Serveur d'exploration Lota lota

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs).

Identifieur interne : 000658 ( Main/Merge ); précédent : 000657; suivant : 000659

Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs).

Auteurs : Ewa L. Gregoraszczuk [Pologne] ; Katarzyna Milczarek ; Anna K. W Jtowicz ; Vidar Berg ; Janneche U. Skaare ; Erik Ropstad

Source :

RBID : pubmed:18024081

Descripteurs français

English descriptors

Abstract

This study investigated in vitro endocrine disrupting effects of three mixtures of POPs: 'Marine mix' extracted from Atlantic cod liver, and two mixtures extracted from burbot liver, 'Mjøsa mix' and 'Losna mix'. The POP mixtures were chemically characterized. Co-culture of theca and granulosa cells, were exposed for 48h with different doses of 'Marine mix', 'Mjøsa mix' or 'Losna mix'. As an end point cell viability was determinated by LDH test, steroid analysis by EIA and caspase-3 by colorimetric substrate. Chemical characterization of the mixtures demonstrated that the 'Marine mix' contained high levels of DDTs and PCBs. In the 'Mjøsa mix', the dominant pollutants were BDEs and HBCD. The concentrations of POPs measured in the 'Losna mix' were considerably lower. All mixtures used in the present study had a stimulatory effect on testosterone and estradiol secretion with 'Marine mix'>'Mjøsa mix'>'Losna mix'. These results show that even a mixture containing background concentrations of POPs significantly affected steroid secretion. A higher steroidogenic response in low dose ranges, compared with high dose ranges indicated xenobiotic-conditioning hormesis. This could complicate predictions of effects in risk assessments.

