Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring
Identifieur interne : 000876 ( Istex/Corpus ); précédent : 000875; suivant : 000877Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring
Auteurs : Jens Kuhn ; Theo O. J. Gründler ; Robert Bauer ; Wolfgang Huff ; Adrian G. Fischer ; Doris Lenartz ; Mohammad Maarouf ; Christian Bührle ; Joachim Klosterkötter ; Markus Ullsperger ; Volker SturmSource :
- Addiction Biology [ 1355-6215 ] ; 2011-10.
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- KwdEn :
Abstract
Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error‐related negativity) linked to anterior mid‐cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.
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DOI: 10.1111/j.1369-1600.2011.00337.x
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ISTEX:04418DE3B54E56D70DEECCDCD71AB971B68E5141Le document en format XML
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Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error‐related negativity) linked to anterior mid‐cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jens Kuhn</name><affiliations><json:string>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</json:string><json:string>E-mail: jens.kuhn@uk‐koeln.de</json:string></affiliations></json:item><json:item><name>Theo O. J. Gründler</name><affiliations><json:string>Max Planck Institute for Neurological Research, Germany</json:string><json:string>Department of Psychology, University of Trier, Germany</json:string></affiliations></json:item><json:item><name>Robert Bauer</name><affiliations><json:string>International Centre for Ethics in the Sciences and Humanities, Eberhard Karls University of Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang Huff</name><affiliations><json:string>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</json:string></affiliations></json:item><json:item><name>Adrian G. 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abuse</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1111/j.1369-1600.2011.00337.x</json:string></doi><id>04418DE3B54E56D70DEECCDCD71AB971B68E5141</id><score>0.41400406</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/04418DE3B54E56D70DEECCDCD71AB971B68E5141/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/04418DE3B54E56D70DEECCDCD71AB971B68E5141/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/04418DE3B54E56D70DEECCDCD71AB971B68E5141/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction</p></availability><date>2011</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring</title><author xml:id="author-1"><persName><forename type="first">Jens</forename><surname>Kuhn</surname></persName><email>jens.kuhn@uk‐koeln.de</email><note type="biography">Equal contribution.</note><affiliation>Equal contribution.</affiliation><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Theo O. J.</forename><surname>Gründler</surname></persName><note type="biography">Equal contribution.</note><affiliation>Equal contribution.</affiliation><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation><affiliation>Department of Psychology, University of Trier, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">Robert</forename><surname>Bauer</surname></persName><affiliation>International Centre for Ethics in the Sciences and Humanities, Eberhard Karls University of Tübingen, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">Wolfgang</forename><surname>Huff</surname></persName><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">Adrian G.</forename><surname>Fischer</surname></persName><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">Doris</forename><surname>Lenartz</surname></persName><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">Mohammad</forename><surname>Maarouf</surname></persName><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation></author><author xml:id="author-8"><persName><forename type="first">Christian</forename><surname>Bührle</surname></persName><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation></author><author xml:id="author-9"><persName><forename type="first">Joachim</forename><surname>Klosterkötter</surname></persName><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation></author><author xml:id="author-10"><persName><forename type="first">Markus</forename><surname>Ullsperger</surname></persName><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation><affiliation>Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, the Netherlands</affiliation></author><author xml:id="author-11"><persName><forename type="first">Volker</forename><surname>Sturm</surname></persName><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation></author></analytic><monogr><title level="j">Addiction Biology</title><idno type="pISSN">1355-6215</idno><idno type="eISSN">1369-1600</idno><idno type="DOI">10.1111/(ISSN)1369-1600</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-10"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="620">620</biblScope><biblScope unit="page" to="623">623</biblScope></imprint></monogr><idno type="istex">04418DE3B54E56D70DEECCDCD71AB971B68E5141</idno><idno type="DOI">10.1111/j.1369-1600.2011.00337.x</idno><idno type="ArticleID">ADB337</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error‐related negativity) linked to anterior mid‐cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Alcohol addiction</term></item><item><term>corticomesolimbic pathway</term></item><item><term>craving</term></item><item><term>deep brain stimulation</term></item><item><term>error‐related negativity</term></item><item><term>nucleus accumbens</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/04418DE3B54E56D70DEECCDCD71AB971B68E5141/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1369-1600</doi><issn