Analysis of fentanyl and sufentanil in hair by GC/MS/MS
Identifieur interne : 000814 ( Istex/Corpus ); précédent : 000813; suivant : 000815Analysis of fentanyl and sufentanil in hair by GC/MS/MS
Auteurs : H. Sachs ; M. Uhl ; G. Hege-Scheuing ; E. SchneiderSource :
- International Journal of Legal Medicine [ 0937-9827 ] ; 1996-12-01.
Abstract
Abstract: Fentanyl and sufentanil are potent narcotic analgesics used only in hospitals as anaesthetic agents. The dependence potential of fentanyl is known. As they are given in doses at the microgram level and their elimination half-life is in the order of a few hours, detection in body fluids is possible only for a short time after administration. Radioimmunological methods are the only ones capable of detecting fentanyl in hair, as normal GC/MS methods for hair analysis are not sensitive enough to detect the drugs after doses in the order of micrograms. We therefore chose GC/MS/MS to analyse fentanyl and sufentanil in two cases where the drugs were given under controlled conditions over several days. The concentration was in the order of less than 100 pg/mg hair.
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DOI: 10.1007/BF01225521
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ISTEX:31CA5D0499248980573952C438E3A4AB4CEFA371Le document en format XML
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Sachs</name><affiliation><mods:affiliation>Institut für Rechtsmedizin, Universität München, Frauenlobstrasse 7a, D-80046, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Uhl, M" sort="Uhl, M" uniqKey="Uhl M" first="M." last="Uhl">M. Uhl</name><affiliation><mods:affiliation>Bayerisches Landeskriminalamt, Maillingerstrasse 15, D-80636, München, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hege Scheuing, G" sort="Hege Scheuing, G" uniqKey="Hege Scheuing G" first="G." last="Hege-Scheuing">G. Hege-Scheuing</name><affiliation><mods:affiliation>Universitätsklinik für Anaesthesiologie, Universität Ulm/Donau, Steinhövelstrasse 6, D-89070, Ulm, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schneider, E" sort="Schneider, E" uniqKey="Schneider E" first="E." last="Schneider">E. 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The dependence potential of fentanyl is known. As they are given in doses at the microgram level and their elimination half-life is in the order of a few hours, detection in body fluids is possible only for a short time after administration. Radioimmunological methods are the only ones capable of detecting fentanyl in hair, as normal GC/MS methods for hair analysis are not sensitive enough to detect the drugs after doses in the order of micrograms. We therefore chose GC/MS/MS to analyse fentanyl and sufentanil in two cases where the drugs were given under controlled conditions over several days. The concentration was in the order of less than 100 pg/mg hair.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>H. Sachs</name><affiliations><json:string>Institut für Rechtsmedizin, Universität München, Frauenlobstrasse 7a, D-80046, München, Germany</json:string></affiliations></json:item><json:item><name>M. Uhl</name><affiliations><json:string>Bayerisches Landeskriminalamt, Maillingerstrasse 15, D-80636, München, Germany</json:string></affiliations></json:item><json:item><name>G. Hege-Scheuing</name><affiliations><json:string>Universitätsklinik für Anaesthesiologie, Universität Ulm/Donau, Steinhövelstrasse 6, D-89070, Ulm, Germany</json:string></affiliations></json:item><json:item><name>E. Schneider</name><affiliations><json:string>Krankenhaus der Barmherzigen Brüder, Nordallee, D-54292, Trier, Germany</json:string></affiliations></json:item></author><articleId><json:string>BF01225521</json:string><json:string>Art10</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>BriefCommunication</json:string></originalGenre><abstract>Abstract: Fentanyl and sufentanil are potent narcotic analgesics used only in hospitals as anaesthetic agents. The dependence potential of fentanyl is known. 