DOI: 10.1016/j.reprotox.2007.10.001
PubMed: 18024081

Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:18024081

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs).</title>
<author>
<name sortKey="Gregoraszczuk, Ewa L" sort="Gregoraszczuk, Ewa L" uniqKey="Gregoraszczuk E" first="Ewa L" last="Gregoraszczuk">Ewa L. Gregoraszczuk</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Kraków, Poland. greg@zuk.iz.uj.edu.pl</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Kraków</wicri:regionArea>
<wicri:noRegion>30-060 Kraków</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Milczarek, Katarzyna" sort="Milczarek, Katarzyna" uniqKey="Milczarek K" first="Katarzyna" last="Milczarek">Katarzyna Milczarek</name>
</author>
<author>
<name sortKey="W Jtowicz, Anna K" sort="W Jtowicz, Anna K" uniqKey="W Jtowicz A" first="Anna K" last="W Jtowicz">Anna K. W Jtowicz</name>
</author>
<author>
<name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name>
</author>
<author>
<name sortKey="Skaare, Janneche U" sort="Skaare, Janneche U" uniqKey="Skaare J" first="Janneche U" last="Skaare">Janneche U. Skaare</name>
</author>
<author>
<name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1016/j.reprotox.2007.10.001</idno>
<idno type="RBID">pubmed:18024081</idno>
<idno type="pmid">18024081</idno>
<idno type="wicri:Area/PubMed/Corpus">000098</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000098</idno>
<idno type="wicri:Area/PubMed/Curation">000098</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000098</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000087</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000087</idno>
<idno type="wicri:Area/Ncbi/Merge">000112</idno>
<idno type="wicri:Area/Ncbi/Curation">000112</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000112</idno>
<idno type="wicri:doubleKey">0890-6238:2008:Gregoraszczuk E:steroid:secretion:following</idno>
<idno type="wicri:Area/Main/Merge">000658</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs).</title>
<author>
<name sortKey="Gregoraszczuk, Ewa L" sort="Gregoraszczuk, Ewa L" uniqKey="Gregoraszczuk E" first="Ewa L" last="Gregoraszczuk">Ewa L. Gregoraszczuk</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Kraków, Poland. greg@zuk.iz.uj.edu.pl</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Kraków</wicri:regionArea>
<wicri:noRegion>30-060 Kraków</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Milczarek, Katarzyna" sort="Milczarek, Katarzyna" uniqKey="Milczarek K" first="Katarzyna" last="Milczarek">Katarzyna Milczarek</name>
</author>
<author>
<name sortKey="W Jtowicz, Anna K" sort="W Jtowicz, Anna K" uniqKey="W Jtowicz A" first="Anna K" last="W Jtowicz">Anna K. W Jtowicz</name>
</author>
<author>
<name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name>
</author>
<author>
<name sortKey="Skaare, Janneche U" sort="Skaare, Janneche U" uniqKey="Skaare J" first="Janneche U" last="Skaare">Janneche U. Skaare</name>
</author>
<author>
<name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name>
</author>
</analytic>
<series>
<title level="j">Reproductive toxicology (Elmsford, N.Y.)</title>
<idno type="ISSN">0890-6238</idno>
<imprint>
<date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Animals (MeSH)</term>
<term>Apoptosis (drug effects)</term>
<term>Caspase 3 (metabolism)</term>
<term>Cell Survival (drug effects)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Coculture Techniques (MeSH)</term>
<term>Cod Liver Oil (chemistry)</term>
<term>Cod Liver Oil (toxicity)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Endocrine Disruptors (chemistry)</term>
<term>Endocrine Disruptors (isolation & purification)</term>
<term>Estradiol (metabolism)</term>
<term>Female (MeSH)</term>
<term>Fish Proteins (metabolism)</term>
<term>Gadiformes (MeSH)</term>
<term>Gadus morhua (MeSH)</term>
<term>Gonadal Steroid Hormones (metabolism)</term>
<term>Granulosa Cells (drug effects)</term>
<term>Granulosa Cells (metabolism)</term>
<term>L-Lactate Dehydrogenase (metabolism)</term>
<term>Norway (MeSH)</term>
<term>Progesterone (metabolism)</term>
<term>Risk Assessment (MeSH)</term>
<term>Swine (MeSH)</term>
<term>Theca Cells (drug effects)</term>
<term>Theca Cells (metabolism)</term>
<term>Time Factors (MeSH)</term>
<term>Water Pollutants, Chemical (isolation & purification)</term>
<term>Water Pollutants, Chemical (toxicity)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Animaux (MeSH)</term>
<term>Apoptose (effets des médicaments et des substances chimiques)</term>
<term>Appréciation des risques (MeSH)</term>
<term>Caspase-3 (métabolisme)</term>
<term>Cellules cultivées (MeSH)</term>
<term>Cellules de la granulosa (effets des médicaments et des substances chimiques)</term>
<term>Cellules de la granulosa (métabolisme)</term>
<term>Cellules thécales (effets des médicaments et des substances chimiques)</term>
<term>Cellules thécales (métabolisme)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Gadiformes (MeSH)</term>
<term>Gadus morhua (MeSH)</term>
<term>Hormones sexuelles stéroïdiennes (métabolisme)</term>
<term>Huile de foie de morue (composition chimique)</term>
<term>Huile de foie de morue (toxicité)</term>
<term>L-Lactate dehydrogenase (métabolisme)</term>
<term>Norvège (MeSH)</term>
<term>Oestradiol (métabolisme)</term>
<term>Perturbateurs endocriniens (composition chimique)</term>
<term>Perturbateurs endocriniens (isolement et purification)</term>
<term>Polluants chimiques de l'eau (isolement et purification)</term>
<term>Polluants chimiques de l'eau (toxicité)</term>
<term>Progestérone (métabolisme)</term>
<term>Protéines de poisson (métabolisme)</term>
<term>Relation dose-effet des médicaments (MeSH)</term>
<term>Suidae (MeSH)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Techniques de coculture (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en">
<term>Cod Liver Oil</term>
<term>Endocrine Disruptors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en">
<term>Endocrine Disruptors</term>
<term>Water Pollutants, Chemical</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Caspase 3</term>
<term>Estradiol</term>
<term>Fish Proteins</term>
<term>Gonadal Steroid Hormones</term>
<term>L-Lactate Dehydrogenase</term>
<term>Progesterone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en">
<term>Water Pollutants, Chemical</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Norway</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr">
<term>Huile de foie de morue</term>
<term>Perturbateurs endocriniens</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Apoptosis</term>
<term>Cell Survival</term>
<term>Granulosa Cells</term>
<term>Theca Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr">
<term>Apoptose</term>
<term>Cellules de la granulosa</term>
<term>Cellules thécales</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr">
<term>Perturbateurs endocriniens</term>
<term>Polluants chimiques de l'eau</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Granulosa Cells</term>
<term>Theca Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Caspase-3</term>
<term>Cellules de la granulosa</term>
<term>Cellules thécales</term>
<term>Hormones sexuelles stéroïdiennes</term>
<term>L-Lactate dehydrogenase</term>
<term>Oestradiol</term>
<term>Progestérone</term>
<term>Protéines de poisson</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en">
<term>Cod Liver Oil</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr">
<term>Huile de foie de morue</term>
<term>Polluants chimiques de l'eau</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Cells, Cultured</term>
<term>Coculture Techniques</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Gadiformes</term>
<term>Gadus morhua</term>
<term>Risk Assessment</term>
<term>Swine</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Animaux</term>
<term>Appréciation des risques</term>
<term>Cellules cultivées</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Gadiformes</term>
<term>Gadus morhua</term>
<term>Norvège</term>
<term>Relation dose-effet des médicaments</term>
<term>Suidae</term>
<term>Techniques de coculture</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Norvège</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">This study investigated in vitro endocrine disrupting effects of three mixtures of POPs: 'Marine mix' extracted from Atlantic cod liver, and two mixtures extracted from burbot liver, 'Mjøsa mix' and 'Losna mix'. The POP mixtures were chemically characterized. Co-culture of theca and granulosa cells, were exposed for 48h with different doses of 'Marine mix', 'Mjøsa mix' or 'Losna mix'. As an end point cell viability was determinated by LDH test, steroid analysis by EIA and caspase-3 by colorimetric substrate. Chemical characterization of the mixtures demonstrated that the 'Marine mix' contained high levels of DDTs and PCBs. In the 'Mjøsa mix', the dominant pollutants were BDEs and HBCD. The concentrations of POPs measured in the 'Losna mix' were considerably lower. All mixtures used in the present study had a stimulatory effect on testosterone and estradiol secretion with 'Marine mix'>'Mjøsa mix'>'Losna mix'. These results show that even a mixture containing background concentrations of POPs significantly affected steroid secretion. A higher steroidogenic response in low dose ranges, compared with high dose ranges indicated xenobiotic-conditioning hormesis. This could complicate predictions of effects in risk assessments.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Eau/explor/LotaV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000658 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000658 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Eau
   |area=    LotaV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:18024081
   |texte=   Steroid secretion following exposure of ovarian follicular cells to three different natural mixtures of persistent organic pollutants (POPs).
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:18024081" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a LotaV3 

Wicri

This area was generated with Dilib version V0.6.39.
Data generation: Fri May 20 09:58:26 2022. Site generation: Fri May 20 10:24:07 2022