Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population
Identifieur interne : 000B42 ( Istex/Corpus ); précédent : 000B41; suivant : 000B43Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population
Auteurs : Hsin-An Chang ; Ru-Band Lu ; Wei-Wen Lin ; Chuan-Chia Chang ; Chih-Lun Chen ; Mee-Jen Shy ; San-Yuan HuangSource :
- Acta Neuropsychiatrica [ 0924-2708 ] ; 2007-12.
English descriptors
Abstract
Background: The Ser9Gly polymorphism in dopamine D3 receptor gene (DRD3) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.
Url:
DOI: 10.1111/j.1601-5215.2007.00214.x
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ISTEX:A69F0013B45C0832B863165A09771AE383D68F23Le document en format XML
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Wei En" uniqKey="Lin W" first="Wei-Wen" last="Lin">Wei-Wen Lin</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chang, Chuan Hia" sort="Chang, Chuan Hia" uniqKey="Chang C" first="Chuan-Chia" last="Chang">Chuan-Chia Chang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Chih Un" sort="Chen, Chih Un" uniqKey="Chen C" first="Chih-Lun" last="Chen">Chih-Lun Chen</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Shy, Mee En" sort="Shy, Mee En" uniqKey="Shy M" first="Mee-Jen" last="Shy">Mee-Jen Shy</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, San Uan" sort="Huang, San Uan" uniqKey="Huang S" first="San-Yuan" last="Huang">San-Yuan Huang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hsy@ndmctsgh.edu.tw</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A69F0013B45C0832B863165A09771AE383D68F23</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1111/j.1601-5215.2007.00214.x</idno><idno type="url">https://api.istex.fr/document/A69F0013B45C0832B863165A09771AE383D68F23/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B42</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title><author><name sortKey="Chang, Hsin N" sort="Chang, Hsin N" uniqKey="Chang H" first="Hsin-An" last="Chang">Hsin-An Chang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lu, Ru And" sort="Lu, Ru And" uniqKey="Lu R" first="Ru-Band" last="Lu">Ru-Band Lu</name><affiliation><mods:affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China</mods:affiliation></affiliation></author><author><name sortKey="Lin, Wei En" sort="Lin, Wei En" uniqKey="Lin W" first="Wei-Wen" last="Lin">Wei-Wen Lin</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chang, Chuan Hia" sort="Chang, Chuan Hia" uniqKey="Chang C" first="Chuan-Chia" last="Chang">Chuan-Chia Chang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Chih Un" sort="Chen, Chih Un" uniqKey="Chen C" first="Chih-Lun" last="Chen">Chih-Lun Chen</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Shy, Mee En" sort="Shy, Mee En" uniqKey="Shy M" first="Mee-Jen" last="Shy">Mee-Jen Shy</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, San Uan" sort="Huang, San Uan" uniqKey="Huang S" first="San-Yuan" last="Huang">San-Yuan Huang</name><affiliation><mods:affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: hsy@ndmctsgh.edu.tw</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropsychiatrica</title><idno type="ISSN">0924-2708</idno><idno type="eISSN">1601-5215</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-12">2007-12</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="344">344</biblScope><biblScope unit="page" to="350">350</biblScope></imprint><idno type="ISSN">0924-2708</idno></series><idno type="istex">A69F0013B45C0832B863165A09771AE383D68F23</idno><idno type="DOI">10.1111/j.1601-5215.2007.00214.x</idno><idno type="ArticleID">ACN214</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0924-2708</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>association</term><term>dopamine D3 receptor gene</term><term>polymorphism</term><term>schizophrenia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: The Ser9Gly polymorphism in dopamine D3 receptor gene (DRD3) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hsin‐An Chang</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Ru‐Band Lu</name><affiliations><json:string>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</json:string><json:string>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China</json:string></affiliations></json:item><json:item><name>Wei‐Wen Lin</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Chuan‐Chia Chang</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Chih‐Lun Chen</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Mee‐Jen Shy</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>San‐Yuan Huang</name><affiliations><json:string>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</json:string><json:string>E-mail: hsy@ndmctsgh.edu.tw</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>association</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopamine D3 receptor gene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>polymorphism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>schizophrenia</value></json:item></subject><articleId><json:string>ACN214</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.581</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>311</abstractCharCount><pdfWordCount>4077</pdfWordCount><pdfCharCount>29059</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>42</abstractWordCount></qualityIndicators><title>Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title><refBibs><json:item><author><json:item><name>KL Davis</name></json:item><json:item><name>RS Kahn</name></json:item><json:item><name>G Ko</name></json:item><json:item><name>M Davidson</name></json:item></author><host><volume>148</volume><pages><last>1486</last><first>1474</first></pages><author></author><title>Am J Psychiatry</title></host><title>Dopamine in schizophrenia: a review and reconceptualization</title></json:item><json:item><author><json:item><name>JM Van Rossum</name></json:item></author><host><volume>160</volume><pages><last>494</last><first>492</first></pages><author></author><title>Arch Int Pharmacodyn Ther</title></host><title>The significance of dopamine‐receptor blockade for the mechanism of action of neuroleptic drugs</title></json:item><json:item><author><json:item><name>P Sokoloff</name></json:item><json:item><name>B Giros</name></json:item><json:item><name>MP Martres</name></json:item><json:item><name>ML Bouthenet</name></json:item><json:item><name>JC Schwartz</name></json:item></author><host><volume>347</volume><pages><last>151</last><first>146</first></pages><author></author><title>Nature</title></host><title>Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics</title></json:item><json:item><author><json:item><name>EV Gurevich</name></json:item><json:item><name>Y Bordelon</name></json:item><json:item><name>RM Shapiro</name></json:item><json:item><name>SE Arnold</name></json:item><json:item><name>RE Gur</name></json:item><json:item><name>JN Joyce</name></json:item></author><host><volume>54</volume><pages><last>232</last><first>225</first></pages><author></author><title>Arch Gen Psychiatry</title></host><title>Mesolimbic dopamine D3 receptors and use of antipsychotics in patients with schizophrenia. 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medicine</json:string><json:string>psychiatry</json:string></scienceMetrix></categories><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1111/j.1601-5215.2007.00214.x</json:string></doi><id>A69F0013B45C0832B863165A09771AE383D68F23</id><score>0.03349959</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/A69F0013B45C0832B863165A09771AE383D68F23/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/A69F0013B45C0832B863165A09771AE383D68F23/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A69F0013B45C0832B863165A09771AE383D68F23/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>2007 Blackwell Munksgaard</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title><author xml:id="author-1"><persName><forename type="first">Hsin‐An</forename><surname>Chang</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author><author xml:id="author-2"><persName><forename type="first">Ru‐Band</forename><surname>Lu</surname></persName><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China</affiliation></author><author xml:id="author-3"><persName><forename type="first">Wei‐Wen</forename><surname>Lin</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author><author xml:id="author-4"><persName><forename type="first">Chuan‐Chia</forename><surname>Chang</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author><author xml:id="author-5"><persName><forename type="first">Chih‐Lun</forename><surname>Chen</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author><author xml:id="author-6"><persName><forename type="first">Mee‐Jen</forename><surname>Shy</surname></persName><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author><author xml:id="author-7"><persName><forename type="first">San‐Yuan</forename><surname>Huang</surname></persName><email>hsy@ndmctsgh.edu.tw</email><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation></author></analytic><monogr><title level="j">Acta Neuropsychiatrica</title><idno type="pISSN">0924-2708</idno><idno type="eISSN">1601-5215</idno><idno type="DOI">10.1111/(ISSN)1601-5215</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-12"></date><biblScope unit="volume">19</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="344">344</biblScope><biblScope unit="page" to="350">350</biblScope></imprint></monogr><idno type="istex">A69F0013B45C0832B863165A09771AE383D68F23</idno><idno type="DOI">10.1111/j.1601-5215.2007.00214.x</idno><idno type="ArticleID">ACN214</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Background: The Ser9Gly polymorphism in dopamine D3 receptor gene (DRD3) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.