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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma</title><author><name sortKey="Jean, Didier" sort="Jean, Didier" uniqKey="Jean D" first="Didier" last="Jean">Didier Jean</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Thomas, Emilie" sort="Thomas, Emilie" uniqKey="Thomas E" first="Emilie" last="Thomas">Emilie Thomas</name><affiliation><nlm:aff id="aff3">Ligue Nationale Contre le Cancer, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Manie, Elodie" sort="Manie, Elodie" uniqKey="Manie E" first="Elodie" last="Manié">Elodie Manié</name><affiliation><nlm:aff id="aff4">INSERM, U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Institut Curie, Centre de Recherche, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Renier, Annie" sort="Renier, Annie" uniqKey="Renier A" first="Annie" last="Renier">Annie Renier</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="De Reynies, Aurelien" sort="De Reynies, Aurelien" uniqKey="De Reynies A" first="Aurélien" last="De Reynies">Aurélien De Reynies</name><affiliation><nlm:aff id="aff3">Ligue Nationale Contre le Cancer, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lecomte, Celine" sort="Lecomte, Celine" uniqKey="Lecomte C" first="Céline" last="Lecomte">Céline Lecomte</name><affiliation><nlm:aff id="aff6">Laboratoire d'Ecotoxicology, Université du Havre, UFR de Sciences et Techniques, UPRES-EA3222, Le Havre, France</nlm:aff></affiliation></author><author><name sortKey="Andujar, Pascal" sort="Andujar, Pascal" uniqKey="Andujar P" first="Pascal" last="Andujar">Pascal Andujar</name><affiliation><nlm:aff id="aff7">Service de Pneumologie et de Pathologie Professionnelle, Hôpital Intercommunal de Créteil, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">INSERM, U955, Equipe 4, IMRB, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Faculté de Médecine, Université Paris-Est, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Fleury Feith, Jocelyne" sort="Fleury Feith, Jocelyne" uniqKey="Fleury Feith J" first="Jocelyne" last="Fleury-Feith">Jocelyne Fleury-Feith</name><affiliation><nlm:aff id="aff10">Service d'Histologie et de Biologie Tumorale, AP-HP, GHU Est, Hôpital Tenon, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Université Pierre et Marie Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Galateau Salle, Francoise" sort="Galateau Salle, Francoise" uniqKey="Galateau Salle F" first="Françoise" last="Galateau-Sallé">Françoise Galateau-Sallé</name><affiliation><nlm:aff id="aff12">Service d'Anatomie Pathologique, Hôpital de la Côte de Nacre, Caen, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff13">INSERM, ERI3, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Giovannini, Marco" sort="Giovannini, Marco" uniqKey="Giovannini M" first="Marco" last="Giovannini">Marco Giovannini</name><affiliation><nlm:aff id="aff14">House Ear Institute, Center for Neural Tumor Research, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Stern, Marc Henri" sort="Stern, Marc Henri" uniqKey="Stern M" first="Marc-Henri" last="Stern">Marc-Henri Stern</name><affiliation><nlm:aff id="aff4">INSERM, U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Institut Curie, Centre de Recherche, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jaurand, Marie Claude" sort="Jaurand, Marie Claude" uniqKey="Jaurand M" first="Marie-Claude" last="Jaurand">Marie-Claude Jaurand</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21281820</idno><idno type="pmc">3070549</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070549</idno><idno type="RBID">PMC:3070549</idno><idno type="doi">10.1016/j.ajpath.2010.10.039</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma</title><author><name sortKey="Jean, Didier" sort="Jean, Didier" uniqKey="Jean D" first="Didier" last="Jean">Didier Jean</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Thomas, Emilie" sort="Thomas, Emilie" uniqKey="Thomas E" first="Emilie" last="Thomas">Emilie Thomas</name><affiliation><nlm:aff id="aff3">Ligue Nationale Contre le Cancer, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Manie, Elodie" sort="Manie, Elodie" uniqKey="Manie E" first="Elodie" last="Manié">Elodie Manié</name><affiliation><nlm:aff id="aff4">INSERM, U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Institut Curie, Centre de Recherche, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Renier, Annie" sort="Renier, Annie" uniqKey="Renier A" first="Annie" last="Renier">Annie Renier</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="De Reynies, Aurelien" sort="De Reynies, Aurelien" uniqKey="De Reynies A" first="Aurélien" last="De Reynies">Aurélien De Reynies</name><affiliation><nlm:aff id="aff3">Ligue Nationale Contre le Cancer, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lecomte, Celine" sort="Lecomte, Celine" uniqKey="Lecomte C" first="Céline" last="Lecomte">Céline Lecomte</name><affiliation><nlm:aff id="aff6">Laboratoire d'Ecotoxicology, Université du Havre, UFR de Sciences et Techniques, UPRES-EA3222, Le Havre, France</nlm:aff></affiliation></author><author><name sortKey="Andujar, Pascal" sort="Andujar, Pascal" uniqKey="Andujar