type="print">1355-6215</issn><issn type="electronic">1369-1600</issn><idGroup><id type="product" value="ADB"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ADDICTION BIOLOGY">Addiction Biology</title></titleGroup></publicationMeta><publicationMeta level="part" position="10104"><doi origin="wiley">10.1111/adb.2011.16.issue-4</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2011-10">October 2011</coverDate></publicationMeta><publicationMeta level="unit" type="shortCommunication" position="10" status="forIssue"><doi origin="wiley">10.1111/j.1369-1600.2011.00337.x</doi><idGroup><id type="unit" value="ADB337"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">BRIEF REPORTS: PRECLINICAL RESEARCH</title></titleGroup><copyright>© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.10 mode:FullText" date="2011-09-19"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-07-18"></event><event type="firstOnline" date="2011-07-18"></event><event type="publishedOnlineFinalForm" date="2011-09-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2013-12-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="620">620</numbering><numbering type="pageLast" number="623">623</numbering></numberingGroup><correspondenceTo>Jens Kuhn, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, Cologne 50937, Germany. E‐mail: <email normalForm="jens.kuhn@uk-koeln.de">jens.kuhn@uk‐koeln.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ADB.ADB337.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="11"></count><count type="wordTotal" number="2259"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring</title><title type="shortAuthors">Jens Kuhn et al.</title><title type="short">Deep brain stimulation in severe alcohol dependence</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1" corresponding="yes"><personName><givenNames>Jens</givenNames><familyName>Kuhn</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2 #a3" noteRef="#fn1"><personName><givenNames>Theo O. J.</givenNames><familyName>Gründler</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4"><personName><givenNames>Robert</givenNames><familyName>Bauer</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Wolfgang</givenNames><familyName>Huff</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Adrian G.</givenNames><familyName>Fischer</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a5"><personName><givenNames>Doris</givenNames><familyName>Lenartz</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a5"><personName><givenNames>Mohammad</givenNames><familyName>Maarouf</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a5"><personName><givenNames>Christian</givenNames><familyName>Bührle</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a1"><personName><givenNames>Joachim</givenNames><familyName>Klosterkötter</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a2 #a6"><personName><givenNames>Markus</givenNames><familyName>Ullsperger</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a5"><personName><givenNames>Volker</givenNames><familyName>Sturm</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="DE"><unparsedAffiliation>Max Planck Institute for Neurological Research, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="DE"><unparsedAffiliation>Department of Psychology, University of Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="DE"><unparsedAffiliation>International Centre for Ethics in the Sciences and Humanities, Eberhard Karls University of Tübingen, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="DE"><unparsedAffiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="NL"><unparsedAffiliation>Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, the Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Alcohol addiction</keyword><keyword xml:id="k2">corticomesolimbic pathway</keyword><keyword xml:id="k3">craving</keyword><keyword xml:id="k4">deep brain stimulation</keyword><keyword xml:id="k5">error‐related negativity</keyword><keyword xml:id="k6">nucleus accumbens</keyword></keywordGroup><supportingInformation><p><b>Figure S1</b> Approach to measure executive functioning and resulting event‐related potential. (a) Schematic diagram of the speeded modified flanker task. The participant has to respond rapidly to the central (target) arrow by pressing the left or right response button according to the direction indicated by the target. The flanking arrows, which in 50% of the trials are incongruent with the target, i.e. point in the opposite direction, were introduced to induce response conflict and resulted in more frequent erroneous responses. (b) Average waveform of the error‐related negativity (ERN) at midline electrode FCz. The ERN amplitude was increased under neural stimulation as compared to baseline and off‐stimulation measurements. Gray shading indicates the analyzed time‐window</p><p><b>Table S1</b> Questionnaire data.</p><p><b>Table S2</b> Electrophysiological and behavioral data.</p><supportingInfoItem><mediaResource alt="supporting info item" href="urn-x:wiley:13556215:media:adb337:ADB_337_sm_suppl"></mediaResource><caption>Supporting info item</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">ABSTRACT</title><p>Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error‐related negativity) linked to anterior mid‐cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p> Equal contribution.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Deep brain stimulation in severe alcohol dependence</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring</title></titleInfo><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Kuhn</namePart><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation><description>Equal contribution.