Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups
Identifieur interne : 000738 ( Istex/Corpus ); précédent : 000737; suivant : 000739Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups
Auteurs : J. Hellhammer ; W. Schlotz ; A A Stone ; K M Pirke ; D. HellhammerSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
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Abstract
Abstract: Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.
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DOI: 10.1196/annals.1314.002
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Hellhammer</name><affiliation><mods:affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: juliane.hellhammer@uni‐trier.de</mods:affiliation></affiliation></author><author><name sortKey="Schlotz, W" sort="Schlotz, W" uniqKey="Schlotz W" first="W" last="Schlotz">W. Schlotz</name><affiliation><mods:affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Stone, A A" sort="Stone, A A" uniqKey="Stone A" first="A A" last="Stone">A A Stone</name><affiliation><mods:affiliation>Department of Psychiatry, SUNY, Stony Brook, New York, USA</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name><affiliation><mods:affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, D" sort="Hellhammer, D" uniqKey="Hellhammer D" first="D" last="Hellhammer">D. Hellhammer</name><affiliation><mods:affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-12">2004-12</date><biblScope unit="volume">1032</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="8">8</biblScope><biblScope unit="page" to="13">13</biblScope></imprint><idno type="ISSN">0077-8923</idno></series><idno type="istex">266ED5AB7FDD7E7DA8533AB71BB8AA2599AFCD04</idno><idno type="DOI">10.1196/annals.1314.002</idno><idno type="ArticleID">NYAS8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>WHR</term><term>allostatic load</term><term>chronic stress</term><term>cortisol</term><term>fibrinogen</term><term>health</term><term>hypocortisolism</term><term>protective and damaging effects</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Abstract: Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J HELLHAMMER</name><affiliations><json:string>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</json:string><json:string>E-mail: juliane.hellhammer@uni‐trier.de</json:string></affiliations></json:item><json:item><name>W SCHLOTZ</name><affiliations><json:string>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>A A STONE</name><affiliations><json:string>Department of Psychiatry, SUNY, Stony Brook, New York, USA</json:string></affiliations></json:item><json:item><name>K M PIRKE</name><affiliations><json:string>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>D HELLHAMMER</name><affiliations><json:string>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cortisol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>allostatic load</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>protective and damaging effects</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hypocortisolism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chronic stress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>health</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fibrinogen</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>WHR</value></json:item></subject><articleId><json:string>NYAS8</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Abstract: Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</abstract><qualityIndicators><score>3.076</score><pdfVersion>1.3</pdfVersion><pdfPageSize>432 x 648 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>898</abstractCharCount><pdfWordCount>1564</pdfWordCount><pdfCharCount>9989</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>126</abstractWordCount></qualityIndicators><title>Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups</title><refBibs><json:item><host><author></author><title>Schmidt, I. 2003. Lebensgeschichtlich frühe Stresserfahrungen und Stressvulnerabilität im Erwachsenenalter. Dissertation, University of Trier.</title></host></json:item><json:item><host><author></author><title>Franke, S. 2003. Psychoendokrinologie bei funktionellen gastrointestinalen Störungen. 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However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>cortisol</term></item><item><term>allostatic load</term></item><item><term>protective and damaging effects</term></item><item><term>hypocortisolism</term></item><item><term>chronic stress</term></item><item><term>health</term></item><item><term>fibrinogen</term></item><item><term>WHR</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/266ED5AB7FDD7E7DA8533AB71BB8AA2599AFCD04/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="12001"><doi origin="wiley">10.1111/nyas.2004.1032.issue-1</doi><titleGroup><title type="main">Biobehavioral Stress Response: Protective and Damaging Effects</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1032">1032</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2004-12">December 2004</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1196/annals.1314.002</doi><idGroup><id type="unit" value="NYAS8"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Biobehavioral Stress Response: Protective and Damaging Effects: Part I. Novel Paradigms for Considering Stress‐Hormone Response</title></titleGroup><eventGroup><event type="firstOnline" date="2006-01-12"></event><event type="publishedOnlineFinalForm" date="2009-07-08"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-02-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="8">8</numbering><numbering type="pageLast" number="13">13</numbering></numberingGroup><correspondenceTo>Address for correspondence: Dr. J. Hellhammer, University of Trier‐Psychobiology, Johanniterufer 15, D‐54290 Trier, Germany. Voice: ++ 651‐201‐3464; fax: ++ 651‐201‐2934. <email normalForm="juliane.hellhammer@uni-trier.de">juliane.hellhammer@uni‐trier.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS8.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="16"></count><count type="linksCrossRef" number="25"></count></countGroup><titleGroup><title type="main">Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>J</givenNames><familyName>HELLHAMMER</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>W</givenNames><familyName>SCHLOTZ</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>A A</givenNames><familyName>STONE</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>K M</givenNames><familyName>PIRKE</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>D</givenNames><familyName>HELLHAMMER</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Psychiatry, SUNY, Stony Brook, New York, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cortisol</keyword><keyword xml:id="k2">allostatic load</keyword><keyword xml:id="k3">protective and damaging effects</keyword><keyword xml:id="k4">hypocortisolism</keyword><keyword xml:id="k5">chronic stress</keyword><keyword xml:id="k6">health</keyword><keyword xml:id="k7">fibrinogen</keyword><keyword xml:id="k8">WHR</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>A<sc>bstract</sc>: </b> Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">HELLHAMMER</namePart><affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</affiliation><affiliation>E-mail: juliane.hellhammer@uni‐trier.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">SCHLOTZ</namePart><affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A A</namePart><namePart type="family">STONE</namePart><affiliation>Department of Psychiatry, SUNY, Stony Brook, New York, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K M</namePart><namePart type="family">PIRKE</namePart><affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">HELLHAMMER</namePart><affiliation>Department of Psychobiology, Trier University, D‐54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-12</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">16</extent></physicalDescription><abstract>Abstract: Overactivity of the hypothalamus‐pituitary‐adrenal axis (HPAA) has been observed in the presence of acute stress and, under chronic conditions, in disorders such as depression and anorexia nervosa as well as in cardiovascular and metabolic disorders. However, there may be other stress‐related disorders (fatigue, pain, etc) that seem to be associated with mild hypocortisolism. This suggests that two major subtypes of the HPAA response to stress need to be discriminated. In this study, we investigated 76 subjects with and without hypocortisolism, respectively, over a 1‐year period. Surprisingly, hypocortisolemic subjects had a lower allostatic load but they scored higher on measures of depression, perceived stress, and physical complaints. We propose a protective role of the hypocortisolemic stress response on cardiovascular and metabolic disorders, particularly in the elderly.</abstract><subject lang="en"><genre>keywords</genre><topic>cortisol</topic><topic>allostatic load</topic><topic>protective and damaging effects</topic><topic>hypocortisolism</topic><topic>chronic stress</topic><topic>health</topic><topic>fibrinogen</topic><topic>WHR</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2004</date><detail type="title"><title>Biobehavioral Stress Response: Protective and Damaging Effects</title></detail><detail type="volume"><caption>vol.</caption><number>1032</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>8</start><end>13</end><total>6</total></extent></part></relatedItem><identifier type="istex">266ED5AB7FDD7E7DA8533AB71BB8AA2599AFCD04</identifier><identifier type="DOI">10.1196/annals.1314.002</identifier><identifier type="ArticleID">NYAS8</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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