</p></abstract><abstract><p>Objective: To determine whether the DRD3 Ser9Gly polymorphism is associated with schizophrenia or influences its psychopathological symptoms in Han Chinese population.</p></abstract><abstract><p>Method: We recruited 256 schizophrenic patients and 285 normal controls matched for gender, age and ethnicity. Pretreatment psychotic symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS) in 128 acutely exacerbated schizophrenic in‐patients. Genotyping of Ser9Gly polymorphism was performed with a polymerase chain reaction restriction fragment length polymorphism method and reconfirmed by a direct sequencing technique.</p></abstract><abstract><p>Results: No significant difference was found between either patients with schizophrenia or with more homogeneous schizophrenic subgroups and healthy controls in genotype distributions and allele frequencies for the DRD3 Ser9Gly polymorphism. Similarly, DRD3 Ser9Gly genotype differences failed to reach significance in PANSS global, positive, negative and general symptoms scores. There is a trend (P = 0.064) towards higher PANSS positive symptoms scores in subjects carrying the Gly/Gly genotype.</p></abstract><abstract><p>Conclusion: This study does not support the role of DRD3 Ser9Gly polymorphism in increasing genetic risk for schizophrenia in Han Chinese population. Still, there is a possibility that the DRD3 Ser9Gly variant may reflect genetic variation of severity of positive symptoms in acutely exacerbated schizophrenia. Further studies are warranted to investigate the effect of the DRD3 Ser9Gly polymorphism in relation to longer time course of schizophrenia, including treatment response to antipsychotics.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>association</term></item><item><term>dopamine D3 receptor gene</term></item><item><term>polymorphism</term></item><item><term>schizophrenia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A69F0013B45C0832B863165A09771AE383D68F23/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1601-5215</doi><issn type="print">0924-2708</issn><issn type="electronic">1601-5215</issn><idGroup><id type="product" value="ACN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA NEUROPSYCHIATRICA">Acta Neuropsychiatrica</title></titleGroup></publicationMeta><publicationMeta level="part" position="12006"><doi origin="wiley">10.1111/acn.2007.19.issue-6</doi><numberingGroup><numbering type="journalVolume" number="19">19</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2007-12">December 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1601-5215.2007.00214.x</doi><idGroup><id type="unit" value="ACN214"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>2007 Blackwell Munksgaard</copyright><eventGroup><event type="firstOnline" date="2007-07-27"></event><event type="publishedOnlineFinalForm" date="2007-07-27"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2013-12-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="344">344</numbering><numbering type="pageLast" number="350">350</numbering></numberingGroup><correspondenceTo>Dr San‐Yuan Huang, Department of Psychiatry,
Tri‐Service General Hospital, No. 325, Cheng‐Kung Road,
Sec. 2, Nei‐Hu District, Taipei 114, Taiwan, Republic of China.
Tel: +886‐2‐8792‐7220;
Fax: +886‐2‐8792‐6715;
E‐mail: <email>hsy@ndmctsgh.edu.tw</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ACN.ACN214.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="46"></count><count type="wordTotal" number="0"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Hsin‐An</givenNames><familyName>Chang</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3"><personName><givenNames>Ru‐Band</givenNames><familyName>Lu</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Wei‐Wen</givenNames><familyName>Lin</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Chuan‐Chia</givenNames><familyName>Chang</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Chih‐Lun</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Mee‐Jen</givenNames><familyName>Shy</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1" corresponding="yes"><personName><givenNames>San‐Yuan</givenNames><familyName>Huang</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CN"><unparsedAffiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">association</keyword><keyword xml:id="k2">dopamine D3 receptor gene</keyword><keyword xml:id="k3">polymorphism</keyword><keyword xml:id="k4">schizophrenia</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><!-- Chang H-A, Lu R-B, Lin W-W, Chang C-C, Chen C-L, Shy M-J, Huang S-Y. Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population.
