisol responses to the experimental stressor in both studied, with peak cortisol levels only slightly eleveated above baseline levels. These differences could not be attributed to affective responses as indicated in ratings on visual analogue scales assessing subjective stress responses (Study 2). A comparison between control women and men (n = 19) again revealed the previously reported result of larger cortisol responses to psychological stress in males. We conclude that the use of OC may interfer with the adrenocortical response to psychological stress and should therefore be viewed as an important intervening variable. While it appears that differences at a supra-adrenal site is responsible for the observed cortisol hyporesponsiveness in OC users, the physiological mechanisms remain to be elucidated.</abstract><note type="content">Section title: Article</note><subject><genre>Keywords</genre><topic>Cortisol</topic><topic>Contraceptive pill</topic><topic>Humans</topic><topic>Laboratory stressor</topic><topic>Affect</topic><topic>Sex steroids</topic></subject><relatedItem type="host"><titleInfo><title>Psychoneuroendocrinology</title></titleInfo><titleInfo type="abbreviated"><title>PNEC</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">1995</dateIssued></originInfo><identifier type="ISSN">0306-4530</identifier><identifier type="PII">S0306-4530(00)X0007-8</identifier><part><date>1995</date><detail type="volume"><number>20</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue pages"><start>451</start><end>559</end></extent><extent unit="pages"><start>509</start><end>514</end></extent></part></relatedItem><identifier type="istex">5058DBCAD6D04EB736B266DE5E1D1CB0E2B07509</identifier><identifier type="DOI">10.1016/0306-4530(94)00078-O</identifier><identifier type="PII">0306-4530(94)00078-O</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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