</description><affiliation>E-mail: jens.kuhn@uk‐koeln.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Theo O. J.</namePart><namePart type="family">Gründler</namePart><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation><affiliation>Department of Psychology, University of Trier, Germany</affiliation><description>Equal contribution.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Bauer</namePart><affiliation>International Centre for Ethics in the Sciences and Humanities, Eberhard Karls University of Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Huff</namePart><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adrian G.</namePart><namePart type="family">Fischer</namePart><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Doris</namePart><namePart type="family">Lenartz</namePart><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mohammad</namePart><namePart type="family">Maarouf</namePart><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Bührle</namePart><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joachim</namePart><namePart type="family">Klosterkötter</namePart><affiliation>Department of Psychiatry and Psychotherapy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Markus</namePart><namePart type="family">Ullsperger</namePart><affiliation>Max Planck Institute for Neurological Research, Germany</affiliation><affiliation>Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, the Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Volker</namePart><namePart type="family">Sturm</namePart><affiliation>Department of Functional Neurosurgery and Stereotaxy, University of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="shortCommunication"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2011-10</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="references">11</extent><extent unit="words">2259</extent></physicalDescription><abstract lang="en">Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error‐related negativity) linked to anterior mid‐cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.</abstract><subject lang="en"><genre>keywords</genre><topic>Alcohol addiction</topic><topic>corticomesolimbic pathway</topic><topic>craving</topic><topic>deep brain stimulation</topic><topic>error‐related negativity</topic><topic>nucleus accumbens</topic></subject><relatedItem type="host"><titleInfo><title>Addiction Biology</title></titleInfo><genre type="journal">journal</genre><note type="content"> Figure S1 Approach to measure executive functioning and resulting event‐related potential. (a) Schematic diagram of the speeded modified flanker task. The participant has to respond rapidly to the central (target) arrow by pressing the left or right response button according to the direction indicated by the target. The flanking arrows, which in 50% of the trials are incongruent with the target, i.e. point in the opposite direction, were introduced to induce response conflict and resulted in more frequent erroneous responses. (b) Average waveform of the error‐related negativity (ERN) at midline electrode FCz. The ERN amplitude was increased under neural stimulation as compared to baseline and off‐stimulation measurements. Gray shading indicates the analyzed time‐window Table S1 Questionnaire data. Table S2 Electrophysiological and behavioral data. Figure S1 Approach to measure executive functioning and resulting event‐related potential. (a) Schematic diagram of the speeded modified flanker task. The participant has to respond rapidly to the central (target) arrow by pressing the left or right response button according to the direction indicated by the target. The flanking arrows, which in 50% of the trials are incongruent with the target, i.e. point in the opposite direction, were introduced to induce response conflict and resulted in more frequent erroneous responses. (b) Average waveform of the error‐related negativity (ERN) at midline electrode FCz. The ERN amplitude was increased under neural stimulation as compared to baseline and off‐stimulation measurements. Gray shading indicates the analyzed time‐window Table S1 Questionnaire data. Table S2 Electrophysiological and behavioral data. Figure S1 Approach to measure executive functioning and resulting event‐related potential. (a) Schematic diagram of the speeded modified flanker task. The participant has to respond rapidly to the central (target) arrow by pressing the left or right response button according to the direction indicated by the target. The flanking arrows, which in 50% of the trials are incongruent with the target, i.e. point in the opposite direction, were introduced to induce response conflict and resulted in more frequent erroneous responses. (b) Average waveform of the error‐related negativity (ERN) at midline electrode FCz. The ERN amplitude was increased under neural stimulation as compared to baseline and off‐stimulation measurements. Gray shading indicates the analyzed time‐window Table S1 Questionnaire data. Table S2 Electrophysiological and behavioral data.Supporting Info Item: Supporting info item - </note><identifier type="ISSN">1355-6215</identifier><identifier type="eISSN">1369-1600</identifier><identifier type="DOI">10.1111/(ISSN)1369-1600</identifier><identifier type="PublisherID">ADB</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>620</start><end>623</end><total>4</total></extent></part></relatedItem><identifier type="istex">04418DE3B54E56D70DEECCDCD71AB971B68E5141</identifier><identifier type="DOI">10.1111/j.1369-1600.2011.00337.x</identifier><identifier type="ArticleID">ADB337</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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