P" first="Pascal" last="Andujar">Pascal Andujar</name><affiliation><nlm:aff id="aff7">Service de Pneumologie et de Pathologie Professionnelle, Hôpital Intercommunal de Créteil, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff8">INSERM, U955, Equipe 4, IMRB, Créteil, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff9">Faculté de Médecine, Université Paris-Est, Créteil, France</nlm:aff></affiliation></author><author><name sortKey="Fleury Feith, Jocelyne" sort="Fleury Feith, Jocelyne" uniqKey="Fleury Feith J" first="Jocelyne" last="Fleury-Feith">Jocelyne Fleury-Feith</name><affiliation><nlm:aff id="aff10">Service d'Histologie et de Biologie Tumorale, AP-HP, GHU Est, Hôpital Tenon, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff11">Université Pierre et Marie Curie, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Galateau Salle, Francoise" sort="Galateau Salle, Francoise" uniqKey="Galateau Salle F" first="Françoise" last="Galateau-Sallé">Françoise Galateau-Sallé</name><affiliation><nlm:aff id="aff12">Service d'Anatomie Pathologique, Hôpital de la Côte de Nacre, Caen, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff13">INSERM, ERI3, Caen, France</nlm:aff></affiliation></author><author><name sortKey="Giovannini, Marco" sort="Giovannini, Marco" uniqKey="Giovannini M" first="Marco" last="Giovannini">Marco Giovannini</name><affiliation><nlm:aff id="aff14">House Ear Institute, Center for Neural Tumor Research, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Zucman Rossi, Jessica" sort="Zucman Rossi, Jessica" uniqKey="Zucman Rossi J" first="Jessica" last="Zucman-Rossi">Jessica Zucman-Rossi</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Stern, Marc Henri" sort="Stern, Marc Henri" uniqKey="Stern M" first="Marc-Henri" last="Stern">Marc-Henri Stern</name><affiliation><nlm:aff id="aff4">INSERM, U830, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Institut Curie, Centre de Recherche, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Jaurand, Marie Claude" sort="Jaurand, Marie Claude" uniqKey="Jaurand M" first="Marie-Claude" last="Jaurand">Marie-Claude Jaurand</name><affiliation><nlm:aff id="aff1">INSERM, U674, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Université Paris Descartes, UMR-S674, Paris, France</nlm:aff></affiliation></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed to elucidate the mechanism of mesothelioma formation. Genomic alterations in murine MM have now been partially characterized. To gain insight into the pathophysiology of mesothelioma, 16 murine and 35 human mesotheliomas were characterized by array-comparative genomic hybridization and were screened for common genomic alterations. Alteration of the 9p21 human region, often by biallelic deletion, was the most frequent alteration in both species, in agreement with the <italic>CDKN2A/CDKN2B</italic> locus deletion in human disease and murine models. Other shared aberrations were losses of 1p36.3–p35 and 13q14–q33 and gains of 5p15.3–p13 regions. However, some differences were noted, such as absence of recurrent alterations in mouse regions corresponding to human chromosome 22. Comparison between altered recurrent regions in asbestos-exposed and non–asbestos-exposed patients showed a significant difference in the 14q11.2–q21 region, which was also lost in fiber-induced murine mesothelioma. A correlation was also demonstrated between genomic instability and tumorigenicity of human mesothelioma xenografts in nude mice. Overall, these data show similarities between murine and human disease, and contribute to the understanding of the influence of fibers in the pathogenesis of mesothelioma and validation of the murine model for preclinical testing.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-title-group><journal-title>The American Journal of Pathology</journal-title></journal-title-group><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn><publisher><publisher-name>American Society for Investigative Pathology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21281820</article-id><article-id pub-id-type="pmc">3070549</article-id><article-id pub-id-type="publisher-id">AJPA134</article-id><article-id pub-id-type="doi">10.1016/j.ajpath.2010.10.039</article-id><article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject><subj-group><subject>Tumorigenesis and Neoplastic Progression</subject></subj-group></subj-group></article-categories><title-group><article-title>Syntenic Relationships between Genomic Profiles of Fiber-Induced Murine and Human Malignant Mesothelioma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jean</surname><given-names>Didier</given-names></name><xref rid="aff1" ref-type="aff">⁎</xref><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Emilie</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author"><name><surname>Manié</surname><given-names>Elodie</given-names></name><xref rid="aff4" ref-type="aff">§</xref><xref rid="aff5" ref-type="aff">¶</xref></contrib><contrib contrib-type="author"><name><surname>Renier</surname><given-names>Annie</given-names></name><xref rid="aff1" ref-type="aff">⁎</xref><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>de