<p><b>Background: </b> The Ser9Gly polymorphism in dopamine D3 receptor gene (<i>DRD3</i>) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.</p><p><b>Objective: </b> To determine whether the <i>DRD3 </i>Ser9Gly polymorphism is associated with schizophrenia or influences its psychopathological symptoms in Han Chinese population.</p><p><b>Method: </b> We recruited 256 schizophrenic patients and 285 normal controls matched for gender, age and ethnicity. Pretreatment psychotic symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS) in 128 acutely exacerbated schizophrenic in‐patients. Genotyping of Ser9Gly polymorphism was performed with a polymerase chain reaction restriction fragment length polymorphism method and reconfirmed by a direct sequencing technique.</p><p><b>Results: </b> No significant difference was found between either patients with schizophrenia or with more homogeneous schizophrenic subgroups and healthy controls in genotype distributions and allele frequencies for the <i>DRD3 </i>Ser9Gly polymorphism. Similarly, <i>DRD3 </i>Ser9Gly genotype differences failed to reach significance in PANSS global, positive, negative and general symptoms scores. There is a trend (<i>P </i>= 0.064) towards higher PANSS positive symptoms scores in subjects carrying the Gly/Gly genotype.</p><p><b>Conclusion: </b> This study does not support the role of <i>DRD3 </i>Ser9Gly polymorphism in increasing genetic risk for schizophrenia in Han Chinese population. Still, there is a possibility that the <i>DRD3 </i>Ser9Gly variant may reflect genetic variation of severity of positive symptoms in acutely exacerbated schizophrenia. Further studies are warranted to investigate the effect of the <i>DRD3 </i>Ser9Gly polymorphism in relation to longer time course of schizophrenia, including treatment response to antipsychotics.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population</title></titleInfo><name type="personal"><namePart type="given">Hsin‐An</namePart><namePart type="family">Chang</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ru‐Band</namePart><namePart type="family">Lu</namePart><affiliation>Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan</affiliation><affiliation>Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wei‐Wen</namePart><namePart type="family">Lin</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chuan‐Chia</namePart><namePart type="family">Chang</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chih‐Lun</namePart><namePart type="family">Chen</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mee‐Jen</namePart><namePart type="family">Shy</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">San‐Yuan</namePart><namePart type="family">Huang</namePart><affiliation>Department of Psychiatry, Tri‐Service General Hospital, Taipei, Taiwan</affiliation><affiliation>E-mail: hsy@ndmctsgh.edu.tw</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-12</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">46</extent></physicalDescription><abstract>Background: The Ser9Gly polymorphism in dopamine D3 receptor gene (DRD3) was considered an important factor in the pathogenesis of schizophrenia. Allele and genotype frequencies of this polymorphism were studied in different ethnic groups of schizophrenic patients. However, the results have been inconclusive.</abstract><abstract>Objective: To determine whether the DRD3 Ser9Gly polymorphism is associated with schizophrenia or influences its psychopathological symptoms in Han Chinese population.</abstract><abstract>Method: We recruited 256 schizophrenic patients and 285 normal controls matched for gender, age and ethnicity. Pretreatment psychotic symptoms were evaluated with the Positive and Negative Symptom Scale (PANSS) in 128 acutely exacerbated schizophrenic in‐patients. Genotyping of Ser9Gly polymorphism was performed with a polymerase chain reaction restriction fragment length polymorphism method and reconfirmed by a direct sequencing technique.</abstract><abstract>Results: No significant difference was found between either patients with schizophrenia or with more homogeneous schizophrenic subgroups and healthy controls in genotype distributions and allele frequencies for the DRD3 Ser9Gly polymorphism. Similarly, DRD3 Ser9Gly genotype differences failed to reach significance in PANSS global, positive, negative and general symptoms scores. There is a trend (P = 0.064) towards higher PANSS positive symptoms scores in subjects carrying the Gly/Gly genotype.</abstract><abstract>Conclusion: This study does not support the role of DRD3 Ser9Gly polymorphism in increasing genetic risk for schizophrenia in Han Chinese population. Still, there is a possibility that the DRD3 Ser9Gly variant may reflect genetic variation of severity of positive symptoms in acutely exacerbated schizophrenia. Further studies are warranted to investigate the effect of the DRD3 Ser9Gly polymorphism in relation to longer time course of schizophrenia, including treatment response to antipsychotics.</abstract><subject lang="en"><genre>keywords</genre><topic>association</topic><topic>dopamine D3 receptor gene</topic><topic>polymorphism</topic><topic>schizophrenia</topic></subject><relatedItem type="host"><titleInfo><title>Acta Neuropsychiatrica</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0924-2708</identifier><identifier type="eISSN">1601-5215</identifier><identifier type="DOI">10.1111/(ISSN)1601-5215</identifier><identifier type="PublisherID">ACN</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>344</start><end>350</end><total>7</total></extent></part></relatedItem><identifier type="istex">A69F0013B45C0832B863165A09771AE383D68F23</identifier><identifier type="DOI">10.1111/j.1601-5215.2007.00214.x</identifier><identifier type="ArticleID">ACN214</identifier><accessCondition type="use and reproduction" contentType="copyright">2007 Blackwell Munksgaard</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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