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Diagnosis and treatment of human poisoning</title><publicationDate>1988</publicationDate></host></json:item><json:item><author><json:item><name>W-L Wang</name></json:item><json:item><name>Ej Cone</name></json:item><json:item><name>J Zacny</name></json:item></author><host><volume>61</volume><pages><last>72</last><first>65</first></pages><author></author><title>Forensic Sci Int</title><publicationDate>1993</publicationDate></host><title>Immunoassay evidence for fentanyl in hair of surgery patients</title><publicationDate>1993</publicationDate></json:item><json:item><host><pages><last>1079</last><first>1076</first></pages><author><json:item><name>Efg Reynolds</name></json:item></author><title>Martindale, the extra pharmacopoeia</title><publicationDate>1993</publicationDate></host></json:item><json:item><author></author><host><author></author><title>Julien RM</title><publicationDate>1988</publicationDate></host><title>A primer of drug action</title><publicationDate>1988</publicationDate></json:item><json:item><host><pages><last>174</last><first>163</first></pages><author><json:item><name>G Barnett</name></json:item><json:item><name>Rs Rapaka</name></json:item></author><title>Designer drugs: an overview. In: Cocaine, marijuana, designer drugs: chemistry, pharmacology and behaviour</title><publicationDate>1989</publicationDate></host></json:item><json:item><author><json:item><name>G Seitz</name></json:item></author><host><volume>137</volume><pages><last>103</last><first>87</first></pages><author></author><title>Pharmazeut Z</title><publicationDate>1992</publicationDate></host><title>Klassiker im Arzneischatz: zentral wirksame Opioid-Analgetika</title><publicationDate>1992</publicationDate></json:item><json:item><author><json:item><name>U Fricke</name></json:item></author><host><volume>134</volume><pages><last>1562</last><first>1549</first></pages><author></author><title>Dtsche Apoth Z</title><publicationDate>1994</publicationDate></host><title>Arzneimittelmarkt 1993: Was war wirklich neu? -Teil 4</title><publicationDate>1994</publicationDate></json:item><json:item><author><json:item><name>M Schulz</name></json:item><json:item><name>J Scholz</name></json:item></author><host><volume>138</volume><pages><last>3733</last><first>3728</first></pages><author></author><title>Pharmazeut Z</title><publicationDate>1993</publicationDate></host><title>Sufentanil, ein neues Opiod (Sufentanil , a new opioid)</title><publicationDate>1993</publicationDate></json:item><json:item><host><author><json:item><name>E Freye</name></json:item></author><title>Opioid agonists, antagonist and mixed narcotic analgesics. Theoretical background and considerations for practical use</title><publicationDate>1987</publicationDate></host></json:item><json:item><author><json:item><name>Gl Henderson</name></json:item></author><host><volume>33</volume><pages><last>575</last><first>569</first></pages><author></author><title>J Forensic Sci</title><publicationDate>1988</publicationDate></host><title>Designer-drugs: past history and future prospects</title><publicationDate>1988</publicationDate></json:item></refBibs><genre><json:string>brief-communication</json:string></genre><host><volume>109</volume><pages><last>215</last><first>213</first></pages><issn><json:string>0937-9827</json:string></issn><issue>4</issue><subject><json:item><value>Medicine/Public Health, general</value></json:item><json:item><value>Forensic Medicine</value></json:item><json:item><value>Medical 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The dependence potential of fentanyl is known. As they are given in doses at the microgram level and their elimination half-life is in the order of a few hours, detection in body fluids is possible only for a short time after administration. Radioimmunological methods are the only ones capable of detecting fentanyl in hair, as normal GC/MS methods for hair analysis are not sensitive enough to detect the drugs after doses in the order of micrograms. We therefore chose GC/MS/MS to analyse fentanyl and sufentanil in two cases where the drugs were given under controlled conditions over several days. The concentration was in the order of less than 100 pg/mg hair.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Medicine/Public Health, general</term></item><item><term>Forensic Medicine</term></item><item><term>Medical Law</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-10-05">Created</change><change when="1996-12-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-23">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-21">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/31CA5D0499248980573952C438E3A4AB4CEFA371/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no 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München</OrgName><OrgAddress><Street>Frauenlobstrasse 7a</Street><Postcode>D-80046</Postcode><City>München</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Bayerisches Landeskriminalamt</OrgName><OrgAddress><Street>Maillingerstrasse 15</Street><Postcode>D-80636</Postcode><City>München</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Universitätsklinik