Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors
Identifieur interne : 000A55 ( Istex/Corpus ); précédent : 000A54; suivant : 000A56Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors
Auteurs : Paul Christian Schulze ; Volker Adams ; Christoph Busert ; Martin Bettag ; Thomas Kahn ; Thomas SchoberSource :
- Lasers in Surgery and Medicine [ 0196-8092 ] ; 2002-03.
English descriptors
- KwdEn :
- MRI, Nd:YAG‐laser, PCNA, apoptosis, glioma.
Abstract
Laser‐induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion.
Url:
DOI: 10.1002/lsm.10019
Links to Exploration step
ISTEX:45F5466C87EACECC3A9F3036EABE921B9BE3005ELe document en format XML
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Germany</mods:affiliation></affiliation></author><author><name sortKey="Busert, Christoph" sort="Busert, Christoph" uniqKey="Busert C" first="Christoph" last="Busert">Christoph Busert</name><affiliation><mods:affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bettag, Martin" sort="Bettag, Martin" uniqKey="Bettag M" first="Martin" last="Bettag">Martin Bettag</name><affiliation><mods:affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kahn, Thomas" sort="Kahn, Thomas" uniqKey="Kahn T" first="Thomas" last="Kahn">Thomas Kahn</name><affiliation><mods:affiliation>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schober, Thomas" sort="Schober, Thomas" uniqKey="Schober T" first="Thomas" last="Schober">Thomas Schober</name><affiliation><mods:affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:45F5466C87EACECC3A9F3036EABE921B9BE3005E</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/lsm.10019</idno><idno type="url">https://api.istex.fr/document/45F5466C87EACECC3A9F3036EABE921B9BE3005E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000A55</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000A55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title><author><name sortKey="Schulze, Paul Christian" sort="Schulze, Paul Christian" uniqKey="Schulze P" first="Paul Christian" last="Schulze">Paul Christian Schulze</name><affiliation><mods:affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Adams, Volker" sort="Adams, Volker" uniqKey="Adams V" first="Volker" last="Adams">Volker Adams</name><affiliation><mods:affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Busert, Christoph" sort="Busert, Christoph" uniqKey="Busert C" first="Christoph" last="Busert">Christoph Busert</name><affiliation><mods:affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bettag, Martin" sort="Bettag, Martin" uniqKey="Bettag M" first="Martin" last="Bettag">Martin Bettag</name><affiliation><mods:affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kahn, Thomas" sort="Kahn, Thomas" uniqKey="Kahn T" first="Thomas" last="Kahn">Thomas Kahn</name><affiliation><mods:affiliation>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schober, Thomas" sort="Schober, Thomas" uniqKey="Schober T" first="Thomas" last="Schober">Thomas Schober</name><affiliation><mods:affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Lasers in Surgery and Medicine</title><title level="j" type="sub">The Official Journal of the American Society for Laser Medicine and Surgery</title><title level="j" type="abbrev">Lasers Surg. Med.</title><idno type="ISSN">0196-8092</idno><idno type="eISSN">1096-9101</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="227">227</biblScope><biblScope unit="page" to="232">232</biblScope></imprint><idno type="ISSN">0196-8092</idno></series><idno type="istex">45F5466C87EACECC3A9F3036EABE921B9BE3005E</idno><idno type="DOI">10.1002/lsm.10019</idno><idno type="ArticleID">LSM10019</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0196-8092</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MRI</term><term>Nd:YAG‐laser</term><term>PCNA</term><term>apoptosis</term><term>glioma</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Laser‐induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Paul Christian Schulze MD</name><affiliations><json:string>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</json:string><json:string>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</json:string></affiliations></json:item><json:item><name>Volker Adams PhD</name><affiliations><json:string>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</json:string></affiliations></json:item><json:item><name>Christoph Busert MD</name><affiliations><json:string>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</json:string></affiliations></json:item><json:item><name>Martin Bettag MD</name><affiliations><json:string>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</json:string></affiliations></json:item><json:item><name>Thomas Kahn MD</name><affiliations><json:string>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</json:string></affiliations></json:item><json:item><name>Prof. Dr. Schober MD</name><affiliations><json:string>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</json:string><json:string>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>apoptosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>glioma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Nd:YAG‐laser</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PCNA</value></json:item></subject><articleId><json:string>LSM10019</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.274</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 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Ellingsen</name></json:item></author><host><volume>38</volume><pages><last>299</last><first>293</first></pages><author></author><title>Photochem Photobiol</title></host><title>Optical properties of human