Reynies</surname><given-names>Aurélien</given-names></name><xref rid="aff3" ref-type="aff">‡</xref></contrib><contrib contrib-type="author"><name><surname>Lecomte</surname><given-names>Céline</given-names></name><xref rid="aff6" ref-type="aff">∥</xref></contrib><contrib contrib-type="author"><name><surname>Andujar</surname><given-names>Pascal</given-names></name><xref rid="aff7" ref-type="aff">⁎⁎</xref><xref rid="aff8" ref-type="aff">††</xref><xref rid="aff9" ref-type="aff">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Fleury-Feith</surname><given-names>Jocelyne</given-names></name><xref rid="aff10" ref-type="aff">§§</xref><xref rid="aff11" ref-type="aff">¶¶</xref></contrib><contrib contrib-type="author"><name><surname>Galateau-Sallé</surname><given-names>Françoise</given-names></name><xref rid="aff12" ref-type="aff">∥∥</xref><xref rid="aff13" ref-type="aff">⁎⁎⁎</xref></contrib><contrib contrib-type="author"><name><surname>Giovannini</surname><given-names>Marco</given-names></name><xref rid="aff14" ref-type="aff">†††</xref></contrib><contrib contrib-type="author"><name><surname>Zucman-Rossi</surname><given-names>Jessica</given-names></name><xref rid="aff1" ref-type="aff">⁎</xref><xref rid="aff2" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>Stern</surname><given-names>Marc-Henri</given-names></name><xref rid="aff4" ref-type="aff">§</xref><xref rid="aff5" ref-type="aff">¶</xref></contrib><contrib contrib-type="author"><name><surname>Jaurand</surname><given-names>Marie-Claude</given-names></name><email>marie-claude.jaurand@inserm.fr</email><xref rid="aff1" ref-type="aff">⁎</xref><xref rid="aff2" ref-type="aff">†</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>⁎</label>INSERM, U674, Paris, France</aff><aff id="aff2"><label>†</label>Université Paris Descartes, UMR-S674, Paris, France</aff><aff id="aff3"><label>‡</label>Ligue Nationale Contre le Cancer, Paris, France</aff><aff id="aff4"><label>§</label>INSERM, U830, Paris, France</aff><aff id="aff5"><label>¶</label>Institut Curie, Centre de Recherche, Paris, France</aff><aff id="aff6"><label>∥</label>Laboratoire d'Ecotoxicology, Université du Havre, UFR de Sciences et Techniques, UPRES-EA3222, Le Havre, France</aff><aff id="aff7"><label>⁎⁎</label>Service de Pneumologie et de Pathologie Professionnelle, Hôpital Intercommunal de Créteil, Créteil, France</aff><aff id="aff8"><label>††</label>INSERM, U955, Equipe 4, IMRB, Créteil, France</aff><aff id="aff9"><label>‡‡</label>Faculté de Médecine, Université Paris-Est, Créteil, France</aff><aff id="aff10"><label>§§</label>Service d'Histologie et de Biologie Tumorale, AP-HP, GHU Est, Hôpital Tenon, Paris, France</aff><aff id="aff11"><label>¶¶</label>Université Pierre et Marie Curie, Paris, France</aff><aff id="aff12"><label>∥∥</label>Service d'Anatomie Pathologique, Hôpital de la Côte de Nacre, Caen, France</aff><aff id="aff13"><label>⁎⁎⁎</label>INSERM, ERI3, Caen, France</aff><aff id="aff14"><label>†††</label>House Ear Institute, Center for Neural Tumor Research, Los Angeles, California</aff><author-notes><corresp id="cor1"><label>⁎</label>Address reprint requests to Marie-Claude Jaurand, Ph.D., INSERM, U674, 27, rue Juliette Dodu, Paris, F-75010, France <email>marie-claude.jaurand@inserm.fr</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2011</year></pub-date><volume>178</volume><issue>2</issue><fpage>881</fpage><lpage>894</lpage><history><date date-type="accepted"><day>21</day><month>10</month><year>2010</year></date></history><permissions><copyright-statement>© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>American Society for Investigative Pathology</copyright-holder></permissions><abstract><p>Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed to elucidate the mechanism of mesothelioma formation. Genomic alterations in murine MM have now been partially characterized. To gain insight into the pathophysiology of mesothelioma, 16 murine and 35 human mesotheliomas were characterized by array-comparative genomic hybridization and were screened for common genomic alterations. Alteration of the 9p21 human region, often by biallelic deletion, was the most frequent alteration in both species, in agreement with the <italic>CDKN2A/CDKN2B</italic> locus deletion in human disease and murine models. Other shared aberrations were losses of 1p36.3–p35 and 13q14–q33 and gains of 5p15.3–p13 regions. However, some differences were noted, such as absence of recurrent alterations in mouse regions corresponding to human chromosome 22. Comparison between altered recurrent regions in asbestos-exposed and non–asbestos-exposed patients showed a significant difference in the 14q11.2–q21 region, which was also lost in fiber-induced murine mesothelioma. A correlation was also demonstrated between genomic instability and tumorigenicity of human mesothelioma xenografts in nude mice. Overall, these data show similarities between murine and human disease, and contribute to the understanding of the influence of fibers in the pathogenesis of mesothelioma and validation of the murine model for preclinical testing.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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