A Highly Polymorphic Poly‐Glutamine Stretch in the Potassium Channel KCNN3 in Migraine
Identifieur interne : 000928 ( Istex/Checkpoint ); précédent : 000927; suivant : 000929A Highly Polymorphic Poly‐Glutamine Stretch in the Potassium Channel KCNN3 in Migraine
Auteurs : Rainald Mössner ; Annette Weichselbaum ; Martin Marziniak ; Christine M. Freitag ; Klaus-Peter Lesch ; Claudia Sommer ; Jobst MeyerSource :
- Headache: The Journal of Head and Face Pain [ 0017-8748 ] ; 2005-02.
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Abstract
Objective.—The present study is designed to further elucidate the molecular genetic basis of migraine with and without aura. Background.—Migraine is a common disease of as yet unknown etiology. Interest in ion channels in migraine has been spurred by molecular genetic findings in familial hemiplegic migraine, since familial hemiplegic migraine type 1 is caused by mutations in the calcium channel gene CACNA1A. Methods.—Given this role of ion channels in migraine, we assessed the potassium channel KCNN3 as a candidate gene for common migraine. We analyzed the highly polymorphic repeat region coding for a poly‐glutamine stretch, which constitutes part of the cytoplasmic tail of the channel protein. Results.—We found an excess of the allele coding for 15 poly‐glutamines in migraine patients. Conclusions.—The potassium channel KCNN3 may thus be of pathophysiological importance in migraine with and without aura.
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DOI: 10.1111/j.1526-4610.2005.05027.x
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Background.—Migraine is a common disease of as yet unknown etiology. Interest in ion channels in migraine has been spurred by molecular genetic findings in familial hemiplegic migraine, since familial hemiplegic migraine type 1 is caused by mutations in the calcium channel gene CACNA1A. Methods.—Given this role of ion channels in migraine, we assessed the potassium channel KCNN3 as a candidate gene for common migraine. We analyzed the highly polymorphic repeat region coding for a poly‐glutamine stretch, which constitutes part of the cytoplasmic tail of the channel protein. Results.—We found an excess of the allele coding for 15 poly‐glutamines in migraine patients. Conclusions.—The potassium channel KCNN3 may thus be of pathophysiological importance in migraine with and without aura.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. 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