Evidence for endocrine disruption in perch (Perca fluviatilis) and roach (Rutilus rutilus) in a remote Swedish lake in the vicinity of a public refuse dump
Identifieur interne : 000108 ( PascalFrancis/Checkpoint ); précédent : 000107; suivant : 000109Evidence for endocrine disruption in perch (Perca fluviatilis) and roach (Rutilus rutilus) in a remote Swedish lake in the vicinity of a public refuse dump
Auteurs : Erik Noaksson [Suède] ; Ulla Tj Rnlund [Suède] ; Albertus T. C. Bosveld [Pays-Bas] ; Lennart BalkSource :
- Toxicology and applied pharmacology [ 0041-008X ] ; 2001.
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Abstract
A two-year study on perch (Perca fluviatilis) in Lake Molnbyggen, Sweden, located in a pristine area but with a public refuse dump in the vicinity, has been conducted. The mechanistic approach through a set of biomarkers during the first year included age, condition, somatic growth, liver, gonad, and spleen weights, and a number of other physiological variables, in addition to ethoxyresorufin O-deethylase, glutathione-S-transferase, glutathione reductase, catalase, and the formation of DNA adducts in the liver. Perch from the uncontaminated Lake Djursjön, located in a neighboring drainage area, were used as reference fish. The most pronounced effect was a 80% reduction in the gonadosomatic index (GSI) for females and a corresponding 36% reduction in males. Fin erosion and shallow open sores were also frequently observed. Biomarkers and later chemical analysis employed indicated that exposure to well-known environmental pollutants was low, suggesting that less well-known antrophogenic substances are responsible for the effects observed in perch from Lake Molnbyggen. During the second year, roach (Rutilus rutilus) of both sexes were also included in this study. In addition, aromatase (P450arom) activity in the brain and testosterone and 17β-estradiol levels in blood plasma were analyzed. Only one-fourth of the female perch were found to be sexually mature, which was associated with decreased GSI, lower P450arom activity, and reduced circulating levels of steroids. The reproductive disorders observed indicates disturbed endocrine function(s), arresting the majority of the female perch in a sexually nonreproducible immature stage. This novel study is the first to report evidence for endocrine disruption in wild populations of fish living in a lake exposed to leakage water from a public refuse dump.
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C." last="Bosveld">Albertus T. C. Bosveld</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Alterra, Green World Research, Wageningen University and Research Centre</s1><s2>6700 AA Wageningen</s2><s3>NLD</s3><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6700 AA Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Balk, Lennart" sort="Balk, Lennart" uniqKey="Balk L" first="Lennart" last="Balk">Lennart Balk</name></author></analytic><series><title level="j" type="main">Toxicology and applied pharmacology</title><title level="j" type="abbreviated">Toxicol. appl. pharmacol.</title><idno type="ISSN">0041-008X</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Toxicology and applied pharmacology</title><title level="j" type="abbreviated">Toxicol. appl. pharmacol.</title><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Endocrine disruptor</term><term>Freshwater environment</term><term>Lakes</term><term>Lota lota</term><term>Perca fluviatilis</term><term>Proximity</term><term>Rutilus rutilus</term><term>Sweden</term><term>Testosterone</term><term>Toxicity</term><term>Waste dumping</term><term>Water pollution</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lac</term><term>Milieu eau douce</term><term>Pollution eau</term><term>Suède</term><term>Proximité</term><term>Décharge déchet</term><term>Testostérone</term><term>Toxicité</term><term>Perca fluviatilis</term><term>Rutilus rutilus</term><term>Lota lota</term><term>Animal</term><term>Perturbateur endocrinien</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Lac</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A two-year study on perch (Perca fluviatilis) in Lake Molnbyggen, Sweden, located in a pristine area but with a public refuse dump in the vicinity, has been conducted. The mechanistic approach through a set of biomarkers during the first year included age, condition, somatic growth, liver, gonad, and spleen weights, and a number of other physiological variables, in addition to ethoxyresorufin O-deethylase, glutathione-S-transferase, glutathione reductase, catalase, and the formation of DNA adducts in the liver. Perch from the uncontaminated Lake Djursjön, located in a neighboring drainage area, were used as reference fish. The most pronounced effect was a 80% reduction in the gonadosomatic index (GSI) for females and a corresponding 36% reduction in males. Fin erosion and shallow open sores were also frequently observed. Biomarkers and later chemical analysis employed indicated that exposure to well-known environmental pollutants was low, suggesting that less well-known antrophogenic substances are responsible for the effects observed in perch from Lake Molnbyggen. During the second year, roach (Rutilus rutilus) of both sexes were also included in this study. In addition, aromatase (P450arom) activity in the brain and testosterone and 17β-estradiol levels in blood plasma were analyzed. Only one-fourth of the female perch were found to be sexually mature, which was associated with decreased GSI, lower P450arom activity, and reduced circulating levels of steroids. The reproductive disorders observed indicates disturbed endocrine function(s), arresting the majority of the female perch in a sexually nonreproducible immature stage. This novel study is the first to report evidence for endocrine disruption in wild populations of fish living in a lake exposed to leakage water from a public refuse dump.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0041-008X</s0></fA01><fA02 i1="01"><s0>TXAPA9</s0></fA02><fA03 i2="1"><s0>Toxicol. appl. pharmacol.</s0></fA03><fA05><s2>174</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Evidence for endocrine disruption in perch (Perca fluviatilis) and roach (Rutilus rutilus) in a remote Swedish lake in the vicinity of a public refuse dump</s1></fA08><fA11 i1="01" i2="1"><s1>NOAKSSON (Erik)</s1></fA11><fA11 i1="02" i2="1"><s1>TJÄRNLUND (Ulla)</s1></fA11><fA11 i1="03" i2="1"><s1>BOSVELD (Albertus T. 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The most pronounced effect was a 80% reduction in the gonadosomatic index (GSI) for females and a corresponding 36% reduction in males. Fin erosion and shallow open sores were also frequently observed. Biomarkers and later chemical analysis employed indicated that exposure to well-known environmental pollutants was low, suggesting that less well-known antrophogenic substances are responsible for the effects observed in perch from Lake Molnbyggen. During the second year, roach (Rutilus rutilus) of both sexes were also included in this study. In addition, aromatase (P450arom) activity in the brain and testosterone and 17β-estradiol levels in blood plasma were analyzed. Only one-fourth of the female perch were found to be sexually mature, which was associated with decreased GSI, lower P450arom activity, and reduced circulating levels of steroids. 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C." last="Bosveld">Albertus T. C. Bosveld</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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