brain</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>30</volume><publisherId><json:string>LSM</json:string></publisherId><pages><total>6</total><last>232</last><first>227</first></pages><issn><json:string>0196-8092</json:string></issn><issue>3</issue><subject><json:item><value>Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1096-9101</json:string></eissn><title>Lasers in Surgery and Medicine</title><doi><json:string>10.1002/(ISSN)1096-9101</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>surgery</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix></categories><publicationDate>2002</publicationDate><copyrightDate>2002</copyrightDate><doi><json:string>10.1002/lsm.10019</json:string></doi><id>45F5466C87EACECC3A9F3036EABE921B9BE3005E</id><score>0.2634327</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/45F5466C87EACECC3A9F3036EABE921B9BE3005E/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/45F5466C87EACECC3A9F3036EABE921B9BE3005E/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/45F5466C87EACECC3A9F3036EABE921B9BE3005E/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><p>Copyright © 2002 Wiley‐Liss, Inc.</p></availability><date>2002</date></publicationStmt><notesStmt><note>BMBF - No. 13N6264;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title><author xml:id="author-1"><persName><forename type="first">Paul Christian</forename><surname>Schulze</surname></persName><roleName type="degree">MD</roleName><affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</affiliation><affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Volker</forename><surname>Adams</surname></persName><roleName type="degree">PhD</roleName><affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Christoph</forename><surname>Busert</surname></persName><roleName type="degree">MD</roleName><affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">Martin</forename><surname>Bettag</surname></persName><roleName type="degree">MD</roleName><affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">Thomas</forename><surname>Kahn</surname></persName><roleName type="degree">MD</roleName><affiliation>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</affiliation></author><author xml:id="author-6"><persName><surname>Schober</surname></persName><roleName type="degree">Prof. Dr.</roleName><affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</affiliation><affiliation>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</affiliation></author></analytic><monogr><title level="j">Lasers in Surgery and Medicine</title><title level="j" type="sub">The Official Journal of the American Society for Laser Medicine and Surgery</title><title level="j" type="abbrev">Lasers Surg. Med.</title><idno type="pISSN">0196-8092</idno><idno type="eISSN">1096-9101</idno><idno type="DOI">10.1002/(ISSN)1096-9101</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03"></date><biblScope unit="volume">30</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="227">227</biblScope><biblScope unit="page" to="232">232</biblScope></imprint></monogr><idno type="istex">45F5466C87EACECC3A9F3036EABE921B9BE3005E</idno><idno type="DOI">10.1002/lsm.10019</idno><idno type="ArticleID">LSM10019</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2002</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Laser‐induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion.</p></abstract><abstract><p>LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining.</p></abstract><abstract><p>Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries.</p></abstract><abstract><p>LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT. Lasers Surg. Med. 30:227‐232, 2002. © 2002 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>apoptosis</term></item><item><term>glioma</term></item><item><term>Nd:YAG‐laser</term></item><item><term>MRI</term></item><item><term>PCNA</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-08-07">Registration</change><change when="2002-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/45F5466C87EACECC3A9F3036EABE921B9BE3005E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9101</doi><issn type="print">0196-8092</issn><issn type="electronic">1096-9101</issn><idGroup><id type="product" value="LSM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="LASERS IN SURGERY AND MEDICINE">Lasers in Surgery and Medicine</title><title type="subtitle">The Official Journal of the American Society for Laser Medicine and Surgery</title><title type="short">Lasers Surg. Med.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/lsm.v30:3</doi><numberingGroup><numbering type="journalVolume" number="30">30</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2002-03">March 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="80" status="forIssue"><doi origin="wiley" registered="yes">10.1002/lsm.10019</doi><idGroup><id type="unit" value="LSM10019"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2002 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2001-08-07"></event><event type="firstOnline" date="2002-03-01"></event><event type="publishedOnlineFinalForm" date="2002-03-01"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">227</numbering><numbering type="pageLast">232</numbering></numberingGroup><correspondenceTo>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:LSM.LSM10019.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="16"></count><count type="wordTotal" number="651"></count></countGroup><titleGroup><title type="main" xml:lang="en">Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title><title type="short" xml:lang="en">EFFECTS OF LITT ON EXPERIMENTAL GLIOMAS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Paul Christian</givenNames><familyName>Schulze</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Volker</givenNames><familyName>Adams</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Christoph</givenNames><familyName>Busert</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Martin</givenNames><familyName>Bettag</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Thomas</givenNames><familyName>Kahn</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4" corresponding="yes"><personName><honorifics>Prof. Dr.