The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae
Identifieur interne : 000015 ( PascalFrancis/Checkpoint ); précédent : 000014; suivant : 000016The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae
Auteurs : F. M. I. Natrah [Belgique, Malaisie] ; Md. Iftakharul Alam [Belgique] ; Sushant Pawar [Belgique] ; A. Shiri Harzevili [Belgique] ; Nancy Nevejan [Belgique] ; Nico Boon [Belgique] ; Patrick Sorgeloos [Belgique] ; Peter Bossier [Belgique] ; Tom Defoirdt [Belgique]Source :
- Veterinary microbiology : (Amsterdam) [ 0378-1135 ] ; 2012.
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- Pascal (Inist)
- Wicri :
- topic : Vétérinaire.
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Abstract
In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1 N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-L-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-L-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.
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Natrah</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Aquaculture, Faculty of Agriculture, University Putra Malaysia</s1><s2>43400 Serdang, Selangor</s2><s3>MYS</s3><sZ>1 aut.</sZ></inist:fA14><country>Malaisie</country><wicri:noRegion>43400 Serdang, Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Iftakharul Alam, Md" sort="Iftakharul Alam, Md" uniqKey="Iftakharul Alam M" first="Md." last="Iftakharul Alam">Md. 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aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Boon, Nico" sort="Boon, Nico" uniqKey="Boon N" first="Nico" last="Boon">Nico Boon</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Sorgeloos, Patrick" sort="Sorgeloos, Patrick" uniqKey="Sorgeloos P" first="Patrick" last="Sorgeloos">Patrick Sorgeloos</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Bossier, Peter" sort="Bossier, Peter" uniqKey="Bossier P" first="Peter" last="Bossier">Peter Bossier</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0341098</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0341098 INIST</idno><idno type="RBID">Pascal:12-0341098</idno><idno type="wicri:Area/PascalFrancis/Corpus">000016</idno><idno type="wicri:Area/PascalFrancis/Curation">000102</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000015</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000015</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae</title><author><name sortKey="Natrah, F M I" sort="Natrah, F M I" uniqKey="Natrah F" first="F. M. I." last="Natrah">F. M. I. Natrah</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Aquaculture, Faculty of Agriculture, University Putra Malaysia</s1><s2>43400 Serdang, Selangor</s2><s3>MYS</s3><sZ>1 aut.</sZ></inist:fA14><country>Malaisie</country><wicri:noRegion>43400 Serdang, Selangor</wicri:noRegion></affiliation></author><author><name sortKey="Iftakharul Alam, Md" sort="Iftakharul Alam, Md" uniqKey="Iftakharul Alam M" first="Md." last="Iftakharul Alam">Md. Iftakharul Alam</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Pawar, Sushant" sort="Pawar, Sushant" uniqKey="Pawar S" first="Sushant" last="Pawar">Sushant Pawar</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Shiri Harzevili, A" sort="Shiri Harzevili, A" uniqKey="Shiri Harzevili A" first="A." last="Shiri Harzevili">A. Shiri Harzevili</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Nevejan, Nancy" sort="Nevejan, Nancy" uniqKey="Nevejan N" first="Nancy" last="Nevejan">Nancy Nevejan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Boon, Nico" sort="Boon, Nico" uniqKey="Boon N" first="Nico" last="Boon">Nico Boon</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Sorgeloos, Patrick" sort="Sorgeloos, Patrick" uniqKey="Sorgeloos P" first="Patrick" last="Sorgeloos">Patrick Sorgeloos</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Bossier, Peter" sort="Bossier, Peter" uniqKey="Bossier P" first="Peter" last="Bossier">Peter Bossier</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author></analytic><series><title level="j" type="main">Veterinary microbiology : (Amsterdam)</title><title level="j" type="abbreviated">Vet. microbiol. : (Amst.)</title><idno type="ISSN">0378-1135</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Veterinary microbiology : (Amsterdam)</title><title level="j" type="abbreviated">Vet. microbiol. : (Amst.)</title><idno type="ISSN">0378-1135</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aeromonas hydrophila</term><term>Aeromonas salmonicida</term><term>Homoserine lactone</term><term>Lota lota</term><term>Quorum sensing</term><term>Veterinary</term><term>Virulence</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Aeromonas hydrophila</term><term>Aeromonas salmonicida</term><term>Lota lota</term><term>Quorum sensing</term><term>Virulence</term><term>Vétérinaire</term><term>Homosérine lactone</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vétérinaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1 N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-L-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-L-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0378-1135</s0></fA01><fA02 i1="01"><s0>VMICDQ</s0></fA02><fA03 i2="1"><s0>Vet. microbiol. : (Amst.)