Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro.
Identifieur interne : 000093 ( PubMed/Curation ); précédent : 000092; suivant : 000094Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro.
Auteurs : Bryanna K. Eisner [Canada] ; Jon A. Doering [Canada] ; Shawn C. Beitel [Canada] ; Steve Wiseman [Canada] ; Jason C. Raine [Canada] ; Markus Hecker [Canada]Source :
- Environmental toxicology and chemistry [ 1552-8618 ] ; 2016.
English descriptors
- KwdEn :
- Animal Testing Alternatives, Animals, Benzofurans (toxicity), Cytochrome P-450 CYP1A1 (biosynthesis), Cytochrome P-450 CYP1A1 (genetics), Dioxins (toxicity), Esocidae, Fishes, In Vitro Techniques, Oncorhynchus mykiss, Polychlorinated Biphenyls (toxicity), Risk Assessment, Rivers, Species Specificity, Water Pollutants, Chemical (toxicity).
- MESH :
- chemical , biosynthesis : Cytochrome P-450 CYP1A1.
- chemical , genetics : Cytochrome P-450 CYP1A1.
- chemical , toxicity : Benzofurans, Dioxins, Polychlorinated Biphenyls, Water Pollutants, Chemical.
- Animal Testing Alternatives, Animals, Esocidae, Fishes, In Vitro Techniques, Oncorhynchus mykiss, Risk Assessment, Rivers, Species Specificity.
Abstract
Dioxin-like compounds of varying toxicities are found in complex mixtures. The toxic equivalency factor (TEF) approach was developed based on the potency of a dioxin-like compound relative to the potency of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) to streamline risk assessment. One limitation of the TEF approach is uncertainty regarding differences in the relative potency of dioxin-like compounds among different species. Relative potencies among fishes are limited, relative to relative potencies among birds and mammals, and TEFs for fishes are based entirely on the model species, rainbow trout (Oncorhynchus mykiss). An in vitro liver explant assay was used to characterize species-specific responses with regard to up-regulation of CYP1A transcript after exposure to 6 dioxin-like compounds in rainbow trout, white sturgeon (Acipenser transmontanus), lake sturgeon (Acipenser fulvescens), and northern pike (Esox lucius). Differences in sensitivities were observed among species after exposure to dioxin-like compounds. The relative potencies developed from liver explants of rainbow trout were comparable to relative potencies developed from embryo toxicity assays. Differences in relative potencies between species with the least and greatest relative potencies were up to 40-fold. To compare relative potencies among species, concentrations of dioxin-like compounds in fish eggs in the Fraser River and in Lake Ontario were used to calculate toxic equivalency quotients (TEQs) determined from TEFs or TCDD equivalents determined from relative potencies. The TEQs underestimated TCDD equivalents for white sturgeon, lake sturgeon, and northern pike, indicating uncertainty in application of TEFs to diverse fishes.
DOI: 10.1002/etc.3173
PubMed: 26202062
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Eisner</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Undergraduate Program, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Undergraduate Program, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Doering, Jon A" sort="Doering, Jon A" uniqKey="Doering J" first="Jon A" last="Doering">Jon A. Doering</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Beitel, Shawn C" sort="Beitel, Shawn C" uniqKey="Beitel S" first="Shawn C" last="Beitel">Shawn C. Beitel</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Wiseman, Steve" sort="Wiseman, Steve" uniqKey="Wiseman S" first="Steve" last="Wiseman">Steve Wiseman</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Raine, Jason C" sort="Raine, Jason C" uniqKey="Raine J" first="Jason C" last="Raine">Jason C. Raine</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author><author><name sortKey="Hecker, Markus" sort="Hecker, Markus" uniqKey="Hecker M" first="Markus" last="Hecker">Markus Hecker</name><affiliation wicri:level="1"><nlm:affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Environmental toxicology and chemistry</title><idno type="eISSN">1552-8618</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal Testing Alternatives</term><term>Animals</term><term>Benzofurans (toxicity)</term><term>Cytochrome P-450 CYP1A1 (biosynthesis)</term><term>Cytochrome P-450 CYP1A1 (genetics)</term><term>Dioxins (toxicity)</term><term>Esocidae</term><term>Fishes</term><term>In Vitro Techniques</term><term>Oncorhynchus mykiss</term><term>Polychlorinated Biphenyls (toxicity)</term><term>Risk Assessment</term><term>Rivers</term><term>Species Specificity</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytochrome P-450 CYP1A1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP1A1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Benzofurans</term><term>Dioxins</term><term>Polychlorinated Biphenyls</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animal Testing Alternatives</term><term>Animals</term><term>Esocidae</term><term>Fishes</term><term>In Vitro Techniques</term><term>Oncorhynchus mykiss</term><term>Risk Assessment</term><term>Rivers</term><term>Species Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dioxin-like compounds of varying toxicities are found in complex mixtures. The toxic equivalency factor (TEF) approach was developed based on the potency of a dioxin-like compound relative to the potency of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) to streamline risk assessment. One limitation of the TEF approach is uncertainty regarding differences in the relative potency of dioxin-like compounds among different species. Relative potencies among fishes are limited, relative to relative potencies among birds and mammals, and TEFs for fishes are based entirely on the model species, rainbow trout (Oncorhynchus mykiss). An in vitro liver explant assay was used to characterize species-specific responses with regard to up-regulation of CYP1A transcript after exposure to 6 dioxin-like compounds in rainbow trout, white sturgeon (Acipenser transmontanus), lake sturgeon (Acipenser fulvescens), and northern pike (Esox lucius). Differences in sensitivities were observed among species after exposure to dioxin-like compounds. The relative potencies developed from liver explants of rainbow trout were comparable to relative potencies developed from embryo toxicity assays. Differences in relative potencies between species with the least and greatest relative potencies were up to 40-fold. To compare relative potencies among species, concentrations of dioxin-like compounds in fish eggs in the Fraser River and in Lake Ontario were used to calculate toxic equivalency quotients (TEQs) determined from TEFs or TCDD equivalents determined from relative potencies. The TEQs underestimated TCDD equivalents for white sturgeon, lake sturgeon, and northern pike, indicating uncertainty in application of TEFs to diverse fishes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26202062</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>16</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1552-8618</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Environmental toxicology and chemistry</Title><ISOAbbreviation>Environ. Toxicol. Chem.</ISOAbbreviation></Journal><ArticleTitle>Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro.</ArticleTitle><Pagination><MedlinePgn>173-81</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/etc.3173</ELocationID><Abstract><AbstractText>Dioxin-like compounds of varying toxicities are found in complex mixtures. The toxic equivalency factor (TEF) approach was developed based on the potency of a dioxin-like compound relative to the potency of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) to streamline risk assessment. One limitation of the TEF approach is uncertainty regarding differences in the relative potency of dioxin-like compounds among different species. Relative potencies among fishes are limited, relative to relative potencies among birds and mammals, and TEFs for fishes are based entirely on the model species, rainbow trout (Oncorhynchus mykiss). An in vitro liver explant assay was used to characterize species-specific responses with regard to up-regulation of CYP1A transcript after exposure to 6 dioxin-like compounds in rainbow trout, white sturgeon (Acipenser transmontanus), lake sturgeon (Acipenser fulvescens), and northern pike (Esox lucius). Differences in sensitivities were observed among species after exposure to dioxin-like compounds. The relative potencies developed from liver explants of rainbow trout were comparable to relative potencies developed from embryo toxicity assays. Differences in relative potencies between species with the least and greatest relative potencies were up to 40-fold. To compare relative potencies among species, concentrations of dioxin-like compounds in fish eggs in the Fraser River and in Lake Ontario were used to calculate toxic equivalency quotients (TEQs) determined from TEFs or TCDD equivalents determined from relative potencies. The TEQs underestimated TCDD equivalents for white sturgeon, lake sturgeon, and northern pike, indicating uncertainty in application of TEFs to diverse fishes.</AbstractText><CopyrightInformation>© 2015 SETAC.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eisner</LastName><ForeName>Bryanna K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Toxicology Undergraduate Program, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doering</LastName><ForeName>Jon A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Toxicology Graduate Program, University of Saskatchewan, Saskatoon, Saskatoon, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beitel</LastName><ForeName>Shawn C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Toxicology Graduate Program, University of Saskatchewan, Saskatoon, Saskatoon, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiseman</LastName><ForeName>Steve</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raine</LastName><ForeName>Jason C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hecker</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of the Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Environ Toxicol Chem</MedlineTA><NlmUniqueID>8308958</NlmUniqueID><ISSNLinking>0730-7268</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001572">Benzofurans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004147">Dioxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>8U54U639VI</RegistryNumber><NameOfSubstance UI="C023614">dibenzofuran</NameOfSubstance></Chemical><Chemical><RegistryNumber>DFC2HB4I0K</RegistryNumber><NameOfSubstance UI="D011078">Polychlorinated Biphenyls</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber><NameOfSubstance UI="D019363">Cytochrome P-450 CYP1A1</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000826" MajorTopicYN="N">Animal Testing Alternatives</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001572" MajorTopicYN="N">Benzofurans</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019363" MajorTopicYN="N">Cytochrome P-450 CYP1A1</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004147" MajorTopicYN="N">Dioxins</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017859" MajorTopicYN="N">Esocidae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005399" MajorTopicYN="Y">Fishes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017686" MajorTopicYN="N">Oncorhynchus mykiss</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011078" MajorTopicYN="N">Polychlorinated Biphenyls</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045483" MajorTopicYN="N">Rivers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alternative testing methods</Keyword><Keyword MajorTopicYN="N">Risk assessment</Keyword><Keyword MajorTopicYN="N">Species differences</Keyword><Keyword MajorTopicYN="N">TEFs</Keyword><Keyword MajorTopicYN="N">Toxic equivalency factors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26202062</ArticleId><ArticleId 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