für Anaesthesiologie</OrgDivision><OrgName>Universität Ulm/Donau</OrgName><OrgAddress><Street>Steinhövelstrasse 6</Street><Postcode>D-89070</Postcode><City>Ulm</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgName>Krankenhaus der Barmherzigen Brüder, Nordallee</OrgName><OrgAddress><Postcode>D-54292</Postcode><City>Trier</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Fentanyl and sufentanil are potent narcotic analgesics used only in hospitals as anaesthetic agents. The dependence potential of fentanyl is known. As they are given in doses at the microgram level and their elimination half-life is in the order of a few hours, detection in body fluids is possible only for a short time after administration. Radioimmunological methods are the only ones capable of detecting fentanyl in hair, as normal GC/MS methods for hair analysis are not sensitive enough to detect the drugs after doses in the order of micrograms. We therefore chose GC/MS/MS to analyse fentanyl and sufentanil in two cases where the drugs were given under controlled conditions over several days. The concentration was in the order of less than 100 pg/mg hair.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Fentanyl</Keyword><Keyword>Sufentanil</Keyword><Keyword>GC/MS/MS</Keyword><Keyword>Hair analysis</Keyword><Keyword>Drug abuse</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Analysis of fentanyl and sufentanil in hair by GC/MS/MS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Analysis of fentanyl and sufentanil in hair by GC/MS/MS</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">H.</namePart><namePart type="family">Sachs</namePart><affiliation>Institut für Rechtsmedizin, Universität München, Frauenlobstrasse 7a, D-80046, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Uhl</namePart><affiliation>Bayerisches Landeskriminalamt, Maillingerstrasse 15, D-80636, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hege-Scheuing</namePart><affiliation>Universitätsklinik für Anaesthesiologie, Universität Ulm/Donau, Steinhövelstrasse 6, D-89070, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Schneider</namePart><affiliation>Krankenhaus der Barmherzigen Brüder, Nordallee, D-54292, Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="BriefCommunication"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1994-10-05</dateCreated><dateIssued encoding="w3cdtf">1996-12-01</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Fentanyl and sufentanil are potent narcotic analgesics used only in hospitals as anaesthetic agents. The dependence potential of fentanyl is known. As they are given in doses at the microgram level and their elimination half-life is in the order of a few hours, detection in body fluids is possible only for a short time after administration. Radioimmunological methods are the only ones capable of detecting fentanyl in hair, as normal GC/MS methods for hair analysis are not sensitive enough to detect the drugs after doses in the order of micrograms. We therefore chose GC/MS/MS to analyse fentanyl and sufentanil in two cases where the drugs were given under controlled conditions over several days. The concentration was in the order of less than 100 pg/mg hair.</abstract><note>Short Communication</note><relatedItem type="host"><titleInfo><title>International Journal of Legal Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Int J Leg Med</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1996-12-01</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Medicine/Public Health, general</topic><topic>Forensic Medicine</topic><topic>Medical Law</topic></subject><identifier type="ISSN">0937-9827</identifier><identifier type="eISSN">1437-1596</identifier><identifier type="JournalID">414</identifier><identifier type="IssueArticleCount">12</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1996</date><detail type="volume"><number>109</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>213</start><end>215</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1996</recordOrigin></recordInfo></relatedItem><identifier type="istex">31CA5D0499248980573952C438E3A4AB4CEFA371</identifier><identifier type="DOI">10.1007/BF01225521</identifier><identifier type="ArticleID">BF01225521</identifier><identifier type="ArticleID">Art10</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1996</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1996</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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