</honorifics><givenNames>Ralf</givenNames><familyName>Schober</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="neuropath@medizin.uni-leipzig.de">neuropath@medizin.uni‐leipzig.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">apoptosis</keyword><keyword xml:id="kwd2">glioma</keyword><keyword xml:id="kwd3">Nd:YAG‐laser</keyword><keyword xml:id="kwd4">MRI</keyword><keyword xml:id="kwd5">PCNA</keyword></keywordGroup><fundingInfo><fundingAgency>BMBF</fundingAgency><fundingNumber>13N6264</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background and Objectives</title><p>Laser‐induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion.</p></section><section xml:id="abs1-2"><title type="main">Study Design/Materials and Methods</title><p>LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining.</p></section><section xml:id="abs1-3"><title type="main">Results</title><p>Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries.</p></section><section xml:id="abs1-4"><title type="main">Conclusions</title><p>LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT. Lasers Surg. Med. 30:227‐232, 2002. © 2002 Wiley‐Liss, Inc.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>EFFECTS OF LITT ON EXPERIMENTAL GLIOMAS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Effects of laser‐induced thermotherapy (LITT) on proliferation and apoptosis of glioma cells in rat brain transplantation tumors</title></titleInfo><name type="personal"><namePart type="given">Paul Christian</namePart><namePart type="family">Schulze</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</affiliation><affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Volker</namePart><namePart type="family">Adams</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>University of Leipzig, Heart Center, Department of Cardiology, Russenstrasse 19, 04289 Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christoph</namePart><namePart type="family">Busert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Bettag</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Mainz, Krankenhaus der Barmherzigen Brueder, Department of Neurosurgery, Nordallee 1, 54292 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas</namePart><namePart type="family">Kahn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Leipzig, Department of Radiology, Liebigstrasse 20a, 04103 Leipzig, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Prof. Dr.</namePart><namePart type="family">Schober</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>University of Leipzig, Department of Neuropathology, Liebigstrasse 26, 04103 Leipzig, Germany</affiliation><affiliation>Department of Neuropathology, Liebigstr. 26, 04103 Leipzig, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2002-03</dateIssued><dateValid encoding="w3cdtf">2001-08-07</dateValid><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">16</extent><extent unit="words">651</extent></physicalDescription><abstract>Laser‐induced thermotherapy (LITT) is an approach to the treatment of brain tumors especially in poorly accessible regions. Its clinical applicability with tumor cell destruction has been shown in several studies. However, no data are known about specific effects on tumors cells due to LITT in the time course of the lesion.</abstract><abstract>LITT was performed in adult Lewis rats with implanted glioma cells in the brain using a standard exposure of 3 W for 30 seconds. Before and following LITT, neoplastic lesions were monitored by MRI. Proliferation of implanted cells and gliosis were assessed by several histological techniques and immunohistochemistry. Apoptosis was detected by TUNEL staining.</abstract><abstract>Our experiments show a destruction of neoplastic cells by LITT but surviving tumor cells at the margin of the lesion. Apoptosis was detected following LITT restricted to residual neoplastic cells. Marginal survival of tumor cells lead to a secondary outgrowth into the necrotic lesion adjacent to sprouting capillaries.</abstract><abstract>LITT is a suitable technique for the treatment of brain neoplasms. However, further investigations are necessary to prevent tumor recurrences after LITT. Lasers Surg. Med. 30:227‐232, 2002. © 2002 Wiley‐Liss, Inc.</abstract><note type="funding">BMBF - No. 13N6264; </note><subject lang="en"><genre>keywords</genre><topic>apoptosis</topic><topic>glioma</topic><topic>Nd:YAG‐laser</topic><topic>MRI</topic><topic>PCNA</topic></subject><relatedItem type="host"><titleInfo><title>Lasers in Surgery and Medicine</title><subTitle>The Official Journal of the American Society for Laser Medicine and Surgery</subTitle></titleInfo><titleInfo type="abbreviated"><title>Lasers Surg. Med.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Article</topic></subject><identifier type="ISSN">0196-8092</identifier><identifier type="eISSN">1096-9101</identifier><identifier type="DOI">10.1002/(ISSN)1096-9101</identifier><identifier type="PublisherID">LSM</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>227</start><end>232</end><total>6</total></extent></part></relatedItem><identifier type="istex">45F5466C87EACECC3A9F3036EABE921B9BE3005E</identifier><identifier type="DOI">10.1002/lsm.10019</identifier><identifier type="ArticleID">LSM10019</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2002 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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