</s0></fA03><fA05><s2>159</s2></fA05><fA06><s2>1-2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae</s1></fA08><fA11 i1="01" i2="1"><s1>NATRAH (F. M. I.)</s1></fA11><fA11 i1="02" i2="1"><s1>IFTAKHARUL ALAM (Md.)</s1></fA11><fA11 i1="03" i2="1"><s1>PAWAR (Sushant)</s1></fA11><fA11 i1="04" i2="1"><s1>SHIRI HARZEVILI (A.)</s1></fA11><fA11 i1="05" i2="1"><s1>NEVEJAN (Nancy)</s1></fA11><fA11 i1="06" i2="1"><s1>BOON (Nico)</s1></fA11><fA11 i1="07" i2="1"><s1>SORGELOOS (Patrick)</s1></fA11><fA11 i1="08" i2="1"><s1>BOSSIER (Peter)</s1></fA11><fA11 i1="09" i2="1"><s1>DEFOIRDT (Tom)</s1></fA11><fA14 i1="01"><s1>Laboratory of Aquaculture & Artemia Reference Center, Ghent University, Rozier 44</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Aquaculture, Faculty of Agriculture, University Putra Malaysia</s1><s2>43400 Serdang, Selangor</s2><s3>MYS</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Coupure Links 653</s1><s2>9000 Gent</s2><s3>BEL</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></fA14><fA20><s1>77-82</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>16884</s2><s5>354000500882030100</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0341098</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Veterinary microbiology : (Amsterdam)</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1 N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-L-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-L-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05B15</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Aeromonas hydrophila</s0><s2>NS</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Aeromonas hydrophila</s0><s2>NS</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Aeromonas hydrophila</s0><s2>NS</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Aeromonas salmonicida</s0><s2>NS</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Aeromonas salmonicida</s0><s2>NS</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Aeromonas salmonicida</s0><s2>NS</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Lota lota</s0><s2>NS</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Lota lota</s0><s2>NS</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Lota lota</s0><s2>NS</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Quorum sensing</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Quorum sensing</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Quorum sensing</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Virulence</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Virulence</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Virulencia</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Vétérinaire</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Veterinary</s0><s5>07</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Veterinario</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homosérine lactone</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Homoserine lactone</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Vibrionaceae</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Vibrionaceae</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Vibrionaceae</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Bactérie</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Bacteria</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Bacteria</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pisces</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Pisces</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Pisces</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fN21><s1>261</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Belgique</li><li>Malaisie</li></country><region><li>Province de Flandre-Orientale</li></region><settlement><li>Gand</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Natrah, F M I" sort="Natrah, F M I" uniqKey="Natrah F" first="F. M. I." last="Natrah">F. M. I. Natrah</name></region><name sortKey="Boon, Nico" sort="Boon, Nico" uniqKey="Boon N" first="Nico" last="Boon">Nico Boon</name><name sortKey="Bossier, Peter" sort="Bossier, Peter" uniqKey="Bossier P" first="Peter" last="Bossier">Peter Bossier</name><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name><name sortKey="Iftakharul Alam, Md" sort="Iftakharul Alam, Md" uniqKey="Iftakharul Alam M" first="Md." last="Iftakharul Alam">Md. Iftakharul Alam</name><name sortKey="Nevejan, Nancy" sort="Nevejan, Nancy" uniqKey="Nevejan N" first="Nancy" last="Nevejan">Nancy Nevejan</name><name sortKey="Pawar, Sushant" sort="Pawar, Sushant" uniqKey="Pawar S" first="Sushant" last="Pawar">Sushant Pawar</name><name sortKey="Shiri Harzevili, A" sort="Shiri Harzevili, A" uniqKey="Shiri Harzevili A" first="A." last="Shiri Harzevili">A. Shiri Harzevili</name><name sortKey="Sorgeloos, Patrick" sort="Sorgeloos, Patrick" uniqKey="Sorgeloos P" first="Patrick" last="Sorgeloos">Patrick Sorgeloos</name></country><country name="Malaisie"><noRegion><name sortKey="Natrah, F M I" sort="Natrah, F M I" uniqKey="Natrah F" first="F. M. I." last="Natrah">F. M. I. Natrah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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